Colonic Involvement in a Patient with Chronic Lymphocytic Leukaemia

Various gastrointestinal infiltrations have been described in patients with chronic lymphocytic leukaemia (CLL). Here, we report a 69-year-old man with CLL and anaemia in whom the macroscopic finding of colonoscopy was normal, but the histological specimens revealed lymphocytic leukemia in ileum and in colon. If a CLL patient has any symptoms suggesting a possible GI manifestation of the haematologic disease or anaemia not explained by bone marrow infiltration or hemolysis, the diagnostic evaluation should include endoscopies with adequate biopsies

Environmental Controls of InSAR-Based Periglacial Ground Dynamics in a Sub-Arctic Landscape

Periglacial environments are characterized by highly dynamic landscapes. Freezing and thawing lead to ground movement, associated with cryoturbation and solifluction. These processes are sensitive to climate change and variably distributed depending on multiple environmental factors. In this study, we used multi-geometry Sentinel-1 Synthetic Aperture Radar Interferometry (InSAR) to investigate the spatial distribution of the mean annual ground velocity in a mountainous landscape in Northern Norway. Statistical modeling was employed to examine how periglacial ground velocity is related to environmental variables characterizing the diverse climatic, geomorphic, hydrological and biological conditions within a 148 km(2) study area. Two-dimensional (2D) InSAR results document mean annual ground velocity up to 15 mm/yr. Vertical and horizontal velocity components in the East-West plane show variable spatial distribution, which can be explained by the characteristics of cryoturbation and solifluction operating differently over flat and sloping terrain. Statistical modeling shows that slope angle and mean annual air temperature variables are the most important environmental factors explaining the distribution of the horizontal and vertical components, respectively. Vegetation and snow cover also have a local influence, interpreted as indicators of the ground material and moisture conditions. The results show contrasted model performance depending on the velocity component used as a response variable. In general, our study highlights the potential of integrating radar remote sensing and statistical modeling to investigate mountainous regions and better understand the relations between environmental factors, periglacial processes and ground dynamics.Peer reviewe

100 years of atmospheric and marine observations at the Finnish Utö Island in the Baltic Sea

The Utö Atmospheric and Marine Research Station introduced in this paper is located on Utö Island (59°46.84′ N, 21°22.13′ E) at the outer edge of the Archipelago Sea, by the Baltic Sea towards the Baltic Proper. Meteorological observations at the island started in 1881 and vertical profiling of seawater temperature and salinity in 1900. Since 1980, the number of observations at Utö has rapidly increased, with a large number of new meteorological, air quality, aerosol, optical and greenhouse gas parameters, and recently, a variety of marine observations. In this study, we analyze long-term changes of atmospheric temperature, cloudiness, sea salinity, temperature and ice cover. Our main dataset consists of 248 367 atmospheric temperature observations, 1632 quality-assured vertical seawater temperature and salinity profiles and 8565 ice maps, partly digitized for this project. We also use North Atlantic Oscillation (NAO), major Baltic inflow (MBI) and Baltic Sea river runoff data from the literature as reference variables to our data. Our analysis is based on a statistical method utilizing a dynamic linear model. The results show an increase in the atmospheric temperature at Utö, but the increase is significantly smaller than on land areas and has taken place only since the early 1980s, with a rate of 0.4 °C decade−1 during the last 35 years. We also see an increase in seawater temperatures, especially on the surface, with an increase of 0.3 °C decade−1 for the last 100 years. In deeper water layers, the increase is smaller and influenced by vertical mixing, which is modulated by inflow of saline water from the North Sea and freshwater inflow from rivers and by wind-driven processes influenced by the local bathymetry. The date when air temperature in the spring exceeds +5 °C became 5 days earlier from the period 1951–1980 to the period 1981–2010 and the date when sea surface water temperature exceeds +4 °C changed to 9 days earlier. Sea ice cover duration at Utö shows a decrease of approximately 50 % during the last 35 years. Based on the combined results, it is possible that the climate at Utö has changed into a new phase, in which the sea ice no longer reduces the local temperature increase caused by the global warming.</p

DNA copy number loss and allelic imbalance at 2p16 in lung cancer associated with asbestos exposure

Five to seven percent of lung tumours are estimated to occur because of occupational asbestos exposure. Using cDNA microarrays, we have earlier detected asbestos exposure-related genomic regions in lung cancer. The region at 2p was one of those that differed most between asbestos-exposed and non-exposed patients. Now, we evaluated genomic alterations at 2p22.1-p16.1 as a possible marker for asbestos exposure. Lung tumours from 205 patients with pulmonary asbestos fibre counts from 0 to 570 million fibres per gram of dry lung, were studied by fluorescence in situ hybridisation (FISH) for DNA copy number alterations (CNA). The prevalence of loss at 2p16, shown by three different FISH probes, was significantly increased in lung tumours of asbestos-exposed patients compared with non-exposed (P=0.05). In addition, a low copy number loss at 2p16 associated significantly with high-level asbestos exposure (P=0.02). Furthermore, 27 of the tumours were studied for allelic imbalances (AI) at 2p22.1–p16.1 using 14 microsatellite markers and also AI at 2p16 was related to asbestos exposure (P=0.003). Our results suggest that alterations at 2p16 combined with other markers could be useful in diagnosing asbestos-related lung cancer

Differential expression of collectins in human placenta and role in inflammation during spontaneous Labor.

© 2014 Yadav et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Collectins, collagen-containing Ca2+ dependent C-type lectins and a class of secretory proteins including SP-A, SP-D and MBL, are integral to immunomodulation and innate immune defense. In the present study, we aimed to investigate their placental transcript synthesis, labor associated differential expression and localization at feto-maternal interface, and their functional implication in spontaneous labor. The study involved using feto-maternal interface (placental/decidual tissues) from two groups of healthy pregnant women at term (≥37 weeks of gestation), undergoing either elective C-section with no labor ('NLc' group, n = 5), or normal vaginal delivery with spontaneous labor ('SLv' group, n = 5). The immune function of SP-D, on term placental explants, was analyzed for cytokine profile using multiplexed cytokine array. SP-A, SP-D and MBL transcripts were observed in the term placenta. The 'SLv' group showed significant up-regulation of SP-D (p = 0.001), and down-regulation of SP-A (p = 0.005), transcripts and protein compared to the 'NLc' group. Significant increase in 43 kDa and 50 kDa SP-D forms in placental and decidual tissues was associated with the spontaneous labor (p<0.05). In addition, the MMP-9-cleaved form of SP-D (25 kDa) was significantly higher in the placentae of 'SLv' group compared to the 'NLc' group (p = 0.002). Labor associated cytokines IL-1α, IL-1β, IL-6, IL-8, IL-10, TNF-α and MCP-1 showed significant increase (p<0.05) in a dose dependent manner in the placental explants treated with nSP-D and rhSP-D. In conclusion, the study emphasizes that SP-A and SP-D proteins associate with the spontaneous labor and SP-D plausibly contributes to the pro-inflammatory immune milieu of feto-maternal tissues.Funding provided by BT/PR15227/BRB/10/906/2011) Department of Biotechnology (DBT), Government of India http://dbtindia.nic.in/index.asp (TM) and Indian Council of Medical Research (ICMR) Junior Research Fellowship (JRF)/Senior Research Fellowship (SRF), Government of India, www.icmr.nic.in (AKY)

Variation of Absorption Angstrom Exponent in Aerosols From Different Emission Sources

The absorption Angstrom exponent (AAE) describes the spectral dependence of light absorption by aerosols. AAE is typically used to differentiate between different aerosol types for example., black carbon, brown carbon, and dust particles. In this study, the variation of AAE was investigated mainly in fresh aerosol emissions from different fuel and combustion types, including emissions from ships, buses, coal-fired power plants, and residential wood burning. The results were assembled to provide a compendium of AAE values from different emission sources. A dual-spot aethalometer (AE33) was used in all measurements to obtain the light absorption coefficients at seven wavelengths (370-950 nm). AAE(470/950) varied greatly between the different emission sources, ranging from -0.2 +/- 0.7 to 3.0 +/- 0.8. The correlation between the AAE(470/950) and AAE(370-950) results was good (R-2 = 0.95) and the mean bias error between these was 0.02. In the ship engine exhaust emissions, the highest AAE(470/950) values (up to 2.0 +/- 0.1) were observed when high sulfur content heavy fuel oil was used, whereas low sulfur content fuels had the lowest AAE(470/950) (0.9-1.1). In the diesel bus exhaust emissions, AAE(470/950) increased in the order of acceleration (0.8 +/- 0.1), deceleration (1.1 +/- 0.1), and steady driving (1.2 +/- 0.1). In the coal-fired power plant emissions, the variation of AAE(470/950) was substantial (from -0.1 +/- 2.1 to 0.9 +/- 1.6) due to the differences in the fuels and flue gas cleaning conditions. Fresh wood-burning derived aerosols had AAE(470/950) from 1.1 +/- 0.1 (modern masonry heater) to 1.4 +/- 0.1 (pellet boiler), lower than typically associated with wood burning, while the burn cycle phase affected AAE variation.Peer reviewe

Dissociable Roles of Cerebral mu-Opioid and Type 2 Dopamine Receptors in Vicarious Pain: A Combined PET-fMRI Study

Neuroimaging studies have shown that seeing others in pain activates brain regions that are involved in first-hand pain, suggesting that shared neuromolecular pathways support processing of first-hand and vicarious pain. We tested whether the dopamine and opioid neurotransmitter systems involved in nociceptive processing also contribute to vicarious pain experience. We used in vivo positron emission tomography to quantify type 2 dopamine and mu-opioid receptor (D2R and MOR, respectively) availabilities in brains of 35 subjects. During functional magnetic resonance imaging, the subjects watched short movie clips depicting persons in painful and painless situations. Painful scenes activated pain-responsive brain regions including anterior insulae, thalamus and secondary somatosensory cortices, as well as posterior superior temporal sulci. MOR availability correlated negatively with the haemodynamic responses during painful scenes in anterior and posterior insulae, thalamus, secondary and primary somatosensory cortices, primary motor cortex, and superior temporal sulci. MOR availability correlated positively with orbitofrontal haemodynamic responses during painful scenes. D2R availability was not correlated with the haemodynamic responses in any brain region. These results suggest that the opioid system contributes to neural processing of vicarious pain, and that interindividual differences in opioidergic system could explain why some individuals react more strongly than others to seeing pain

Going carless in different urban fabrics: socio-demographics of household car ownership

Diverse physical features of urban areas alongside socio-demographic characteristics affect car ownership, and hence the daily mobility choices. As a case of sustainable mobility, we explore how various urban environments and socio-demographics associate with the spatial and social distribution of household car ownership and carlessness in the Helsinki Metropolitan Area, Finland. Three urban fabrics characterizing the study area are established based on the transportation mode (walking, public transportation, or automobile) the physical urban environment primarily supports. The national level Monitoring System of Spatial Structure and Urban Form database, and the National Travel Survey (2016) are utilized to further include spatial and socio-demographic variables into our analysis across these fabrics. Our results show that households with and without cars differ in terms of residential distance to the city center, neighborhood density, house type, and socio-demographic profiles. Single pensioners and students are most likely to be carless, whereas families represent the opposite. Within the carless households the differences are also evident between different groups. For the more affluent households residing in dense and well-connected areas, and mostly possessing driver's licenses, carlessness is presumably a choice. Contrarily, many other carless households represent the less affluent often located in the more distant, low-density, and less accessible areas, while also possessing less driver's licenses, making carlessness more of a constraint, as the local urban fabric does not support such lifestyle. Consequently, carless households should be increasingly recognized as a focus group in sustainable urban planning in terms of identifiable best practices and potential vulnerability

Brain Basis of Psychopathy in Criminal Offenders and General Population.

Psychopathy is characterized by persistent antisocial behavior, impaired empathy, and egotistical traits. These traits vary also in normally functioning individuals. Here, we tested whether such antisocial personalities are associated with similar structural and neural alterations as those observed in criminal psychopathy. Subjects were 100 non-convicted well-functioning individuals, 19 violent male offenders, and 19 matched controls. Subjects underwent T1-weighted magnetic resonance imaging and viewed movie clips with varying violent content during functional magnetic resonance imaging. Psychopathic traits were evaluated with Levenson Self-Report Psychopathy Scale (controls) and Psychopathy Checklist-Revised (offenders). Psychopathic offenders had lower gray matter density (GMD) in orbitofrontal cortex and anterior insula. In the community sample, affective psychopathy traits were associated with lower GMD in the same areas. Viewing violence increased brain activity in periaqueductal grey matter, thalamus, somatosensory, premotor, and temporal cortices. Psychopathic offenders had increased responses to violence in thalamus and orbitofrontal, insular, and cingulate cortices. In the community sample, impulsivity-related psychopathy traits were positively associated with violence-elicited responses in similar areas. We conclude that brain characteristics underlying psychopathic spectrum in violent psychopathy are related to those observed in well-functioning individuals with asocial personality features