301 research outputs found
Prearchaic land use in Grass Valley, Nevada: A novel statistical implementation of optimal distribution modeling
posterUsing Prearchaic (PA) sites in Grass Valley, NV (Fig. 1), this project investigates (i) environmental factors driving variation in PA settlement and (ii) geomorphological factors driving variation in PA surface visibility. Building on previous research [1,2], we evaluate variables using Ideal Free Distribution [3] and Maximum Entropy (MaxEnt) [4]
Numic fires: modeling the effects of anthropogenic fire on foraging decisions in the Great Basin
PosterAcross Western North America, hunter-gatherers modified their surrounding environment with the application of fire (1; 11; 15). However, to date we lack a general theoretical framework to investigate the reasons why people would burn or its effects on traditional foraging economies. To begin to fill in these gaps, here we examine the immediate benefits fire may provide in the context of driving rabbits in shrubland ecosystems across the ethnographic Great Basin occupied by Numic speaking foragers. Poster for the Society for American Archaeology 80th Annual Meeting, San Francisco, CA (2015)
The Lantern Vol. 6, No. 2, March 1938
âą Among Our Contributors âą Of Special Interest To You! âą Jenny Lee âą The Arguments Against Isolation âą The Note âą Visit of the Grandchildren âą One Finds God âą To The North Lies New Hampshire âą The Two Camps in Washington âą Substitutes âą At Times It Seems So Very Strange âą Episode on a Lake Shore âą My Campus Song âą Irony âą A Chinese Mysteryhttps://digitalcommons.ursinus.edu/lantern/1017/thumbnail.jp
The Lantern Vol. 6, No. 1, December 1937
âą After Thinking Things Over âą Ho! Ho! The Mistletoe! âą Unrealized Dreams âą Two Preeminent Victorians âą The Thing âą Progression âą It Wasn\u27t in the Lines âą He Was the Most Perfect Man âą College (C)lasses âą Robins and Roses âą The Commuter âą When the Rose is Dead âą Truth in Print âą Alias Mike Romanoff âą Winslow Homer âą When I Was Young âą Maurice Evans, a Great Shakespearean âą Among Our Contributors âą Of Manx and Man âą A Sanguinary Pirate âą Conversation Has an Adventure âą Ursinus\u27 Neediest Casehttps://digitalcommons.ursinus.edu/lantern/1016/thumbnail.jp
The Lantern Vol. 5, No. 3, May 1937
âą Dedication âą Dr. McClure: An Ursinus Man âą Roar, O Wind! âą To the Ladies! âą The Futility of Dying âą The Symbolism of the British Crown âą Oh! âą It Might Have Been âą Treat Yourself? âą Three Writers âą Hawaii in June âą On Being a Twin âą Black Magic âą Triangle âą Who Longs? âą A Son Passes âą Sing an Old-Fashioned Song âą Questioning âą An Argument About a Fish âą That Morning Eye-Opener âą Scoop for the Sun âą The Dead Do Not Die Once âą Give Us Timehttps://digitalcommons.ursinus.edu/lantern/1010/thumbnail.jp
Identification of Class I HLA T Cell Control Epitopes for West Nile Virus
The recent West Nile virus (WNV) outbreak in the United States underscores the importance of understanding human immune responses to this pathogen. Via the presentation of viral peptide ligands at the cell surface, class I HLA mediate the T cell recognition and killing of WNV infected cells. At this time, there are two key unknowns in regards to understanding protective T cell immunity: 1) the number of viral ligands presented by the HLA of infected cells, and 2) the distribution of T cell responses to these available HLA/viral complexes. Here, comparative mass spectroscopy was applied to determine the number of WNV peptides presented by the HLA-A*11:01 of infected cells after which T cell responses to these HLA/WNV complexes were assessed. Six viral peptides derived from capsid, NS3, NS4b, and NS5 were presented. When T cells from infected individuals were tested for reactivity to these six viral ligands, polyfunctional T cells were focused on the GTL9 WNV capsid peptide, ligands from NS3, NS4b, and NS5 were less immunogenic, and two ligands were largely inert, demonstrating that class I HLA reduce the WNV polyprotein to a handful of immune targets and that polyfunctional T cells recognize infections by zeroing in on particular HLA/WNV epitopes. Such dominant HLA/peptide epitopes are poised to drive the development of WNV vaccines that elicit protective T cells as well as providing key antigens for immunoassays that establish correlates of viral immunity. © 2013 Kaabinejadian et al
Melanoma staging: Evidenceâbased changes in the American Joint Committee on Cancer eighth edition cancer staging manual
Answer questions and earn CME/CNETo update the melanoma staging system of the American Joint Committee on Cancer (AJCC) a large database was assembled comprising >46,000 patients from 10 centers worldwide with stages I, II, and III melanoma diagnosed since 1998. Based on analyses of this new database, the existing seventh edition AJCC stage IV database, and contemporary clinical trial data, the AJCC Melanoma Expert Panel introduced several important changes to the Tumor, Nodes, Metastasis (TNM) classification and stage grouping criteria. Key changes in the eighth edition AJCC Cancer Staging Manual include: 1) tumor thickness measurements to be recorded to the nearest 0.1 mm, not 0.01 mm; 2) definitions of T1a and T1b are revised (T1a, <0.8 mm without ulceration; T1b, 0.8â1.0 mm with or without ulceration or <0.8 mm with ulceration), with mitotic rate no longer a T category criterion; 3) pathological (but not clinical) stage IA is revised to include T1b N0 M0 (formerly pathologic stage IB); 4) the N category descriptors âmicroscopicâ and âmacroscopicâ for regional node metastasis are redefined as âclinically occultâ and âclinically apparentâ; 5) prognostic stage III groupings are based on N category criteria and T category criteria (ie, primary tumor thickness and ulceration) and increased from 3 to 4 subgroups (stages IIIAâIIID); 6) definitions of N subcategories are revised, with the presence of microsatellites, satellites, or inâtransit metastases now categorized as N1c, N2c, or N3c based on the number of tumorâinvolved regional lymph nodes, if any; 7) descriptors are added to each M1 subcategory designation for lactate dehydrogenase (LDH) level (LDH elevation no longer upstages to M1c); and 8) a new M1d designation is added for central nervous system metastases. This evidenceâbased revision of the AJCC melanoma staging system will guide patient treatment, provide better prognostic estimates, and refine stratification of patients entering clinical trials. CA Cancer J Clin 2017;67:472â492. © 2017 American Cancer Society.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/139981/1/caac21409_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/139981/2/caac21409-sup-0001-suppinfo01.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/139981/3/caac21409.pd
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals, we identified 35 common variant loci associated with QT interval that collectively explain âŒ8-10% of QT-interval variation and highlight the importance of calcium regulation in myocardial repolarization. Rare variant analysis of 6 new QT interval-associated loci in 298 unrelated probands with LQTS identified coding variants not found in controls but of uncertain causality and therefore requiring validation. Several newly identified loci encode proteins that physically interact with other recognized repolarization proteins. Our integration of common variant association, expression and orthogonal protein-protein interaction screens provides new insights into cardiac electrophysiology and identifies new candidate genes for ventricular arrhythmias, LQTS and SCD
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