Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study.

Background: Acute illness, existing co-morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a pragmatic prognostic model to stratify patients according to risk of developing AKI after major gastrointestinal surgery. Methods: This prospective multicentre cohort study included consecutive adults undergoing elective or emergency gastrointestinal resection, liver resection or stoma reversal in 2-week blocks over a continuous 3-month period. The primary outcome was the rate of AKI within 7 days of surgery. Bootstrap stability was used to select clinically plausible risk factors into the model. Internal model validation was carried out by bootstrap validation. Results: A total of 4544 patients were included across 173 centres in the UK and Ireland. The overall rate of AKI was 14·2 per cent (646 of 4544) and the 30-day mortality rate was 1·8 per cent (84 of 4544). Stage 1 AKI was significantly associated with 30-day mortality (unadjusted odds ratio 7·61, 95 per cent c.i. 4·49 to 12·90; P < 0·001), with increasing odds of death with each AKI stage. Six variables were selected for inclusion in the prognostic model: age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker. Internal validation demonstrated good model discrimination (c-statistic 0·65). Discussion: Following major gastrointestinal surgery, AKI occurred in one in seven patients. This preoperative prognostic model identified patients at high risk of postoperative AKI. Validation in an independent data set is required to ensure generalizability

Measurement of CP observables in B⁰ → DK ^∗0 with D →K⁺ K⁻

The decay B 0 → DK *0 and the charge conjugate mode are studied using 1.0 fb−1 of pp collision data collected by the LHCb experiment at s√=7 TeV in 2011. The CP asymmetry between the B 0 → DK *0 and the B−−0→DK−−∗0 decay rates, with the neutral D meson in the CP-even final state K + K −, is found to be AKKd=−0.45±0.23±0.02, where the first uncertainty is statistical and the second is systematic. In addition, favoured B 0 → DK *0 decays are reconstructed with the D meson in the non-CP eigenstate K +π−. The ratio of the B-flavour averaged decay rates in D decays to CP and non-CP eigenstates is measured to be RKKd=1.36+0.37−0.32±0.07, where the ratio of the branching fractions of D 0 → K −π+ to D 0 → K + K − decays is included as multiplicative factor. The CP asymmetries measured with two control channels, the favoured B 0 → DK *0 decay with D → K +π− and the B−−0s→DK∗0 decay with D→K + K −, are also reported

Fluorescent Imidazolium-Based Cyclophane for Detection of Guanosine-5 &apos;-triphosphate and I(-) in Aqueous Solution of Physiological pH

A new water-soluble and fluorescent imidazollum-anthracene cyclophane (1) effectively recognizes the biologically Important GTP and I- over other anions in a 100% aqueous solution of physiological pH 7.4. Fluorescence and H-1 NMR spectra and ab initio calculations demonstrate that emission arises from the formation of an excimer state and quenching occurs upon GTP/I- binding through (C-H)(+)center dot center dot center dot A(-) hydrogen bond interactions.X114246sciescopu

The ( k , s ) (k,s)(k,s) -fractional calculus of k-Mittag-Leffler function

Abstract In this paper, we introduce the ( k , s ) $(k, s)$ -fractional integral and differential operators involving k-Mittag-Leffler function E k , ρ , β δ ( z ) $E_{k,\rho,\beta}^{\delta}(z)$ as its kernel. Also, we establish various properties of these operators. Further, we consider a number of certain consequences of the main results

Erratum to: The ( k , s ) (k,s)(k,s) -fractional calculus of k-Mittag-Leffler function

Abstract In this note we present some corrections to our previous paper (Nisar et al. in Adv. Differ. Equ. 2017:118, 2017)

An Imidazolium-Based Fluorescent Cyclophane for the Selective Recognition of Iodide

X111919sciescopu

A highly selective fluorescent chemosensor for guanosine-5 &apos;-triphosphate via excimer formation in aqueous solution of physiological pH

A new water-soluble and fluorescent imidazolium-anthracene cyclophane 1 effectively recognizes and differentiates the biologically important GTP and ATP in 100% aqueous solution of physiological pH 7.4. Fluorescence, H-1-NMR spectra and ab initio calculations demonstrate that excimer formation and fluorescence enhancement occur upon GTP and ATP binding, respectively, through (C-H)(+)center dot center dot center dot A hydrogen bond interactions.open113841sciescopu