Prozercon banazensis sp. Nov. (Acari: Mesostigmata: Zerconidae), a new species of zerconid mite from Turkey, with a new record

In this study, Prozercon banazensis sp. nov. is described and illustrated from female and deutonymph specimens collected in Kütahya and Uşak provinces (Turkey). Morphological features of P. morazae Ujvári, 2011, which is a new record for the Turkish fauna, are also given with drawings. Information on habitat and distribution for each species is also provided. © TÜBİTAK

Differentiation Of Cord Blood Mesenchymal Stem Cells To Bone Tissue For Tissue Engineering Applications

Tez (Yüksek Lisans) -- İstanbul Teknik Üniversitesi, Fen Bilimleri Enstitüsü, 2010Thesis (M.Sc.) -- İstanbul Technical University, Institute of Science and Technology, 2010Kemik mühendisliği uygulamalarına olan ihtiyaç, yaygın travmalar ve kemik kırıklarının geniş çaplı iyileştirilmesine yönelik klinik yaklaşımlar ile ilgili olarak giderek artmaktadır. Otolog kemik nakli halen kemik iyileşmesine yönelik uygulamaların başında gelmektedir. Yine de, kemik nakli için kullanılacak nakil örneklerinin düşük hacimleri, donör bölgelerin azlığı, sağlam ve güçlü kemik oluşumu sağlamak için yeni arayışların doğmasına yol açmıştır. Doku mühendisliği, hücrelerin yeniden organizasyonunu sağlayarak aktarılabilir doku örnekleri üretimine yoğunlaşmıştır. Diğer dokularla ilgili çalışmaların aksine kemik doku mühendisliğinde hücre, sinyal molekülleri ve 3 boyutlu yapıların katıldığı birçok yaklaşım vardır. Bu yüzden, in vitro çalışmalar in vivo koşullarda kullanılabilecek ve kemik oluşumunu sağlayacak yapay iskelet yapılarının verimliliğini araştırmaya yönelmiştir. Kemik oluşturmak için kullanılan yapay iskeletlerin yapımında biyoseramikler, biyopolimerler, metaller ve farklı bileşikler gibi çeşitli biyomateryaller kullanılmaktadır. Bu materyallerin, osteo-iletken, hücreler için tutunma yüzeyi oluşturan, hücre çoğalımını destekleyici ve biyomoleküler sinyallerin iletimi sağlayacak şekilde üretilmesi hedeflenmektedir. Mezenkimal kök hücreler, birçok farklı dokuya farklılaşma potansiyeli taşıyan multipotent progenitör hücrelerdir. Mezenkimal kök hücrelerin vücuttaki yaygın dağılımına örnek olarak, kemik iliği, yağ dokusu, kordon, kordon kanı, iskelet kasları, periost, sinovial zarlar, dermis, perisitler, trabeküler kemik, akciğer dokusu, diş pulpası ve periodontal ligamentlerde bulunabilirliği örnek olarak verilebilir. Mezenkimal kök hücreler, daha önce kemik iliğinden, yağ dokusundan, kordon kanından, amniotik sıvıdan, plasentadan ve sinavial zarlardan izole edilmiştir. Bu çalışma, temel olarak insan kordon kanından izole edilmiş mezenkimal kök hücrelerin yeni sentezlenmiş hidroksiapatit içeren poli(N-vinil-2prolidon-co-maleik asit) polimeri üzerinde 3 boyutlu bir şekilde kemik dokusuna farklılaştırılmasını hedeflemektedir. Çalışmanın biyobenzetme özü, kullanılacak olan yapının, gerçek insan kemik parçalarının davranışlarını in vivo kuşullarda gerekli olan moleküler, biyokimyasal ve morfolojik olarak taklit etmeyi amaçlamasındır.The demand for engineered bone is becoming increasingly high due to the need for curing traumas and fractures in clinics. Autologous bone grafts still seem to be the gold standards for progressive bone regeneration. However, the limitations regarding the produced volumes of bone grafts and donor scarcity is leading the approaches into finding alternative techniques to advance stable bone formation. Tissue engineering is a developing area that focuses on generating tissue replacements using arrangements of cells. In contrast to many tissues, there are may approaches to bone tissue engineering all involving cells, signalling molecules and 3-D scaffolds. Still this emerging field seeks the development of viable substitutes that maintain the function of the human bone-tissue. Therefore, in vitro studies have been focused to screening the efficiency of newly designed scaffolds for in vivo utilization for restoring bone regeneration. Different kind of biomaterials, such as bio-ceramics, biopolymers, metals, and composites have been used in bone tissue engineering to form the bone scaffold. Scaffold materials for bone tissue engineering applications can be engineered to be osteoconductive, providing a substrate for tissue growth that helps adhesion, proliferation, and differentiated function of bone forming cells. In addition it is also highly desirable that the scaffold has the ability to promote ECM secretion, and to carry biomolecular signals. Mesenchymal stem cells (MSCs) comprise a population of multipotent progenitor cells capable of differentiating into many tissues. The diverse in vivo distribution of MSCs comprises mainly the bone marrow, adipose tissue, human umbilical cord, blood, skeletal muscles, periosteum, synovial membrane, dermis, pericytes, trabecular bone, lung tissue, dental pulp and periodontal ligaments. MSCs are reported to be isolated from various sources of tissues besides bone marrow, such as adipose tissue, umbilical cord blood (UCB), amniotic fluid, membrane, placenta and synovial tissue. This study primarily focuses on the use of mesenchymal stem cells derived from umbilical cord blood on a newly synthesized hydroxyapatite containing poly(N-vinyl-2 prolydone-co-maleic acid) scaffold assigning the MSCs to differentiate towards forming bone in a 3D manner. The biomimetic essence of the study derives mimicking the actual fragment of human bone with respect to all necessary aspect of in vivo conditions, i.e. molecular, biochemical and morphological.Yüksek LisansM.Sc

Examining the Etiology of Patients Diagnosed With Polyneuropathy According to Subtypes

DergiPark: 379019tmsjAims: In this study, the aim is to classify the patients who were diagnosed with polyneuropathy in Trakya University Health Services Research and Application Center Neurology Polyclinics EMG Lab between years 2014 and 2015, relevant to their subtypes (axonal, sensorial and sensorimotor), and to investigate the causes and their relation to each subtype.Methods: The reports of 144 patients diagnosed with polyneuropathy in between 2014 and 2015 were scannedretrospectively. The patients were represented with age, gender, polyneuropathy type and etiologic inference. The correlation between the diagnosis of polyneuropathy and its underlying etiology was analyzed with the SPSS software and presented statistically. Patients were categorized in accordance to their polyneuropathy types by chi-square test. As descriptive statistics, numbers and percentages, arithmetic mean ± standard deviation and median (minimum-maximum) values were provided.Results: It is seen that the patients whose application is related to diabetes, cancer, chemotherapy, dysproteinemia,AIDS, B12 vitamin insufficiency and pyridoxine intoxication have a higher rate of polyneuropathy. Meanwhile, no significant difference among the causes of the three polyneuropathy types was found.Conclusion: Thorough and attentive investigation on the etiology of patients who were diagnosed with polyneuropathy can lead to pre-diagnosi

An Analysis of Pre-service Elementary School Teachers' Skills in Geometrical Drawing Using Isometric Pape

The aim of this study was to determine pre-service elementary school teachers’ capabilities of deciding the viewpoint and perspective in geometrical drawing. The study examined geometrical drawings the participants did on isometric paper. This is a case study, a qualitative study method, and the study data were analyzed using written documents. The study sample included 34 senior students in the Education Faculty’s Elementary School Teaching Program at a Turkish public university. They were selected from approximately 205 pre-service teachers. The students participated in the study on a voluntary basis. The study results revealed that the pre-service teachers generally had weak skills in geometrical drawing. The participants had better skills in building structures which they saw from the air using unit blocks, and forming a structure of which they had the direct views (left and right; front and back) using unit blocks. However, the participants had weaker skills in drawing the direct views of the structures they had built, recognizing the connections between the left-right views and front-back views of the structures and drawing the structures they built on isometric paper in perspective

AKADEMİSYENLERİN DAVRANIŞSAL ÖNYARGILARI İLE FİNANSAL OKURYAZARLIK DÜZEYLERİ ARASINDAKİ İLİŞKİ: TOKAT GAZİOSMANPAŞA ÜNİVERSİTESİ ÜZERİNE BİR ARAŞTIRMA

Bu çalışmanın amacı, Tokat Gaziosmanpaşa Üniversitesi akademik personelinin davranışsal önyargıları ile finansal okuryazarlık düzeyleri arasındaki ilişkiyi tespit etmektir. Ayrıca örneklemde yer alan üniversitenin fakülte, yüksekokul ve meslek yüksekokullarında görevli akademik personelin davranışsal önyargıları ile finansal okuryazarlık düzeylerinin benzer ve farklı noktalarının neler olduğunu ortaya koymaktadır. Bunlara ek olarak, akademik personelin cinsiyet, unvan ve gelir durumu gibi demografik özellikleri ile davranışsal önyargıları ve finansal okuryazarlık düzeyleri arasındaki ilişkiyi tespit etmek amaçlanmıştır. Bu amaç doğrultusunda, Tokat Gaziosmanpaşa Üniversitesi akademik personeline online anket uygulanmıştır. Anketler üniversitenin tüm akademik personeline yönlendirilmiş olup 379 katılımcıya ulaşılmıştır. Uygulanan anket ile elde edilen veriler SPSS paket programı ile analiz edilmiştir. Yapılan analiz sonuçlarına göre ankete katılan akademik personelin yüksek düzeyde finansal okuryazar olmasına rağmen yine de orta düzeyde davranışsal önyargıların etkisi altında kaldığı tespit edilmiştir. Akademisyenlerin davranışsal önyargıları ile finansal okuryazarlık düzeyi arasında pozitif yönlü ve çok zayıf bir ilişki tespit edilmiş olup akademisyenlerin finansal okuryazarlık düzeyleri davranışsal önyargılarını %21,3 oranında etkilediği sonucuna ulaşılmıştır

Assessment of the socioeconomic cost of drug use and addiction and ıts relationship with crime

Dünya’da son yıllarda artan bir madde kullanım eğilimi kaydedilmektedir. Birçok toplum için madde kullanımı ve bağımlılığı sosyoekonomik maliyeti azımsanamayacak düzeyde önemli bir biyopsikososyal problem olarak tanımlanmaktadır. Sosyo-ekonomik maliyeti açısından madde kullanımının ve bağımlılığının değerlendirilmesi ve suç ile ilişkisinin ortaya konması özellikle sağlık, madde, ekonomi ve sosyal politikalarının oluşturulmasında büyük bir önem taşımaktadır. Suç madde kullanımının ve bağımlılığının sosyoekonomik maliyeti kapsamında değerlendirilmektedir. Madde kullanımı, bağımlılığı ve suç arasındaki ilişki ise sürekli tartışılan bir konudur. Literatürde madde kullanımı ve suç ilişkisini açıklayan farklı modeller geliştirilmiştir. Bu çalışmada madde kullanımı ve bağımlılığı sosyoekonomik maliyet açısından ele alınmış ve suç ile ilişkisi madde-suç ilişkisi üzerine yapılan teorik ve ampirik çalışmalar çerçevesinde değerlendirilmiştir. Bu çalışmada madde kullanımı ve bağımlılığı ile ilişkili olarak toplumların uzun süreli maliyetler ile yüzleştikleri ve madde ve suç arasındaki ilişkinin tek bir modelle açıklanamayacağı sonucuna varılmıştır.In recent years, an increasing trend of drug use has been recorded in the world. According to many societies, drug use and addiction are defined as an important biopsychosocial problem that socio-economic cost cannot be underestimated. In terms of its socio-economic costs, assessment of drug use and addiction and revealing its relationship with crime are crucial especially in the formulation of health, drug, economy and social policies. Crime is considered within the scope of the socio-economic cost of drug use and addiction. The relationship between drug use, addiction and crime is a controversial issue. Different models have been developed in the literature to explain the relationship between drug and crime. In this study, drug use and addiction were discussed in terms of socio-economic costs and its relationship with crime was evaluated within the framework of theoretical and empirical studies on drug-crime relationships. In this study, it was concluded that societies face long-term costs related to drug use and addiction and the relationship between drug and crime could not be explained by a single model

Development and Assessment of a Coping Scale for Infertile Women in Turkey

Infertile women feel more psychological stress and pressure than their husbands, and the prevalence of anxiety and depression among them are higher. This study aimed to develop a culture-specific measurement tool to identify the strategies of infertile women in dealing with infertility-related problems. This was a scale development study. This study was carried out in three different fertility centers in the three largest cities in Turkey. The data were collected using personal information form and through the application of a Coping Scale for Infertile Women (CSIW) protocol. Ways of Coping with Stress Inventory. Cronbach‘s alpha, Intraclass Correlation Coefficient and Spearman‘s Rank correlation analyses were used to determine the reliability of the scale. The results of explanatory factor analysis and a factor structure of the Coping Scale for Infertile Women, comprising 50 items, were examined, and the data were determined to be suitable to perform factor analysis. The internal consistency of the scale was found to be 0.880. The number of factors in the scale was 10, and the internal consistency of the factors was 0.720. The results showed that the CSIW had good reliability and validity.Keywords: Infertility, Women, Coping, Scale developmen

X-Linked Lymphoproliferative Syndrome and Common Variable Immunodeficiency May Not Be Differentiated by SH2D1A and XIAP/BIRC4 Genes Sequence Analysis

The X-linked lymphoproliferative syndrome (XLP) is a rare, inherited immunodeficiency characterized by recurrent episodes of hemophagocytic lymphohistiocytosis, hypogammaglobulinemia, and/or lymphomas. Recently, X-linked inhibitor of apoptosis (XIAP/BIRC4) gene defects, in families with XLP but without SH2D1A gene defects, has been defined. The distinction from primary immunodeficiencies with a defined genetic cause is mandatory. A six-year-old male patient was admitted with the complaints of persistent general lymphadenopathy, for two years had fever, bilateral cervical multiple microlymphadenopathy, hepatic/splenic enlargement with laboratory findings as decreased serum immunoglobulins, negative EBV VCA IgM (viral capsid antigen) and anti-EBV EA (antibody to early D antigen), positive EBV VCA IgG (viral capsid antigen) and EBV EBNA (antibody to nuclear antigen). SH2D1A gene analysis was negative. XIAP/BIRC4 sequencing revealed two novel single nucleotide variants (exon 7, 1978G > A, and 1996T > A) in the 3′UTR of the gene in both patient and mother which were not disease causing. XIAP protein expression was found to be normal. The clinical and laboratory resemblance, no gene mutations, and normal XIAP protein expression led us to think that there may be another responsible gene for XLP. The patient will to be followed up as CVID until he presents new diagnostic signs or until the identification of a new gene

Social Appearance Anxiety in Adult Patients with Acne: A Cross-Sectional Study

The severity of acne may not directly reflect the psychological state of a patient. The aim of the present study was to evaluate the social appearance anxiety with overall morbidity in patients with acne. One hundred adult patients with acne and 67 age and sex-matched healthy controls were enrolled in the study. The patients and controls were asked to complete the Social Appearance Anxiety Scale (SAAS) and the General Health Questionnaire-12 (GHQ-12). Acne severity was evaluated objectively by the Global Acne Grading System (GAGS) and subjectively by the Visual Analogue Scale (VAS).  The mean score on SAAS (37.69±13.53; mean ± Standard deviation) was significantly higher than in the control group (32.48±9.34) (p=0.05). No significant difference was observed between the GHQ-12 scores of the acne (2.19±2.64) and the control group (1.63±2.2) (p=0.152). There was no correlation between the GAGS and the VAS (p=0.417). The SAAS scores of the patients with acne were correlated with the GAGS scores (p=0.05) but not correlated with VAS (p=0.481). The GHQ-12 scores were not correlated with GAGS (p=0.96) or with VAS (p=507). No statistical correlation was established between sex and the GAGS scores (p=0.385), SAAS scores (p=0.611), and GHQ-12 scores (p=0.196). The duration of acne was not correlated with SAAS scores (p=0.814) or with GHQ-12 scores (p=0.24). Social appearance anxiety is significant in adult patients with acne and it is correlated with objective acne severity. However, acne does not seem to be associated with substantial psychological distress or formal psychiatric disorder in adults.   </p