A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.

We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10⁻¹²) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 × 10⁻¹¹) on 19q12 maps to CCNE1 and rs11892031 (P = 1 × 10⁻⁷) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide associations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate associations for the GSTM1 deletion (P = 4 × 10⁻¹¹) and a tag SNP for NAT2 acetylation status (P = 4 × 10⁻¹¹), and found interactions with smoking in both regions. Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis

A Survey of the General Public’s Views on the Ethics of using AI in Education

Recent scandals arising from the use of algorithms for user profiling to further political and marketing gain have popularized the debate over the ethical and legal implications of using such ‘artificial intelligence’ in social media. The need for a legal framework to protect the general public’s data is not new, yet it is not clear whether recent changes in data protection law in Europe, with the introduction of the GDPR, have highlighted the importance of privacy and led to a healthy concern from the general public over online user tracking and use of data. Like search engines, social media and online shopping platforms, intelligent tutoring systems aim to personalize learning and thus also rely on algorithms that automatically profile individual learner traits. A number of studies have been published on user perceptions of trust in robots and computer agents. Unsurprisingly, studies of AI in education have focused on efficacy, so the extent of learner awareness, and acceptance, of tracking and profiling algorithms remains unexplored. This paper discusses the ethical and legal considerations for, and presents a case study examining the general public’s views of, AI in education. A survey was recently taken of attendees at a national science festival event highlighting state-of-the-art AI technologies in education. Whilst most participants (77%) were worried about the use of their data, in learning systems fewer than 8% of adults were ‘not happy’ being tracked, as opposed to nearly two-thirds (63%) of children surveyed

Present state and future perspectives of using pluripotent stem cells in toxicology research

The use of novel drugs and chemicals requires reliable data on their potential toxic effects on humans. Current test systems are mainly based on animals or in vitro–cultured animal-derived cells and do not or not sufficiently mirror the situation in humans. Therefore, in vitro models based on human pluripotent stem cells (hPSCs) have become an attractive alternative. The article summarizes the characteristics of pluripotent stem cells, including embryonic carcinoma and embryonic germ cells, and discusses the potential of pluripotent stem cells for safety pharmacology and toxicology. Special attention is directed to the potential application of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) for the assessment of developmental toxicology as well as cardio- and hepatotoxicology. With respect to embryotoxicology, recent achievements of the embryonic stem cell test (EST) are described and current limitations as well as prospects of embryotoxicity studies using pluripotent stem cells are discussed. Furthermore, recent efforts to establish hPSC-based cell models for testing cardio- and hepatotoxicity are presented. In this context, methods for differentiation and selection of cardiac and hepatic cells from hPSCs are summarized, requirements and implications with respect to the use of these cells in safety pharmacology and toxicology are presented, and future challenges and perspectives of using hPSCs are discussed