Dermot Bolger and the Dual Carriageway

Kearney Colbert. Dermot Bolger and the Dual Carriageway. In: Études irlandaises, Hors-Série 1994. L'Irlande aujourd'hui / Ireland Today pp. 25-39

L'influence de l'hellénisme dans l'oeuvre de William Butler Yeats (de Platon à Homère)

Ces travaux ont pour but d'analyser l'influence de l' Hellénisme dans l'œuvre de William Butler Yeats, dans la limite comprise entre la Grèce archaïque et le cinquième siècle avant Jésus Christ. Cette influence s'est exercée dans deux domaines différents, la philosophie et la littérature. Nous commençons notre étude en posant un dilemme philosophique avec deux chapitres dans lesquels nous opposons les thèmes Platoniciens récurrents dans l'œuvre de Yeats, dans le second nous posons le rejet possible de cette main mise de Platon dans l'esprit de l'auteur. Dans notre seconde partie, nous procédons à une étude de la poésie de Yeats et de sa filiation grecque, tout d'abord dans le domaine mythologique, élégiaque et lyrique, puis dans le domaine de l'épopée avec l'influence d'Homère. Notre troisième partie est consacrée à la tragédie, Yeats ayant développé une forme de théâtre très semblable à la tragédie grecque attique. Nous concluons ce travail sur une note de réconciliation concernant l'affrontement traditionnel entre le héros et le saint dans la pensée de Yeats.This dissertation aims at analysing the influence of Hellenism in William Butler Yeats's work within the framework of archaic Greece and the fifth century B. C. The filiations between Yeats and the Greeks can be noticed in two different realms of study: firstly philosophy, secondly literature. Our first part shall deal with philosophy, stating the initial dilemma in Yeats's thought: that of Plato's ascendancy and the poet's possible rejection of it in his middle years. In our second part, we shall study the mythological and literary similarities between Yeats's poetry and that of the Greek world, stressing the importance of Homer in particular. Our third part shall be devoted to Attic tragedy, Yeats having clearly been inspired by the three Greek playwrights. Lastly, a fourth development shall consist in reasserting Plato's hold on Yeats's thoughts through a reassessment of the poet's own system which is set out in A Vision. We end on a note of reconciliation concerning the famous Yeatsian dichotomy between hero and saint.RENNES2-BU Centrale (352382101) / SudocSudocFranceF

Necroptotic cell death in anti-cancer therapy

Necroptosis is one the best-characterized forms of regulated necrosis. Necroptosis is mediated by the kinase activities of receptor interacting protein kinase-1 and receptor interacting protein kinase-3, which eventually lead to the activation of mixed lineage kinase domain-like. Necroptosis is characterized by rapid permeabilization of the plasma membrane, which is associated with the release of the cell content and subsequent exposure of damage-associated molecular patterns (DAMPs) and cytokines/chemokines. This release underlies the immunogenic nature of necroptotic cancer cells and their ability to induce efficient anti-tumor immunity. Triggering necroptosis has become especially important in experimental cancer treatments as an alternative to triggering apoptosis because one of the hallmarks of cancer is the blockade or evasion of apoptosis. In this review, we discuss recent advances in necroptosis research and the functional consequences of necroptotic cancer cell death, with focus on its immunogenicity and its role in the activation of anti-tumor immunity. Next, we discuss the molecular mechanisms of phosphatidylserine exposure during necroptosis and its role in the recognition of necroptotic cells. We also highlight the complex role of the necroptotic pathway in tumor promotion and suppression and in metastasis. Future studies will show whether necroptosis is truly a better strategy to overcome apoptosis resistance and provide the insights needed for development of novel treatment strategies for cancer