Cell culture oxygen utilization as orthogonal measure of biomass for feed control

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Lucy: Navigating a Jupiter Trojan Tour

In January 2017, NASA selected the Lucy mission to explore six Jupiter Trojan asteroids. These six bodies, remnants of the primordial material that formed the outer planets, were captured in the Sun-Jupiter L4 and L5 Lagrangian regions early in the solar system formation. These particular bodies were chosen because of their diverse spectral properties and the chance to observe up close for the first time two orbiting approximately equal mass binaries, Patroclus and Menoetius. KinetX, Inc. is the primary navigation supplier for the Lucy mission. This paper describes preliminary navigation analyses of the approach phase for each Trojan encounter

Effect of Intensive Training on Mood With No Effect on Brain-Derived Neurotrophic Factor

Purpose Monitoring mood state is a useful tool for avoiding non-functional overreaching (NFOR). Brain derived neurotrophic factor (BDNF) is implicated in stress-related mood disorders. The purpose of the present study was to investigate the impact of intensified training-induced mood disturbance on plasma BDNF concentrations at rest and in response to exercise.  Methods Eight cyclists performed 1 week of normal (NT), 1 week of intensified (INT) and 1 week of recovery (REC) training. Fasted blood samples were collected before and after exercise, on day 7 of each training week and were analyzed for plasma BDNF and cortisol concentrations. A 24-item Profile Of Mood State questionnaire was administered on day 7 of each training week and global mood score (GMS) was calculated. Results Time trial performance was impaired during INT (p=0.01) and REC (p=0.02) compared with NT. Basal plasma cortisol (NT=153±16 ng/ml, INT=130±11 ng/ml, REC=150±14 ng/ml) and BDNF (NT=484±122 pg/ml, INT=488±122 pg/ml, REC=383±56 pg/ml) concentrations were similar between training conditions. Likewise, similar exercise-induced increases in cortisol and BDNF concentrations were observed between training conditions. GMS was 32% greater during INTvs.NT (P<0.001). Conclusion Consistent with a state of functional overreaching (FOR), impairments in performance and mood state with INT were restored after one week of REC. These results support evidence that mood changes before plasma BDNF concentrations as a biochemical marker of FOR and that cortisol is not a useful marker for predicting FOR

Flares, Rotation, Activity Cycles and a Magnetic Star-Planet Interaction Hypothesis for the Far Ultraviolet Emission of GJ 436

Variability in the far ultraviolet (FUV) emission produced by stellar activity affects photochemistry and heating in orbiting planetary atmospheres. We present a comprehensive analysis of the FUV variability of GJ 436, a field-age, M2.5V star ($P_\mathrm{rot}\approx44$ d) orbited by a warm, Neptune-size planet ($M \approx 25\ M_\oplus$, $R \approx 4.1\ R_\oplus$, $P_\mathrm{orb}\approx2.6$ d). Observations at three epochs from 2012 to 2018 span nearly a full activity cycle, sample two rotations of the star and two orbital periods of the planet, and reveal a multitude of brief flares. Over 2012-2018, the star's $7.75\pm0.10$ yr activity cycle produced the largest observed variations, $38\pm3$% in the summed flux of major FUV emission lines. In 2018, variability due to rotation was $8\pm2$%. An additional $11\pm1$% scatter at 10 min cadence, treated as white noise in fits, likely has both instrumental and astrophysical origins. Flares increased time-averaged emission by 15% over the 0.88 d of cumulative exposure, peaking as high as 25$\times$ quiescence. We interpret these flare values as lower limits given that flares too weak or too infrequent to have been observed likely exist. GJ 436's flare frequency distribution (FFD) at FUV wavelengths is unusual compared to other field-age M dwarfs, exhibiting a statistically-significant dearth of high energy ($>4\times 10^{28}$ erg) events that we hypothesize to be the result of a magnetic star-planet interaction (SPI) triggering premature flares. If an SPI is present, GJ 436 b's magnetic field strength must be $\lesssim$100 G to explain the statistically insignificant increase in orbit-phased FUV emission.Comment: 18 pages, 9 figures, accepted to the Astronomical Journa

Beyond prejudice: Are negative evaluations the problem and is getting us to like one another more the solution?

publication-status: Acceptedtypes: ArticleThis is a post print version of an article published in Behavioral and Brain Sciences, 2012, 35 (6), pp 438-439 DOI: http://dx.doi.org/10.1017/S0140525X12001252 Copyright © Cambridge University Press 2012For most of the history of prejudice research, negativity has been treated as its emotional and cognitive signature, a conception that continues to dominate work on the topic. By this definition, prejudice occurs when we dislike or derogate members of other groups. Recent research, however, has highlighted the need for a more nuanced and ‘inclusive’ (Eagly 2004) perspective on the role of intergroup emotions and beliefs in sustaining discrimination. On the one hand, several independent lines of research have shown that unequal intergroup relations are often marked by attitudinal complexity, with positive responses such as affection and admiration mingling with negative responses such as contempt and resentment. Simple antipathy is the exception rather than the rule. On the other hand, there is mounting evidence that nurturing bonds of affection between the advantaged and the disadvantaged sometimes entrenches rather than disrupts wider patterns of discrimination. Notably, prejudice reduction interventions may have ironic effects on the political attitudes of the historically disadvantaged, decreasing their perceptions of injustice and willingness to engage in collective action to transform social inequalities. These developments raise a number of important questions. Has the time come to challenge the assumption that negative evaluations are inevitably the cognitive and affective hallmarks of discrimination? Is the orthodox concept of prejudice in danger of side-tracking, if not obstructing, progress towards social justice in a fuller sense? What are the prospects for reconciling a prejudice reduction model of change, designed to get people to like one another more, with a collective action model of change, designed to ignite struggles to achieve intergroup equality

IL-6 Mediated Degeneration of Forebrain GABAergic Interneurons and Cognitive Impairment in Aged Mice through Activation of Neuronal NADPH Oxidase

BACKGROUND:Multiple studies have shown that plasma levels of the pro-inflammatory cytokine interleukin-6 (IL-6) are elevated in patients with important and prevalent adverse health conditions, including atherosclerosis, diabetes, obesity, obstructive sleep apnea, hypertension, and frailty. Higher plasma levels of IL-6, in turn, increase the risk of many conditions associated with aging including age-related cognitive decline. However, the mechanisms underlying this association between IL-6 and cognitive vulnerability remain unclear. METHODS AND FINDINGS:We investigated the role of IL-6 in brain aging in young (4 mo) and aged (24 mo) wild-type C57BL6 and genetically-matched IL-6(-/-) mice, and determined that IL-6 was necessary and sufficient for increased neuronal expression of the superoxide-producing immune enzyme, NADPH-oxidase, and this was mediated by non-canonical NFkappaB signaling. Furthermore, superoxide production by NADPH-oxidase was directly responsible for age-related loss of parvalbumin (PV)-expressing GABAergic interneurons, neurons essential for normal information processing, encoding, and retrieval in hippocampus and cortex. Targeted deletion of IL-6 or elimination of superoxide by chronic treatment with a superoxide-dismutase mimetic prevented age-related loss of PV-interneurons and reversed age-related cognitive deficits on three standard tests of spatial learning and recall. CONCLUSIONS:Present results indicate that IL-6 mediates age-related loss of critical PV-expressing GABAergic interneurons through increased neuronal NADPH-oxidase-derived superoxide production, and that rescue of these interneurons preserves cognitive performance in aging mice, suggesting that elevated peripheral IL-6 levels may be directly and mechanistically linked to long-lasting cognitive deficits in even normal older individuals. Further, because PV-interneurons are also selectively affected by commonly used anesthetic agents and drugs, our findings imply that IL-6 levels may predict adverse CNS effects in older patients exposed to these compounds through specific derangements in inhibitory interneurons, and that therapies directed at lowering IL-6 may have cognitive benefits clinically

An ultrahot Neptune in the Neptune desert

About 1 out of 200 Sun-like stars has a planet with an orbital period shorter than one day: an ultrashort-period planet. All of the previously known ultrashort-period planets are either hot Jupiters, with sizes above 10 Earth radii (R⊕), or apparently rocky planets smaller than 2 R⊕. Such lack of planets of intermediate size (the ‘hot Neptune desert’) has been interpreted as the inability of low-mass planets to retain any hydrogen/helium (H/He) envelope in the face of strong stellar irradiation. Here we report the discovery of an ultrashort-period planet with a radius of 4.6 R⊕ and a mass of 29 M⊕, firmly in the hot Neptune desert. Data from the Transiting Exoplanet Survey Satellite revealed transits of the bright Sun-like star LTT 9779 every 0.79 days. The planet’s mean density is similar to that of Neptune, and according to thermal evolution models, it has a H/He-rich envelope constituting 9.0^(+2.7)_(−2.9)% of the total mass. With an equilibrium temperature around 2,000 K, it is unclear how this ‘ultrahot Neptune’ managed to retain such an envelope. Follow-up observations of the planet’s atmosphere to better understand its origin and physical nature will be facilitated by the star’s brightness (V_(mag) = 9.8)

PANC Study (Pancreatitis: A National Cohort Study): national cohort study examining the first 30 days from presentation of acute pancreatitis in the UK

Abstract Background Acute pancreatitis is a common, yet complex, emergency surgical presentation. Multiple guidelines exist and management can vary significantly. The aim of this first UK, multicentre, prospective cohort study was to assess the variation in management of acute pancreatitis to guide resource planning and optimize treatment. Methods All patients aged greater than or equal to 18 years presenting with acute pancreatitis, as per the Atlanta criteria, from March to April 2021 were eligible for inclusion and followed up for 30 days. Anonymized data were uploaded to a secure electronic database in line with local governance approvals. Results A total of 113 hospitals contributed data on 2580 patients, with an equal sex distribution and a mean age of 57 years. The aetiology was gallstones in 50.6 per cent, with idiopathic the next most common (22.4 per cent). In addition to the 7.6 per cent with a diagnosis of chronic pancreatitis, 20.1 per cent of patients had a previous episode of acute pancreatitis. One in 20 patients were classed as having severe pancreatitis, as per the Atlanta criteria. The overall mortality rate was 2.3 per cent at 30 days, but rose to one in three in the severe group. Predictors of death included male sex, increased age, and frailty; previous acute pancreatitis and gallstones as aetiologies were protective. Smoking status and body mass index did not affect death. Conclusion Most patients presenting with acute pancreatitis have a mild, self-limiting disease. Rates of patients with idiopathic pancreatitis are high. Recurrent attacks of pancreatitis are common, but are likely to have reduced risk of death on subsequent admissions. </jats:sec

Open source software package using a semi-empirical mesh-grid method for the modeling of germanium detector efficiencies

textTraditional approaches in gamma-ray spectroscopy for determining the absolute full-energy peak efficiencies of germanium detectors are primarily either too time consuming or not economically viable. In addition, these approaches are difficult to use for arbitrary source shapes and counting geometries. An open source software package, KMESS (Kevin's Mesh Efficiency Simulator Software), was developed to address these problems. KMESS uses a new semi-empirical mesh-grid method to predict the absolute full-energy peak efficiencies of n- and p-type germanium detectors in both coaxial and closed-ended configurations. The model assumes that any gamma-ray source shape can be treated as a collection of point sources. The code was written in a modular form, making it easy to adapt for other detector configurations and materials. A suite of webbased graphical front-end tools was also developed to make the execution of KMESS user-friendly. KMESS can predict most full-energy peak efficiencies to within 10% accuracy for the energy range 100-1800 keV in less than 10 minutes.Mechanical Engineerin