Surveillance post-AMM des vaccins

La surveillance pharmacoépidémiologique post-AMM (autorisation de mise sur le marché) est indispensable pour préciser le rapport risque/efficacité des vaccins dans les conditions usuelles d'utilisation. Cette surveillance doit permettre d'évaluer leur innocuité à long terme et à large échelle et permet de disposer d'éléments d'information permettant de décider le cas échéant le retrait d'un vaccin. La surveillance épidémiologique permet d'apprécier l'impact à long terme de la protection conférée par un vaccin et comporte la surveillance de l'incidence et de la mortalité des maladies à prévention vaccinale mais également la réceptivité de la population aux agents infectieux. Elle permet par ailleurs de vérifier l'adéquation de la sélection des souches vaccinales avec les souches circulantes

Additional file 1: of Medical follow-up of workers exposed to lung carcinogens: French evidence-based and pragmatic recommendations

Composition of working group and reading group, consulted databases and keywords used. (DOCX 15 kb

Maintien en emploi des patients atteints de cancer

Return to work is a public health priority which led the French Health Authority to publish recommendations about "return to work and health: prevention of exclusion from work". The aim of this article is to present a literature review of return to work after cancer. Studies about medium-term and long-term effects of cancer are sparse. They suggest worker durable effects. Factors associated with return to work are linked to the patient characteristics, to characteristics of the illness and the treatment, to the workplace and to the help provided to the patient during the return to work process. A specific plan for returning to work in 3 phases (situation comprehension, identification of negative and positive factors for returning to work, implementation of measures concerning the patient, the workplace and the coordination between return to work actors) should be built for each patient, involving the worker, the occupational practitioner, the general and specialist practitioners

Additional file 2: of Medical follow-up of workers exposed to lung carcinogens: French evidence-based and pragmatic recommendations

Level of risk of BPC associated with occupational risks. (DOCX 123 kb

Low-temperature optical constants of amorphous silicate dust analogues

International audienceContext. Cosmic dust models are key ingredients in advancing our understanding of astronomical environments as diverse as interstellar clouds in galaxies, circumstellar envelopes around evolved and young stars, and protoplanetary disks. Such models consist of several dust populations, each with different compositions and size distributions. They may also consider different grain shapes, although most models assume spherical grains. All include a component of silicate dust. The absorption and emission properties of these dust components are calculated from the optical constants of each dust material which have various experimental, phenomenological, and theoretical origins depending on the model. Aims. We aim to provide the community with new sets of optical constants for amorphous silicate dust analogues at low temperatures. The analogues consist of four Mg-rich silicate samples of stoichiometry ranging from enstatite to olivine, and of eight samples of Mgand Fe-rich silicates with a pyroxene stoichiometry and differing magnesium and iron content. Methods. We calculated the optical constants from transmission measurements using the Kramers-Kronig relations, assuming that the grains are small compared to the wavelength and prolate in shape with axis ratios of 1.5 and 2 for the Mg-and Fe-rich samples, respectively. Results. New optical constants for silicate dust analogues of various compositions were calculated over the wavelength range from 5 to 800 µm or 1000 µm, depending on the sample, and at temperatures of 10, 30, 100, 200, and 300 K. We determined the uncertainties on the derived optical constants based on the assumptions used to calculate them. To facilitate the use of these data in cosmic dust models, we provide optical constants extrapolated outside the measured spectral range into the ultraviolet(UV)/visual(VIS)/nearinfrared(NIR) and millimetre and centimetre wavelength ranges, as well as formulae that can be used to interpolate the optical constants at any temperature in the range 10 − 300 K

FILTER-FREE LIGHT ABSORPTION MEASUREMENT OF VOLCANIC ASHES AND AMBIENT PARTICULATE MATTER USING MULTI-WAVELENGTH PHOTOACOUSTIC SPECTROSCOPY

International audienc

Follow-up for pregnant women during the COVID-19 pandemic: French national authority for health recommendations

International audienc

A national media mass campaign improves beliefs and behaviours about low back pain in the general population and in general practitioners

International audienceIntroduction: Previous international mass-media campaigns for low back pain (LBP) have had conflicting impacts on the general population. The objective was to evaluate the impact of a national back pain campaign conducted between 2017 and 2019 on beliefs and behaviours of general practitioners and the general population in France.Methods: Between 2017 and 2019, a mass-media campaign was used to disseminate positive messages about LBP using several media, along with a parallel campaign addressed to general practitioners. An email survey before the campaign and 6 and 18 months after the campaign started evaluated beliefs and behaviours among a representative sample of the 2 target populations (3500 people from the gen-eral population and 700 general practitioners before the campaign, and 2000 people and 300 general practitioners 6 and 18 months after).Results: Overall, 56% of the general population respondents before the campaign and 74% and 75% at 6 and 18 months after adhered to the statement "One should maintain physical activity" when dealing with LBP. Conversely, the percentage adhering to the statement "The best treatment is resting" decreased significantly from 68% before the campaign to 45% at 6 and 18 months after. Physicians reported delivering more reassurance and giving more documentation to patients after the campaign. They prescribed less sick leave during the first consultation (65% before the campaign, 46% and 30% at 6 and 18 months after).Conclusion: A mass-media campaign aimed at the public and general practitioners in France significantly modified beliefs and behaviours about LBP.(c) 2023 Published by Elsevier Masson SAS on behalf of Socie acute accent te acute accent franc , aise de rhumatologie

Recommandations et arbre décisionnel sur la prise en charge de la lombalgie avec ou sans radiculalgie

Objectif: Développer et valider des recommandations françaises à destination des professionnels de santé prenant en charge les patients présentant une lombalgie commune avec ou sans radiculalgie. Méthodes: Afin de synthétiser la littérature existante, un rapport d’élaboration a été créé à partir d’une revue systématique des méta-analyses publiées sur la lombalgie entre 2015 et 2018 ainsi que des recommandations internationales publiées entre 2013 et 2018, pour synthétiser l’état des connaissances scientifiques. Un groupe d’experts multidisciplinaire comprenant 17 professionnels de santé impliqués dans la prise en charge de la lombalgie et 2 représentants des patients a été constitué. Ce groupe a élaboré des recommandations préliminaires ainsi qu’un parcours de soins. Après consultation de 25 institutions académiques, une version définitive des recommandations et de l’arbre décisionnel a été validée. Pour chaque recommandation, un accord entre experts a été évalué par la méthode RAND/UCLA. Résultats: Le groupe d’experts a rédigé 32 recommandations préliminaires, dont un parcours de soins, qui a été modifié après consultation des institutions académiques. Le consensus du groupe d’experts multidisciplinaire a été évalué pour chaque recommandation finale : 32 recommandations ont été évaluées comme appropriées ; aucune n’a été évaluée comme incertaine ou inappropriée. Une approbation forte a été obtenue pour 27 recommandations et faible pour 5. Conclusion: Ces nouvelles recommandations introduisent plusieurs concepts dans la prise en charge de la lombalgie, notamment la nécessité d’identifier précocement les lombalgies à risque de chronicité afin de permettre une prise en charge accélérée et si nécessaire pluridisciplinaire