The peripheral cannabinoid receptor Cb2 in leukemia

Acute myeloid leukemia (AML) is a blood cell disorder characterized by an accumulation of immature blasts in bone marrow and blood. Human AML is frequently characterized by non-random chromosome translocations resulting in the generation of specific transforming fusion genes and fusion proteins, of which a significant number has been cloned, e.g. AML1-ETO fusion gene in AML with a t(8;21) translocation or PML-RAR in cases with translocation t(15;17). However, in approximately 40 - 50% of AML cases no chromosomal abnormalities are evident, indicating that other more subtle mutations are responsible for the leukemic transformation of myeloid precursor cells. Moreover, AML, like other cancers, is a multigenic disease resulting from an accumulation of multiple genetic aberrations. Thus even in cases with well-characterized translocations, additional genetic defects have likely contributed to the development of AML. The identification and functional analysis of novel disease genes in AML is a major goal of our research group. One approach utilized to identify novel disease genes in leukemia is retroviral insertional mutagenesis. Mice injected with murine leukemia viruses (MuLVs) develop leukemia following proviral insertion into or near potential disease genes. Viral insertions found in a particular locus in independent tumors are called common virus integration sites, cVIS, and mark the locations of potential proto-oncogenes or tumor suppressor genes. The mouse strain and the type of retrovirus used will determine the kind of leukemia that will develop. We used NIH/Swiss mice injected with Cas-Br-M MuLV which develop frequently myeloid leukemias. Using this combination, we previously identified the cVIS Evi11 and demonstrated that the gene encoding the peripheral cannabinoid receptor Cb2 is the likely target gene. Cb2 encodes a seven transmembrane receptor that belongs to the G proteincoupled receptor (GPCR) family and is predominantly present on B lymphocytes. The main objective of the work presented in this thesis is to determine whether Cb2 is indeed a proto-oncogene and, if so, by which mechanism it may transform hematopoietic precursor cells

Stability of derivations under weak-2-local continuous perturbations

[EN] Let ¿ be a compact Hausdorff space and let A be a C¿ -algebra. We prove that if every weak-2-local derivation on A is a linear derivation and every derivation on C(¿, A) is inner, then every weak-2-local derivation ¿ : C(¿, A) ¿ C(¿, A) is a (linear) derivation. As a consequence we derive that, for every complex Hilbert space H, every weak-2-local derivation ¿ : C(¿, B(H)) ¿ C(¿, B(H)) is a (linear) derivation. We actually show that the same conclusion remains true when B(H) is replaced with an atomic von Neumann algebra. With a modified technique we prove that, if B denotes a compact C¿ -algebra (in particular, when B = K(H)), then every weak-2-local derivation on C(¿, B) is a (linear) derivation. Among the consequences, we show that for each von Neumann algebra M and every compact Hausdorff space ¿, every 2-local derivation on C(¿, M) is a (linear) derivation.E. Jorda is partially supported by the Spanish Ministry of Economy and Competitiveness Project MTM2013-43540-P and Generalitat Valenciana Grant AICO/2016/054. A. M. Peralta is partially supported by the Spanish Ministry of Economy and Competitiveness and European Regional Development Fund Project No. MTM2014-58984-P and Junta de Andalucia Grant FQM375.Jorda Mora, E.; Peralta, AM. (2017). Stability of derivations under weak-2-local continuous perturbations. Aequationes Mathematicae. 91(1):99-114. https://doi.org/10.1007/s00010-016-0438-7S99114911Akemann C.A., Johnson B.E.: Derivations of non-separable C*-algebras. J. Funct. Anal. 33, 311–331 (1979)Alexander J.: Compact Banach algebras. Proc. London Math. Soc. 18, 1–18 (1968)Aupetit B.: A Primer on Spectral Theory (Universitext). Springer, New York (1991)Ayupov, Sh., Arzikulov, F.N.: 2-Local derivations on algebras of matrix-valued functions on a compact. (2015) (preprint) arXiv:1509.05701v1Ayupov Sh., Kudaybergenov K.K.: 2-local derivations on von Neumann algebras. Positivity 19(3), 445–455 (2015) doi: 10.1007/s11117-014-0307-3Cabello J.C., Peralta A.M.: Weak-2-local symmetric maps on C*-algebras. Linear Algebra Appl. 494, 32–43 (2016) doi: 10.1016/j.laa.2015.12.024Cabello, J.C., Peralta, A.M.: On a generalized Šemrl’s theorem for weak-2-local derivations on B(H). Banach J. Math. Anal. (to appear) arXiv:1511.07987v2Essaleh A.B.A., Peralta A.M., Ramírez M.I.: Weak-local derivations and homomorphisms on C*-algebras. Linear Multilinear Algebra 64(2), 169–186 (2016). doi: 10.1080/03081087.2015.1028320Johnson, B.E.: Cohomology in Banach algebras, vol. 127. Memoirs of the American Mathematical Society, Providence (1972)Johnson B.E.: Local derivations on C*-algebras are derivations. Trans. Amer. Math. Soc. 353, 313–325 (2001)Kadison R.V.: Derivations of operator algebras. Ann. Math. 83(2), 280–293 (1966)Kadison R.V.: Local derivations. J. Algebra 130, 494–509 (1990)Kadison R.V., Lance E.C., Ringrose J.R.: Derivations and automorphisms of operator algebras II. J. Funct. Anal. 1, 204–221 (1947)Niazi M., and Peralta, A.M.: Weak-2-local derivations on $${\mathbb{M}_n}$$ M n . FILOMAT (to appear)Niazi M., Peralta A.M.: Weak-2-local *-derivations on B(H) are linear *-derivations. Linear Algebra Appl. 487, 276–300 (2015)Ringrose J.R.: Automatic continuity of derivations of operator algebras. J. London Math. Soc. (2) 5, 432–438 (1972)Runde, V.: Lectures on Amenability. Lecture Notes in Mathematics, vol. 1774. Springer, Berlin (2002)Sakai S.: On a conjecture of Kaplansky. Tohoku Math. J. 12, 31–33 (1960)Sakai S.: C*-algebras and W*-algebras. Springer, Berlin (1971)Šemrl P.: Local automorphisms and derivations on B(H). Proc. Amer. Math. Soc. 125, 2677–2680 (1997)Stampfli J.G.: The norm of a derivation. Pac. J. Math. 33(3), 737–747 (1970)Takesaki M.: Theory of operator algebras I. Springer, Berlin (1979

Systemic Lymphadenopathy as the Initial Presentation of Malignant Mesothelioma: A Report of Three Cases

Systemic lymph node metastasis is a rare event in malignant mesothelioma. It is even more exceptional when systemic lymph node metastasis is the initial clinical presentation. Review of literature discloses only four cases in which metastatic lymphadenopathy was the only symptom of malignant mesothelioma. We, herewith, report three cases where the initial diagnosis of malignant mesothelioma was made by biopsy of enlarged lymph nodes, which were the only clinical presentation. Immunohistochemistry played a pivotal role in elucidating the mesothelial origin of their unusual systemic lymph node metastasis

Leisure Movie Watching: A New Context for Everyday Information Seeking

Information seeking research in Library and Information Science (LIS) has grown to encompass not only occupational situations, but non-work or everyday life situations. This sub-field has come to be known as everyday life information seeking (ELIS). In a discipline that continuously struggles to avoid appearing antiquated to the communities where it operates, researching information seeking in everyday contexts is a way for libraries to remain useful and viable to the general public. This study explores the information seeking behavior of leisure movie watchers. People engage with movies as a form of recreation, entertainment, as well as knowledge. Through semi-structured interviews as well as assessing participants' information horizons, analysis will focus on emerging themes of information source preference as well as process. Results address implications for librarians, systems designers, film scholars, and ELIS researchers developing frameworks for leisure contexts

Tingley's problem for p-Schatten von Neumann classes

[EN] Let H and H' be the complex Hilbert spaces. For p is an element of] 1, infinity[\{2} we consider the Banach space C-p(H) of all p-Schatten von Neumann operators, whose unit sphere is denoted by S(C-p(H)). In this paper we prove that every surjective isometry Delta: S(C-p(H)) -> S(C-p(H')) can be extended to a complex linear or to a conjugate linear surjective isometry T: C-p(H) -> C-p(H').The first and third authors were partially supported by the Spanish Ministry of Science, Innovation and Universities (MICINN) and European RegionalDevelopment Fund project no. PGC2018-093332-B-I00, Programa Operativo FEDER 2014-2020 and Consejeria de Economia y Conocimiento de la Junta de Andalucia grant number A-FQM-242-UGR18, and Junta de Andalucia grant FQM375. The second author was partially supported by the project MTM2016-76647-P.Fernández-Polo, FJ.; Jorda Mora, E.; Peralta, AM. (2020). Tingley's problem for p-Schatten von Neumann classes. Journal of Spectral Theory. 10(3):809-841. https://doi.org/10.4171/JST/313S80984110

Supercyclicity of weighted composition operators on spaces of continuous functions

[EN] Our study is focused on the dynamics of weighted composition operators defined on a locally convex space E similar to. (C( X), tp) with X being a topological Hausdorff space containing at least two different points and such that the evaluations {dx : x. X} are linearly independent in E similar to. We prove, when X is compact and E is a Banach space containing a nowhere vanishing function, that a weighted composition operator Cw,. is never weakly supercyclic on E. We also prove that if the symbol. lies in the unit ball of A(D), then every weighted composition operator can never be tp-supercyclic neither on C( D) nor on the disc algebra A(D). Finally, we obtain Ansari-Bourdon type results and conditions on the spectrum for arbitrary weakly supercyclic operators, and we provide necessary conditions for a composition operator to be weakly supercyclic on the space of holomorphic functions defined in non necessarily simply connected planar domains. As a consequence, we show that no composition operator can be weakly supercyclic neither on the space of holomorphic functions on the punctured disc nor in the punctured plane.The authors are very thankful to the referee for his/her careful reading of the manuscript and his/her valuable comments and observations. The first and the second author were supported by MEC, MTM2016-76647-P. The third author was supported by MEC, MTM2016-75963-P and GVA/2018/110.Beltrán-Meneu, MJ.; Jorda Mora, E.; Murillo Arcila, M. (2020). Supercyclicity of weighted composition operators on spaces of continuous functions. Collectanea mathematica. 71(3):493-509. https://doi.org/10.1007/s13348-019-00274-1493509713Albanese, A., Jornet, D.: A note on supercyclic operators in locally convex spaces. Mediterr. J. Math. 16, 107 (2019). https://doi.org/10.1007/s00009-019-1386-yAleman, A., Suciu, L.: On ergodic operator means in Banach spaces. Integr. Equ. Oper. Theory 85(2), 259–287 (2016)Ansari, S.: Hypercyclic and cyclic vectors. J. Funct. Anal. 128(2), 374–383 (1995)Ansari, S.I., Bourdon, P.S.: Some properties of cyclic operators. Acta Sci. Math. 63, 195–207 (1997)Bayart, F., Matheron, É.: Hyponormal operators, weighted shifts and weak forms of supercyclicity. Proc. Edinb. Math. Soc. 49, 1–15 (2006)Bayart, F., Matheron, É.: Dynamics of Linear Operators. Cambridge University Press, Cambridge (2009)Bermudo, S., Montes-Rodríguez, A., Shkarin, S.: Orbits of operators commuting with the Volterra operator. J. Math. Pures Appl. 89(2), 145–173 (2008)Bernal-Rodríguez, L., Montes-Rodríguez, A.: Universal functions for composition operators. Complex Var. Theory Appl. 27(1), 47–56 (1995)Bès, J.: Dynamics of weighted composition operators. Complex Anal. Oper. Theory 8, 159–176 (2014)Bonet, J., Peris, A.: Hypercyclic operators on non-normable Fréchet spaces. J. Funct. Anal. 159, 587–595 (1998)Bourdon, P.S., Shapiro, J.S.: Cyclic Phenomena for Composition Operators, Mem. Am. Math. Soc. 125 (1997), no. 596, Providence, Rhode IslandChan, K.C., Sanders, R.: A weakly hypercyclic operator that is not norm hypercyclic. J. Oper. Theory 52, 39–59 (2004)Duggal, B.P.: Weak supercyclicity: dynamics of paranormal operators. Rend. Circ. Mat. Palermo 65(2), 297–306 (2016)Fernández, C., Galbis, A., Jordá, E.: Dynamics and spectra of composition operators on the Schwartz space. J. Funct. Anal. 274(12), 3503–3530 (2018)Grosse-Erdmann, K.G., Mortini, R.: Universal functions for composition operators with non-automorphic symbol. J. Anal. Math. 107, 355–376 (2009)Cowen, C., MacCluer, B.: Composition Operators on Spaces of Analytic Functions, Studies in Advanced Mathematics. CRC Press, Boca Raton (1995)Garling, D.J.H.: A Course in Mathematical Analysis: Volume III, Complex analysis, Measure and Integration. Cambridge University Press, New York (2013)Garrido, M.I., Jaramillo, J.A.: Variations on the Banach–Stone theorem. In: IV Course on Banach spaces and Operators (Laredo, 2001), Extracta Math. 17, 351–383 (2002)Gadgil, S.: Dynamics on the circle-interval dynamics and rotation number. Reson. J. Sci. Educ. 8(11), 25–36 (2003)Grosse-Erdmann, K.G., Peris, A.: Linear Chaos. Springer, Berlin (2011)Gunatillake, G.: Invertible weighted composition operators. J. Funct. Anal. 261, 831–860 (2011)Herrero, D.A.: Limits of hypercyclic and supercyclic operators. J. Funct. Anal. 99(1), 179–190 (1991)Hilden, H.M., Wallen, L.J.: Some cyclic and non-cyclic vectors of certain operators. Indiana Univ. Math. J. 23, 557–565 (1974)Kalmes, T.: Dynamics of weighted composition operators on function spaces defined by local properties. Studia Math. 249(3), 259–301 (2019)Kamali, Z., Hedayatian, K., Khani Robati, B.: Non-weakly supercyclic weighted composition operators. Abstr. Appl. Anal. Art. (2010) ID 143808Köthe, G.: Topological Vector Spaces II. Springer, New York (1979)Liang, Y.X., Zhou, Z.H.: Supercyclic tuples of the adjoint weighted composition operators on Hilbert spaces. Bull. Iran. Math. Soc. 41(1), 121–139 (2015)Milnor, J.: Dynamics in One Complex Variable, 3rd edn. Princeton University Press, Princeton (2006)Montes-Rodríguez, A., Rodríguez-Martínez, A., Shkarin, S.: Cyclic behaviour of Volterra composition operators. Proc. Lond. Math. Soc. 103(3), 535–562 (2011)Montes-Rodríguez, A., Shkarin, S.: Non-weakly supercyclic operators. J. Oper. Theory 58(1), 39–62 (2007)Moradi, A., Khani Robati, B., Hedayatian, K.: Non-weakly supercyclic classes of weighted composition operators on Banach spaces of analytic functions. Bull. Belg. Math. Soc. Simon Stevin 24(2), 227–241 (2017)Peris, A.: Multi-hypercyclic operators are hypercyclic. Math. Z. 236(4), 779–786 (2001)Sanders, R.: Weakly supercyclic operators. J. Math. Anal. Appl. 292, 148–159 (2004)Sanders, R.: An isometric bilateral shift that is weakly supercyclic. Integr. Equ. Oper. Theory 53, 547–552 (2005)Shapiro, J.H.: Composition Operators and Classical Function Theory. Universitext. Tracts in Mathematics. Springer, New York (1993)Shapiro, J.H.: Simple connectivity and linear chaos. Rend. Circ. Mat. Palermo (2) Suppl 56, 27–48 (1998)Shkarin, S.: Non-sequential weak supercyclicity and hypercyclicity. J. Funct. Anal. 242(1), 37–77 (2007)de Welington, M., van Strien, S.: One-Dimensional Dynamics. Springer, Berlin (1993)Yousefi, B., Rezaei, H.: Hypercyclic property of weighted composition operators. Proc. Am. Math. Soc. 135(10), 3263–3271 (2007

Spatial and temporal variations of the seasonal sea level cycle in the northwest Pacific

The seasonal sea level variations observed from tide gauges over 1900-2013 and gridded satellite altimeter product AVISO over 1993-2013 in the northwest Pacific have been explored. The seasonal cycle is able to explain 60-90% of monthly sea level variance in the marginal seas, while it explains less than 20% of variance in the eddy-rich regions. The maximum annual and semi-annual sea level cycles (30cm and 6cm) are observed in the north of the East China Sea and the west of the South China Sea respectively. AVISO was found to underestimate the annual amplitude by 25% compared to tide gauge estimates along the coasts of China and Russia. The forcing for the seasonal sea level cycle was identified. The atmospheric pressure and the steric height produce 8-12cm of the annual cycle in the middle continental shelf and in the Kuroshio Current regions separately. The removal of the two attributors from total sea level permits to identify the sea level residuals that still show significant seasonality in the marginal seas. Both nearby wind stress and surface currents can explain well the long-term variability of the seasonal sea level cycle in the marginal seas and the tropics because of their influence on the sea level residuals. Interestingly, the surface currents are a better descriptor in the areas where the ocean currents are known to be strong. Here, they explain 50-90% of inter-annual variability due to the strong links between the steric height and the large-scale ocean currents

A photon calorimeter using lead tungstate crystals for the CEBAF Hall A Compton polarimeter

The performances of the calorimeter of the Jlab Hall A Compton Polarimeter have been measured using the Mainz tagged photon beam.Comment: 13 page