Multi-Criteria Decision Analysis (MCDA) in Forest Operations – an Introductional Review

Decision making in forestry is very complex and requires consideration of trade-offs among economic, environmental, and social criteria. Different multi-criteria decision analysis (MCDA) methods have been developed for structuring and exploring the decision-making process of such problems. Although MCDA methods are often used for forest management problems, they are rarely used for forest operation problems. This indicates that scholars and practitioners working with forest operations are either unaware of MCDA methods, or see no benefit in using these methods. Therefore, the prime objective of this review was to make MCDA methods more intelligible (compared with current level of understanding) to novice users within the field of forest operations. For that purpose, basic ideas as well as the strengths and limitations of selected MCDA methods are presented. The second objective was to review applications of MCDA methods in forest operations. The review showed that MCDA applications are suitable for forest operation problems on all three planning levels – strategic, tactical, and operational – but with least use on the operational level. This is attributed to: 1) limited availability of temporally relevant and correct data, 2) lack of time (execution of MCDA methods is time consuming), and 3) many operational planning problems are solved with regards to an economic criterion, with other criteria serving more as frames. However, with increased importance of environmental and social aspects, incorporating MCDA methods into the decision-making process on the operational planning horizon (e.g., by developing MCDAbased guidelines for forestry work) is essential

Lymphoid organisation in labial salivary gland biopsies is a possible predictor for the development of malignant lymphoma in primary Sjögren's syndrome

Objective The development of non-Hodgkin's lymphoma (NHL) confers a high risk of mortality in primary Sjogren's syndrome (pSS) patients, but the sensitivity and specificity of proposed lymphoma predictors are insufficient for practical use. The performance of lymphoid organisation in the form of germinal centre (GC)-like lesions was evaluated in labial salivary gland biopsies taken at pSS diagnosis as a potential lymphoma-predicting biomarker. Methods Labial salivary gland tissue biopsies available from two Swedish pSS research cohorts (n = 175) were re-evaluated by light microscopy in a blind study in order to identify GC-like structures as a sign of ectopic lymphoid tissue formation and organisation. A linkage study was performed with the Swedish Cancer Registry for lymphoma identification. The risk of developing NHL in GC-positive patients in comparison with GC-negative patients was evaluated using Kaplan-Meier statistics and log-rank test. Associations between GC-like structures and clinical and/or laboratory disease markers were also determined using. 2 or Fisher's exact tests. Results At diagnosis, 25% of pSS patients had GC-like structures in their salivary glands. Seven of the 175 patients studied (14% GC+ and 0.8% GC-) developed NHL during 1855 patient-years at risk, with a median onset of 7 years following the initial diagnostic salivary gland biopsy. Six of the seven patients had GC-like structures at diagnosis; the remaining patient was GC negative at the time of diagnosis (p=0.001). Conclusions The detection of GC-like structures by light microscopy in pSS diagnostic salivary biopsies is proposed as a highly predictive and easy-to-obtain marker for NHL development. This allows for risk stratification of patients and the possibility to initiate preventive B-cell-directed therapy

Analysis of decision-making processes for strategic technology investments in Swedish large-scale forestry

Technological development gives forest companies opportunities to maintain competitiveness in the highly cost-sensitive market for forest products. However, no previous studies have examined the technological development decisions made by forest companies or the support tools used when making them. We therefore aimed to describe and analyze 1) the processes used when making such decisions, 2) the associated decision situations, and 3) the use of and need for decision sup-port tools in these processes, with a harwarder concept as case. Semi-structured interviews were conducted with respondents from six forestry organizations. Two theoretical frameworks were used to analyze the interviews, one for unstructured decision processes and one for decision situations. The respondents' descriptions of their decision processes were consistent with those observed in other industries, and it was shown that decision-making could potentially be improved by invest-ing more resources into diagnosing the problem at hand. The main objective in decision-making was to maximize economic criteria while satisfying threshold requirements relating to criteria such as operator well-being, soil rutting, and wood value. When facing large uncertainties, inter-viewees preferred to gather data through operational trials and/or scientific studies. If confronted with large uncertainties that could not be reduced, they proceeded with development only if the potential gains exceeded the estimated uncertainties, and implemented innovations in a stepwise manner. These results indicate a need for greater use of existing decision-support tools such as problem-structuring methods to enable more precise diagnoses, simulations to better understand new innovations, and optimization to better evaluate their theoretical large-scale potential

Energy Harvesting from the Cardiovascular System, or How to Get a Little Help from Yourself

Human energy harvesting is envisioned as a remedy to the weight, the size, and the poor energy density of primary batteries in medical implants. The first implant to have necessarily raised the idea of a biological power supply was the pacemaker in the early 1960s. So far, review articles on human energy harvesting have been rather unspecific and no tribute has been given to the early role of the pacemaker and the cardiovascular system in triggering research in the field. The purpose of the present article is to provide an up-to-date review of research efforts targeting the cardiovascular system as an alternative energy source for active medical implants. To this end, a chronological survey of the last 14 most influential publications is proposed. They include experimental and/or theoretical studies based on electromagnetic, piezoelectric, or electrostatic transducers harnessing various forms of energy, such as heart motion, pressure gradients, and blood flow. Technical feasibility does not imply clinical applicability: although most of the reported devices were shown to harvest an interesting amount of energy from a physiological environment, none of them were tested in vivo for a longer period of tim

Multi-Criteria Decision Analysis (MCDA) in Forest Operations – an Introductional Review

Decision making in forestry is very complex and requires consideration of trade-offs among economic, environmental, and social criteria. Different multi-criteria decision analysis (MCDA) methods have been developed for structuring and exploring the decision-making process of such problems. Although MCDA methods are often used for forest management problems, they are rarely used for forest operation problems. This indicates that scholars and practitioners working with forest operations are either unaware of MCDA methods, or see no benefit in using these methods. Therefore, the prime objective of this review was to make MCDA methods more intelligible (compared with current level of understanding) to novice users within the field of forest operations. For that purpose, basic ideas as well as the strengths and limitations of selected MCDA methods are presented. The second objective was to review applications of MCDA methods in forest operations. The review showed that MCDA applications are suitable for forest operation problems on all three planning levels – strategic, tactical, and operational – but with least use on the operational level. This is attributed to: 1) limited availability of temporally relevant and correct data, 2) lack of time (execution of MCDA methods is time consuming), and 3) many operational planning problems are solved with regards to an economic criterion, with other criteria serving more as frames. However, with increased importance of environmental and social aspects, incorporating MCDA methods into the decision-making process on the operational planning horizon (e.g., by developing MCDAbased guidelines for forestry work) is essential

A study of flotation-REST (restricted environmental stimulation therapy) as an insomnia treatment

Objectives: Flotation-REST is a treatment for deep relaxation, where a person is contained in a stimuli-restricted environment and floats in water with high salt content. The aim was to investigate the effects from flotation-REST on people with insomnia diagnosis, as previous studies of flotation-REST have demonstrated some effects on sleep but have limitations regarding sample selections and sleep measures. Material and Methods: Six participants were recruited through an outpatient psychiatry clinic and posters on a university campus. All participants fulfilled criteria for insomnia diagnosis and four fulfilled criteria for major depressive disorder. Using a single case experimental design, daily changes were investigated on sleep logs regarding sleep onset latency (SOL), wake after sleep onset (WASO), total sleep time (TST), and sleep efficiency over the course of 12 sessions consisting of 45 min of flotation-REST. No other treatments were offered simultaneously. Questionnaire data on insomnia severity (the ISI) and depressive severity (the MADRS) were also collected. Results: Three participants improved on their most salient insomnia symptom (long SOL or WASO), and two improved on sleep efficiency. The improvements were maintained 2 months after treatment. Insomnia severity decreased for three patients, whereas depressive severity decreased for five. No changes in TST were found and two patients did not improve on any sleep measure. The two participants who benefitted the most were students in their 20s. Discussion: The results were mixed. Flotation-REST may be beneficial for young adults with sleep-onset insomnia but more research is warranted

DNA methylation-based subtype prediction for pediatric acute lymphoblastic leukemia

Peer reviewe