524 research outputs found

    Controlled Composition Studies of Calcium Carbonate and Sulfate Crystal Growth

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    A highly reproducible seeded crystal growth method is described for the study of calcium carbonate and sulfate crystallization reactions in which the solution composition is maintained constant by the potentiometrically controlled addition of reagents .. Both hydrogen and calcium specific ion electrodes may be used to control the reactions and the rates are measured with a precision hitherto unattainable even at very low supersaturations. For calcium carbonate, the rate of crystallization is proportional to the square of the relative supersaturation expressed in terms of the activities of the free ion species. The inhibiting influence of a phosphonate additive upon the rate of growth is discussed

    Interpreting abuse from self-representational drawings: a mixed-method study

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    This interdisciplinary research studied the intuitive process affecting the diagnostic interpretations of drawings. It utilized quantitative and qualitative methods to examine how subjectivity and heuristic strategies of interpreters might affect how accurately the interpreters differentiate between self-representational drawings created by persons who have experienced abuse and persons who have not been abused. This study used a non-clinical sample of 196 self-representational drawings created by college students, and 60 independent judges who were naive to the diagnostic interpretation of drawings. The first purpose of this study was to introduce a unified, semiotic-naturalistic framework and an empirically grounded methodology for analyzing visual interpretation in general that, in particular, could be used for the diagnostic analysis of images to identify drawers who have suffered interpersonal abuse. The second purpose was to assess the diagnostic utility of a novel, self-portrait drawing protocol, titled Inside Me¬–Outside Me, which I developed for gauging drawers’ self-perceptions and worldviews. The third purpose was to examine the relationships between interpreter’s diagnostic performance and gender, exposure to abuse, and professional expertise. The fourth purpose was to identify heuristic strategies that are intuitively used in interpretation and how those heuristics affect interpretations and accuracy. There were three quantitative and qualitative main findings of this study. First, the study indicated that judges who self-identified as having been abused more often saw indicators of abuse than judges who did not self-identify as having been abused. In particular, female judges who self-identified as having been abused saw indicators of abuse more frequently than female judges who did not self-identify as having been abused, and more often than both abused and non-abused male judges. The results obtained in this study expand the literature on the role of interpreter subjectivity in the interpretation of diagnostic drawings by indicating the effect of experiencing abuse on subsequent interpretations. Second, the study identified a number of recurring visual characteristics, to which many different judges assigned the same meanings. Third, judges who reported utilizing specific heuristic strategies as the criteria for classification of drawings were more accurate than judges who did not indicate using such strategies. Furthermore, this study found a number of specific heuristic judgment strategies that were used independently by different judges. Those heuristics included: ease-of-understanding, out-of-the-norm, dominance, gestalt, elaboration, and normalcy. This finding indicates a potential for further research, linking visual interpretation with visual cognition and decision making. The results of this study, however tentative, suggest that interpretation is not an idiosyncratic process, but may be seen as cognition-based processes working in tandem with cultural factors. Discussion includes the potential implications of this study for research and practice in visual analysis, education, psychological assessment, therapy, and advocacy against domestic violence and intimate partner abuse

    A Novel Silicon Micromachined Integrated MCM Thermal Management System

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    "Micromachining" is a chemical means of etching three-dimensional structures, typically in single- crystalline silicon. These techniques are leading toward what is coming to be referred to as MEMS (Micro Electro Mechanical Systems), where in addition to the ordinary two-dimensional (planar) microelectronics, it is possible to build three-dimensional n-ticromotors, electrically- actuated raicrovalves, hydraulic systems and much more on the same microchip. These techniques become possible because of differential etching rates of various crystallographic planes and materials used for semiconductor n-ticrofabfication. The University of Cincinnati group in collaboration with Karl Baker at NASA Lewis were the first to form micro heat pipes in silicon by the above techniques. Current work now in progress using MEMS technology is now directed towards the development of the next generation in MCM (Multi Chip Module) packaging. Here we propose to develop a complete electronic thermal management system which will allow densifica6on in chip stacking by perhaps two orders of magnitude. Furthermore the proposed technique will allow ordinary conu-nercial integrated chips to be utilized. Basically, the new technique involves etching square holes into a silicon substrate and then inserting and bonding commercially available integrated chips into these holes. For example, over a 100 1/4 in. by 1 /4 in. integrated chips can be placed on a 4 in. by 4 in. silicon substrate to form a Multi-Chip Module (MCM). Placing these MCM's in-line within an integrated rack then allows for three-diniensional stacking. Increased miniaturization of microelectronic circuits will lead to very high local heat fluxes. A high performance thermal management system will be specifically designed to remove the generated energy. More specifically, a compact heat exchanger with milli / microchannels will be developed and tested to remove the heat through the back side of this MCM assembly for moderate and high heat flux applications, respectively. The high heat load application of particular interest in mind is the motor controller developed by Martin Marietta for Nasa to control the thruster's directional actuators on space vechicles. Work is also proposed to develop highly advanced and improved porous wick structures for use in advanced heat loops. The porous wick will be micromachined from silicon using MEMS technology, thus permitting far superior control of pore size and pore distribution (over wicks made from sintered n-ietals), which in turn is expected to led to significantly improved heat loop performance

    Rio grande cone tectono-stratigraphic model – brazil: seismic sequences

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    Anålisis sísmicos integrados con técnicas de interpretación, procesamiento, información de velocidades y datos geofísicos permiten modelar diferentes rasgos de tipo tectónico, estructural o geomorfológico. Este trabajo se constituye en una primera aproximación a un modelo tridimensional de un rasgo geomorfológico ubicado en el fondo oceånico. El modelo inicial comprende una configuración bidimensional de una grilla interpretada a partir de secciones sísmicas llevadas a un volumen tridimensional, esto mediante la concepción de una aproximación dos y medio dimensional. Ademås de un cambio de configuración, se hizo un anålisis de atributos sobre las imågenes de las secciones y se determinaron las características presentes desde un årea de la plataforma, hasta el offshore del sudeste Brasilero. El rasgo geomorfológico a tratar es conocido como el Conode Rio Grande, el cual pudo ser caracterizando con sus principales estructuras tectónicas y estratigråficas, mediante la cartografía y modelamiento tridimensional del subsuelo, con la integración geológica, geofísica y geomorfológica. La geomorfología del cono, se ve influenciada por procesos gravitacionales, corrientes defondo, estructuras de tipo tectónico y composición litológica, como sus principales controladores que estån presentes a partir del Neógeno. Así, a partir de la interpretación sísmica pueden ser extractados diferentes estructuras tectónicas, sedimentarias y geoformas, por ejemplo presencia de fallas, pliegues, canales, levee naturales, contornitos, etc

    Phenotype and genotype associations of lung carcinoma with atypical adenomatoid hyperplasia, squamous cell dysplasia, and chromosome alterations in non-neoplastic bronchial mucosa

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    Abstract The frequency of preneoplastic lesions of the lung and bronchial mucosa as well as potential genotype alterations in spatial relationship to pulmonary malignancies still need intensive investigations in order to understand the occurrence and manifestation of lung cancer in detail. To investigate the contemporary manifestation of lung cancer precursor lesions, peripheral (non-neoplastic) lung parenchyma and bronchial mucosa of operated lung carcinomas were analyzed at distinct distances (1, 2, 3, and 4 cm) from the tumor boundary for pre-neoplastic lesions -atypical adenomatoid hyperplasia (AAH) and squamous cell dysplasia (SCD), in 150 surgical specimens. Short-term tissue cultures of additional 55 primary and secondary lung tumors and their surrounding non-neoplastic bronchial mucosa were performed at the same distances in order to search for chromosome alterations, i.e. genotype aberrations. In phenotype observations, atypical adenomatoid hyperplasia was noted in 19/150 (13%) cases, and squamous cell dysplasia in 46/150 (31%) cases. The degree of cellular atypia decreased with increasing distance from the tumor boundary in both AAH and SCM. AAH was observed more frequently in adenocarcinomas, SCQ more frequently in squamous cell carcinomas. In genotype observations, the average number of abnormal metaphases measured 4.5/10 high power fields (HPF) in primary lung carcinomas, and only 2/10 in metastases. Data indicate that the so-called preneoplastic lesions in the lung are not completely tumor-precursor lesions, but, in addition, induced by the tumor itself

    Phytoplankton calcification as an effective mechanism to prevent cellular calcium poisoning

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    Marine phytoplankton have developed the remarkable ability to tightly regulate the concentration of free calcium ions in the intracellular cytosol at a level of ~ 0.1 ÎŒmol L−1 in the presence of seawater Ca2+ concentrations of 10 mmol L−1. The low cytosolic calcium ion concentration is of utmost importance for proper cell signalling function. While the regulatory mechanisms responsible for the tight control of intracellular Ca2+ concentration are not completely understood, phytoplankton taxonomic groups appear to have evolved different strategies, which may affect their ability to cope with changes in seawater Ca2+ concentrations in their environment on geological timescales. For example, the Cretaceous (145 to 66 Ma), an era known for the high abundance of coccolithophores and the production of enormous calcium carbonate deposits, exhibited seawater calcium concentrations up to 4 times present-day levels. We show that calcifying coccolithophore species (Emiliania huxleyi, Gephyrocapsa oceanica and Coccolithus braarudii) are able to maintain their relative fitness (in terms of growth rate and photosynthesis) at simulated Cretaceous seawater calcium concentrations, whereas these rates are severely reduced under these conditions in some non-calcareous phytoplankton species (Chaetoceros sp., Ceratoneis closterium and Heterosigma akashiwo). Most notably, this also applies to a non-calcifying strain of E. huxleyi which displays a calcium sensitivity similar to the non-calcareous species. We hypothesize that the process of calcification in coccolithophores provides an efficient mechanism to alleviate cellular calcium poisoning and thereby offered a potential key evolutionary advantage, responsible for the proliferation of coccolithophores during times of high seawater calcium concentrations. The exact function of calcification and the reason behind the highly ornate physical structures of coccoliths remain elusive

    Incremental Value of Computed Tomography Perfusion for Final Infarct Prediction in Acute Ischemic Cerebellar Stroke

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    Background The diagnosis of ischemic cerebellar stroke is challenging because of nonspecific symptoms and very limited accuracy of commonly applied computed tomography (CT) imaging. Advances in CT perfusion imaging provide increasing value in the detection of posterior circulation stroke, but the prognostic value remains unclear. We aimed to identify imaging parameters that predict morphologic outcome in cerebellar stroke patients using advanced CT including whole‐brain CT perfusion (WB‐CTP). Methods and Results We selected all subjects with cerebellar WB‐CTP perfusion deficits and follow‐up‐confirmed cerebellar infarction from a consecutive cohort with suspected stroke who underwent WB‐CTP. Posterior‐circulation‐Acute‐Stroke‐Prognosis‐Early‐CT‐Score (pc‐ASPECTS) was determined on noncontrast CT, CT angiography source images, and on parametric WB‐CTP maps. Cerebellar perfusion deficit volumes on all maps and the final infarction volume on follow‐up imaging were quantified. Uni‐ and multivariate regression analyses were performed. Sixty patients fulfilled the inclusion criteria. pc‐ASPECTS on CT angiography source images (ß, −9.239; 95% CI, −14.220 to −4.259; P0.05). Conclusions In contrast to noncontrast CT and CT angiography, WB‐CTP imaging contains prognostic information for morphologic outcome in patients with acute cerebellar stroke

    Strong absorption by interstellar hydrogen fluoride: Herschel/HIFI observations of the sight-line to G10.6-0.4 (W31C)

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    We report the detection of strong absorption by interstellar hydrogen fluoride along the sight-line to the submillimeter continuum source G10.6-0.4 (W31C). We have used Herschel's HIFI instrument, in dual beam switch mode, to observe the 1232.4763 GHz J=1-0 HF transition in the upper sideband of the Band 5a receiver. The resultant spectrum shows weak HF emission from G10.6-0.4 at LSR velocities in the range -10 to -3 km/s, accompanied by strong absorption by foreground material at LSR velocities in the range 15 to 50 km/s. The spectrum is similar to that of the 1113.3430 GHz 1(11)-0(00) transition of para-water, although at some frequencies the HF (hydrogen fluoride) optical depth clearly exceeds that of para-H2O. The optically-thick HF absorption that we have observed places a conservative lower limit of 1.6E+14 cm-2 on the HF column density along the sight-line to G10.6-0.4. Our lower limit on the HF abundance, 6E-9 relative to hydrogen nuclei, implies that hydrogen fluoride accounts for between ~ 30 and 100% of the fluorine nuclei in the gas phase along this sight-line. This observation corroborates theoretical predictions that - because the unique thermochemistry of fluorine permits the exothermic reaction of F atoms with molecular hydrogen - HF will be the dominant reservoir of interstellar fluorine under a wide range of conditions.Comment: Accepted for publication in Astronomy and Astrophysics (Herschel special issue). This revised version corrects a typographic error in the HTML abstract, in which the lower limit on the HF abundance (should be 6E-9) was previously misstated. The abstract in the PDF version is correct and the latter has not been modifie

    Interstellar OH+, H2O+ and H3O+ along the sight-line to G10.6-0.4

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    We report the detection of absorption lines by the reactive ions OH+, H2O+ and H3O+ along the line of sight to the submillimeter continuum source G10.6−-0.4 (W31C). We used the Herschel HIFI instrument in dual beam switch mode to observe the ground state rotational transitions of OH+ at 971 GHz, H2O+ at 1115 and 607 GHz, and H3O+ at 984 GHz. The resultant spectra show deep absorption over a broad velocity range that originates in the interstellar matter along the line of sight to G10.6−-0.4 as well as in the molecular gas directly associated with that source. The OH+ spectrum reaches saturation over most velocities corresponding to the foreground gas, while the opacity of the H2O+ lines remains lower than 1 in the same velocity range, and the H3O+ line shows only weak absorption. For LSR velocities between 7 and 50 kms−1^{-1} we estimate total column densities of NN(OH+) >2.5×1014> 2.5 \times 10^{14} cm−2^{-2}, NN(H2O+) ∌6×1013\sim 6 \times 10^{13} cm−2^{-2} and NN(H3O+) ∌4.0×1013\sim 4.0 \times 10^{13} cm−2^{-2}. These detections confirm the role of O+^+ and OH+^+ in initiating the oxygen chemistry in diffuse molecular gas and strengthen our understanding of the gas phase production of water. The high ratio of the OH+ by the H2O+ column density implies that these species predominantly trace low-density gas with a small fraction of hydrogen in molecular form
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