17 research outputs found
Características clínicas e epidemiológicas de lesões entre adolescentes atendidos em um pronto-socorro na cidade de Ribeirão Preto, São Paulo
CONTEXT AND OBJECTIVE: Injuries are an important cause of morbidity during adolescence, but can be avoided through learning about some of their characteristics. This study aimed to identify the most frequent injuries among adolescents attended at an emergency service. DESIGN AND SETTING: Retrospective descriptive study on adolescents attended at the emergency service of the Teaching Health Center, Faculdade de Medicina de Ribeirão Preto (FMRP), between January 1, 2009, and September 30, 2009. METHODS: Age, sex, type of injury, site, day and time of occurrence, part of body involved, care received, whether the adolescent was accompanied at the time of injury and whether any type of counseling regarding injury prevention had been given were analyzed. RESULTS: Among 180 adolescents attended, 106 (58.8%) were boys and 74 (41.1%) were girls. Their ages were: 10 to 12 (66/36.6%), 12 to 14 (60/33.3%) and 14 to 16 years (54/30%). The injuries had occurred in public places (47.7%) and at home (21.1%). The main types were bruises (45.1%) and falls (39.2%), involving upper limbs (46.1%), lower limbs (31%) and head/neck (13.1%). The injuries occurred in the afternoon (44.4%) and morning (30%), on Mondays (17.7%) and Thursdays (16.6%). Radiological examinations were performed on 53.8%. At the time of injury, 76.1% of the adolescents were accompanied. Some type of counseling about injury prevention had been received by 39.4%. CONCLUSIONS: Although the injuries were of low severity, preventive attitudes need to be incorporated in order to reduce the risks and provide greater safety for adolescents
Epidemiological and clinical characteristics of injuries among adolescents attended at an emergency service in the city of Ribeirao Preto, Sao Paulo
CONTEXT AND OBJECTIVE: Injuries are an important cause of morbidity during adolescence, but can be avoided through learning about some of their characteristics. This study aimed to identify the most frequent injuries among adolescents attended at an emergency service. DESIGN AND SETTING: Retrospective descriptive study on adolescents attended at the emergency service of the Teaching Health Center, Faculdade de Medicina de Ribeirao Preto (FMRP), between January 1, 2009, and September 30, 2009. METHODS: Age, sex, type of injury, site, day and time of occurrence, part of body involved, care received, whether the adolescent was accompanied at the time of injury and whether any type of counseling regarding injury prevention had been given were analyzed. RESULTS: Among 180 adolescents attended, 106 (58.8%) were boys and 74 (41.1%) were girls. Their ages were: 10 to 12 (66/36.6%), 12 to 14 (60/33.3%) and 14 to 16 years (54/30%). The injuries had occurred in public places (47.7%) and at home (21.1%). The main types were bruises (45.1%) and falls (39.2%), involving upper limbs (46.1%), lower limbs (31%) and head/neck (13.1%). The injuries occurred in the afternoon (44.4%) and morning (30%), on Mondays (17.7%) and Thursdays (16.6%). Radiological examinations were performed on 53.8%. At the time of injury, 76.1% of the adolescents were accompanied. Some type of counseling about injury prevention had been received by 39.4%. CONCLUSIONS: Although the injuries were of low severity, preventive attitudes need to be incorporated in order to reduce the risks and provide greater safety for adolescents
Studies on an (<i>S</i>)‑2-Amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic Acid (AMPA) Receptor Antagonist IKM-159: Asymmetric Synthesis, Neuroactivity, and Structural Characterization
IKM-159
was developed and identified as a member of a new class
of heterotricyclic glutamate analogues that act as AMPA receptor-selective
antagonists. However, it was not known which enantiomer of IKM-159
was responsible for its pharmacological activities. Here, we report
in vivo and in vitro neuronal activities of both enantiomers of IKM-159
prepared by enantioselective asymmetric synthesis. By employment of
(<i>R</i>)-2-amino-2-(4-methoxyphenyl)ethanol as a chiral
auxiliary, (2<i>R</i>)-IKM-159 and the (2<i>S</i>)-counterpart were successfully synthesized in 0.70% and 1.5% yields,
respectively, over a total of 18 steps. Both behavioral and electrophysiological
assays showed that the biological activity observed for the racemic
mixture was reproduced only with (2<i>R</i>)-IKM-159, whereas
the (2<i>S</i>)-counterpart was inactive in both assays.
Racemic IKM-159 was crystallized with the ligand-binding domain of
GluA2, and the structure revealed a complex containing (2<i>R</i>)-IKM-159 at the glutamate binding site. (2<i>R</i>)-IKM-159
locks the GluA2 in an open form, consistent with a pharmacological
action as competitive antagonist of AMPA receptors
Studies on an (<i>S</i>)‑2-Amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic Acid (AMPA) Receptor Antagonist IKM-159: Asymmetric Synthesis, Neuroactivity, and Structural Characterization
IKM-159
was developed and identified as a member of a new class
of heterotricyclic glutamate analogues that act as AMPA receptor-selective
antagonists. However, it was not known which enantiomer of IKM-159
was responsible for its pharmacological activities. Here, we report
in vivo and in vitro neuronal activities of both enantiomers of IKM-159
prepared by enantioselective asymmetric synthesis. By employment of
(<i>R</i>)-2-amino-2-(4-methoxyphenyl)ethanol as a chiral
auxiliary, (2<i>R</i>)-IKM-159 and the (2<i>S</i>)-counterpart were successfully synthesized in 0.70% and 1.5% yields,
respectively, over a total of 18 steps. Both behavioral and electrophysiological
assays showed that the biological activity observed for the racemic
mixture was reproduced only with (2<i>R</i>)-IKM-159, whereas
the (2<i>S</i>)-counterpart was inactive in both assays.
Racemic IKM-159 was crystallized with the ligand-binding domain of
GluA2, and the structure revealed a complex containing (2<i>R</i>)-IKM-159 at the glutamate binding site. (2<i>R</i>)-IKM-159
locks the GluA2 in an open form, consistent with a pharmacological
action as competitive antagonist of AMPA receptors