L'assegnazione della casa familiare nella crisi delle coppie di fatto

Questo elaborato si propone di affrontare l'assegnazione della casa familiare nella patologia del rapporto di coppie non unite dal vincolo del matrimonio, alla luce della recente riforma del d.lgs. 154/2013. Dopo un'attenta ricognizione della disciplina generale in tema di assegnazione della casa coniugale nelle procedure di separazione e di divorzio, il lavoro si focalizza sulla sorte della casa familiare a seguito di crisi nelle coppie di fatto, evidenziando il mancato riconoscimento giuridico da parte del nostro ordinamento e, di conseguenza, l'insufficiente considerazione normativa di tali situazioni. Eppure, il legame fra casa familiare quale centro degli affetti e consuetudini di vita, e coppie di fatto che abbiano instaurato una convivenza stabile e duratura alla stregua di quella comunione di vita materiale e spirituale peculiare dello stato coniugale, si rivela talvolta fondamentale. Soprattutto in presenza di figli, il cui interesse deve essere considerato prioritariamente ex lege, ed i quali hanno diritto a permanere nella casa familiare a seguito di carenza dell'affectio tra i genitori non sposati. I titoli giuridici di detenzione più diffusi, oltre alla proprietà, sono la locazione ed il comodato, con relativa disciplina differenziata. Vengono inoltre esposti gli strumenti che possono essere esperiti a baluardo dell'interesse del convivente più debole e dei figli a rimanere nell'habitat domestico, quali l'ordine di allontanamento dalla casa familiare ed il procedimento della “crisi” tra genitori non coniugati, e la tutela successoria. La giurisprudenza ha avuto un rilievo fondamentale, dapprima la Corte Costituzionale con la storica sentenza n. 404/1988,e più di recente la Corte di Cassazione con le sue pronunce concernenti convivenza more uxorio e diritti in materia di possesso e comodato

Risultati esame EICR Studenti Erasmus 18 Dicembre 2017

La verbalizzazione NON è automatica, ma deve avvenire espressa ACCETTAZIONE del voto tramite mail ([email protected]) con oggetto "Verbalizzazione esame del 18 dicembre 2017", indicando poi Nome, Cognome, nr.di matricola e voto riportato

Cancer Tissue Engineering: development of new 3D models and technologies to support cancer research

The activity of research of this thesis focuses on the relevance that appropriate models reproducing the in vivo tumor microenvironment are essential for improving cancer biology knowledge and for testing new anticancer compounds. Animal models are proven not to be entirely compatible with the human system, and the success rates between animal and human studies are still unsatisfactory. On the other hand, 2D cell cultures fail to reproduce some aspects of tumor system. These limitations have a significant weight especially during the screening of novel antitumor drugs, as it was demonstrated that cells are less sensitive to treatments when in contact with their microenvironment. To obtain the same tumor cell inhibition levels observed in vivo, the culture environment has to reflect the 3D natural environment. Natural or synthetic hydrogels reported successful outcomes in mimicking ECM environment. During this PhD, I developed different gel-based scaffolds to be use as substrates for the culture of breast cancer cells. In detail, I developed different gels for low and highly aggressive cancer cell lines (i.e. MCF-7 and MDA-MB-231), obtaining significant results as regards the reproduction of key features normally present into the in vivo environment. Considering the importance of the metastasis process in breast cancer evolution, I then focused on a new set-up for the observation of cancer cell motility and invasion. In particular, I combined a bioreactor-based bioengineering approach with single cell analysis of Circulating Tumor Cells (CTCs). This part of work was carried out at the Dipartiment of Biomedicine of the University of Basel (CH) that, among its equipment, has a cell celector machine for single cell analysis. At the end of this work, I provided a proof-of-concept that the approach can work, as well as evidence that the cells can be extracted from the device and used for molecular analysis

Implementation and Benchmarking of a Crypto Processor for a NB-IoT SoC Platform

The goal of this Master’s Thesis is to investigate the implementation of cryptographic algorithms for IoT and how these encryption systems can be integrated in a NarrowBand IoT platform. Following 3rd Generation Partnership Project (3GPP) specifications, the Evolved Packet System (EPS) Encryption Algorithms (EEA) and EPS Integrity Algorithms (EIA) have been implemented and tested. The latter are based on three different ciphering algorithms, used as keystream generators: Advanced Encryption Standard (AES), SNOW 3G and ZUC. These algorithms are used in Long Term Evolution (LTE) terminals to perform user data confidentiality and integrity protection. In the first place, a thorough study of the algorithms has been conducted. Then, we have used Matlab to generate a reference model of the algorithms and the High-Level Synthesis (HLS) design flow to generate the Register-Transfer Level (RTL) description from algorithmic descriptions in C++. The keystream generation and integrity blocks have been tested at RTL level. The confidentiality block has been described along with the control, datapath and interface block at a RTL level using System C language. The hardware blocks have been integrated into a processor capable of performing hardware confidentiality and integrity protection: the crypto processor. This Intellectual Property (IP) has been integrated and tested in a cycle accurate virtual platform. The outcome of this Master’s Thesis is a crypto processor capable of performing the proposed confidentiality and integrity algorithms under request.The Internet of Things (IoT) is one of the big revolutions that our society is expected to go through in the near future. This represents the inter-connection of devices, sensors, controllers, and any items, refereed as things, through a network that enables machine-to-machine communication. The number of connected devices will greatly increase. The applications taking advantage of IoT will enable to develop a great amount of technologies such as smart homes, smart cities and intelligent transportation. The possibilities allowed are huge and not yet fully explored. Picture yourself in the near future having a nice dinner with some friends. Then, you suddenly recall that your parking ticket expires in five minutes and unfortunately your car is parked some blocks away. You are having a good time and feel lazy to walk all the way to where you parked your car to pay for a time extension. Luckily enough, the parking meter is part of the IoT network and allows you, with the recently installed new application in your smart-phone, to pay this bill from anywhere you are. This payment will be sent to the parking meter and your time will be extended. Problem solved, right? Well, the risk comes when you perform your payment, not knowing that your "worst enemy" has interceded this communication and is able to alter your transaction. Perhaps, this individual decides to cancel your payment and you will have to pay a fine. Or even worse, this person steals your banking details and uses your money to take the vacations you’ve always wanted. There are many examples in our everyday life where we expose our personal information. With an increasing number of devices existing and using wireless communications without the action of an human, the security is a key aspect of IoT. This Master’s Thesis addresses the need to cover these security breaches in a world where an increasing amount of devices are communicating with each other. With the expansion of IoT where billions of devices will be connected wirelessly, our data will be widely spread over the air. The user will not be able to protect their sensible data without these securing capabilities. Therefore, different security algorithms used in today’s and tomorrow’s wireless technologies have been implemented on a chip to secure the communication. The confidentiality and integrity algorithms aim to solve the two aspects of the problem: protect the secrecy of banking details and prevent the alteration of the communication’s information. In this Master’s Thesis we have developed a hardware processor for securing data during a wireless communication, specifically designed for IoT applications. The developed system is realized with minimal area and power in mind, so that they can be fitted even in the smallest devices. We have compared many different hardware architectures, and after exploring many possible implementations, we have implemented the security algorithms on a hardware platform. We believe the content of this Thesis work is of great interest to anybody interested in hardware security applied to the IoT field. Furthermore, due to the processes and methodology used in this work, it will also be of interest to people who want to know more about how higher level programming languages can be used to describe such a specialized circuit, like one performing security algorithms. Finally, people interested in hardware and software co-simulation will find in this project a good example of the utilization of such system modeling technique

Design of decorated self-assembling peptide hydrogels as architecture for mesenchymal stem cells

Hydrogels from self-assembling ionic complementary peptides have been receiving a lot of interest from the scientific community as mimetic of the extracellular matrix that can offer three-dimensional supports for cell growth or can become vehicles for the delivery of stem cells, drugs or bioactive proteins. In order to develop a 3D "architecture" for mesenchymal stem cells, we propose the introduction in the hydrogel of conjugates obtained by chemoselective ligation between a ionic-complementary self-assembling peptide (called EAK) and three different bioactive molecules: an adhesive sequence with 4 Glycine-Arginine-Glycine-Aspartic Acid-Serine-Proline (GRGDSP) motifs per chain, an adhesive peptide mapped on h-Vitronectin and the growth factor Insulin-like Growth Factor-1 (IGF-1). The mesenchymal stem cell adhesion assays showed a significant increase in adhesion and proliferation for the hydrogels decorated with each of the synthesized conjugates; moreover, such functionalized 3D hydrogels support cell spreading and elongation, validating the use of this class of self-assembly peptides-based material as very promising 3D model scaffolds for cell cultures, at variance of the less realistic 2D ones. Furthermore, small amplitude oscillatory shear tests showed that the presence of IGF-1-conjugate did not alter significantly the viscoelastic properties of the hydrogels even though differences were observed in the nanoscale structure of the scaffolds obtained by changing their composition, ranging from long, well-defined fibers for conjugates with adhesion sequences to the compact and dense film for the IGF-1-conjugate

Mechanisms of Disease Progression and Resistance to Tyrosine Kinase Inhibitor Therapy in Chronic Myeloid Leukemia: An Update

Chronic myeloid leukemia (CML) is characterized by the presence of the BCR-ABL1 fusion gene, which encodes a constitutive active tyrosine kinase considered to be the pathogenic driver capable of initiating and maintaining the disease. Despite the remarkable efficacy of tyrosine kinase inhibitors (TKIs) targeting BCR-ABL1, some patients may not respond (primary resistance) or may relapse after an initial response (secondary resistance). In a small proportion of cases, development of resistance is accompanied or shortly followed by progression from chronic to blastic phase (BP), characterized by a dismal prognosis. Evolution from CP into BP is a multifactorial and probably multistep phenomenon. Increase in BCR-ABL1 transcript levels is thought to promote the onset of secondary chromosomal or genetic defects, induce differentiation arrest, perturb RNA transcription, editing and translation that together with epigenetic and metabolic changes may ultimately lead to the expansion of highly proliferating, differentiation-arrested malignant cells. A multitude of studies over the past two decades have investigated the mechanisms underlying the closely intertwined phenomena of drug resistance and disease progression. Here, we provide an update on what is currently known on the mechanisms underlying progression and present the latest acquisitions on BCR-ABL1-independent resistance and leukemia stem cell persistence

Risultati Esame EICR Erasmus del 17 Dicembre 2015

La verbalizzazione non è automatica, ma deve avvenire espressa accettazione del voto tramite mail ([email protected]) con oggetto "verbalizzazione esame", indicando poi Nome, Cognome, nr.di matricola e voto riportato