Feeding habits of Black-billed Magpie during the breeding season in Mediterranean Iberia: the role of birds and eggs

[Capsule]: Feeding habits of the Black-billed Magpie are of interest for researchers, conservationists and hunters since magpies are considered as predators of eggs and chicks of both songbirds and gamebirds. [Aims]: To characterize the feeding habits of magpies during their breeding season in agricultural environments of central Spain, and to assess the occurrence and incidence of birds and eggs in the magpie's diet. [Methods]: Diet was determined by the analysis of gizzard contents from 118 culled magpies. The diet was described as the frequency of occurrence (FO) and the percentage of volume (VOL) of a certain food item and for each gizzard. [Results]: Magpies presented a generalist diet, which included a wide range of foods. Arthropods and cereal seeds were the most frequently consumed food groups (FO > 60%). Eggs and birds were consumed only occasionally (FO < 6% and 17%, respectively; percentage of volume, VOL < 4%). [Conclusion]: Our findings suggest that other birds and their eggs do not represent an important food for magpies in Mediterranean agricultural environments under the conditions found during this study. Nevertheless, more complex studies in different scenarios (i.e. different population sizes of magpies and prey), and over longer temporal scales, are still necessary to clarify this controversial issue.The study was funded by Consejería de Medio Ambiente of Junta de Comunidades de Castilla-La Mancha (Project PREG-05-23). F. Díaz-Ruiz holds a postdoctoral contract financed by the European Social Fund (ESF) and the Junta de Comunidades de Castilla-La Mancha (Operational Programme FSE 2007/2013). M. Delibes-Mateos is supported by the Talentia Postdoc Program launched by the Andalusian Knowledge Agency, co-funded by the European Union’s Seventh Framework Program, Marie Skłodowska-Curie actions (COFUND – Grant Agreement n° 267226) and the Ministry of Economy, Innovation, Science and Employment of the Junta de Andalucía.Peer Reviewe

Memoria de ejecución del proyecto de difusión y promoción del Grado en Ingeniería Geológica

Memoria ID-0225. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2014-2015

H-alpha kinematics of S4G spiral galaxies-II. Data description and non-circular motions

We present a kinematical study of 29 spiral galaxies included in the Spitzer Survey of Stellar Structure in Galaxies, using Halpha Fabry-Perot data obtained with the Galaxy Halpha Fabry-Perot System instrument at the William Herschel Telescope in La Palma, complemented with images in the R-band and in Halpha. The primary goal is to study the evolution and properties of the main structural components of galaxies through the kinematical analysis of the FP data, complemented with studies of morphology, star formation and mass distribution. In this paper we describe how the FP data have been obtained, processed and analysed. We present the resulting moment maps, rotation curves, velocity model maps and residual maps. Images are available in FITS format through the NASA/IPAC Extragalactic Database and the Centre de Donn\'ees Stellaires. With these data products we study the non-circular motions, in particular those found along the bars and spiral arms. The data indicate that the amplitude of the non-circular motions created by the bar does not correlate with the bar strength indicators. The amplitude of those non-circular motions in the spiral arms does not correlate with either arm class or star formation rate along the spiral arms. This implies that the presence and the magnitude of the streaming motions in the arms is a local phenomenon.Comment: 23 pages, 14 figures, without appendices, accepted to be published in MNRA

Title: p38δ Regulates IL6 Expression Modulating ERK Phosphorylation in Preadipocytes.

IL6 is an essential cytokine in metabolism regulation and for intercommunication among different organs and tissues. IL6 produced by different tissues has different functions and therefore it is very important to understand the mechanism of its expression in adipose tissue. In this work we demonstrated that IL6 expression in mouse preadipocytes, like in human, is partially dependent on Wnt5a and JNK. Using mouse preadipocytes lacking each one of the p38 SAPK family members, we have shown that IL6 expression is also p38γ and p38δ dependent. In fact, the lack of some of these two kinases increases IL6 expression without altering that of Wnt5a. Moreover, we show that the absence of p38δ promotes greater ERK1/2 phosphorylation in a MEK1/2 independent manner, and that this increased ERK1/2 phosphorylation state is contributing to the higher IL6 expression in p38δ-/- preadipocytes. These results suggest a new crosstalk between two MAPK signaling pathway, p38δ and ERK1/2, where p38δ modulates the phosphorylation state of ERK1/2.JMC-G was recipient of a Ramón y Cajal contract (RYC2015–17867). SD-C and CMM-Q were recipients of Fellowships from the Junta de Extremadura. SG-J was a recipient of a Fellowship from the Universidad de Extremadura. This work was supported by BFU 2017–85547-P grant from the Spanish Ministry of Economy and IB18014 grant from Junta de Extremadura to JMC-G and GR15164 grant from Junta de Extremadura to FC All Spanish and Junta de Extremadura funding are co-sponsored by the European Union FEDER program.S

In vivo murine model of acquired resistance in myeloma reveals differential mechanisms for lenalidomide and pomalidomide in combination with dexamethasone

The development of resistance to therapy is unavoidable in the history of multiple myeloma patients. Therefore, the study of its characteristics and mechanisms is critical in the search for novel therapeutic approaches to overcome it. This effort is hampered by the absence of appropriate preclinical models, especially those mimicking acquired resistance. Here we present an in vivo model of acquired resistance based on the continuous treatment of mice bearing subcutaneous MM1S plasmacytomas. Xenografts acquired resistance to two generations of immunomodulatory drugs (IMiDs; lenalidomide and pomalidomide) in combination with dexamethasone, that was reversible after a wash-out period. Furthermore, lenalidomide-dexamethasone (LD) or pomalidomide-dexamethasone (PD) did not display cross-resistance, which could be due to the differential requirements of the key target Cereblon and its substrates Aiolos and Ikaros observed in cells resistant to each combination. Differential gene expression profiles of LD and PD could also explain the absence of cross-resistance. Onset of resistance to both combinations was accompanied by upregulation of the mitogen-activated protein kinaseextracellular signal-regulated kinase (ERK) kinase (MEK)ERK pathway and addition of selumetinib, a small-molecule MEK inhibitor, could resensitize resistant cells. Our results provide insights into the mechanisms of acquired resistance to LD and PD combinations and offer possible therapeutic approaches to addressing IMiD resistance in the clinic.Peer Reviewe

How does neighbourhood socio-economic status affect the interrelationships between functioning dimensions in first episode of psychosis? A network analysis approach

The links between psychosis and socio-economic disadvantage have been widely studied. No previous study has analysed the interrelationships and mutual influences between functioning dimensions in first episode of psychosis (FEP) according to their neighbourhood household income, using a multidimensional and transdiagnostic perspective. 170 patients and 129 controls, participants in an observational study (AGES-CM), comprised the study sample. The WHO Disability Assessment Schedule (WHODAS 2.0) was used to assess functioning, whereas participants' postcodes were used to obtain the average household income for each neighbourhood, collected by the Spanish National Statistics Institute (INE). Network analyses were conducted with the aim of defining the interrelationships between the different dimensions of functioning according to the neighbourhood household income. Our results show that lower neighbourhood socioeconomic level is associated with lower functioning in patients with FEP. Moreover, our findings suggest that “household responsibilities” plays a central role in the disability of patients who live in low-income neighbourhoods, whereas “dealing with strangers” is the most important node in the network of patients who live in high-income neighbourhoods. These results could help to personalize treatments, by allowing the identification of potential functioning areas to be prioritized in the treatment of FEP according to the patient's neighbourhood characteristic

Proyecto UNIHCOS: cohorte dinámica de estudiantes universitarios para el estudio del consumo de drogas y otras adicciones

[ES] La etapa universitaria da lugar a cambios sociales y personales, que se relacionan con la adquisición y/o consolidación de estilos y hábitos de vida que pueden determinar el estado de salud futuro. Una inadecua da nutrición, un alto nivel de sedentarismo, conductas sexuales de riesgo, el abuso de las nuevas tecnologías o el inicio en el consumo de drogas tanto legales como ilegales, son algunas de las conductas más destacables de esta etapa. Con el objeto de conocer cómo se establecen y consolidan los hábitos y estilos de vida en la etapa universitaria y sus efectos sobre la salud futura nace el proyecto uniHcos. Se trata del estudio de una cohorte dinámica de estudiantes universitarios que se incorporan al proyecto durante el primer curso académico y serán seguidos durante su permanencia en la universidad y vida laboral. El seguimiento se realizará bienalmente y para la captación y recogida de información se utilizarán las nuevas tecnologías on-line. El objetivo del presente trabajo es dar a conocer el proyecto uniHcos a la comunidad científica así como presentar los resultados preliminares encontrados hasta el momento en las dos cohortes establecidas desde el 2011S

Next Generation Flow for highly sensitive and standardized detection of minimal residual disease in multiple myeloma

[EN]Flow cytometry has become a highly valuable method to monitor minimal residual disease (MRD) and evaluate the depth of complete response (CR) in bone marrow (BM) of multiple myeloma (MM) after therapy. However, current flow-MRD has lower sensitivity than molecular methods and lacks standardization. Here we report on a novel next generation flow (NGF) approach for highly sensitive and standardized MRD detection in MM. An optimized 2-tube 8-color antibody panel was constructed in five cycles of design-evaluation-redesign. In addition, a bulk-lysis procedure was established for acquisition of ⩾107 cells/sample, and novel software tools were constructed for automatic plasma cell gating. Multicenter evaluation of 110 follow-up BM from MM patients in very good partial response (VGPR) or CR showed a higher sensitivity for NGF-MRD vs conventional 8-color flow-MRD -MRD-positive rate of 47 vs 34% (P=0.003)-. Thus, 25% of patients classified as MRD-negative by conventional 8-color flow were MRD-positive by NGF, translating into a significantly longer progression-free survival for MRD-negative vs MRD-positive CR patients by NGF (75% progression-free survival not reached vs 7 months; P=0.02). This study establishes EuroFlow-based NGF as a highly sensitive, fully standardized approach for MRD detection in MM which overcomes the major limitations of conventional flow-MRD methods and is ready for implementation in routine diagnostics.This work has been supported by the International Myeloma Foundation-Black Swan Research Initiative, the Red Temática de Investigación Cooperativa en Cáncer (RTICC); grant SA079U14 from the Consejería de Educación, Junta de Castilla y León, Valladolid, Spain and; grant DTS15/00119 from Instituto de Salud Carlos III, Ministerio de Economía y Competitividad, Madrid, Spain

Heart failure in COVID-19 patients: prevalence, incidence and prognostic implications

Aims: Data on the impact of COVID-19 in chronic heart failure (CHF) patients and its potential to trigger acute heart failure (AHF) are lacking. The aim of this work was to study characteristics, cardiovascular outcomes and mortality in patients with confirmed COVID-19 infection and a prior diagnosis of heart failure (HF). Further aims included the identification of predictors and prognostic implications for AHF decompensation during hospital admission and the determination of a potential correlation between the withdrawal of HF guideline-directed medical therapy (GDMT) and worse outcomes during hospitalization. Methods and results: Data for a total of 3080 consecutive patients with confirmed COVID-19 infection and follow-up of at least 30 days were analysed. Patients with a previous history of CHF (n = 152, 4.9%) were more prone to the development of AHF (11.2% vs. 2.1%; P < 0.001) and had higher levels of N-terminal pro brain natriuretic peptide. In addition, patients with previous CHF had higher mortality rates (48.7% vs. 19.0%; P < 0.001). In contrast, 77 patients (2.5%) were diagnosed with AHF, which in the vast majority of cases (77.9%) developed in patients without a history of HF. Arrhythmias during hospital admission and CHF were the main predictors of AHF. Patients developing AHF had significantly higher mortality (46.8% vs. 19.7%; P < 0.001). Finally, the withdrawal of beta-blockers, mineralocorticoid receptor antagonists and angiotensin-converting enzyme inhibitors or angiotensin receptor blockers was associated with a significant increase in in-hospital mortality. Conclusions: Patients with COVID-19 have a significant incidence of AHF, which is associated with very high mortality rates. Moreover, patients with a history of CHF are prone to developing acute decompensation after a COVID-19 diagnosis. The withdrawal of GDMT was associated with higher mortalit

The interplay between functioning problems and symptoms in first episode of psychosis: an approach from network analysis

The relationship between psychotic symptoms and global measures of functioning has been widely studied. No previous study has assessed so far the interplay between specific clinical symptoms and particular areas of functioning in first-episode psychosis (FEP) using network analysis methods. A total of 191 patients with FEP (age 24.45 ± 6.28 years, 64.9% male) participating in an observational and longitudinal study (AGES-CM) comprised the study sample. Functioning problems were assessed with the WHO Disability Assessment Schedule (WHODAS), whereas the Positive and Negative Syndrome Scale (PANSS) was used to assess symptom severity. Network analysis were conducted with the aim of analysing the patterns of relationships between the different dimensions of functioning and PANSS symptoms and factors at baseline. According to our results, the most important nodes were “conceptual disorganization”, “emotional withdrawal”, “lack of spontaneity and flow of conversation”, “delusions”, “unusual thought content”, “dealing with strangers” and “poor rapport”. Our findings suggest that these symptoms and functioning dimensions should be prioritized in the clinical assessment and management of patients with FEP. These areas may also become targets of future early intervention strategies, so as to improve quality of life in this populationThis work was supported by the Madrid Regional Government (R&D activities in Biomedicine (grant number S2017/BMD-3740 - AGES-CM 2-CM)) and Structural Funds of the European Union. Ana Izquierdo’s work is supported by the PFIS predoctoral program (FI17/00138) from the Instituto de Salud Carlos III (Spain) and co-funded by the European Union (ERDF/ESF, "A way to make Europe”/ “Investing in your future”) and The Biomedical Research Foundation of La Princesa University Hospital. Angela Ib´a˜nez thanks the support of CIBERSAM and of the Spanish Ministry of Science, Innovation and Universities. Instituto de Salud Carlos III (PI16/00834 and PI19/01295) co-financed by ERDF Funds from the European Commission. Covadonga M. Díaz-Caneja holds a Juan Rod´es Grant from Instituto de Salud Carlos III (JR19/00024). Celso Arango was supported by the Spanish Ministry of Science and Innovation. Instituto de Salud Carlos III (SAM16PE07CP1, PI16/02012, PI19/ 024), co-financed by ERDF Funds from the European Commission, “A way of making Europe”, CIBERSAM. Madrid Regional Government (B2017/BMD-3740 AGES-CM-2), European Union Structural Funds. European Union Seventh Framework Program under grant agreements FP7-4-HEALTH-2009-2.2.1-2-241909 (Project EU-GEI), FP7- HEALTH- 2013-2.2.1-2-603196 (Project PSYSCAN) and FP7- HEALTH-2013- 2.2.1-2-602478 (Project METSY); and European Union H2020 Program under the Innovative Medicines Initiative 2 Joint Undertaking (grant agreement No 115916, Project PRISM, and grant agreement No 777394, Project AIMS-2-TRIALS), Fundaci´on Familia Alonso, Fundaci´on Alicia Koplowitz and Fundaci´on Mutua Madrile˜n