Operating System Support for Mobile Agents

An "agent" is a process that may migrate through a computer network in order to satisfy requests made by its clients. Agents implement a computational metaphor that is analogous to how most people conduct business in their daily lives: visit a place, use a service (perhaps after some negotiation), and then move on. Thus, for the computer illiterate, agents are an attractive way to describe network-wide computations. Agents are also useful abstractions for programmers who must implement distributed applications. This is because in the agent metaphor, the processor or "place" the computation is performed is not hidden from the programmer, but the communications channels are. Most current research on agents has focused on language design and application issues. The TACOMA project (Tromso And COrnell Moving Agents) has, instead, focused on operating system support for agents and how agents can be used to solve problems traditionally addressed by operating systems. We have implemented prototype systems to support agents using UNIX and using Tcl/Tk on top of Horus. This paper outlines insights and questions based on that experience. We discuss abstractions needed by an operating system to support agents, and discuss some problems that arise in connection with electronic commerce involving agents

E-GIS; European Level Developments of Flexible Learning Models Within Geographical Information Science (GIS) For Vocational Training

E-GIS is a Leonardo pilot project, within Geographical Information Science (GIS), to be implemented over a three year period, 2002-05. The main objectives of the project is to establish co-operation between European Universities and GIS user organisations and to develop modularised courses intended for Internet based learning, establish links of communications between the partners in the project in order to disseminate and share “best practises” in different teaching situations and for different types of students. The course modules to be developed, all together, will constitute a one-year programme within GIS. This project mainly targets full time students, private and civil service employees within the EU but also similar categories in non-EU countries. The course modules are supposed to be flexible both in time and in “tempo”. However, synchronous group models will also be considered. The outcomes of the project will be high level content, new net-based pedagogic method suited for accessing target groups of great diversity as regards pedagogic traditions, access to computers and bandwidth. Cooperation between the institutions will, certainly, give higher level courses than the individual institutions could possibly themselves

An introduction to the TACOMA distributed system. Version 1.0

This report briefly introduces TACOMA Version 1.0. This distributed system supports agents, computations that can roam the internet. The report presents the TACOMA project, the computational model, how to get started, and the basic TACOMA abstractions

Automatic detection of the mental foramen for estimating mandibular cortical width in dental panoramic radiographs: the seventh survey of the Tromsø Study (Tromsø7) in 2015-2016

Objective To apply deep learning to a data set of dental panoramic radiographs to detect the mental foramen for automatic assessment of the mandibular cortical width. Methods Data from the seventh survey of the Tromsø Study (Tromsø7) were used. The data set contained 5197 randomly chosen dental panoramic radiographs. Four pretrained object detectors were tested. We randomly chose 80% of the data for training and 20% for testing. Models were trained using GeForce RTX 2080 Ti with 11 GB GPU memory (NVIDIA Corporation, Santa Clara, CA, USA). Python programming language version 3.7 was used for analysis. Results The EfficientDet-D0 model showed the highest average precision of 0.30. When the threshold to regard a prediction as correct (intersection over union) was set to 0.5, the average precision was 0.79. The RetinaNet model achieved the lowest average precision of 0.23, and the precision was 0.64 when the intersection over union was set to 0.5. The procedure to estimate mandibular cortical width showed acceptable results. Of 100 random images, the algorithm produced an output 93 times, 20 of which were not visually satisfactory. Conclusions EfficientDet-D0 effectively detected the mental foramen. Methods for estimating bone quality are important in radiology and require further development

Machine Learning in Chronic Pain Research: A Scoping Review

Given the high prevalence and associated cost of chronic pain, it has a significant impact on individuals and society. Improvements in the treatment and management of chronic pain may increase patients’ quality of life and reduce societal costs. In this paper, we evaluate state-of-the-art machine learning approaches in chronic pain research. A literature search was conducted using the PubMed, IEEE Xplore, and the Association of Computing Machinery (ACM) Digital Library databases. Relevant studies were identified by screening titles and abstracts for keywords related to chronic pain and machine learning, followed by analysing full texts. Two hundred and eighty-seven publications were identified in the literature search. In total, fifty-three papers on chronic pain research and machine learning were reviewed. The review showed that while many studies have emphasised machine learning-based classification for the diagnosis of chronic pain, far less attention has been paid to the treatment and management of chronic pain. More research is needed on machine learning approaches to the treatment, rehabilitation, and self-management of chronic pain. As with other chronic conditions, patient involvement and self-management are crucial. In order to achieve this, patients with chronic pain need digital tools that can help them make decisions about their own treatment and care

A Lectin HPLC Method to Enrich Selectively-glycosylated Peptides from Complex Biological Samples

Glycans are an important class of post-translational modifications. Typically found on secreted and extracellular molecules, glycan structures signal the internal status of the cell. Glycans on tumor cells tend to have abundant sialic acid and fucose moieties. We propose that these cancer-associated glycan variants be exploited for biomarker development aimed at diagnosing early-stage disease. Accordingly, we developed a mass spectrometry-based workflow that incorporates chromatography on affinity matrices formed from lectins, proteins that bind specific glycan structures. The lectins Sambucus nigra (SNA) and Aleuria aurantia (AAL), which bind sialic acid and fucose, respectively, were covalently coupled to POROS beads (Applied Biosystems) and packed into PEEK columns for high pressure liquid chromatography (HPLC). Briefly, plasma was depleted of the fourteen most abundant proteins using a multiple affinity removal system (MARS-14; Agilent). Depleted plasma was trypsin-digested and separated into flow-through and bound fractions by SNA or AAL HPLC. The fractions were treated with PNGaseF to remove N-linked glycans, and analyzed by LC-MS/MS on a QStar Elite. Data were analyzed using Mascot software. The experimental design included positive controls—fucosylated and sialylated human lactoferrin glycopeptides—and negative controls—high mannose glycopeptides from Saccharomyces cerevisiae—that were used to monitor the specificity of lectin capture. Key features of this workflow include the reproducibility derived from the HPLC format, the positive identification of the captured and PNGaseF-treated glycopeptides from their deamidated Asn-Xxx-Ser/Thr motifs, and quality assessment using glycoprotein standards. Protocol optimization also included determining the appropriate ratio of starting material to column capacity, identifying the most efficient capture and elution buffers, and monitoring the PNGaseF-treatment to ensure full deglycosylation. Future directions include using this workflow to perform mass spectrometry-based discovery experiments on plasma from breast cancer patients and control individuals

Altered metabolic landscape in IDH‐mutant gliomas affects phospholipid, energy, and oxidative stress pathways

Heterozygous mutations in NADP‐dependent isocitrate dehydrogenases (IDH) define the large majority of diffuse gliomas and are associated with hypermethylation of DNA and chromatin. The metabolic dysregulations imposed by these mutations, whether dependent or not on the oncometabolite D‐2‐hydroxyglutarate (D2HG), are less well understood. Here, we applied mass spectrometry imaging on intracranial patient‐derived xenografts of IDH‐mutant versus IDH wild‐type glioma to profile the distribution of metabolites at high anatomical resolution in situ. This approach was complemented by in vivo tracing of labeled nutrients followed by liquid chromatography–mass spectrometry (LC‐MS) analysis. Selected metabolites were verified on clinical specimen. Our data identify remarkable differences in the phospholipid composition of gliomas harboring the IDH1 mutation. Moreover, we show that these tumors are characterized by reduced glucose turnover and a lower energy potential, correlating with their reduced aggressivity. Despite these differences, our data also show that D2HG overproduction does not result in a global aberration of the central carbon metabolism, indicating strong adaptive mechanisms at hand. Intriguingly, D2HG shows no quantitatively important glucose‐derived label in IDH‐mutant tumors, which suggests that the synthesis of this oncometabolite may rely on alternative carbon sources. Despite a reduction in NADPH, glutathione levels are maintained. We found that genes coding for key enzymes in de novo glutathione synthesis are highly expressed in IDH‐mutant gliomas and the expression of cystathionine‐β‐synthase (CBS) correlates with patient survival in the oligodendroglial subtype. This study provides a detailed and clinically relevant insight into the in vivo metabolism of IDH1‐mutant gliomas and points to novel metabolic vulnerabilities in these tumors

HYPSO-1 CubeSat: First Images and In-Orbit Characterization

The HYPSO-1 satellite, a 6U CubeSat carrying a hyperspectral imager, was launched on 13 January 2022, with the Goal of imaging ocean color in support of marine research. This article describes the development and current status of the mission and payload operations, including examples of agile planning, captures with low revisit time and time series acquired during a campaign. The in-orbit performance of the hyperspectral instrument is also characterized. The usable spectral range of the instrument is in the range of 430 nm to 800 nm over 120 bands after binning during nominal captures. The spatial resolvability is found empirically to be below 2.2 pixels in terms of Full-Width at Half-Maximum (FWHM) at 565 nm. This measure corresponds to an inherent ground resolvable resolution of 142 m across-track for close to nadir capture. In the across-track direction, there are 1216 pixels available, which gives a swath width of 70 km. However, the 684 center pixels are used for nominal captures. With the nominal pixels used in the across-track direction, the nadir swath-width is 40 km. The spectral resolution in terms of FWHM is estimated to be close to 5 nm at the center wavelength of 600 nm, and the Signal-to-Noise Ratio (SNR) is evaluated to be greater than 300 at 450 nm to 500 nm for Top-of-Atmosphere (ToA) signals. Examples of images from the first months of operations are also shown.publishedVersio

Whole-brain in-vivo measurements of the Axonal G-Ratio in a group of 37 healthy volunteers

The g-ratio, quantifying the ratio between the inner and outer diameters of a fiber, is an important microstructural characteristic of fiber pathways and is functionally related to conduction velocity. We introduce a novel method for estimating the MR g-ratio non-invasively across the whole brain using high-fidelity magnetization transfer (MT) imaging and single-shell diffusion MRI. These methods enabled us to map the MR g-ratio in vivo across the brain's prominent fiber pathways in a group of 37 healthy volunteers and to estimate the inter-subject variability. Effective correction of susceptibility-related distortion artifacts was essential before combining the MT and diffusion data, in order to reduce partial volume and edge artifacts. The MR g-ratio is in good qualitative agreement with histological findings despite the different resolution and spatial coverage of MRI and histology. The MR g-ratio holds promise as an important non-invasive biomarker due to its microstructural and functional relevance in neurodegeneration