26 research outputs found
Black Demands at Denison: an Alumni View, by Rick Kean \u2766
Black Demands at Denison: an Alumni View, by Rick Kean \u276
Exile Vol. XI No. 2
FICTION
Don\u27t Break Bread with Strangers by Thomas Getz 5-12
Story by Kathy Swiger 17-20
The Last of the Flag Pole Sitters 25-29
POETRY
Muttering: A Letter by Gretchen Schenk 14-15
Poem by Jane Pearson 20
Marina in March by Karen Combs 21
of the pope too slow in recovery by Bill C. West Jr. 22
Poem by Jim Nichols 23
Poem by Judy Strange 23
Haiku by Bonnie Bishop 29
ART
Pen and Ink by Dan Thaxton 4
Linocut by Richard Machlan 13
Etching by Lynne Wiley 16
Woodcut by Lela Giles 22
Charcoal by Carol Kubie 2
Synthesis of 5,6-dideoxy-6-phosphono-d-arabino-hexose, an isosteric phosphonate analogue of d-arabinose 5-phosphate
Dataset for: High resolution studies of hydride transfer in the ferredoxin:NADP+ reductase superfamily
Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme best known for catalyzing the transfer of electrons from ferredoxin (Fd) to NADP+ to make NADPH during photosynthesis. It is also the prototype for a broad enzyme superfamily, including the NADPH oxidases (NOXs) that all catalyze similar FAD-enabled electron transfers between NAD(P)H and one-electron carriers. Here we define further mechanistic details of the NAD(P)H ⇌ FAD hydride-transfer step of the reaction based on spectroscopic studies and high resolution (~1.5 Å) crystallographic views of the nicotinamide-flavin interaction in crystals of corn root FNR Tyr316Ser and Tyr316Ala variants soaked with either nicotinamide, NADP+, or NADPH. The spectra obtained from FNR crystal complexes match those seen in solution and the complexes reveal active site packing interactions and patterns of covalent distortion of the FAD that imply significant active site compression that would favor catalysis. Furthermore, anisotropic B-factors show that the mobility of the C4 atom of the nicotinamide in the FNR:NADP+ complex has a directionality matching that expected for boat-like excursions of the nicotinamide ring thought to enhance hydride transfer. Arguments are made for the relevance of this binding mode to catalysis, and specific consideration is given to how the results extrapolate to provide insight to structure-function relations for the membrane-bound NOX enzymes for which little structural information has been available
Purification and characterization of cytidine 5'-triphosphate:cytidine 5'-monophosphate-3-deoxy-D-manno-octulosonate cytidylyltransferase
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Best practices for addressing missing data through multiple imputation
A common challenge in developmental research is the amount of incomplete and missing data that occurs from respondents failing to complete tasks or questionnaires, as well as from disengaging from the study (i.e., attrition). This missingness can lead to biases in parameter estimates and, hence, in the interpretation of findings. These biases can be addressed through statistical techniques that adjust for missing data, such as multiple imputation. Although multiple imputation is highly effective, it has not been widely adopted by developmental scientists given barriers such as lack of training or misconceptions about imputation methods. Utilizing default methods within statistical software programs like listwise deletion is common but may introduce additional bias. This manuscript is intended to provide practical guidelines for developmental researchers to follow when examining their data for missingness, making decisions about how to handle that missingness and reporting the extent of missing data biases and specific multiple imputation procedures in publications
Broadening the model of science - Recognizing different types of contributions
Resources for Society for the Improvement of Psychological Science (2016) Meeting - Diversity & Alternative Contribution