A two-zone model for the emission from RX J1713.7-3946

We study the acceleration and radiation of charged particles in the shock waves of supernova remnants using a recent version of the "box model". According to this, particles are accelerated in an energy-dependent region around the shock by the first order Fermi mechanism and lose energy through radiation. The particle distribution function is obtained from a spatially averaged kinetic equation that treats the energy losses self-consistently. There exists also a second population that consists of those particles that escape behind the shock where they also radiate. The energy distribution of this population is calculated in a similar manner. The application of the model to the supernova remnant RX J1713.7-3946, which was recently confirmed as a TeV source by H.E.S.S., shows that the X-ray emission can be attributed to electron synchrotron radiation while in gamma-rays there are contributions from both electrons and protons, with protons playing the dominant role. Additionally, there are strong indications that particles diffuse in turbulence that has a Kolmogorov spectrum.Comment: 6 pages, 2 figures, accepted by Astronomy and Astrophysic

Prospects for identifying the sources of the Galactic cosmic rays with IceCube

We quantitatively address whether IceCube, a kilometer-scale neutrino detector under construction at the South Pole, can observe neutrinos pointing back at the accelerators of the Galactic cosmic rays. The photon flux from candidate sources identified by the Milagro detector in a survey of the TeV sky is consistent with the flux expected from a typical cosmic-ray generating supernova remnant interacting with the interstellar medium. We show here that IceCube can provide incontrovertible evidence of cosmic-ray acceleration in these sources by detecting neutrinos. We find that the signal is optimally identified by specializing to events with energies above 30 TeV where the atmospheric neutrino background is low. We conclude that evidence for a correlation between the Milagro and IceCube sky maps should be conclusive after several years.Comment: 5 pages, 5 figures; part of the text and some figures have changed, conclusions remain the same; equals journal versio

Comparison of Oxygenation Trends in the Latissimus Dorsi Across Handle Types During Seated Row Exercise

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On the nonthermal X-ray emission in blazar jets

We consider particle acceleration to high energy via diffusive shock acceleration in a simple, self-consistent shock in jet model for blazars. Electrons are assumed to be accelerated at a shock front in relativistic jets and radiate synchrotron emission in a post-shock region. The full time, space and momentum dependence of the electron distribution function is used for a calculation of the nonthermal synchrotron spectra. We discuss the evolution of the spectral index by varying the rate at which particles enter the acceleration process. The results indicate that the synchrotron spectral index displays a characteristic looplike behaviour with intensity (as has been observed in several blazars), where the orientation of the loop depends on whether the acceleration time scale is comparable to the synchrotron cooling time scale or not. We show that our model provides a good fit to the observed evolution of the spectral index of Mkn 421 during a flare in 1994.Comment: 6 pages, 3 figures, conference proceedin

Merge over move and the Extended Projection Principle: MOM and the EPP Revisited

A class of proposals are examined that aim to avoid problems that arise in various instantiations of the ‘Merge over Move’ (MOM) cost-ofoperation distinction. It is concluded that while the mechanisms introduced there exhibit independently interesting features, they subtract substantially from the interest of the MOM economy of derivation explanations. The removal of an assumption will then be considered that makes the core cases involving there-constructions a problem to begin with: that non-finite T must host a specifier position (checking an EPP/D-feature). Denying the existence of such features removes the problem that the MOM distinction was introduced to solve, allowing the core cases of associate-movement vs. expletive-insertion to arise as a case of true optionality. Consequences for other phenomena are examined and the proposal is found to be consistent with much recent research investigating these phenomena.En este trabajo se examina una serie de propuestas destinadas a evitar problemas relacionados con varios casos de la distinción Ensamble sobre Movimiento (EsM) tomando como base el coste de la operación. Se concluye que mientras que los mecanismos introducidos en estas propuestas muestran rasgos que pueden ser interesantes de manera independiente, estos mismos se apartan sustancialmente del interés de las explicaciones derivacionales del marco EsM, basado en la economía. Será entonces cuando se considerará la eliminación de una asunción que convierta los casos básicos que implican construcciones-there en un problema con el que empezar: que el T no-finito ha de contener una posición de especificador (para cotejar un rasgo PPE/D). Negar la existencia de dichos rasgos elimina el problema para el que la distinción EsM se introdujo, permitiendo que los casos esenciales de movimiento del asociado frente a la inserción directa del expletivo se conviertan en un caso de verdadera opcionalidad. Se examinan consecuencias para otros fenómenos y se concluye que la propuesta es compatible con gran parte de las investigaciones recientes que estudian estos fenómenos.É analisada uma classe de propostas que procuram evitar problemas que emergem em v{rias instanciações da distinção de ‘Merge sobre Move’ (MOM). Conclui-se que, enquanto os mecanismos aí introduzidos exibem independentemente propriedades interessantes, eles subtraem substancialmente ao interesse das explicações da economia de derivação de MOM. A remoção de uma assunção será assim considerada, aquela que faz com que os casos centrais envolvendo construções com there constituam um problema: T não-finito deve abrigar uma posição Spec (satisfazendo uma propriedade do PPE/D). Negar a existência de tais propriedades remove o problema que a distinção MOM procurou resolver, permitindo aos casos centrais de movimento-associado vs inserção de expletivo emergir como um caso de verdadeira opcionalidade. São analisadas consequências para outros fenómenos e a proposta demonstra ser consistente com muita da investigação recente sobre os fenómenos

CXCL12 Chemokine Expression and Secretion Regulates Colorectal Carcinoma Cell Anoikis through Bim-Mediated Intrinsic Apoptosis

BACKGROUND: Resistance to anoikis, apoptosis triggered by a loss of cellular adhesion to the underlying extracellular matrix, is a hallmark of metastatic cancer. Previously we have shown re-establishment of CXCL12 expression in colorectal carcinoma cells inhibits metastasis by enhancing anoikis sensitivity. The objective of these studies was to define the signaling mechanisms regulating CXCL12-mediated anoikis. METHODOLOGY/PRINCIPAL FINDINGS: Adhesion, examined by crystal violet staining, immunofluorescence microscopy, and immunoblot analysis indicated decreased focal adhesion signaling corresponding with loss of adhesion in cells constitutively simulated by CXCL12. Loss of adhesion was inhibited by pertussis toxin treatment, indicating CXCL12 regulating anoikis through G(αi)-protein coupled receptors. Non-adherent HCT116 and HT29 colorectal carcinoma cells expressing CXCL12 exhibited enhanced anoikis sensitivity by propidium iodide staining, caspase activity assays, and immunoblot compared to GFP control cells. CXCL12 producing carcinomas cultured on poly-HEMA displayed heightened Bim and loss of Mcl-1 and Bcl-2 preceding cytochrome c release, and caspase-9 activation. RNAi knockdown of Bim reversed anoikis sensitivity of CXCL12-expressing cells and fostered increased soft-agar foci formation and hepatic tumors in an orthotopic mouse model of metastasis. CONCLUSIONS/SIGNIFICANCE: These data indicate CXCL12 provides a barrier to metastasis by increasing anoikis via activation of a Bim-mediated intrinsic apoptotic pathway. These results underscore the importance of retaining CXCL12 expression to sensitize colorectal carcinomas to anoikis and minimize tumor progression

A relativistic partially electromagnetic planar plasma shock

We model relativistically colliding plasma by PIC simulations in one and two spatial dimensions, taking an ion-to-electron mass ratio of 400. Energy dissipation by a wave precursor of mixed polarity and different densities of the colliding plasma slabs results in a relativistic forward shock forming on millisecond timescales. The forward shock accelerates electrons to ultrarelativistic energies and reflects upstream ions, which drag the electrons along to preserve the plasma quasi-neutrality. No reverse shock forms. The shock may be representative for internal gamma ray burst shocks

In which shell-type SNRs should we look for gamma-rays and neutrinos from p-p collisions?

We present a simple analytic model for the various contributions to the non-thermal emission from shell type SNRs, and show that this model's results reproduce well the results of previous detailed calculations. We show that the \geq 1 TeV gamma ray emission from the shell type SNRs RX J1713.7-3946 and RX J0852.0-4622 is dominated by inverse-Compton scattering of CMB photons (and possibly infra-red ambient photons) by accelerated electrons. Pion decay (due to proton-proton collisions) is shown to account for only a small fraction, \lesssim10^-2, of the observed flux, as assuming a larger fractional contribution would imply nonthermal radio and X-ray synchrotron emission and thermal X-ray Bremsstrahlung emission that far exceed the observed radio and X-ray fluxes. Models where pion decay dominates the \geq 1 TeV flux avoid the implied excessive synchrotron emission (but not the implied excessive thermal X-ray Bremsstrahlung emission) by assuming an extremely low efficiency of electron acceleration, K_ep \lesssim 10^-4 (K_ep is the ratio of the number of accelerated electrons and the number of accelerated protons at a given energy). We argue that observations of SNRs in nearby galaxies imply a lower limit of K_ep \gtrsim 10^-3, and thus rule out K_ep values \lesssim 10^-4 (assuming that SNRs share a common typical value of K_ep). It is suggested that SNRs with strong thermal X-ray emission, rather than strong non-thermal X-ray emission, are more suitable candidates for searches of gamma rays and neutrinos resulting from proton-proton collisions. In particular, it is shown that the neutrino flux from the SNRs above is probably too low to be detected by current and planned neutrino observatories (Abridged).Comment: 13 pages, 1 figure, accepted for publication in JCAP, minor revision

Escape-limited Model of Cosmic-ray Acceleration Revisited

The spectrum of cosmic rays (CRs) is affected by their escape from an acceleration site. This may have been observed not only in the gamma-ray spectrum of young supernova remnants (SNRs) such as RX J1713.7-3946, but also in the spectrum of CRs showering on the Earth. The escape-limited model of cosmic-ray acceleration is studied in general. We discuss the spectrum of CRs running away from the acceleration site. The model may also constrain the spectral index at the acceleration site and the ansatz with respect to the unknown injection process into the particle acceleration. We apply our model to CR acceleration in SNRs and in active galactic nuclei (AGN), which are plausible candidates of Galactic and extragalactic CRs, respectively. In particular, for young SNRs, we take account of the shock evolution with cooling of escaping CRs in the Sedov phase. The spectrum of escaping CRs generally depends on the physical quantities at the acceleration site, such as the spectral index, the evolution of the maximum energy of CRs and the evolution of the number of CRs. It is found that the spectrum of run-away particles can be both softer and harder than that of the acceleration site. The model could explain spectral indices of both Galactic and extragalactic CRs produced by SNRs and AGNs, respectively, suggesting the unified picture of CR acceleration.Comment: 11 pages, 2 figures, submitted to Astronomy and Astrophysic