3,439 research outputs found
Functional Brain Basis of Hypnotizability
Context Focused hypnotic concentration is a model for brain control over sensation and behavior. Pain and anxiety can be effectively alleviated by hypnotic suggestion, which modulates activity in brain regions associated with focused attention, but the specific neural network underlying this phenomenon is not known.
Objective To investigate the brain basis of hypnotizability.
Design Cross-sectional, in vivo neuroimaging study performed from November 2005 through July 2006.
Setting Academic medical center at Stanford University School of Medicine.
Patients Twelve adults with high and 12 adults with low hypnotizability.
Main Outcome Measures Functional magnetic resonance imaging to measure functional connectivity networks at rest, including default-mode, salience, and executive-control networks; structural T1 magnetic resonance imaging to measure regional gray and white matter volumes; and diffusion tensor imaging to measure white matter microstructural integrity.
Results High compared with low hypnotizable individuals had greater functional connectivity between the left dorsolateral prefrontal cortex, an executive-control region of the brain, and the salience network composed of the dorsal anterior cingulate cortex, anterior insula, amygdala, and ventral striatum, involved in detecting, integrating, and filtering relevant somatic, autonomic, and emotional information using independent component analysis. Seed-based analysis confirmed elevated functional coupling between the dorsal anterior cingulate cortex and the dorsolateral prefrontal cortex in high compared with low hypnotizable individuals. These functional differences were not due to any variation in brain structure in these regions, including regional gray and white matter volumes and white matter microstructure.
Conclusions Our results provide novel evidence that altered functional connectivity in the dorsolateral prefrontal cortex and dorsal anterior cingulate cortex may underlie hypnotizability. Future studies focusing on how these functional networks change and interact during hypnosis are warranted
Differential transactivation of sphingosine-1-phosphate receptors modulates NGF-induced neurite extension
The process of neurite extension after activation of the TrkA tyrosine kinase receptor by nerve growth factor (NGF) involves complex signaling pathways. Stimulation of sphingosine kinase 1 (SphK1), the enzyme that phosphorylates sphingosine to form sphingosine-1-phosphate (S1P), is part of the functional TrkA signaling repertoire. In this paper, we report that in PC12 cells and dorsal root ganglion neurons, NGF translocates SphK1 to the plasma membrane and differentially activates the S1P receptors S1P1 and S1P2 in a SphK1-dependent manner, as determined with specific inhibitors and small interfering RNA targeted to SphK1. NGF-induced neurite extension was suppressed by down-regulation of S1P1 expression with antisense RNA. Conversely, when overexpressed in PC12 cells, transactivation of S1P1 by NGF markedly enhanced neurite extension and stimulation of the small GTPase Rac, important for the cytoskeletal changes required for neurite extension. Concomitantly, differentiation down-regulated expression of S1P2 whose activation would stimulate Rho and inhibit neurite extension. Thus, differential transactivation of S1P receptors by NGF regulates antagonistic signaling pathways that modulate neurite extension
Measurement in Economics and Social Science
The paper discusses measurement, primarily in economics, from both analytical and historical perspectives. The historical section traces the commitment to ordinalism on the part of economic theorists from the doctrinal disputes between classical economics and marginalism, through the struggle of orthodox economics against socialism down to the cold-war alliance between mathematical social science and anti-communist ideology. In economics the commitment to ordinalism led to the separation of theory from the quantitative measures that are computed in practice: price and quantity indexes, consumer surplus and real national product. The commitment to ordinality entered political science, via Arrow’s ‘impossibility theorem’, effectively merging it with economics, and ensuring its sterility. How can a field that has as its central result the impossibility of democracy contribute to the design of democratic institutions?
The analytical part of the paper deals with the quantitative measures mentioned above. I begin with the conceptual clarification that what these measures try to achieve is a restoration of the money metric that is lost when prices are variable. I conclude that there is only one measure that can be embedded in a satisfactory economic theory, free from unreasonable restrictions. It is the Törnqvist index as an approximation to its theoretical counterpart the Divisia index.
The statistical agencies have at various times produced different measures for real national product and its components, as well as related concepts. I argue that all of these are flawed and that a single deflator should be used for the aggregate and the components. Ideally this should be a chained Törnqvist price index defined on aggregate consumption.
The social sciences are split. The economic approach is abstract, focused on the assumption of rational and informed behavior, and tends to the political right. The sociological approach is empirical, stresses the non-rational aspects of human behavior and tends to the political left. I argue that the split is due to the fact that the empirical and theoretical traditions were never joined in the social sciences as they were in the natural sciences. I also argue that measurement can potentially help in healing this split
CHARIS Science: Performance Simulations for the Subaru Telescope's Third-Generation of Exoplanet Imaging Instrumentation
We describe the expected scientific capabilities of CHARIS, a high-contrast
integral-field spectrograph (IFS) currently under construction for the Subaru
telescope. CHARIS is part of a new generation of instruments, enabled by
extreme adaptive optics (AO) systems (including SCExAO at Subaru), that promise
greatly improved contrasts at small angular separation thanks to their ability
to use spectral information to distinguish planets from quasistatic speckles in
the stellar point-spread function (PSF). CHARIS is similar in concept to GPI
and SPHERE, on Gemini South and the Very Large Telescope, respectively, but
will be unique in its ability to simultaneously cover the entire near-infrared
, , and bands with a low-resolution mode. This extraordinarily broad
wavelength coverage will enable spectral differential imaging down to angular
separations of a few , corresponding to 0.\!\!''1. SCExAO
will also offer contrast approaching at similar separations,
0.\!\!''1--0.\!\!''2. The discovery yield of a CHARIS survey will
depend on the exoplanet distribution function at around 10 AU. If the
distribution of planets discovered by radial velocity surveys extends unchanged
to 20 AU, observations of 200 mostly young, nearby stars targeted
by existing high-contrast instruments might find 1--3 planets. Carefully
optimizing the target sample could improve this yield by a factor of a few,
while an upturn in frequency at a few AU could also increase the number of
detections. CHARIS, with a higher spectral resolution mode of , will
also be among the best instruments to characterize planets and brown dwarfs
like HR 8799 cde and And b.Comment: 13 pages, 7 figures, proceedings from SPIE Montrea
Evidence and Ideology in Macroeconomics: The Case of Investment Cycles
The paper reports the principal findings of a long term research project on the description and explanation of business cycles. The research strongly confirmed the older view that business cycles have large systematic components that take the form of investment cycles. These quasi-periodic movements can be represented as low order, stochastic, dynamic processes with complex eigenvalues. Specifically, there is a fixed investment cycle of about 8 years and an inventory cycle of about 4 years. Maximum entropy spectral analysis was employed for the description of the cycles and continuous time econometrics for the explanatory models. The central explanatory mechanism is the second order accelerator, which incorporates adjustment costs both in relation to the capital stock and the rate of investment. By means of parametric resonance it was possible to show, both theoretically and empirically how cycles aggregate from the micro to the macro level. The same mathematical tool was also used to explain the international convergence of cycles. I argue that the theory of investment cycles was abandoned for ideological, not for evidential reasons. Methodological issues are also discussed
New Classification of the Dictyostelids
Traditional morphology-based taxonomy of dictyostelids is rejected by molecular phylogeny. A new classification is presented based on monophyletic entities with consistent and strong molecular phylogenetic support and that are, as far as possible, morphologically recognizable. All newly named clades are diagnosed with small subunit ribosomal RNA (18S rRNA) sequence signatures plus morphological synapomorphies where possible. The two major molecular clades are given the rank of order, as Acytosteliales ord. nov. and Dictyosteliales. The two major clades within each of these orders are recognized and given the rank of family as, respectively, Acytosteliaceae and Cavenderiaceae fam. nov. in Acytosteliales, and Dictyosteliaceae and Raperosteliaceae fam. nov. in Dictyosteliales. Twelve genera are recognized: Cavenderia gen. nov. in Cavenderiaceae, Acytostelium, Rostrostelium gen. nov. and Heterostelium gen. nov. in Acytosteliaceae, Tieghemostelium gen. nov., Hagiwaraea gen. nov., Raperostelium gen. nov. and Speleostelium gen. nov. in Raperosteliaceae, and Dictyostelium and Polysphondylium in Dictyosteliaceae. The polycephalum complex is treated as Coremiostelium gen. nov. (not assigned to family) and the polycarpum complex as Synstelium gen. nov. (not assigned to order and family). Coenonia, which may not be a dictyostelid, is treated as a genus incertae sedis. Eighty-eight new combinations are made at species and variety level, and Dictyostelium ammophilum is validated
Science and Ideology in Economic, Political, and Social Thought
This paper has two sources: One is my own research in three broad areas: business cycles, economic measurement and social choice. In all of these fields I attempted to apply the basic precepts of the scientific method as it is understood in the natural sciences. I found that my effort at using natural science methods in economics was met with little understanding and often considerable hostility. I found economics to be driven less by common sense and empirical evidence, then by various ideologies that exhibited either a political or a methodological bias, or both. This brings me to the second source: Several books have appeared recently that describe in historical terms the ideological forces that have shaped either the direct areas in which I worked, or a broader background. These books taught me that the ideological forces in the social sciences are even stronger than I imagined on the basis of my own experiences.
The scientific method is the antipode to ideology. I feel that the scientific work that I have done on specific, long standing and fundamental problems in economics and political science have given me additional insights into the destructive role of ideology beyond the history of thought orientation of the works I will be discussing
The PTF Orion Project: a Possible Planet Transiting a T-Tauri Star
We report observations of a possible young transiting planet orbiting a
previously known weak-lined T-Tauri star in the 7-10 Myr old Orion-OB1a/25-Ori
region. The candidate was found as part of the Palomar Transient Factory (PTF)
Orion project. It has a photometric transit period of 0.448413 +- 0.000040
days, and appears in both 2009 and 2010 PTF data. Follow-up low-precision
radial velocity (RV) observations and adaptive optics imaging suggest that the
star is not an eclipsing binary, and that it is unlikely that a background
source is blended with the target and mimicking the observed transit. RV
observations with the Hobby-Eberly and Keck telescopes yield an RV that has the
same period as the photometric event, but is offset in phase from the transit
center by approximately -0.22 periods. The amplitude (half range) of the RV
variations is 2.4 km/s and is comparable with the expected RV amplitude that
stellar spots could induce. The RV curve is likely dominated by stellar spot
modulation and provides an upper limit to the projected companion mass of M_p
sin i_orb < 4.8 +- 1.2 M_Jup; when combined with the orbital inclination, i
orb, of the candidate planet from modeling of the transit light curve, we find
an upper limit on the mass of the planetary candidate of M_p < 5.5 +- 1.4
M_Jup. This limit implies that the planet is orbiting close to, if not inside,
its Roche limiting orbital radius, so that it may be undergoing active mass
loss and evaporation.Comment: Corrected typos, minor clarifications; minor updates/corrections to
affiliations and bibliography. 35 pages, 10 figures, 3 tables. Accepted to
Ap
Retired A Stars and Their Companions: Eighteen New Jovian Planets
We report the detection of eighteen Jovian planets discovered as part of our
Doppler survey of subgiant stars at Keck Observatory, with follow-up Doppler
and photometric observations made at McDonald and Fairborn Observatories,
respectively. The host stars have masses 0.927 < Mstar /Msun < 1.95, radii 2.5
< Rstar/Rsun < 8.7, and metallicities -0.46 < [Fe/H] < +0.30. The planets have
minimum masses 0.9 MJup 0.76 AU.
These detections represent a 50% increase in the number of planets known to
orbit stars more massive than 1.5 Msun and provide valuable additional
information about the properties of planets around stars more massive
thantheSun.Comment: ApJS accepted. The \rotate command prevented proper compilation. As a
result Tables 19 and 21 do not fit onto the page, causing the final columns
(S_HK, Nobs, respectively) to be omitte
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