Selection and appointment in international adjudication : insights from political science

Stiansen’s work was supported by the Research Council of Norway through its Centres of Excellence funding scheme, project number 223274 (PluriCourts). Financial support for Larsson’s work was provided by the Swedish Research Council, project no. 2018-01693.This article summarizes insights from political science and empirical legal scholarship concerning selection and appointment of adjudicators to permanent international courts (ICs). This scholarship suggests that designers of ICs face challenging trade-offs in balancing judicial independence and accountability, as well as in promoting descriptive representation and necessary qualifications on the bench. The article considers different institutional design features related to appointment procedures: representation, reappointment, screening procedures and procedures for removing judges. Representation is discussed in a series of sections considering full or selective representation, voting rules and geographic and gender quotas and aspirational targets. Throughout, we draw on data on 24 ICs to illustrate the different appointment procedures and institutional features.Publisher PDFPeer reviewe

Mitochondria directly influence fertilisation outcome in the pig

The mitochondrion is explicitly involved in cytoplasmic regulation and is the cell's major generator of ATP. Our aim was to determine whether mitochondria alone could influence fertilisation outcome. In vitro, oocyte competence can be assessed through the presence of glucose-6-phosphate dehydrogenase (G6PD) as indicated by the dye, brilliant cresyl blue (BCB). Using porcine in vitro fertilisation (IVF), we have assessed oocyte maturation, cytoplasmic volume, fertilisation outcome, mitochondrial number as determined by mtDNA copy number, and whether mitochondria are uniformly distributed between blastomeres of each embryo. After staining with BCB, we observed a significant difference in cytoplasmic volume between BCB positive (BCB+) and BCB negative (BCB-) oocytes. There was also a significant difference in mtDNA copy number between fertilised and unfertilised oocytes and unequal mitochondrial segregation between blastomeres during early cleavage stages. Furthermore, we have supplemented BCB- oocytes with mitochondria from maternal relatives and observed a significant difference in fertilisation outcomes following both IVF and intracytoplasmic sperm injection (ICSI) between supplemented, sham-injected and non-treated BCB- oocytes. We have therefore demonstrated a relationship between oocyte maturity, cytoplasmic volume, and fertilisation outcome and mitochondrial content. These data suggest that mitochondrial number is important for fertilisation outcome and embryonic development. Furthermore, a mitochondrial pre-fertilisation threshold may ensure that, as mitochondria are diluted out during post-fertilisation cleavage, there are sufficient copies of mtDNA per blastomere to allow transmission of mtDNA to each cell of the post-implantation embryo after the initiation of mtDNA replication during the early postimplantation stages

Governing sustainability transitions: contrasting experimental arenas through the lens of Agenda 2030

In 2015, the necessity of fundamental societal change was outlined in a universal, transnational agreement with the headline of “transforming our world”. The UN 2030 Agenda for Sustainable Development includes 17 Sustainable Development Goals, ranging from ending poverty and establishing gender equality to halting climate change and sustainable cities and communities. Building on UN and scholarly debates, we put forward two key principles to guide the realization of Agenda 2030: transformation (to sustainability) and integration. Transformation refers to the understanding that fundamental change is necessary to achieve sustainability; Integration recognizes that such change is dependent upon different perspectives, such as sustainability dimensions and the SDGs themselves, and different actors. At the same time, laboratories in real world contexts have emerged from various discourses, and are portrayed as settings to host potentially transformative experimentation and innovation processes and integrate various perspectives and actors. Sustainability related labs contribute a significant share to all labs existing. Despite their proliferation across the local, regional and national levels, it remains unclear how different laboratory settings might relate to processes of integration and transformation. Labs have seldom been attached explicitly to Agenda 2030 in practice, and a systematic assessment of the suitability of labs to support agenda 2030 so far is lacking. Hence, the main aim of this work-in-progress paper is to situate existing lab approaches from real world contexts in relation to the ambitions of Agenda 2030. It is guided by the following main research question: What is the capacity of labs in real world contexts in contributing to agenda 2030 by processes of transformation and integration? The paper presents the progress of an ongoing study, which intends to employ a step-based systematic review approach. Firstly, we highlight and unpack the key principles to guide the realization of Agenda 2030: transformation (to sustainability) and integration, and propose an analytical framework related to these principles. Secondly, and currently ongoing, we investigate a breadth of lab approaches building on a systematic review to draw out their capacities to contribute to transformation and integration. Results of the first stage are presented, before the paper ends by outlining the ongoing data collection process, describes the sample and provides a brief outlook

Learning while creating value for sustainability transitions: The case of Challenge Lab at Chalmers University of Technology

To achieve a sustainable future, a variety of societal systems need to be transformed and new ways of social collaboration created. Higher education institutions play an important role in guiding these changes, through education, research, and outreach. In this paper, we study a lab-based learning environment, the Challenge Lab, where master’s degree students engage in, and create value in support of, the transition to a sustainable society. Three student cases are analyzed in-depth to understand how the Lab functions as an expansive learning process and provides space for transformative and integrative value creation. The Lab’s guiding methodology is based on backcasting from principles, combined with clarifying the students’ core values and drivers. The role of the teacher in such a learning environment is to provide the basis for the process by facilitating and guiding. Provided with the right conditions, these students have the ability to challenge underlying assumptions about how systems work and to build trust by facilitating dialogue among actors in society. The students perceived the opportunity to engage in real-world challenges as meaningful, drew valuable lessons for their future, and got to know themselves better. In this transitional period of achieving ambitious sustainability goals and targets, students’ ability to be a source of change – maybe the most important source inside higher education institutions – deserves much more attention

A Sustainability Lighthouse—Supporting Transition Leadership and Conversations on Desirable Futures

Central in leadership for sustainability transitions is the capability to create transformative momentum in a sustainable (desirable) direction, calling for meaningful conversations on sustainable futures. The aim of this study is to develop a conceptual framework to inspire and support such conversations. A qualitative literature review of sustainability conceptualizations was conducted, followed by a thematic analysis. The resulting framework consists of an overarching question and an accompanying set of categories for four sustainability dimensions: the social, the economic, the ecological, and ‘human needs and wellbeing’. Furthermore, the framework is visualized as a lighthouse for pedagogical reasons. We foresee that the lighthouse might be of value in processes guiding socio-technical transitions towards sustainability in three different ways: (1) by attempting to bridge the issue of ‘transition’ with that of ‘sustainability’; (2) as part of a backcasting process; and (3) modes of transdisciplinary research where relevant actors take part in the conversation. The study is related to over 20 years of experience from working with a backcasting approach engaging with sustainability transitions in a variety of processes. We invite further dialogue on how one may approach the concept of sustainability to inspire and support conversations on sustainable futures

The Free Will Theorem

On the basis of three physical axioms, we prove that if the choice of a particular type of spin 1 experiment is not a function of the information accessible to the experimenters, then its outcome is equally not a function of the information accessible to the particles. We show that this result is robust, and deduce that neither hidden variable theories nor mechanisms of the GRW type for wave function collapse can be made relativistic. We also establish the consistency of our axioms and discuss the philosophical implications.Comment: 31 pages, 6figure

Transmission of mitochondrial DNA following assisted reproduction and nuclear transfer

Review of the articleMitochondria are the organelles responsible for producing the majority of a cell's ATP and also play an essential role in gamete maturation and embryo development. ATP production within the mitochondria is dependent on proteins encoded by both the nuclear and the mitochondrial genomes, therefore co-ordination between the two genomes is vital for cell survival. To assist with this co-ordination, cells normally contain only one type of mitochondrial DNA (mtDNA) termed homoplasmy. Occasionally, however, two or more types of mtDNA are present termed heteroplasmy. This can result from a combination of mutant and wild-type mtDNA molecules or from a combination of wild-type mtDNA variants. As heteroplasmy can result in mitochondrial disease, various mechanisms exist in the natural fertilization process to ensure the maternal-only transmission of mtDNA and the maintenance of homoplasmy in future generations. However, there is now an increasing use of invasive oocyte reconstruction protocols, which tend to bypass mechanisms for the maintenance of homoplasmy, potentially resulting in the transmission of either form of mtDNA heteroplasmy. Indeed, heteroplasmy caused by combinations of wild-type variants has been reported following cytoplasmic transfer (CT) in the human and following nuclear transfer (NT) in various animal species. Other techniques, such as germinal vesicle transfer and pronuclei transfer, have been proposed as methods of preventing transmission of mitochondrial diseases to future generations. However, resulting embryos and offspring may contain mtDNA heteroplasmy, which itself could result in mitochondrial disease. It is therefore essential that uniparental transmission of mtDNA is ensured before these techniques are used therapeutically

Modification of the conductance of single fullerene molecules by endohedral doping

We use scanning tunneling microscopy to establish controlled contacts to single molecules of endohedrally doped Ce(2)@C(80) fullerenes with C(60) as a reference. The stability of the experimental setup allows for the determination of the conductance of Ce(2)@C(80) relative to the conductance of C(60). The endohedral doping reduces the conductance of Ce(2)@C(80) by a factor of about five with respect to C(60). Ab initio calculations show that the reason for this reduced conductance is the absence of electron orbitals delocalized over the cage of Ce(2)@C(80) in the energy window of the conductance measurement. (C) 2009 American Institute of Physics. (doi:10.1063/1.3236529