Low Back Injuries in Male Ballet Dancers: A Review of the Literature

TITLE: Low Back Injuries in Male Ballet Dancers: A Review of the Literature ABSTRACT BODY: Purpose: Repetitive practice of motions that can require extremes for hip and lumbar spine range of motion increase injury risk for dancers. Male dancers have increased risk of lost dancing days from injury related to lifts of female dancers. This is a review of the available literature examining spine injuries in male dancers. Methods: A literature search was performed using the keywords: male, dancer, ballet, pain, injury, and low back pain. The following databases were used: Cochrane Library, CINAHL, Pubmed, and PEDro. To expand our search, we examined references of our target papers for further relevant research. Studies were deemed relevant if they were about spine injuries and ballet dancers. Results: There are very few studies that investigate the types and frequency of injuries in male ballet dancers. For the studies that examine male ballet dancer spine injuries, they do not provide evidence for prevention of such injuries. Overall, there are very few studies on this topic with only one systematic review in 2008. We recommend that future research focus on rehabilitation and injury prevention in male ballet dancers. Conclusions: Despite spine injuries being common in dancers, there is no evidence based way to identify those at risk for injury and how to prevent reinjury. Future studies are needed to provide high-quality evidence for identifying those at risk for spine injuries, and on effective interventions for ballet dancers. Clinical Relevance: As with other athletes, dancers can experience the negative effects of physical injury to their personal lives. To date, athletic injury research is mostly focused on professional sports such as football, baseball, etc despite dancers experiencing similar work participation issues with injury. This paper provides a starting point for future research into injury detection and rehabilitation in dancers. Authors: Steere KB, Duncan A, Johnstone K, Lux E. References: 1. Ramkumar PN, Farber J, Arnouk J, Varner KE, McCulloch PC. Injuries in a Professional Ballet Dance Company. Journal of Dance Medicine & Science. 2016;20(1):30-37. 2. d’Hemecourt PA, Luke A. Sport-Specific Biomechanics of Spinal Injuries in Aesthetic Athletes (Dancers, Gymnasts, and Figure Skaters). Clinics in Sports Medicine. 2012;31(3):397-408. doi:10.1016/j.csm.2012.03.010. 3. Allen N, Nevill A, Brooks J, Koutedakis Y, Wyon M. Ballet Injuries: Injury Incidence and Severity Over 1 Year. J Orthop Sports Phys Ther. 2012;42(9):781-A1. doi:10.2519/jospt.2012.3893. 4. Gottschlich LM, Young CC. Spine Injuries in Dancers. Current Sports Medicine Reports (American College of Sports Medicine). 2011;10(1):40-44. 5. Hincapié CA, Morton EJ, Cassidy JD. Musculoskeletal Injuries and Pain in Dancers: A Systematic Review. Archives of Physical Medicine and Rehabilitation. 2008;89(9):1819-1829. doi:10.1016/j.apmr.2008.02.020

Investigating the feasibility of co-production of digital media with students

The Learning Development (LD) team has a suite of online videos which aim to provide students with support and guidance in a range of academic skills. The usage statistics show that they are more widely used than other content, for example PDF guides or Xerte activities. Many of these videos are created by academic and professional staff and are ‘talking heads’ which may encourage the students to become passive learners. Two LD tutors and a Media and Journalism lecturer collaborated on a project to co-produce academic skills videos with students. Students were given a brief to create videos based on their own experience of study skills. They also took part in focus groups and a survey to find out more about their perception of educational videos and the experience of creating their own. As well as creating original content for use by students, the project explored the benefits and challenges of such an approach. The aim is to create a model of co-production which could be used by other subject areas and student cohorts

Viewpoints. 75 Sides to Freie Universität Berlin

Das Buch mit 75 Illustrationen und Kurztexten ist eine Reise durch die Geschichte und Welt der Freien Universität Berlin und entstand im April 2023 anlässlich ihres 75-jährigen Gründungsjubiläums. Die Bilder zeigen, ohne Anspruch auf Vollständigkeit, mit Augenzwinkern, eine vernetzte und internationale Universität, die sich seit ihren Anfängen und fortwährend ihren Leitwerten Freiheit, Gerechtigkeit und Wahrheit verpflichtet fühlt und zu einem bedeutenden Teil der Stadt und des Wissenschaftsraums Berlin geworden ist. Aspekte ihrer Geschichte und Gegenwart wurden künstlerisch interpretiert von Yves Haltner, einem Schweizer Illustrator und Grafiker, der in Berlin lebt und arbeitet.The book containing 75 illustrations and short texts is a journey through the history and world of Freie Universität Berlin. It was created in April 2023 to mark the occasion of the 75th anniversary of the university’s founding. With a hint of irony and pointed fragmentary playfulness, the images depict a connected, international university deeply committed to its core values: freedom, justice, truth. The university has become an important part of Berlin as a city and research hub. Various aspects of the past and present of the university were artistically interpreted by Yves Haltner, a Swiss illustrator and graphic designer who lives and works in Berlin

Next Generation Very Large Array Memo No. 6, Science Working Group 1: The Cradle of Life

This paper discusses compelling science cases for a future long-baseline interferometer operating at millimeter and centimeter wavelengths, like the proposed Next Generation Vary Large Array (ngVLA). We report on the activities of the Cradle of Life science working group, which focused on the formation of low- and high-mass stars, the formation of planets and evolution of protoplanetary disks, the physical and compositional study of Solar System bodies, and the possible detection of radio signals from extraterrestrial civilizations. We propose 19 scientific projects based on the current specification of the ngVLA. Five of them are highlighted as possible Key Science Projects: (1) Resolving the density structure and dynamics of the youngest HII regions and high-mass protostellar jets, (2) Unveiling binary/multiple protostars at higher resolution, (3) Mapping planet formation regions in nearby disks on scales down to 1 AU, (4) Studying the formation of complex molecules, and (5) Deep atmospheric mapping of giant planets in the Solar System. For each of these projects, we discuss the scientific importance and feasibility. The results presented here should be considered as the beginning of a more in-depth analysis of the science enabled by such a facility, and are by no means complete or exhaustive.Comment: 51 pages, 12 figures, 1 table. For more information visit https://science.nrao.edu/futures/ngvl

Efficacy and Safety of Three Antiretroviral Regimens for Initial Treatment of HIV-1: A Randomized Clinical Trial in Diverse Multinational Settings

Background: Antiretroviral regimens with simplified dosing and better safety are needed to maximize the efficiency of antiretroviral delivery in resource-limited settings. We investigated the efficacy and safety of antiretroviral regimens with once-daily compared to twice-daily dosing in diverse areas of the world. Methods and Findings: 1,571 HIV-1-infected persons (47% women) from nine countries in four continents were assigned with equal probability to open-label antiretroviral therapy with efavirenz plus lamivudine-zidovudine (EFV+3TC-ZDV), atazanavir plus didanosine-EC plus emtricitabine (ATV+DDI+FTC), or efavirenz plus emtricitabine-tenofovir-disoproxil fumarate (DF) (EFV+FTC-TDF). ATV+DDI+FTC and EFV+FTC-TDF were hypothesized to be non-inferior to EFV+3TC-ZDV if the upper one-sided 95% confidence bound for the hazard ratio (HR) was ≤1.35 when 30% of participants had treatment failure. An independent monitoring board recommended stopping study follow-up prior to accumulation of 472 treatment failures. Comparing EFV+FTC-TDF to EFV+3TC-ZDV, during a median 184 wk of follow-up there were 95 treatment failures (18%) among 526 participants versus 98 failures among 519 participants (19%; HR 0.95, 95% CI 0.72–1.27; p = 0.74). Safety endpoints occurred in 243 (46%) participants assigned to EFV+FTC-TDF versus 313 (60%) assigned to EFV+3TC-ZDV (HR 0.64, CI 0.54–0.76; p<0.001) and there was a significant interaction between sex and regimen safety (HR 0.50, CI 0.39–0.64 for women; HR 0.79, CI 0.62–1.00 for men; p = 0.01). Comparing ATV+DDI+FTC to EFV+3TC-ZDV, during a median follow-up of 81 wk there were 108 failures (21%) among 526 participants assigned to ATV+DDI+FTC and 76 (15%) among 519 participants assigned to EFV+3TC-ZDV (HR 1.51, CI 1.12–2.04; p = 0.007). Conclusion: EFV+FTC-TDF had similar high efficacy compared to EFV+3TC-ZDV in this trial population, recruited in diverse multinational settings. Superior safety, especially in HIV-1-infected women, and once-daily dosing of EFV+FTC-TDF are advantageous for use of this regimen for initial treatment of HIV-1 infection in resource-limited countries. ATV+DDI+FTC had inferior efficacy and is not recommended as an initial antiretroviral regimen

Milk fat globule epidermal growth factor–8 blockade triggers tumor destruction through coordinated cell-autonomous and immune-mediated mechanisms

Carcinogenesis reflects the dynamic interplay of transformed cells and normal host elements, but cancer treatments typically target each compartment separately. Within the tumor microenvironment, the secreted protein milk fat globule epidermal growth factor–8 (MFG-E8) stimulates disease progression through coordinated αvβ3 integrin signaling in tumor and host cells. MFG-E8 enhances tumor cell survival, invasion, and angiogenesis, and contributes to local immune suppression. We show that systemic MFG-E8 blockade cooperates with cytotoxic chemotherapy, molecularly targeted therapy, and radiation therapy to induce destruction of various types of established mouse tumors. The combination treatments evoke extensive tumor cell apoptosis that is coupled to efficient dendritic cell cross-presentation of dying tumor cells. This linkage engenders potent antitumor effector T cells but inhibits FoxP3+ T reg cells, thereby achieving long-term protective immunity. Collectively, these findings suggest that systemic MFG-E8 blockade might intensify the antitumor activities of existing therapeutic regimens through coordinated cell-autonomous and immune-mediated mechanisms

Mathematical Modelling of Cell-Fate Decision in Response to Death Receptor Engagement

Cytokines such as TNF and FASL can trigger death or survival depending on cell lines and cellular conditions. The mechanistic details of how a cell chooses among these cell fates are still unclear. The understanding of these processes is important since they are altered in many diseases, including cancer and AIDS. Using a discrete modelling formalism, we present a mathematical model of cell fate decision recapitulating and integrating the most consistent facts extracted from the literature. This model provides a generic high-level view of the interplays between NFκB pro-survival pathway, RIP1-dependent necrosis, and the apoptosis pathway in response to death receptor-mediated signals. Wild type simulations demonstrate robust segregation of cellular responses to receptor engagement. Model simulations recapitulate documented phenotypes of protein knockdowns and enable the prediction of the effects of novel knockdowns. In silico experiments simulate the outcomes following ligand removal at different stages, and suggest experimental approaches to further validate and specialise the model for particular cell types. We also propose a reduced conceptual model implementing the logic of the decision process. This analysis gives specific predictions regarding cross-talks between the three pathways, as well as the transient role of RIP1 protein in necrosis, and confirms the phenotypes of novel perturbations. Our wild type and mutant simulations provide novel insights to restore apoptosis in defective cells. The model analysis expands our understanding of how cell fate decision is made. Moreover, our current model can be used to assess contradictory or controversial data from the literature. Ultimately, it constitutes a valuable reasoning tool to delineate novel experiments

Exosomes Communicate Protective Messages during Oxidative Stress; Possible Role of Exosomal Shuttle RNA

BACKGROUND: Exosomes are small extracellular nanovesicles of endocytic origin that mediate different signals between cells, by surface interactions and by shuttling functional RNA from one cell to another. Exosomes are released by many cells including mast cells, dendritic cells, macrophages, epithelial cells and tumour cells. Exosomes differ compared to their donor cells, not only in size, but also in their RNA, protein and lipid composition. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we show that exosomes, released by mouse mast cells exposed to oxidative stress, differ in their mRNA content. Also, we show that these exosomes can influence the response of other cells to oxidative stress by providing recipient cells with a resistance against oxidative stress, observed as an attenuated loss of cell viability. Furthermore, Affymetrix microarray analysis revealed that the exosomal mRNA content not only differs between exosomes and donor cells, but also between exosomes derived from cells grown under different conditions; oxidative stress and normal conditions. Finally, we also show that exposure to UV-light affects the biological functions associated with exosomes released under oxidative stress. CONCLUSIONS/SIGNIFICANCE: These results argue that the exosomal shuttle of RNA is involved in cell-to-cell communication, by influencing the response of recipient cells to an external stress stimulus

Prevention of HIV-1 Infection with Early Antiretroviral Therapy

Antiretroviral therapy that reduces viral replication could limit the transmission of human immunodeficiency virus type 1 (HIV-1) in serodiscordant couples