Role of Panchakarma in management of Gridhrasi

Panchakarma is a fruitful measure and its extensive efficacies are classified in different dimensions to cure different types of complicated diseases. Vamana, Virechana, Niruha, Anuvasana and Nasya are the five procedures and subsequently even Vamana, Virechana, Basti, Nasya and Rakta Mokshana are broadly termed as Panchakarma in day to day practices.The new diseases are evolving with intense gravity and therefore to combat those, Panchakarma is a very effective measure. In present era competition and advancement have led to hectic and stressful life, man has eventually forgotten the absolute enjoyment and solitary affection of nature and as a result is facing many health problems. Gridhrasi is no exception, it is correlated to sciatica in modern science where low back ache radiating to toes in the lateral aspect of the thigh associated with stiffness is the main complaint

Management of Khalitya through Pracchana followed by Vanadhanyakadi Lepa - A Case Report

Alopecia is caused by androgen and genetic factors. Androgens cause hair follicles to shrink and eventually disappear if they are not addressed. It is inherited as an autosomal dominant trait. A 26-year-old male presented to the Panchakarma OPD Sri Dharmasthala Manjunatheshwara College of Ayurveda and Hospital, Hassan, with complaints of gradual hair loss and scalp itching over a two-year period. It was diagnosed as a case of Khalitya and was treated with Udwartana to Shira Pradesha, Pracchana, and Lepa application. The Norman Hamilton scale, hair pull test and symptoms before and after treatment were used to evaluate the case. Following treatment, there was a significant reduction in symptoms and significant hair growth

Cortical suspensory endobutton versus aperture interference screw fixation for arthroscopic anterior cruciate ligament reconstruction using hamstring graft: a prospective study

Background: Anterior cruciate ligament injury is a common injury which occurs in sports with an annual incidence of 68.6% per 100,000 population. Anatomic arthroscopic reconstruction remains the main stay treatment of ACL injury. Fixation of graft is classified as direct and indirect. To compare the stability of knee joint, complications in arthroscopic anterior cruciate ligament reconstruction by aperture interference screw fixation versus suspensory device fixation in femur. Methods: The randomized control study was conducted in department of orthopedics, The Oxford Medical College Hospital and RC from 2020-2021. 30 knees were operated, Ethical clearance taken and patient is followed up for six months. Results: The preoperative Tegner Lysholm knee score was poor in both groups. Post-op in interference screw group, 12 patients 80% had excellent functional outcome, 3 patients 20% had good outcome. In the Endbutton group, 11 patients (73%) had excellent outcome while 4 patients (27%) had good outcome. Conclusions: Suspensory device fixation gives equivalent results when compared to aperture screw fixation. complications of screw fixation were graft rupture cyst formation; complications of suspensory devices were loosening of graft and bungee cord effect. Hence, Both the techniques showed no statistical difference in post operative outcome

Facial Skin Disease Detection using Image Processing

Busy lifestyle, modernization, increasing pollution and unhealthy diet have led to problems which people are neglecting. Not drinking enough water, stress and hormonal changes are causing problems to skin. Causes may be situational or genetic. Few skin conditions are minor while others can be life-threatening. The skin is the largest organ of the body and is composed of water, proteins, fats and minerals. Problems appear on outer layer of the skin that is epidermis. Skin diseases are considered to be the fourth most common cause of human illness. Skin diseases are observed to increase with age and were seen frequently in both men and women. Skin disorders can be temporary or permanent. Skin diseases have an impact on individual, family and social life caused by inadequate self-treatment which may also induce psychological problems. In recent years, use of computer technologies is becoming practically universal for both personal and professional issues. Facial skin problem identification and recognition has evolved to a great extent over the years. Detection of skin diseases is done using Convolution Neural Network (CNN) and image processing methods. CNN yields better performance in terms of accuracy, precision and results than the existing conventional methods. Image processing uses digital computer to process the images through an algorithm. We focus on features like skin tone, skin texture and color. We present a brief review about various facial skin problems providing more insight about the effective models and algorithms used

Impact evaluation of marine fisheries interventions among Tribal Fisher Commune of Car Nicobar Island, India

Fisheries and tourism are two important sectors that provide livelihood and employment in the tropical Islands. Andaman and Nicobar group of Islands is a biodiversity hotspot in the Bay of Bengal inhabited by settler population along with indigenous tribal communities. The Nicobar tribal community is one among occupying the Nicobar group of Islands in the majority and are quite socialized tribal communities of the Islands. Agriculture, animal husbandry and fisheries are the major sectors that contribute to the livelihood and nutritional security of the Nicobar tribes. Traditional fishing activities have been a part of their culture over the years however, tribal youths were reluctant in taking up fishing as a profession considering the changing scenario and alternative employment options. To reinstate fisheries as a profession and to improve their livelihood and employment opportunities, interventions were carried out in Car Nicobar Island. The interventions were mainly aimed towards increasing fish catches, to expand their fishing grounds and to sensitize safe fishing and navigation practices. Fishing inputs such as modern fishing boats, GPS and outboard engines were provided as inputs to tribal fishers based on the outcome of an expert consultation meeting. Structured questionnaires were prepared to analyze the impact of the interventions. The results indicated that the interventions led to a significant improvement (p <0.001) in the expansion of their fishing grounds (3.47 ± 0.2 km), reduced time spent to reach the fishing grounds (2.3 ± 0.25 hour) and increased catch per unit effort (7.93 ± 1.23 kg/boat). This study shows that the targeted interventions coupled with awareness and sensitization programmes could make fishing activities profitable, attractive and can motivate the unemployed youths to opt for fishing as a profession

Fisheries governance in the tropical archipelago of Andaman and Nicobar – opinions and strategies for sustainable management

Globally, marine fisheries sector provides livelihood, food security and employment to the fishers engaged in subsistence, artisanal and industrial fishing activities. The dependency on marine fish supplies keeps rising globally leading to intense competition, fishery conflicts and unsustainable fishing practices which threatens the sustainability and leading to the depletion of marine fishery resources. Andaman and Nicobar Islands (ANI) in India is a tropical archipelago cited as an example where marine fishery resources were considered to be highly underutilized vis-a-vis the harvestable potential

Quantification and visualization of the variability of phytoplankton assemblage in a semi-lotic seasonal Canal in Sundarbans, India

Canals of Sundarbans in India are highly vulnerable to anthropogenic pressures which directly or indirectly impact the biological components of such ecosystems. Being at the base of the trophic pyramid, phytoplankton is exposed to environmental stressors and the impact will be reflected in the upper strata of the aquatic food chain. Hence, phytoplankton communities along with their interrelationship with environmental parameters were assessed in Bhetkimari canal, a semi-lotic system in Indian Sundarbans during June 2017 to September 2018. Seventy-seven species under 66 genera were recorded with Cyanophyceae (34%) as a major contributor, followed by Bacillariophyceae (31%) and Chlorophyceae (22%). Diatoms dominated round the year in terms of diversity (25 species) with maximum contribution from Pennales. ANOVA (post-hoc test) showed significant temporal heterogeneity (p≤0.05) in phytoplankton distribution in the canal. The Margalef richness index (d) and Shannon-Weiner diversity index (H′) were 2.59±0.43 and 2.26±0.59, respectively indicating that the environment is good and phytoplankton diversity in the system is moderate. Water temperature, dissolved oxygen, total alkalinity and nutrients (nitrate, silicate and phosphate) were the explanatory variables in shaping the phytoplankton assemblages in the canal, which was evident from Canonical correspondence analysis. The salient findings of this study can add to the existing knowledge on the abundance and d

Imaging tumour hypoxia with positron emission tomography.

Hypoxia, a hallmark of most solid tumours, is a negative prognostic factor due to its association with an aggressive tumour phenotype and therapeutic resistance. Given its prominent role in oncology, accurate detection of hypoxia is important, as it impacts on prognosis and could influence treatment planning. A variety of approaches have been explored over the years for detecting and monitoring changes in hypoxia in tumours, including biological markers and noninvasive imaging techniques. Positron emission tomography (PET) is the preferred method for imaging tumour hypoxia due to its high specificity and sensitivity to probe physiological processes in vivo, as well as the ability to provide information about intracellular oxygenation levels. This review provides an overview of imaging hypoxia with PET, with an emphasis on the advantages and limitations of the currently available hypoxia radiotracers.Cancer Research UK (CRUK) funded the National Cancer Research Institute (NCRI) PET Research Working party to organise a meeting to discuss imaging cancer with hypoxia tracers and Positron Emission Tomography. IF was funded by CRUK and is also supported by the Chief Scientific Office. ALH is supported by CRUK and the Breast Cancer Research Foundation. RM is funded by NIHR Cambridge Biomedical Research Centre.This is the accepted manuscript. The final version is available from Nature Publishing at http://www.nature.com/bjc/journal/vaop/ncurrent/full/bjc2014610a.html

Compartmental Genomics in Living Cells Revealed by Single-Cell Nanobiopsy

The ability to study the molecular biology of living single cells in heterogeneous cell populations is essential for next generation analysis of cellular circuitry and function. Here, we developed a single-cell nanobiopsy platform based on scanning ion conductance microscopy (SICM) for continuous sampling of intracellular content from individual cells. The nanobiopsy platform uses electrowetting within a nanopipette to extract cellular material from living cells with minimal disruption of the cellular milieu. We demonstrate the subcellular resolution of the nanobiopsy platform by isolating small subpopulations of mitochondria from single living cells, and quantify mutant mitochondrial genomes in those single cells with high throughput sequencing technology. These findings may provide the foundation for dynamic subcellular genomic analysis

Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes

Epidemiologic studies show an increased risk of non-Hodgkin lymphoma (NHL) in patients with autoimmune disease (AD), due to a combination of shared environmental factors and/or genetic factors, or a causative cascade: chronic inflammation/antigen-stimulation in one disease leads to another. Here we assess shared genetic risk in genome-wide-association-studies (GWAS). Secondary analysis of GWAS of NHL subtypes (chronic lymphocytic leukemia, diffuse large B-cell lymphoma, follicular lymphoma, and marginal zone lymphoma) and ADs (rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis). Shared genetic risk was assessed by (a) description of regional genetic of overlap, (b) polygenic risk score (PRS), (c)"diseasome", (d)meta-analysis. Descriptive analysis revealed few shared genetic factors between each AD and each NHL subtype. The PRS of ADs were not increased in NHL patients (nor vice versa). In the diseasome, NHLs shared more genetic etiology with ADs than solid cancers (p = .0041). A meta-analysis (combing AD with NHL) implicated genes of apoptosis and telomere length. This GWAS-based analysis four NHL subtypes and three ADs revealed few weakly-associated shared loci, explaining little total risk. This suggests common genetic variation, as assessed by GWAS in these sample sizes, may not be the primary explanation for the link between these ADs and NHLs