Knowledge, attitude and practice about breast cancer screening and related factors among women referred to health care centers in Boroujen in 2005

زمینه و هدف: سرطان پستان شایع ترین سرطان در زنان است. به طوری 16 کل سرطان ها را در ایران به خود اختصاص می دهد و در ایالات متحده آمریکا چهارمین علت مرگ زنان به شمار می آید. از آنجایی که روش های غربالگری از جمله بهترین روش های تشخیص زودرس سرطان پستان می باشند که انجام آنها به طور چشمگیری از شیوع سرطان پیشگیری می کند، لذا این مطالعه به منظور بررسی آگاهی، نگرش و عملکرد زنان مراجعه کننده به مراکز بهداشتی درمانی شهر بروجن نسبت به روشهای غربالگری سرطان پستان انجام گردید. روش بررسی: در یک مطالعه توصیفی - تحلیلی تعداد 400 زن بالای 20 سال از طریق نمونه گیری آسان انتخاب شدند. اطلاعات با استفاده از یک پرسشنامه که شامل مشخصات دموگرافیک و سؤالات آگاهی، نگرش و عملکرد بود جمع آوری گردید. این اطلاعات توسط آزمون های رگرسیون لوجستیک و آزمون کای دو مورد تجزیه و تحلیل قرارگرفت. یافته ها: نتایج نشان داد 8/37 افراد از خودآزمائی، 8/7 از معاینه فیزیکی و 6 افراد از ماموگرافی آگاهی داشتند. نگرش کلی در مورد روشهای غربالگری 6/15 منفی 7/67 در حد متوسط و 7/16 مثبت بود. 1/47 افراد به انجام خودآزمائی، 2/71 به معاینه فیزیکی و 9/68 به انجام ماموگرافی تمایل داشتند. 5/4 افراد خودآزمائی را بطور مرتب و ماهیانه انجام می دادند. در 3/16 افراد معاینه فیزیکی توسط پزشک و کارکنان بهداشتی انجام شده بود که فقط 4 به منظور غربالگری صورت گرفته بود. 3/4 افراد ماموگرافی غربالگری انجام داده بودند. مهمترین عامل مؤثر بر خودآزمائی، سابقه وجود بیماری خوش خیم پستان در فرد بود (05/0

Control Plane Compression

We develop an algorithm capable of compressing large networks into a smaller ones with similar control plane behavior: For every stable routing solution in the large, original network, there exists a corresponding solution in the compressed network, and vice versa. Our compression algorithm preserves a wide variety of network properties including reachability, loop freedom, and path length. Consequently, operators may speed up network analysis, based on simulation, emulation, or verification, by analyzing only the compressed network. Our approach is based on a new theory of control plane equivalence. We implement these ideas in a tool called Bonsai and apply it to real and synthetic networks. Bonsai can shrink real networks by over a factor of 5 and speed up analysis by several orders of magnitude.Comment: Extended version of the paper appearing in ACM SIGCOMM 201

Morphological variability of the Aspius aspius taeniatus (Eichwald, 1831) in the Southern Caspian Sea Basin

Traditional morphometric measurements and meristic counts were used to investigate the hypothesis of population fragmentation of Mash mahi, Aspius aspius taeniatus (Eichwald, 1831) among two fishing areas in southern Caspian Sea basin (Tonekabon:32 specimens and Sari:34 specimens ). Univariate analysis of variance showed significant differences between the means of the two groups for 12 out of 26 standardized morphometric measurement and three out of nine meristic counts. In discriminant function analysis (DFA), the proportion of individuals correctly classified into their original groups was 82.1% and 61.2% for morphometric and meristic characteristics, respectively. Clustering based on Euclidean distances among groups of centroids using an UPGMA and also principal component analysis’ results (PCA) for morphometric and meristic data indicated that two samples of Mash mahi were distinct from each other in these regions, while there were a relatively high degree of overlap between two locations

Comparison of quinolone and β-lactam resistance among Escherichia coli strains isolated from urinary tract infections

The growing frequency of antibiotic resistances is now a universal problem. Increasing resistance to new generations of β-lactam and quinolone antibiotics in multidrug- resistant Enterobacteriaceae isolates is considered an emergency health issue worldwide. The aim of this study was to evaluate plasmid-mediated quinolone resistance genes in ESBL-producing Escherichia coli isolated from urinary tract infections (UTIs). In our study ESBL- producing isolates were assessed by screening methods. After determination of antimicrobial susceptibility, detection of ESBLs and quinolone resistance genes was performed. A total of 97 ESBL-producing E. coli were determined. The blaTEM, blaSHV and blaCTX-M genes were detected in 90 isolates. The blaTEM was the most frequent- ly detected gene (46.4), followed by blaSHV (31.9) and blaCTX-M (14.4). The most prevalent quinolone resistance gene among ESBL-producing isolates was oqxAB which found in 67 isolates (69.1). The frequencies of the aac(6�)-Ib-cr, qnr and qepA were 65 (67), 8 (8.2) and 6 (6.2), respectively. Our data indicate that the prevalence of plasmid-mediated quinolone resistance genes in ESBL-positive isolates is increasing. The co-dissemination of PMQR and ESBL genes among E. coli isolates can be considered a threat to public health. Therefore, prescription of antibiotics against infectious disease should be managed carefully. © 2016, International Society of Musculoskeletal and Neuronal Interactions. All rights reserved

Epidemiological alteration in pathogens found in ground meat in Iran: unexpected predominance of vancomycin-resistant Enterococcus faecalis

Colonization of the human and animal intestinal tract with potential pathogenic bacteria is correlated with the risk of contamination of food products. The current study analyzed the prevalence of Enterococcus faecalis and Escherichia coli O157H7 in ground meat in Ilam, Iran. Both index organisms were identified following standard food microbiological methods. For E. faecalis, the susceptibility to vancomycin was tested, and PCR was used to check for the vanA gene. E. faecalis was present in all 24 ground meat samples, with no E. coli O157H7 detected in samples. The analysis showed the presence of the vanA gene in 5/24 vancomycin resistant enterococci. In conclusion, this study for the first time demonstrates the presence of vancomycin-resistant enterococci in ground meat in Iran. This observation warrants further epidemiologic investigation and should be followed up in the future

Molecular identification of fungi microfossils in a Neoproterozoic shale rock

Precambrian fossils of fungi are sparse, and the knowledge of their early evolution and the role they played in the colonization of land surface are limited. Here, we report the discovery of fungi fossils in a 810 to 715 million year old dolomitic shale from the Mbuji-Mayi Supergroup, Democratic Republic of Congo. Syngenetically preserved in a transitional, subaerially exposed paleoenvironment, these carbonaceous filaments of ~5 μm in width exhibit low-frequency septation (pseudosepta) and high-angle branching that can form dense interconnected mycelium-like structures. Using an array of microscopic (SEM, TEM, and confocal laser scanning fluorescence microscopy) and spectroscopic techniques (Raman, FTIR, and XANES), we demonstrated the presence of vestigial chitin in these fossil filaments and document the eukaryotic nature of their precursor. Based on those combined evidences, these fossil filaments and mycelium-like structures are identified as remnants of fungal networks and represent the oldest, molecularly identified remains of Fungi

Delayed Effect of Dendritic Cells Vaccination on Survival in Glioblastoma: A Systematic Review and Meta‐Analysis

Background: Dendritic cell vaccination (DCV) strategies, thanks to a complex immune response, may flare tumor regression and improve patients’ long‐term survival. This meta‐analysis aims to assess the efficacy of DCV for newly diagnosed glioblastoma patients in clinical trials. Meth-ods: The study databases, including PubMed, Web of Knowledge, Google Scholar, Scopus, and Cochrane, were searched by two blinded investigators considering eligible studies based on the following keywords: “glioblastoma multiforme”, “dendritic cell”, “vaccination”, “immunother-apy”, “immune system”, “immune response”, “chemotherapy”, “recurrence”, and “te-mozolomide”. Among the 157 screened, only 15 articles were eligible for the final analysis. Results: Regimens including DCV showed no effect on 6‐month progression‐free survival (PFS, HR = 1.385, 95% CI: 0.822–2.335, p = 0.673) or on 6‐month overall survival (OS, HR = 1.408, 95% CI: 0.882–2.248, p = 0.754). In contrast, DCV led to significantly longer 1‐year OS (HR = 1.936, 95% CI: 1.396–2.85, p = 0.001) and longer 2‐year OS (HR = 3.670, 95% CI: 2.291–5.879, p = 0.001) versus control groups. Hence, introducing DCV could lead to increased 1 and 2‐year survival of patients by 1.9 and 3.6 times, respectively. Conclusion: Antitumor regimens including DCV can effectively improve mid-term survival in patients suffering glioblastoma multiforme (GBM), but its impact emerges only after one year from vaccination. These data indicate the need for more time to achieve an anti‐GBM immune response and suggest additional therapeutics, such as checkpoint inhibitors, to empower an earlier DCV action in patients affected by a very poor prognosis

Granzyme A-producing T helper cells are critical for acute graft-versus-host disease

Acute graft-versus-host disease (aGVHD) can occur after hematopoietic cell transplant in patients undergoing treatment for hematological malignancies or inborn errors. Although CD4+ T helper (Th) cells play a major role in aGVHD, the mechanisms by which they contribute, particularly within the intestines, have remained elusive. We have identified a potentially novel subset of Th cells that accumulated in the intestines and produced the serine protease granzyme A (GrA). GrA+ Th cells were distinct from other Th lineages and exhibited a noncytolytic phenotype. In vitro, GrA+ Th cells differentiated in the presence of IL-4, IL-6, and IL-21 and were transcriptionally unique from cells cultured with either IL-4 or the IL-6/IL-21 combination alone. In vivo, both STAT3 and STAT6 were required for GrA+ Th cell differentiation and played roles in maintenance of the lineage identity. Importantly, GrA+ Th cells promoted aGVHD-associated morbidity and mortality and contributed to crypt destruction within intestines but were not required for the beneficial graft-versus-leukemia effect. Our data indicate that GrA+ Th cells represent a distinct Th subset and are critical mediators of aGVHD