Prospectus, September 28, 1973

OVERWHELMING RESPONSE TO ACTIVITIES WEEK; Four File Petitions For Senator; Variety Talent Needed For October Show; David Stanley Named To Head Parkland Prospectus Staff; Reactions To New Drinking Law; Toy For Kids And War; Guest Editorial; Prospectus In Perspective: Student President\u27s Report; Boycott Non-Union Lettuce; Roving Counselors New Addition To FSM Centers; Lake: \u27Energy...Essence of Art\u27; Walker Defends Positions On Schools, Lakes; Board Approves Operating Budget; New Faculty Members; Counselors\u27 Schedule For FSM; Prospectus Plan Presented To Board Members; Want To Sing, Swing, Play?; Students Find Voice In College Government; Candidates Draft Platforms, Elections On Oct. 10-11; Black Art/Poetry; Dental Services Free To Students; Audubon Society Opens Season; Monday\u27s Coach; Hustler Is Hustled As King Wins Crown; Outreach Program To Bridge Gap; \u27A Quarter\u27s Worth\u27 Selects Editor; Mailer To Lecture At River Forest; Mike Scruggs Wins Football Contest; Road Rally & Sports Car Club; Earle Grabs Successive Cross Country Titles; Linksmen Seventh In Golf Opener; Touch Football Gets Underway, Intramurals In Full Swing; Trucker\u27s Lead Bowling League; Fast Freddy\u27s Football Forecast; Carlin Social Parody Blows Mind; Mutt and Mortie; Board Discusses Student Rep; Dear Mr. Secretary; Explicit Needs Fulfilled By Black Groups; The Short Circuit; Letters From Our Readers; Debate Competition Opens Against Western Illinois; Classified Ads; Faculty Wives Outline Programs; Program List For 1973-74; LRC Ready For Students; Rosh Hashanah Signals Start Of Jewish Holidays; Callboard; I. E. Team Plans Intercollegiate Competition; Krannert Art Center Schedule; Staff Requests News Releaseshttps://spark.parkland.edu/prospectus_1973/1005/thumbnail.jp

Prospectus, October 12, 1973

AGNEW RESIGNS VICE-PRESIDENCY; Small Turnout For Election; Prospectus Editors Announced; Walk Attracts Over 600; All Amendments Pass; Prospectus In Perspective: Excellent Bike Path Choice, Letters From Our Readers, New Magazine Coming, At this point in time.....; The Short Circuit; Drama Department Introduces New Lounge Theatre; United Way Campaign Begins; Announces $19,290 Bog Award; Ieardi Headlines Talent Program; Road Rally Club; New Breed of Businessman: Young College Graduate; Student Appointed As Board Member; New Concept For P/C Typing Classes; New Name, Faces For Magazine; Parkland Team To Debate At Bradley Oct. 20; Parkland Instructor Hospitalized at Mercy; PCA Appoints Student Affairs Committee Members; C-U Politics To Be Discussed At Forum; Walk For Mankind; Parkland Announces Bike Rules; Student Senate Reviews Charters, Future Plans; Gayle Wright Chosen To Advise Capstone; Vet\u27s Outreach Aids Readjustment; Prospectus Gains Two Campus Cartoonists; Seminar Planned On \u27Volunteering\u27; P/C Biologists At IACCB Convention; \u27Siege\u27 Shocking, Relevant Film; Faculty Members To Hold Offices; Winter Registration Information; Parkland Student Wins Santa Fe Scholarship; Birthday Wishes; Pre-Registration Benefits All; Target Program To Sponsor Open House; Women Voters Begin Sale Of ERA Bracelet; Ferlinghetti Sues San Francisco Police; Applications Must Be Filed; A Column By And For Women: Born To Be A Woman, The Way It Used To Be, The Lib, I Am Woman; Mutt and Mortie; Fast Freddy\u27s Football Forecast; Fall Intramural; Bowling Bulletin Board; Football Results; Dennis Bailen Wins Fast Freddy; Monday\u27s Coach; Rugby Play Not Football; Harriers Slump To Third, Fourth; Hiser Receives Babe Ruth Award; Graduation; TARGET Sets Sights On Juveniles; Classified Ads; Johnson Calls For Truth, Integrity; Gammon: \u27Everyone Born With Ability\u27; Student President\u27s Report; Lives Changed By Jesus Christ; Cruisin\u27 \u2773; Candidates Learn Voting Procedure; Speleunkers Travel Virgin Paths; Krannert Art Center Schedule; Illini Student Union Movies; Lab Develops Self-Study Habits; Callboard; Race To Fund Town With Doctor; Council Member Proposes Later Bar Hourshttps://spark.parkland.edu/prospectus_1973/1004/thumbnail.jp

Genetic mechanisms of critical illness in COVID-19.

Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 ×  10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice

Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers of brain injury, inflammatory mediators, and autoantibodies in 203 hospitalised participants; 111 with acute sera (1–11 days post-admission) and 92 convalescent sera (56 with COVID-19-associated neurological diagnoses). Here we show that compared to 60 uninfected controls, tTau, GFAP, NfL, and UCH-L1 are increased with COVID-19 infection at acute timepoints and NfL and GFAP are significantly higher in participants with neurological complications. Inflammatory mediators (IL-6, IL-12p40, HGF, M-CSF, CCL2, and IL-1RA) are associated with both altered consciousness and markers of brain injury. Autoantibodies are more common in COVID-19 than controls and some (including against MYL7, UCH-L1, and GRIN3B) are more frequent with altered consciousness. Additionally, convalescent participants with neurological complications show elevated GFAP and NfL, unrelated to attenuated systemic inflammatory mediators and to autoantibody responses. Overall, neurological complications of COVID-19 are associated with evidence of neuroglial injury in both acute and late disease and these correlate with dysregulated innate and adaptive immune responses acutely

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

Stratifying Deterioration Risk by Acuity at Admission Offers Triage Insights for Coronavirus Disease 2019 Patients.

OBJECTIVES: Triaging patients at admission to determine subsequent deterioration risk can be difficult. This is especially true of coronavirus disease 2019 patients, some of whom experience significant physiologic deterioration due to dysregulated immune response following admission. A well-established acuity measure, the Rothman Index, is evaluated for stratification of patients at admission into high or low risk of subsequent deterioration. DESIGN: Multicenter retrospective study. SETTING: One academic medical center in Connecticut, and three community hospitals in Connecticut and Maryland. PATIENTS: Three thousand four hundred ninety-nine coronavirus disease 2019 and 14,658 noncoronavirus disease 2019 adult patients admitted to a medical service between January 1, 2020, and September 15, 2020. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Performance of the Rothman Index at admission to predict in-hospital mortality or ICU utilization for both general medical and coronavirus disease 2019 populations was evaluated using the area under the curve. Precision and recall for mortality prediction were calculated, high- and low-risk thresholds were determined, and patients meeting threshold criteria were characterized. The Rothman Index at admission has good to excellent discriminatory performance for in-hospital mortality in the coronavirus disease 2019 (area under the curve, 0.81-0.84) and noncoronavirus disease 2019 (area under the curve, 0.90-0.92) populations. We show that for a given admission acuity, the risk of deterioration for coronavirus disease 2019 patients is significantly higher than for noncoronavirus disease 2019 patients. At admission, Rothman Index-based thresholds segregate the majority of patients into either high- or low-risk groups; high-risk groups have mortality rates of 34-45% (coronavirus disease 2019) and 17-25% (noncoronavirus disease 2019), whereas low-risk groups have mortality rates of 2-5% (coronavirus disease 2019) and 0.2-0.4% (noncoronavirus disease 2019). Similarly large differences in ICU utilization are also found. CONCLUSIONS: Acuity level at admission may support rapid and effective risk triage. Notably, in-hospital mortality risk associated with a given acuity at admission is significantly higher for coronavirus disease 2019 patients than for noncoronavirus disease 2019 patients. This insight may help physicians more effectively triage coronavirus disease 2019 patients, guiding level of care decisions and resource allocation

Editorial: Thank You to Our 2018 Peer Reviewers

On behalf of the journal, AGU, and the scientific community, the Editors would like tosincerely thank those who reviewed manuscripts forGeophysical Research Lettersin 2018. Thehours reading and commenting on manuscripts not only improves the manuscripts but also increases thescientific rigor of future research in thefield. We particularly appreciate the timely reviews, in lightof the demands imposed by the rapid review process atGeophysical Research Letters. With the revival of the "major revisions" decisions, we appreciate the reviewers' efforts on multiple versions of some manuscripts.Many of those listed below went beyond and reviewed three or more manuscripts for our journal,and those are indicated in italics. In total, 4,484 referees contributed to 7,557 individual reviews in journal.Thank you again. We look forward to the coming year of exciting advances in thefieldand communicating those advances to our community and to the broader public