Synthesis of Copper-Chelates Derived from Amino Acids and Evaluation of Their Efficacy as Copper Source and Growth Stimulator for <i>Lactuca sativa</i> in Nutrient Solution Culture

Five tetradentate ligands were synthesized from l-amino acids and utilized for the synthesis of <b>Cu­(II)-chelates 1</b>–<b>5</b>. The efficacy of Cu­(II)-chelates as copper (Cu) source and growth stimulator in hydroponic cultivation was evaluated with <i>Lactuca sativa</i>. Their stability test was performed at pH 4–10. The results suggested that <b>Cu­(II)-chelate 3</b> is the most pH tolerant complex. Levels of Cu, Zn, and Fe accumulated in plants supplied with Cu­(II)-chelates were compared with those supplied with CuSO₄ at the same Cu concentration of 8.0 μM. The results showed that <b>Cu­(II)-chelate 3</b> significantly enhanced Cu, Zn, and Fe content in shoot by 35, 15, and 48%, respectively. Application of <b>Cu­(II)-chelate 3</b> also improved plant dry matter yield by 54%. According to the results, <b>Cu­(II)-chelate 3</b> demonstrated the highest stimulating effect on plant growth and plant mineral accumulation so that it can be used as an alternative to CuSO₄ for supplying Cu in nutrient solutions and enhancing the plant growth

A model of modified meta -iodobenzylguanidine conjugated gold nanoparticles for neuroblastoma treatment

International audience127 I-modified m IBG was successfully synthesized and grafted covalently to the surface of carboxylated PEG-GNPs. The particles were not toxic to the normal fibroblast cells while specifically internalized into neuroblastoma cells line via NET