Generalized quantum electrodynamics in the framework of Generalized BRST transformation

Podolsky's electromagnetism which explains some of unresolved problems of usual QED has been investigated in the framework of finite field dependent (FFBRST) BRST transformation. In this generalized QED (GQED), BRST invariant effective theories are written using generalized Lorenz gauge, $(1+\frac{\Box }{m_p^2})\partial^\mu A_\mu=0$ and no mixing gauge condition $(1+\frac{\Box }{m_p^2})^\frac{1}{2} \ \partial^\mu A_\mu=0$, it contains higher order derivative terms. No Mixing gauge is free from UV divergences in the radiative correction and easier to handle. We construct appropriate FFBRST transformation to obtain generating functional in no mixing gauge from that of in Lorenz gauge. We show that all these BRST invariant effective theories in GQED are basically same and are inter-connected with appropriately constructed FFBRST transformations.Comment: 13 Pages, No fig

ON KENMOTSU MANIFOLDS WITH SEMI-SYMMETRIC METRIC CONNECTION

The aim of the present paper is to study the properties of locally and globally $\phi$-concircularly symmetric Kenmotsu manifolds endowed with a semi-symmetric metric connection. First, we will prove that the locally $\phi$-symmetric and the globally $\phi$-concircularly symmetric Kenmotsu manifolds are equivalent. Next, we will study three dimensional locally $\phi$-symmetric, locally $\phi$-concircularly symmetric and locally $\phi$-concircularly recurrent Kenmotsu manifolds with respect to such connection and will obtain some geometrical results. In the end, we will construct a non-trivial example of Kenmotsu manifold admitting a semi-symmetric metric connection and validate our results. 

AZD1775 Induces Toxicity Through Double-Stranded DNA Breaks Independently of Chemotherapeutic Agents in p53-Mutated Colorectal Cancer Cells

AZD1775 is a small molecule WEE1 inhibitor used in combination with DNA-damaging agents to cause premature mitosis and cell death in p53-mutated cancer cells. Here we sought to determine the mechanism of action of AZD1775 in combination with chemotherapeutic agents in light of recent findings that AZD1775 can cause double-stranded DNA (DS-DNA) breaks. AZD1775 significantly improved the cytotoxicity of 5-FU in a p53-mutated colorectal cancer cell line (HT29 cells), decreasing the IC50 from 9.3 μM to 3.5 μM. Flow cytometry showed a significant increase in the mitotic marker pHH3 (3.4% vs. 56.2%) and DS-DNA break marker γH2AX (5.1% vs. 50.7%) for combination therapy compared to 5-FU alone. Combination therapy also increased the amount of caspase-3 dependent apoptosis compared to 5-FU alone (4% vs. 13%). The addition of exogenous nucleosides to combination therapy significantly rescued the increased DS-DNA breaks and caspase-3 dependent apoptosis almost to the levels of 5-FU monotherapy. In conclusion, AZD1775 enhances 5-FU cytotoxicity through increased DS-DNA breaks, not premature mitosis, in p53-mutated colorectal cancer cells. This finding is important for designers of future clinical trials when considering the optimal timing and duration of AZD1775 treatment

PERFORMANCE ANALYSIS OF SUPERCHARGING OF TWO WHEELERS

ABSTRACT The objective of this work is to increase the torque and power of the two wheeler by supercharging the vehicle. For this purpose LML freedom 125 cc is analysed for the work and certain parameters like torque, power, and specific fuel consumption vs rpm are calculated. The data calculated is used in software Engine Analyser for analysis purpose together with the data of supercharger. It can be seen that power and torque of the engine increases from 7 to 11 KW and 9 to 13 NM at 7500 and 9000 RPM respectively

The Decision for Indian Human Spaceflight Programme-Political Perspectives, National Relevance and Technological Challenges

In recent times, debate is intense for an Indian Human Space flight programme. An assessment of the challenges in the development of a human space flight transport system has been studied by India - centring on development of indigenous launch capability for a two-member crew to low earth orbit and return safely to pre-determined destination on earth. However, India has yet to take a decision for a human space flight programme. At National Institute for Advanced Studies (NIAS), we have looked into the decision-process that could lead to the crucial decision. We feel that establishing a political perspective for commitment, building a national consensus and also addressing the technological challenges are important steps. Our paper addresses these in a holistic manner: • a critical factor of engagements at political level to obtain commitment for long term implications - of almost 20-30 years, needs to be initiated. The democratic, multi-party framework of India - which has to deal with aspirations of Indian society will also have to decide on the long-term development of Indian human space flight programme. It will be a critical exercise to build the political perspectives. • consider the financial implications of a long-term human space-flight programme development - not just the one-time investments required for demonstrating national capability BUT also for continued human space flight pursuit with national gain. The assessment of returns and benefits has to be clearly articulated. • key technological challenges - crew module design, environmental control and life support system, mission management with human in-loop, crew escape system, launch facilities, astronaut training etc. We also feel that strategic options are important - in terms of indigenous technology development cycles, technology acquisition, collaborative synergies at international level or even alignment/competing with growing global private initiatives in human space-flight programme. The papers outlines the above and identifies some key parameters that would determine decision and goals for India to pursue human space flight - including, attraction for long term commitments and deepening investments at the cost of competing priorities, articulation of economic outcomes, apportionment of benefits across diverse political interests and time-frames, various risk dimensions and ascertainment of public perceptions, impact on social objectives, international cooperation and positioning, achieving high technological excellence in multiple sectors. The paper finally would outline the path that still needs to be pursued for the national decision

Translating Biomarkers of Cholangiocarcinoma for Theranosis: A Systematic Review

Cholangiocarcinoma (CCA) is a rare disease with poor outcomes and limited research efforts into novel treatment options. A systematic review of CCA biomarkers was undertaken to identify promising biomarkers that may be used for theranosis (therapy and diagnosis). MEDLINE/EMBASE databases (1996–2019) were systematically searched using two strategies to identify biomarker studies of CCA. The PANTHER Go-Slim classification system and STRING network version 11.0 were used to interrogate the identified biomarkers. The TArget Selection Criteria for Theranosis (TASC-T) score was used to rank identified proteins as potential targetable biomarkers for theranosis. The following proteins scored the highest, CA9, CLDN18, TNC, MMP9, and EGFR, and they were evaluated in detail. None of these biomarkers had high sensitivity or specificity for CCA but have potential for theranosis. This review is unique in that it describes the process of selecting suitable markers for theranosis, which is also applicable to other diseases. This has highlighted existing validated markers of CCA that can be used for active tumor targeting for the future development of targeted theranostic delivery systems. It also emphasizes the relevance of bioinformatics in aiding the search for validated biomarkers that could be repurposed for theranosis

Preparation and characterization of rice husk derived cellulose and polyvinyl alcohol blended heat sealable packaging film

453-459A greener route for efficient extraction of chemically modified cellulose (CMC) from rice husk has been demonstrates. The extracted CMC is solution blended with polyvinyl alcohol (PVA) under optimized conditions to prepare CMC blended polyvinyl alcohol (CMC-b-PVA) packaging film. Further, the developed film has been characterized by Fourier transform infrared spectrophotometer, shore D, optical microscope, universal testing machine and soil burial test. The obtained results disclose the significant improvements in the mechanical properties by 1.49 times and reduced water vapor transmission rate by 33.33 % than PVA film due to reinforcement effect of CMC in PVA matrix. Furthermore, a heat sealed packet from the developed CMC-b-PVA film has been developed, which exhibits the comparable properties to commercially used flexible polyvinyl chloride films in packaging of edible packets along with optimized water barrier and biodegradable nature

Blind Restoration of Motion Blurred Barcode Images using Ridgelet Transform and Radial Basis Function Neural Network

The aim of any image restoration techniques is recovering the original image from a degraded observation. One of the most common degradation phenomena in images is motion blur. In case of blind image restoration accurate estimation of motion blur parameters is required for deblurring of such images. This paper proposed a novel technique for estimating the parameters of motion blur using ridgelet transform. Initially, the energy of ridgelet coefficients is used to estimate the blur angle and then blur length is estimated using a radial biases function neural network. This work is tested on different barcode images with varying parameters of blur. The simulation results show that the proposed method improves the restoration performance