Entropic manifestations of topological order in three dimensions

We evaluate the entanglement entropy of exactly solvable Hamiltonians corresponding to general families of three-dimensional topological models. We show that the modification to the entropic area law due to three-dimensional topological properties is richer than the two-dimensional case. In addition to the reduction of the entropy caused by a nonzero vacuum expectation value of contractible loop operators, a topological invariant emerges that increases the entropy if the model consists of nontrivially braiding anyons. As a result the three-dimensional topological entanglement entropy provides only partial information about the two entropic topological invariants

High-speed Photometric Observations of ZZ Ceti White Dwarf Candidates

We present high-speed photometric observations of ZZ Ceti white dwarf candidates drawn from the spectroscopic survey of bright DA stars from the Villanova White Dwarf Catalog by Gianninas et al., and from the recent spectroscopic survey of white dwarfs within 40 parsecs of the Sun by Limoges et al. We report the discovery of six new ZZ Ceti pulsators from these surveys, and several photometrically constant DA white dwarfs, which we then use to refine the location of the ZZ Ceti instability strip.Comment: 4 pages, 1 table, 2 figures, to appear in "19th European White Dwarf Workshop" in the ASP Conference Serie

Topological phases from higher gauge symmetry in 3+1 dimensions

We propose an exactly solvable Hamiltonian for topological phases in 3 + 1 dimensions utilizing ideas from higher lattice gauge theory, where the gauge symmetry is given by a finite 2-group. We explicitly show that the model is a Hamiltonian realization of Yetter's homotopy 2-type topological quantum field theory whereby the ground-state projector of the model defined on the manifold M 3 is given by the partition function of the underlying topological quantum field theory for M 3 × [ 0 , 1 ] . We show that this result holds in any dimension and illustrate it by computing the ground state degeneracy for a selection of spatial manifolds and 2-groups. As an application we show that a subset of our model is dual to a class of Abelian Walker-Wang models describing 3 + 1 dimensional topological insulators

Detection of Chern numbers and entanglement in topological two-species systems through subsystem winding numbers

Topological invariants, such as the Chern number, characterize topological phases of matter. Here we provide a method to detect Chern numbers in systems with two distinct species of fermion, such as spins, orbitals or several atomic states. We analytically show that the Chern number can be decomposed as a sum of component specific winding numbers, which are themselves physically observable. We apply this method to two systems, the quantum spin Hall insulator and a staggered topological superconductor, and show that (spin) Chern numbers are accurately reproduced. The measurements required for constructing the component winding numbers also enable one to probe the entanglement spectrum with respect to component partitions. Our method is particularly suited to experiments with cold atoms in optical lattices where time-of-flight images can give direct access to the relevant observables

Preferences across the Menstrual Cycle for Masculinity and Symmetry in Photographs of Male Faces and Bodies

Background: Previous studies have shown that women increase their preference for masculinity during the fertile phase of the menstrual cycle. Evidence for a similar preference shift for symmetry is equivocal. These studies have required participants to choose between subtle variations in computer-generated stimuli, and preferences for more natural stimuli have not been investigated. Methodology/Principal Findings: Our study employed photographs of individual males to investigate women’s preferences for face and body masculinity and symmetry across the menstrual cycle. We collected attractiveness ratings from 25 normally cycling women at high- and low-fertility days of the menstrual cycle. Attractiveness ratings made by these women were correlated with independent ratings of masculinity and symmetry provided by different sets of raters. We found no evidence for any cyclic shift in female preferences. Correlations between attractiveness and masculinity, and attractiveness and symmetry did not differ significantly between high- and low-fertility test sessions. Furthermore, there was no significant difference between high- and low-fertility ratings of attractiveness. Conclusions: These results suggest that a menstrual cycle shift in visual preferences for masculinity and symmetry may be too subtle to influence responses to real faces and bodies, and subsequent mate-choice decisions

Preventive medicine of von Hippel-Lindau disease-associated pancreatic neuroendocrine tumors

Pancreatic neuroendocrine tumors (PanNETs) are rare in von Hippel-Lindau disease (VHL) but cause serious morbidity and mortality. Management guidelines for VHL-PanNETs continue to be based on limited evidence, and survival data to guide surgical management are lacking. We established the European-American-Asian-VHL-PanNET-Registry to assess data for risks for metastases, survival and long-term outcomes to provide best management recommendations. Of 2330 VHL patients, 273 had a total of 484 PanNETs. Median age at diagnosis of PanNET was 35 years (range 10-75). Fifty-five (20%) patients had metastatic PanNETs. Metastatic PanNETs were significantly larger (median size 5 vs 2\u2009cm; P\u20091.5\u2009cm in diameter were operated. Ten-year survival was significantly longer in operated vs non-operated patients, in particular for PanNETs <2.8\u2009cm vs 652.8\u2009cm (94% vs 85% by 10 years; P\u2009=\u20090.020; 80% vs 50% at 10 years; P\u2009=\u20090.030). This study demonstrates that patients with PanNET approaching the cut-off diameter of 2.8\u2009cm should be operated. Mutations in exon 3, especially of codons 161/167 are at enhanced risk for metastatic PanNETs. Survival is significantly longer in operated non-metastatic VHL-PanNETs

Evaluation of appendicitis risk prediction models in adults with suspected appendicitis

Background Appendicitis is the most common general surgical emergency worldwide, but its diagnosis remains challenging. The aim of this study was to determine whether existing risk prediction models can reliably identify patients presenting to hospital in the UK with acute right iliac fossa (RIF) pain who are at low risk of appendicitis. Methods A systematic search was completed to identify all existing appendicitis risk prediction models. Models were validated using UK data from an international prospective cohort study that captured consecutive patients aged 16–45 years presenting to hospital with acute RIF in March to June 2017. The main outcome was best achievable model specificity (proportion of patients who did not have appendicitis correctly classified as low risk) whilst maintaining a failure rate below 5 per cent (proportion of patients identified as low risk who actually had appendicitis). Results Some 5345 patients across 154 UK hospitals were identified, of which two‐thirds (3613 of 5345, 67·6 per cent) were women. Women were more than twice as likely to undergo surgery with removal of a histologically normal appendix (272 of 964, 28·2 per cent) than men (120 of 993, 12·1 per cent) (relative risk 2·33, 95 per cent c.i. 1·92 to 2·84; P < 0·001). Of 15 validated risk prediction models, the Adult Appendicitis Score performed best (cut‐off score 8 or less, specificity 63·1 per cent, failure rate 3·7 per cent). The Appendicitis Inflammatory Response Score performed best for men (cut‐off score 2 or less, specificity 24·7 per cent, failure rate 2·4 per cent). Conclusion Women in the UK had a disproportionate risk of admission without surgical intervention and had high rates of normal appendicectomy. Risk prediction models to support shared decision‐making by identifying adults in the UK at low risk of appendicitis were identified

Modelling chloride and CO{sub 2} chemistry at the Wairakei geothermal field, New Zealand

The chloride and CO2 chemistry at the Wairakei geothermal field, New Zealand has been modelled using an extended version of the geothermal simulator TOUGH2 which solves the equations for the transport of reacting chemical species in multi-phase fluids. Reactions involving the speciation of aqueous CO2 to H2CO3 and HCO3-, are included in the model. Because CO2 speciation in water is pH dependent, a reaction involving the most important weak acid buffer at Wairakei (H4SiO4) has also been included. A ‘Henry’s Law’ reaction expresses the equilibrium between the aqueous and vapour components of CO2. The chloride is treated as a conservative, non-reacting species which is present only in the liquid phase. Results from the model are compared with measured chloride and CO2 data from Wairakei covering the period 1959 to 1987

Cutaneous perfusion dynamics of the lower abdomen in healthy normal weight, overweight and obese women: methods development using infrared thermography with applications for future wound management after caesarean section

Background: Evidence has shown an association between obesity and an increased risk of wound infection after caesarean section. This study was designed to examine if abdominal subcutaneous adiposity impacts upon cutaneous perfusion dynamics. Methods: Mild cool challenge, followed by real-time video thermography, was developed to map the appearance of abdominal ‘hot spots’. Correspondence of marked ‘spots’ with audible Doppler and colour and power Doppler ultrasound was performed. Results: 60 healthy, afebrile, women (20–68 years; BMI 18.5–44 kg/m2) were recruited. Hot spot appearance consistently corresponded with audible Doppler sounds. Colour and power Doppler ultrasound revealed vessels at depths of 3–22 mm. No statistically significant interactions for BMI, abdominal circumference or environmental parameters were observed for hot spot count. The temperature of cold stimulus was significant for effects on spot count, but only for the first minute (p = 0.001). Thereafter, effects on spot numbers were not significant. Conclusions: Cutaneous ‘perforator’ mapping of the abdomen (via hot spot appearance) in healthy women, as a potential and future method for risk of perfusion-dependent wound healing complications, reveals that bedside mapping of skin perfusion is feasible over a short interval. Hot spot number was not influenced by BMI or indicators of central fat distribution (abdominal circumference) indicating variability in an individual’s vascular anatomy. This study provides the underpinning methodology for personalised perfusion assessment after incisional surgery which may be a more reliable indicator of potential healing complications than body habitus as is currently the norm