AS COMPETIÇÕES INFANTOJUVENIS À LUZ DA PEDAGOGIA DO ESPORTE

O presente artigo de revisão objetiva estabelecer quais categorias são essenciais à um modelo de competição esportiva infantojuvenil. A coleta de dados foi realizada em quatro fases: 1) Identificação das fontes; 2) Compilação; 3) Fichamento; e 4) Análise e interpretação. Os resultados apontam para duas categorias pilares do modelo competitivo infantojuvenil: a) A competição enquanto elemento estruturante da formação integral do indivíduo e b) A competição de acordo com as possibilidades e expectativas do público infantojuvenil. Verificada a carência de estudos na área, espera-se que esta pesquisa fomente o desenvolvimento de estudos empíricos para identificar necessidades específicas de cada modalidade

Manifestações psiquiátricas na reumatologia: uma revisão sistemática / Psychiatric manifestations in rheumatology: a systematic review

Doenças reumatológicas, são doenças crônicas que geralmente apresentam múltiplas causas. São representadas principalmente pela artrite reumatoide e lúpus eritematoso sistêmico. Sabe-se, no entanto, que existe uma ligação entre os processos autoimunes subjacentes às doenças reumáticas e aos transtornos mentais. O objetivo desta revisão foi avaliar as manifestações psiquiátricas em pacientes com condições reumatológicas. Uma busca sistemática na literatura foi realizada, nos portais BIREME e PubMed de estudos publicados nos últimos 10 anos. A busca foi realizada utilizando descritores em português e seus correspondentes em inglês: “artrite reumatoide”, “lúpus eritematoso sistêmico”, “esclerose sistêmica” e “síndrome de Sjögren” e “manifestações psiquiátricas”. Os artigos que foram incluídos após leitura na íntegra, tiveram seus dados coletados em instrumento padronizado e elaborado antes do início da busca. foram identificados e adicionados através da estratégia de busca 14 artigos. Ansiedade, depressão, incapacidade cognitiva e insônia estão entre as manifestações psiquiátricas mais prevalentes. A frequente presença de manifestações psiquiátricas na reumatologia acende um alerta entre os profissionais para priorizar a qualidade de vida de seus pacientes, reduzindo suas limitações

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear understanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5,6,7 vast areas of the tropics remain understudied.8,9,10,11 In the American tropics, Amazonia stands out as the world's most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepresented in biodiversity databases.13,14,15 To worsen this situation, human-induced modifications16,17 may eliminate pieces of the Amazon's biodiversity puzzle before we can use them to understand how ecological communities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple organism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region's vulnerability to environmental change. 15%–18% of the most neglected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lost

Role of miRNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer

Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic miRNAs and downregulated tumour-suppressor miRNAs in this type of cancer. In this review, we provide an overview of the role of miRNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. Moreover, we discuss the influence of polymorphisms and epigenetic modifications on miRNA activity.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fed Univ Para, Hosp Univ Joao de Barros Barreto, Nucleo Pesquisas Oncol, 2 Piso UNACON,Av Mundurucus, BR-66073000 Belem, PA, BrazilUniv Fed Sao Paulo, Dept Morfol & Genet, Disciplina Genet, BR-04021001 Sao Paulo, BrazilFed Univ Para, Lab Citogenet Humana, Inst Ciencias Biol, BR-66073000 Belem, PA, BrazilDisciplina de Genética, Departamento de Morfologia e Genética, Universidade Federal de São Paulo, São Paulo 04021-001, BrazilWeb of Scienc