234 research outputs found
Wood-based beams strengthened with FRP laminates: improved performance with pre-stressed systems
Using bonded fibre-reinforced polymer (FRP)
laminates for strengthening wooden structural members has
been shown to be an effective and economical method. In
this paper, properties of suitable FRP materials, adhesives
and two ways of strengthening beams exposed to bending
moment are presented. Passive or slack reinforcement is
one way of strengthening. The most effective way of such a
strengthening was to place reinforcement laminates on both
tension and compression side of the beam. However, the
FRP material is only partially utilised. The second way is
to apply pre-stressing in FRP materials prior to bonding to
tension side of flexural members and this way was shown
to provide the most effective utilisation of these materials.
The state of the art of such a strengthening and various
methods are discussed. Increasing the load-bearing capacity,
introducing a pre-cambering effect and thus improving
serviceability which often governs the design and reducing
the amount of FRP reinforcement needed are some of the
main advantages. A recent development on how to avoid
the requirement for anchoring the laminates at the end of
the beams to avoid premature debonding is shown, and the
advantage of such a system is described
A YAC contig in Xp21 containing the adrenal hypoplasia congenita and glycerol kinase deficiency genes
The gene loci for adrenal hypoplasia congenita (AHC) and glycerol kinase deficiency (GK) map in Xp21 distal to Duchenne muscular dystrophy (DMD), and proximal to DXS28 (C7), by analysis of patient deletions. We have constructed a yeast artificial chromosome (YAC) contig encompassing a 1.2 Mb region extending distally from DMD, and containing DXS708 (JC-1), the distal junction clone of a patient with GK and DMD. A pulsed-field gel electrophoresis map of the YAC contig identified 3 potential CpG islands. Whole YAC hybridization identified cosmids both for construction of cosmid contigs, and isolation of single copy probes. Thirteen new single copy probes and DXS28 and DXS708 were hybridized on a panel of patients; the deletion mapping indicates that the YAC contig contains both GK and at least part of AHC, and together with the physical map defines a GK critical region of 50-250 kb. In one AHC patient with a cytogenetically detectable deletion we used the new probes to characterize a complex double deletion. Non-overlapping deletions observed in other unrelated AHC patients indicate that the AHC gene is large, extending over at least 200-500 kb. This mapping provides the basis for the identification of the AHC and GK gene
Towards sustainable blue growth: Outline of the joint Baltic Sea and the North Sea research and innovation programme 2018-2023
Ursinus College Alumni Journal, November 1961
The president\u27s wife writes âą Mater Ursini âą The Ursinus College European tour âą Admiral Moreell looks at a philosopher âą Zucker looks at Moreell âą A woman\u27s approach to peace âą Founders\u27 Day âą 1962 Forum programs âą Cutting campus âą From Alaska to Greenland âą Faith and freedom in Taiwan âą Reginald Helfferich honored âą Poet King âą Henry P. Laughlin, \u2738 âą Robert Pease, \u2733 âą Ursinus student at White House conference âą Harleston R. Wood âą Football âą Soccer âą Hockey âą Basketball âą Wrestling âą 53.5% contribute to Loyalty Fund in 1961 âą Progress report 1962 campaign âą 1961 campaign results âą The Century Club âą Loyalty Fund all-stars âą Loyalty Fund kick-off dinner âą Matching gifts âą Results of the 1961 Loyalty Fund campaign âą Contributors to the 1961 Loyalty Fund campaign âą Class notes âą Weddings âą Births âą Necrology âą Sing along with us âą New faculty membershttps://digitalcommons.ursinus.edu/alumnijournal/1072/thumbnail.jp
Chaste : Cancer, Heart and Soft Tissue Environment
Funding: UK Engineering and Physical Sciences Research Council [grant number EP/N509711/1 (J.K.)].Chaste (Cancer, Heart And Soft Tissue Environment) is an open source simulation package for the numerical solution of mathematical models arising in physiology and biology. To date, Chaste development has been driven primarily by applications that include continuum modelling of cardiac electrophysiology (âCardiac Chasteâ), discrete cell-based modelling of soft tissues (âCell-based Chasteâ), and modelling of ventilation in lungs (âLung Chasteâ). Cardiac Chaste addresses the need for a high-performance, generic, and verified simulation framewor kfor cardiac electrophysiology that is freely available to the scientific community. Cardiac chaste provides a software package capable of realistic heart simulations that is efficient, rigorously tested, and runs on HPC platforms. Cell-based Chaste addresses the need for efficient and verified implementations of cell-based modelling frameworks, providing a set of extensible tools for simulating biological tissues. Computational modelling, along with live imaging techniques, plays an important role in understanding the processes of tissue growth and repair. A wide range of cell-based modelling frameworks have been developed that have each been successfully applied in a range of biological applications. Cell-based Chaste includes implementations of the cellular automaton model, the cellular Potts model, cell-centre models with cell representations as overlapping spheres or Voronoi tessellations, and the vertex model. Lung Chaste addresses the need for a novel, generic and efficient lung modelling software package that is both tested and verified. It aims to couple biophysically-detailed models of airway mechanics with organ-scale ventilation models in a package that is freely available to the scientific community.Publisher PDFPeer reviewe
Measurement of the B0-anti-B0-Oscillation Frequency with Inclusive Dilepton Events
The - oscillation frequency has been measured with a sample of
23 million \B\bar B pairs collected with the BABAR detector at the PEP-II
asymmetric B Factory at SLAC. In this sample, we select events in which both B
mesons decay semileptonically and use the charge of the leptons to identify the
flavor of each B meson. A simultaneous fit to the decay time difference
distributions for opposite- and same-sign dilepton events gives ps.Comment: 7 pages, 1 figure, submitted to Physical Review Letter
Exploring the constraint profile of winter sports resort tourist segments
Many studies have confirmed the importance of market segmentation both theoretically and empirically. Surprisingly though, no study has so far addressed the issue from the perspective of leisure constraints. Since different consumers face different barriers, we look at participation in leisure activities as an outcome of the negotiation process that winter sports resort tourists go through, to balance between related motives and constraints. This empirical study reports the findings on the applicability of constraining factors in segmenting the tourists who visit winter sports resorts. Utilizing data from 1,391 tourists of winter sports resorts in Greece, five segments were formed based on their constraint, demographic and behavioral profile. Our findings indicate that such segmentation sheds light on factors that could potentially limit the full utilization of the market. To maximize utilization, we suggest customizing marketing to the profile of each distinct winter sports resort tourist segment that emerge
A YAC contig in Xp21 containing the adrenal hypoplasia congenita and glycerol kinase deficiency genes
The gene loci for adrenal hypoplasia congenita (AHC) and glycerol kinase deficiency (GK) map in Xp21 distal to Duchenne muscular dystrophy (DMD), and proximal to DXS28 (C7), by analysis of patient deletions. We have constructed a yeast artificial chromosome (YAC) contig encompassing a 1.2 Mb region extending distally from DMD, and containing DXS708 (JC-1), the distal junction clone of a patient with GK and DMD. A pulsed-field gel electrophoresis map of the YAC contig identified 3 potential CpG islands. Whole YAC hybridization identified cosmids both for construction of cosmid contigs, and isolation of single copy probes. Thirteen new single copy probes and DXS28 and DXS708 were hybridized on a panel of patients; the deletion mapping indicates that the YAC contig contains both GK and at least part of AHC, and together with the physical map defines a GK critical region of 50-250 kb. In one AHC patient with a cytogenetically detectable deletion we used the new probes to characterize a complex double deletion. Non-overlapping deletions observed in other unrelated AHC patients indicate that the AHC gene is large, extending over at least 200-500 kb. This mapping provides the basis for the identification of the AHC and GK gene
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Randomised control trial of the effectiveness of an integrated psychosocial health promotion intervention aimed at improving health and reducing substance use in established psychosis (IMPaCT)
© 2017 The Author(s). Background: People with psychosis have a reduced life expectancy of 10-20years, largely due to cardiovascular disease. This trial aimed to determine the effectiveness of a modular health promotion intervention (IMPaCT Therapy) in improving health and reducing cardiovascular risk in psychosis. Methods: A multicentre, two arm, parallel cluster RCT was conducted across five UK mental health NHS trusts. Community care coordinators (CC) were randomly assigned to training and supervision in delivering IMPaCT Therapy or treatment as usual (TAU) to current patients with psychosis (cluster). The primary outcome was the physical and mental health subscales of the Short form-36 (SF-36) questionnaire. Results: Of 104 care coordinators recruited, 52 (with 213 patients) were randomised to deliver IMPaCT therapy and 52 (with 193 patients) randomised to TAU. Of 406 patients, 318 (78%) and 301 (74%) attended 12- and 15-month follow-up respectively. IMPaCT therapy showed no significant effect on the physical or mental health component SF-36 scores versus TAU at 12 or 15months. No effect was observed for cardiovascular risk indicators, except for HDL cholesterol, which improved more with IMPACT therapy than TAU (Treatment effect (95% CI); 0.085 (0.007 to 0.16); p= 0.034). The 22% of patients who received > 180min of IMPACT Therapy in addition to usual care achieved a greater reduction in waist circumference than did controls, which was clinically significant. Conclusion: Training and supervising community care coordinators to use IMPaCT therapy in patients with psychosis is insufficient to significantly improve physical or mental health quality of life. The search for effective, pragmatic interventions deliverable in health care services continues. Trial registration: The trial was retrospectively registered with ISRCTN registry on 23/4/2010 at ISRCTN58667926 ; recruitment started on 01/03/2010 with first randomization on 09.08.2010 ISRCTN58667926
Improving physical health and reducing substance use in psychosis - randomised control trial (IMPACT RCT): study protocol for a cluster randomised controlled trial
The National Institute for Health Research funds the IMPACT programme at
Kingâs College London and South London and Maudsley NHS Foundation
Trust (ref: RP-PG-0606-1049)
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