Incidencia de sepsis en pacientes de la unidad de cuidados intensivos, Hospital Carlos Roberto Huembes, enero - diciembre 2013.

Estudio Descriptivo de corte transversal. Entre los resultados más importantes se destaca que los grupos de edades más frecuentes fueron los mayores de 51 años con 35.71% siendo el sexo masculino el de mayor predominio con un 57.14%. En el tercer Trimestre del periodo se obtuvo mayor número de paciente con un 35.71%. La colonización Bacteriana predominante fue por Gram positivos en un 57.14% y en relación a la clasificación la Sepsis no complicada obtuvo mayor número de casos. El tratamiento de protocolo fue adecuado en 57.14 %. Se obtuvo un 71.43% de egresos vivos; con un periodo de estancia promedio entre 1-7 días. La Diabetes Mellitus fue el antecedente patológico con mayor prevalencia. Los exámenes de laboratorio se cumplieron según protocolo en la mayoría de casos y la antibioticoterapia indicada se cumplió en tiempo y forma según protocolo. La técnica de Asepsia y Antisepsia mas utilizada por el personal del servicio fue el lavado de manos. En base a lo anterior se considera de importancia aplicar la máxima prioridad a estos pacientes con una atención consensuada entre los servicios y juntos tomar decisiones que ayuden a reducir la tasa de Morbimortalidad siendo el paso fundamental para iniciar las medidas terapéuticas y uso de antibioticoterapia

Influencia de la actividad física y los hábitos nutricionales sobre el riesgo de síndrome metabólico

The combination of several risk factors caused by obesity, sedentary lifestyle or different genetic factors, leads to suffer "metabolic syndrome", which increases the chance of developing cardiovascular disease. Objectives: Describe the risk of cardiovascular disease in members of Guardia Civil from a military complex in Madrid. Material and method: Descriptive cross-sectional study carried out by a 30 questions-survey, analytics and anthropometric measurements to the Guardia Civil staff who came to the medical service of their quartering between September 1 and October 31, 2014. Results: Sample of 76 subjects aged 20-62. 7’89% of individuals have three or more parameters related with metabolic syndrome diagnosis.Conclusions: Sedentary lifestyle and poor nutritional habits act negatively in lipid profile, blood pressure and BMI, increasing the risk of metabolic syndrome and, therefore, cardiovascular diseasesLa conjunción de varios factores de riesgo originados por la obesidad, el sedentarismo o por diversos factores genéticos, lleva a padecer el llamado “Síndrome Metabólico”, que incrementa la posibilidad de desarrollar enfermedades cardiovasculares. Objetivos: Describir el riesgo de padecer enfermedades cardiovasculares que tienen los miembros de la Guardia Civil de un complejo militar de Madrid. Material y método: Estudio descriptivo transversal, realizado mediante encuesta de 30 preguntas, analítica y medidas antropométricas al personal de la Guardia Civil que acudió al servicio médico de su acuartelamiento entre el 1 de septiembre y el 31 de octubre de 2014. Resultados: Muestra de 76 sujetos de entre 20 y 62 años. El 7’89% de los individuos tiene tres o más parámetros para el diagnóstico del Síndrome Metabólico. Conclusiones: El sedentarismo y los malos hábitos nutricionales actúan negativamente en el perfil lipídico, TA y el IMC de los individuos, haciendo que estos tengan más probabilidades de padecer SM y, por tanto, enfermedades cardiovasculares

Control of Strongyles in first-season grazing ewe lambs by integrating deworming and thrice-weekly administration of parasiticidal fungal spores

Research Areas: MicrobiologyParasiticidal fungi have been used in several in vivo experiments in livestock farms worldwide, constituting an effective tool for the biocontrol of gastrointestinal parasites in grazing animals. In the first year of study, two groups of eight first-season pasturing ewe lambs infected by strongyles were dewormed with albendazole, and then, the test group received an oral dose of 106 chlamydospores of Mucor circinelloides and 106 Duddingtonia flagrans individually and thrice a week from mid-September to May (FS1), while the control group remained without fungi (CT1). In the second year, two new groups of first-season grazing ewe lambs were treated with ivermectin and subjected to the same experimental design (FS2 and CT2, respectively). The anthelmintic efficacy was 96.6% (CT1), 95.6% (FS1), 96.1% (CT2), and 95.1% (FS2). The counts of strongyle egg output increased in the control groups (CT1 and CT2) throughout the study and reached numbers higher than 600 eggs per gram of feces (EPG), while in FS1 and FS2, they were <250 EPG. The values of red blood cell parameters registered for CT1 and CT2 were lower than those of the reference standards, while a significant increment was recorded in FS1 and FS2, and values within the physiological range were attained. It is concluded that integrating efficient anthelminthic deworming with rotational pasturing and the regular intake of chlamydospores of M. circinelloides and D. flagrans provides a helpful strategy for maintaining low levels of strongyle egg output in first-season grazing ewe lambs and improves their health status.info:eu-repo/semantics/publishedVersio

The E6 Oncoprotein from HPV16 Enhances the Canonical Wnt/?-Catenin Pathway in Skin Epidermis In Vivo

The contribution of the Wnt signaling pathway to human papilloma virus (HPV)-induced carcinogenesis is poorly understood. In high-grade dysplastic lesions that are caused by high-risk HPVs (HR-HPV), ?-catenin is often located in the cell nucleus, which suggests that Wnt pathway may be involved in the development of HPV-related carcinomas. Most of the oncogenic potential of HR-HPVs resides on the PDZ-binding domain of E6 protein. We hypothesized that the PDZ-binding domain of the HPV16-E6 oncoprotein induces the nuclear accumulation of ?-catenin due to its capacity to degrade PDZ-containing cellular targets. To test this hypothesis, we evaluated the staining pattern of ?-catenin in the skin epidermis of transgenic mice expressing the full-length E6 oncoprotein (K14E6 mice) and measured LacZ gene expression in K14E6 mice that were crossed with a strain expressing LacZ that was knocked into the Axin2 locus (Axin2+/LacZ mice). Here, we show that the E6 oncoprotein enhances the nuclear accumulation of ?-catenin, the accumulation of cellular ?-catenin–responsive genes, and the expression of LacZ. None of these effects were observed when a truncated E6 oncoprotein that lacks the PDZ-binding domain was expressed alone (K14E6?PDZ mice) or in combination with Axin2+/LacZ. Conversely, cotransfection with either E6 or E6?PDZ similarly enhanced canonical Wnt signaling in short-term in vitro assays that used a luciferase Wnt/?-catenin/TCF-dependent promoter. We propose that the activation of canonical Wnt signaling could be induced by the HPV16-E6 oncoprotein; however, the participation of the E6 PDZ-binding domain seems to be important in in vivo models only. Mol Cancer Res; 10(2); 250–8. ©2011 AACR

Desarrollo de un dispositivo electrónico para el diagnóstico del Síndrome de Apnea Obstructiva del Sueño

El presente proyecto consiste en el desarrollo de un dispositivo electrónico portable, fácil de utilizar y de bajo costo para el diagnóstico del Síndrome de Apnea Obstructiva del Sueño (SAOS), a partir del Microcontrolador MCU ATMEGA 2560, e integrados electrónicos como amplificadores operacionales. Con el cual es posible que partiendo de los datos obtenidos por el dispositivo especializado durante la noche de sueño se pueda diagnosticar la presencia de SAOS

Cuando los instagrammers son los adultos

En el marco de los temas relacionados al marketing, se encuentran varias estrategias que afectan la conducta de compra de los consumidores con la finalidad de informar o persuadir sobre los beneficios que brinda determinado producto o servicio. Las empresas ecuatorianas utilizan dichas estrategias para captar la atención de clientes actuales y potenciales, con la finalidad de generar: posicionamiento de mercado, top of mind, captación e incremento del market share, satisfacción de los clientes y por supuesto, mayores ventas de los bienes que ofrecen. Esta recopilación de artículos académicos, aborda diversas estrategias manejadas por las pymes ecuatorianas, con sus correspondientes respuestas de mercado en los consumidores, manejando temas tales como: neuromarketing, marketing digital, cultura de consumo y comportamiento de compra

Prevalence, Incidence, and Outcomes of Hyperkalaemia in Patients with Chronic Heart Failure and Reduced Ejection Fraction from a Spanish Multicentre Study: SPANIK-HF Design and Baseline Characteristics

[Abstract] Hyperkalaemia is a growing concern in the treatment of patients with heart failure and reduced ejection fraction (HFrEF) as it limits the use of some prognostic-modifying drugs and has a negative impact on prognosis. The objective of the present study was to estimate the prevalence of hyperkalaemia in outpatients with HFrEF and its impact on achieving optimal medical treatment. For this purpose, a multicentre, prospective, and observational study was carried out on consecutive HFrEF patients who were monitored as outpatients in heart failure (HF) units and who, in the opinion of their doctor, received optimal medical treatment. A total of 565 HFrEF patients were included from 16 specialised HF units. The mean age was 66 ± 12 years, 78% were male, 45% had an ischemic cause, 39% had atrial fibrillation, 43% were diabetic, 42% had a glomerular filtration rate < 60 mL/min/1.7 m2, and the mean left ventricular ejection fraction was 31 ± 7%. Treatment at the study entry included: 76% on diuretics, 13% on ivabradine, 7% on digoxin, 18.9% on angiotensin-conversing enzyme inhibitors (ACEi), 11.3% on angiotensin receptors blockers (ARBs), 63.8% on angiotensin-neprilysin inhibitors (ARNi), 78.5% on mineralocorticoid receptor antagonists (MRAs), and 92.9% on beta-blockers. Potassium levels in the baseline analysis were: ≤5 mEq/L = 80.5%, 5.1–5.4 mEq/L = 13.8%, 5.5–5.9 mEq/L = 4.6%, and ≥6 mEq/L = 1.06%. Hyperkalaemia was the reason for not prescribing or reaching the target dose of an MRAs in 34.8% and 12.5% of patients, respectively. The impact of hyperkalaemia on not prescribing or dropping below the target dose in relation to ACEi, ARBs, and ARNi was significantly less. In conclusion, hyperkalaemia is a frequent problem in the management of patients with HFrEF and a limiting factor in the optimisation of medical treatment.AstraZeneca Farmacéutica; ESR-17-1324

RICORS2040 : The need for collaborative research in chronic kidney disease

Chronic kidney disease (CKD) is a silent and poorly known killer. The current concept of CKD is relatively young and uptake by the public, physicians and health authorities is not widespread. Physicians still confuse CKD with chronic kidney insufficiency or failure. For the wider public and health authorities, CKD evokes kidney replacement therapy (KRT). In Spain, the prevalence of KRT is 0.13%. Thus health authorities may consider CKD a non-issue: very few persons eventually need KRT and, for those in whom kidneys fail, the problem is 'solved' by dialysis or kidney transplantation. However, KRT is the tip of the iceberg in the burden of CKD. The main burden of CKD is accelerated ageing and premature death. The cut-off points for kidney function and kidney damage indexes that define CKD also mark an increased risk for all-cause premature death. CKD is the most prevalent risk factor for lethal coronavirus disease 2019 (COVID-19) and the factor that most increases the risk of death in COVID-19, after old age. Men and women undergoing KRT still have an annual mortality that is 10- to 100-fold higher than similar-age peers, and life expectancy is shortened by ~40 years for young persons on dialysis and by 15 years for young persons with a functioning kidney graft. CKD is expected to become the fifth greatest global cause of death by 2040 and the second greatest cause of death in Spain before the end of the century, a time when one in four Spaniards will have CKD. However, by 2022, CKD will become the only top-15 global predicted cause of death that is not supported by a dedicated well-funded Centres for Biomedical Research (CIBER) network structure in Spain. Realizing the underestimation of the CKD burden of disease by health authorities, the Decade of the Kidney initiative for 2020-2030 was launched by the American Association of Kidney Patients and the European Kidney Health Alliance. Leading Spanish kidney researchers grouped in the kidney collaborative research network Red de Investigación Renal have now applied for the Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS) call for collaborative research in Spain with the support of the Spanish Society of Nephrology, Federación Nacional de Asociaciones para la Lucha Contra las Enfermedades del Riñón and ONT: RICORS2040 aims to prevent the dire predictions for the global 2040 burden of CKD from becoming true

Combined searches for the production of supersymmetric top quark partners in proton-proton collisions at root s=13 TeV

A combination of searches for top squark pair production using proton-proton collision data at a center-of-mass energy of 13 TeV at the CERN LHC, corresponding to an integrated luminosity of 137 fb(-1) collected by the CMS experiment, is presented. Signatures with at least 2 jets and large missing transverse momentum are categorized into events with 0, 1, or 2 leptons. New results for regions of parameter space where the kinematical properties of top squark pair production and top quark pair production are very similar are presented. Depending on themodel, the combined result excludes a top squarkmass up to 1325 GeV for amassless neutralino, and a neutralinomass up to 700 GeV for a top squarkmass of 1150 GeV. Top squarks with masses from 145 to 295 GeV, for neutralino masses from 0 to 100 GeV, with a mass difference between the top squark and the neutralino in a window of 30 GeV around the mass of the top quark, are excluded for the first time with CMS data. The results of theses searches are also interpreted in an alternative signal model of dark matter production via a spin-0 mediator in association with a top quark pair. Upper limits are set on the cross section for mediator particle masses of up to 420 GeV