4,893 research outputs found
Standard Error of Empirical Bayes Estimate in NONMEM® VI.
The pharmacokinetics/pharmacodynamics analysis software NONMEM® output provides model parameter estimates and associated standard errors. However, the standard error of empirical Bayes estimates of inter-subject variability is not available. A simple and direct method for estimating standard error of the empirical Bayes estimates of inter-subject variability using the NONMEM® VI internal matrix POSTV is developed and applied to several pharmacokinetic models using intensively or sparsely sampled data for demonstration and to evaluate performance. The computed standard error is in general similar to the results from other post-processing methods and the degree of difference, if any, depends on the employed estimation options
Electron correlations in MnGaAs as seen by resonant electron spectroscopy and dynamical mean field theory
After two decades from the discovery of ferromagnetism in Mn-doped GaAs, its
origin is still debated, and many doubts are related to the electronic
structure. Here we report an experimental and theoretical study of the valence
electron spectrum of Mn-doped GaAs. The experimental data are obtained through
the differences between off- and on-resonance photo-emission data. The
theoretical spectrum is calculated by means of a combination of
density-functional theory in the local density approximation and dynamical
mean-field theory (LDA+DMFT), using exact diagonalisation as impurity solver.
Theory is found to accurately reproduce measured data, and illustrates the
importance of correlation effects. Our results demonstrate that the Mn states
extend over a broad range of energy, including the top of the valence band, and
that no impurity band splits off from the valence band edge, while the induced
holes seem located primarily around the Mn impurity.Comment: 5 pages, 4 figure
Polarized Neutron Laue Diffraction on a Crystal Containing Dynamically Polarized Proton Spins
We report on a polarized-neutron Laue diffraction experiment on a single
crystal of neodynium doped lanthanum magnesium nitrate hydrate containing
polarized proton spins. By using dynamic nuclear polarization to polarize the
proton spins, we demonstrate that the intensities of the Bragg peaks can be
enhanced or diminished significantly, whilst the incoherent background, due to
proton spin disorder, is reduced. It follows that the method offers unique
possibilities to tune continuously the contrast of the Bragg reflections and
thereby represents a new tool for increasing substantially the signal-to-noise
ratio in neutron diffraction patterns of hydrogenous matter.Comment: 5 pages, 3 figure
The Distribution of Redshifts in New Samples of Quasi-stellar Objects
Two new samples of QSOs have been constructed from recent surveys to test the
hypothesis that the redshift distribution of bright QSOs is periodic in
. The first of these comprises 57 different redshifts among all
known close pairs or multiple QSOs, with image separations 10\arcsec,
and the second consists of 39 QSOs selected through their X-ray emission and
their proximity to bright comparatively nearby active galaxies. The redshift
distributions of the samples are found to exhibit distinct peaks with a
periodic separation of in identical to that claimed
in earlier samples but now extended out to higher redshift peaks and 4.47, predicted by the formula but never seen before. The periodicity
is also seen in a third sample, the 78 QSOs of the 3C and 3CR catalogues. It is
present in these three datasets at an overall significance level -
, and appears not to be explicable by spectroscopic or similar
selection effects. Possible interpretations are briefly discussed.Comment: submitted for publication in the Astronomical Journal, 15 figure
Can we always get the entanglement entropy from the Kadanoff-Baym equations? The case of the T-matrix approximation
We study the time-dependent transmission of entanglement entropy through an
out-of-equilibrium model interacting device in a quantum transport set-up. The
dynamics is performed via the Kadanoff-Baym equations within many-body
perturbation theory. The double occupancy , needed to determine the entanglement entropy, is obtained from
the equations of motion of the single-particle Green's function. A remarkable
result of our calculations is that can become negative, thus not permitting to evaluate the
entanglement entropy. This is a shortcoming of approximate, and yet conserving,
many-body self-energies. Among the tested perturbation schemes, the -matrix
approximation stands out for two reasons: it compares well to exact results in
the low density regime and it always provides a non-negative . For the second part of this statement, we
give an analytical proof. Finally, the transmission of entanglement across the
device is diminished by interactions but can be amplified by a current flowing
through the system.Comment: 6 pages, 6 figure
Pharmacokinetic Interactions for Drugs with a Long Half-Life—Evidence for the Need of Model-Based Analysis
Absorbing boundary conditions for dynamical many-body quantum systems
In numerical studies of the dynamics of unbound quantum mechanical systems,
absorbing boundary conditions are frequently applied. Although this certainly
provides a useful tool in facilitating the description of the system, its
applications to systems consisting of more than one particle is problematic.
This is due to the fact that all information about the system is lost upon
absorption of one particle; a formalism based solely on the Scrh{\"o}dinger
equation is not able to describe the remainder of the system as particles are
lost. Here we demonstrate how the dynamics of a quantum system with a given
number of identical fermions may be described in a manner which allows for
particle loss. A consistent formalism which incorporates the evolution of
sub-systems with a reduced number of particles is constructed through the
Lindblad equation. Specifically, the transition from an -particle system to
an -particle system due to a complex absorbing potential is achieved by
relating the Lindblad operators to annihilation operators. The method allows
for a straight forward interpretation of how many constituent particles have
left the system after interaction. We illustrate the formalism using
one-dimensional two-particle model problems.Comment: 16 pages, 5 figure
Fluvial carbon dioxide emission from the Lena River basin during the spring flood
Greenhouse gas (GHG) emission from inland waters of permafrost-affected regions is one of the key factors of circumpolar aquatic ecosystem response to climate warming and permafrost thaw. Riverine systems of central and eastern Siberia contribute a significant part of the water and carbon (C) export to the Arctic Ocean, yet their C exchange with the atmosphere remains poorly known due to lack of in situ GHG concentration and emission estimates. Here we present the results of continuous in situ pCO2 measurements over a 2600 km transect of the Lena River main stem and lower reaches of 20 major tributaries (together representing a watershed area of 1 661 000 km2, 66 % of the Lena's basin), conducted at the peak of the spring flood. The pCO2 in the Lena (range 400-1400 μatm) and tributaries (range 400-1600 μatm) remained generally stable (within ca. 20 %) over the night-day period and across the river channels. The pCO2 in tributaries increased northward with mean annual temperature decrease and permafrost increase; this change was positively correlated with C stock in soil, the proportion of deciduous needleleaf forest, and the riparian vegetation. Based on gas transfer coefficients obtained from rivers of the Siberian permafrost zone (kCombining double low line4.46 md-1), we calculated CO2 emission for the main stem and tributaries. Typical fluxes ranged from 1 to 2 gCm-2d-1 (>99 % CO2, <1 % CH4), which is comparable with CO2 emission measured in the Kolyma, Yukon, and Mackenzie rivers and permafrost-affected rivers in western Siberia. The areal C emissions from lotic waters of the Lena watershed were quantified by taking into account the total area of permanent and seasonal water of the Lena basin (28 000 km2 ). Assuming 6 months of the year to be an open water period with no emission under ice, the annual C emission from the whole Lena basin is estimated as 8.3±2.5 TgCyr-1, which is comparable to the DOC and dissolved inorganic carbon (DIC) lateral export to the Arctic Ocean
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