Ecosystem responses to climate change at a Low Arctic and a High Arctic long-term research site

© The Author(s), 2017. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Ambio 46, Supple. 1 (2017): 160-173, doi:10.1007/s13280-016-0870-x.Long-term measurements of ecological effects of warming are often not statistically significant because of annual variability or signal noise. These are reduced in indicators that filter or reduce the noise around the signal and allow effects of climate warming to emerge. In this way, certain indicators act as medium pass filters integrating the signal over years-to-decades. In the Alaskan Arctic, the 25-year record of warming of air temperature revealed no significant trend, yet environmental and ecological changes prove that warming is affecting the ecosystem. The useful indicators are deep permafrost temperatures, vegetation and shrub biomass, satellite measures of canopy reflectance (NDVI), and chemical measures of soil weathering. In contrast, the 18-year record in the Greenland Arctic revealed an extremely high summer air-warming of 1.3°C/decade; the cover of some plant species increased while the cover of others decreased. Useful indicators of change are NDVI and the active layer thickness.The Toolik research was supported in part by NSF Grants DEB 0207150, DEB 1026843, ARC 1107701, and ARC 1504006

Low-Temperature Phase Transitions in a Soluble Oligoacene and Their Effect on Device Performance and Stability

The use of organic semiconductors in high-performance organic field-effect transistors requires a thorough understanding of the effects that processing conditions, thermal, and bias-stress history have on device operation. Here, we evaluate the temperature dependence of the electrical properties of transistors fabricated with 2,8-difluoro-5,11-bis(triethylsilylethynyl)anthradithiophene, a material that has attracted much attention recently due to its exceptional electrical properties. We have discovered a phase transition at T = 205 K and discuss its implications on device performance and stability. We examined the impact of this low-temperature phase transition on the thermodynamic, electrical, and structural properties of both single crystals and thin films of this material. Our results show that while the changes to the crystal structure are reversible, the induced thermal stress yields irreversible degradation of the devices

Quantitative Analysis of the Density of Trap States at the Semiconductor-Dielectric Interface in Organic Field-Effect Transistors

The electrical properties of organic field-effect transistors are governed by the quality of the constituting layers, and the resulting interfaces. We compare the properties of the same organic semiconductor film, 2,8-difluoro- 5,11-bis (triethylsilylethynyl) anthradithiophene, with bottom SiO2 dielectric and top Cytop dielectric and find a 10× increase in charge carrier mobility, from 0.17 ± 0.19 cm2 V−1 s−1 to 1.5 ± 0.70 cm2 V−1 s−1, when the polymer dielectric is used. This results from a significant reduction of the trap density of states in the semiconductor band-gap, and a decrease in the contact resistance

A systematic review of biomarkers for disease progression in Parkinson's disease

Peer reviewedPublisher PD

Functional Evolution of cis-Regulatory Modules at a Homeotic Gene in Drosophila

It is a long-held belief in evolutionary biology that the rate of molecular evolution for a given DNA sequence is inversely related to the level of functional constraint. This belief holds true for the protein-coding homeotic (Hox) genes originally discovered in Drosophila melanogaster. Expression of the Hox genes in Drosophila embryos is essential for body patterning and is controlled by an extensive array of cis-regulatory modules (CRMs). How the regulatory modules functionally evolve in different species is not clear. A comparison of the CRMs for the Abdominal-B gene from different Drosophila species reveals relatively low levels of overall sequence conservation. However, embryonic enhancer CRMs from other Drosophila species direct transgenic reporter gene expression in the same spatial and temporal patterns during development as their D. melanogaster orthologs. Bioinformatic analysis reveals the presence of short conserved sequences within defined CRMs, representing gap and pair-rule transcription factor binding sites. One predicted binding site for the gap transcription factor KRUPPEL in the IAB5 CRM was found to be altered in Superabdominal (Sab) mutations. In Sab mutant flies, the third abdominal segment is transformed into a copy of the fifth abdominal segment. A model for KRUPPEL-mediated repression at this binding site is presented. These findings challenge our current understanding of the relationship between sequence evolution at the molecular level and functional activity of a CRM. While the overall sequence conservation at Drosophila CRMs is not distinctive from neighboring genomic regions, functionally critical transcription factor binding sites within embryonic enhancer CRMs are highly conserved. These results have implications for understanding mechanisms of gene expression during embryonic development, enhancer function, and the molecular evolution of eukaryotic regulatory modules

The Application of Nanoparticles of Waste Tires in Remediating Boron from Desalinated Water

A waste tire rubber (WTR) collected from the remains discarded tires has exhibited a noteworthy capacity to adsorb Boron. In the current study, the boron adsorption remediation from water at selected pH values, initial boron concentration, contact time, adsorbent dosage and particle size were examined using the WTR, the chemically modified WTR, and nano-WTR. The adsorption isotherms were best fitted to the Freundlich model with a high correlation coefficient (R2 :0.89-0.99), while the adsorption kinetics were satisfactorily described by the pseudo second order kinetic equation with correlation coefficient (R2: 1).The boron remediation using the WTR, the chemically modified-WTR and nano-WTR at low boron concentration (≤ 17.7 mg/L) were comparable with other adsorbents. The highest adsorption capacities for WTR, chemically modified-WTR and nano-WTR at initial concentration of 17.5 mg/L were 16.7 ± 1.3 mg/g, 13.8 ± 1.9 mg/g and 12.7 ± 1.8mg/g, respectively.This publication was made possible by UREP # (19-171-1-031) from the Qatar National Research Fund (a member of Qatar Foundation)

Search for Gravitational Waves from Scorpius X-1 in LIGO O3 Data With Corrected Orbital Ephemeris

Improved observational constraints on the orbital parameters of the low-mass X-ray binary Scorpius~X-1 were recently published in Killestein et al (2023). In the process, errors were corrected in previous orbital ephemerides, which have been used in searches for continuous gravitational waves from Sco~X-1 using data from the Advanced LIGO detectors. We present the results of a re-analysis of LIGO detector data from the third observing run of Advanced LIGO and Advanced Virgo using a model-based cross-correlation search. The corrected region of parameter space, which was not covered by previous searches, was about 1/3 as large as the region searched in the original O3 analysis, reducing the required computing time. We have confirmed that no detectable signal is present over a range of gravitational-wave frequencies from $25\textrm{Hz}$ to $1600\textrm{Hz}$, analogous to the null result of Abbott et al (2022). Our search sensitivity is comparable to that of Abbott et al (2022), who set upper limits corresponding, between $100\textrm{Hz}$ and $200\textrm{Hz}$, to an amplitude $h_0$ of about $10^{-25}$ when marginalized isotropically over the unknown inclination angle of the neutron star's rotation axis, or less than $4\times 10^{-26}$ assuming the optimal orientation.Comment: 8 pages, 3 figures, 2 tables. Typeset with AASTeX 6.3.1. Accepted for publication in The Astrophysical Journal. arXiv admin note: text overlap with arXiv:2209.0286

Aurora-A Mitotic Kinase Induces Endocrine Resistance through Down-Regulation of ERα Expression in Initially ERα+ Breast Cancer Cells

Development of endocrine resistance during tumor progression represents a major challenge in the management of estrogen receptor alpha (ERα) positive breast tumors and is an area under intense investigation. Although the underlying mechanisms are still poorly understood, many studies point towards the ‘cross-talk’ between ERα and MAPK signaling pathways as a key oncogenic axis responsible for the development of estrogen-independent growth of breast cancer cells that are initially ERα+ and hormone sensitive. In this study we employed a metastatic breast cancer xenograft model harboring constitutive activation of Raf-1 oncogenic signaling to investigate the mechanistic linkage between aberrant MAPK activity and development of endocrine resistance through abrogation of the ERα signaling axis. We demonstrate for the first time the causal role of the Aurora-A mitotic kinase in the development of endocrine resistance through activation of SMAD5 nuclear signaling and down-regulation of ERα expression in initially ERα+ breast cancer cells. This contribution is highly significant for the treatment of endocrine refractory breast carcinomas, because it may lead to the development of novel molecular therapies targeting the Aurora-A/SMAD5 oncogenic axis. We postulate such therapy to result in the selective eradication of endocrine resistant ERαlow/− cancer cells from the bulk tumor with consequent benefits for breast cancer patients

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