75 research outputs found
Lymphocyte Subsets Show Different Response Patterns to In Vivo Bound Natalizumab—A Flow Cytometric Study on Patients with Multiple Sclerosis
- Author
- A Baumann
- A Harrer
- A Lutterotti
- A Millonig
- Andrea Harrer
- B Bielekova
- CH Polman
- CH Polman
- DB Clifford
- DC Roopenian
- DH Miller
- Elisabeth Haschke-Becher
- Eugen Trinka
- F Zohren
- G Defer
- Georg Pilz
- GR Foster
- J Kraus
- J Kraus
- J Kraus
- Joerg Kraus
- Johann Sellner
- Katrin Oppermann
- L Airas
- LF Kastrukoff
- LF Kastrukoff
- M Cavers
- M Krumbholz
- M Niino
- M Saraste
- M Skarica
- MA Cooper
- Max Einhaeupl
- MJ Eikelenboom
- MM del Pilar
- O Stuve
- O Stuve
- P Wipfler
- P Wipfler
- PA Calabresi
- Pablo Villoslada
- Peter Wipfler
- PS Sorensen
- SA Houff
- Shahrzad Afazel
- Stefan Golaszewski
- T Rispens
- TA Yednock
- UH von Andrian
- WA Sheremata
- Wolfgang Hitzl
- Publication venue
- Public Library of Science
- Publication date
- 20/02/2012
- Field of study
Natalizumab is an effective monoclonal antibody therapy for the treatment of relapsing- remitting multiple sclerosis (RRMS) and interferes with immune cell migration into the central nervous system by blocking the α4 subunit of very-late activation antigen-4 (VLA-4). Although well tolerated and very effective, some patients still suffer from relapses in spite of natalizumab therapy or from unwanted side effects like progressive multifocal leukoencephalopathy (PML). In search of a routine-qualified biomarker on the effectiveness of natalizumab therapy we applied flow cytometry and analyzed natalizumab binding to α4 and α4 integrin surface levels on T-cells, B-cells, natural killer (NK) cells, and NKT cells from 26 RRMS patients under up to 72 weeks of therapy. Four-weekly infusions of natalizumab resulted in a significant and sustained increase of lymphocyte-bound natalizumab (p<0.001) which was paralleled by a significant decrease in detectability of the α4 integrin subunit on all lymphocyte subsets (p<0.001). We observed pronounced natalizumab accumulations on T and B cells at single measurements in all patients who reported clinical disease activity (n = 4). The natalizumab binding capacity of in vitro saturated lymphocytes collected during therapy was strongly diminished compared to treatment-naive cells indicating a therapy-induced reduction of α4. Summing up, this pilot study shows that flow cytometry is a useful method to monitor natalizumab binding to lymphocytes from RRMS patients under therapy. Investigating natalizumab binding provides an opportunity to evaluate the molecular level of effectiveness of natalizumab therapy in individual patients. In combination with natalizumab saturation experiments, it possibly even provides a means of studying the feasability of patient-tailored infusion intervals. A routine-qualified biomarker on the basis of individual natalizumab saturation on lymphocyte subsets might be an effective tool to improve treatment safety
AI is a viable alternative to high throughput screening: a 318-target study
- Author
- Abaffy Tatjana
- Abraham Elena Theres
- Abrahão Jônatas Santos
- Abramyan Tigran M.
- Agianian Bogos
- Agogo-Mawuli Percy
- Agoulnik Alexander I.
- Agrawal Rajendra K.
- Aguilera Elena
- Ahmed Mostafa
- Akk Gustav
- Akopian Tatos
- Al-Yozbaki Minnatallah
- Aldhamen Yasser Ali
- Alkan Cigdem
- Alramadhani Dina
- Alteen Matthew G.
- Alvarez Guzmán
- Ammendola Serena
- Anastasio Noelle C.
- Anderson Brandon M.
- Anderson Deborah H.
- Andricopulo Adriano D.
- Angell Richard M.
- Anthis Nicholas J.
- Antonelli Lorenzo
- Apfel Athena Marie
- Arias Juan Antonio Sanchez
- Arozarena Imanol
- Arrigoni Cristina
- Artía Zoraima
- Ashkar Shireen R.
- Ashton Mark R.
- Austin Richard C.
- Ayachi Aicha Gharbi
- Azeem Syeda Maryam
- Bailey-Elkin Ben A.
- Balakrishnan Bijina
- Balaña-Fouce Rafael
- Ballatore Carlo
- Banerjee Sourav
- Banerji Versha
- Banjo Toshihiro
- Barghash Marim M.
- Batey Robert A.
- Battistoni Andrea
- Baumann Ulrich
- Bdira Fredj Ben
- Bedi Mel
- Ben-Johny Manu
- Bergman Bastiaan
- Bernard Denzil
- Berti Andrew
- Bharambe Nikhil
- Bishop Ozlem Tastan
- Blanchet Xavier
- Blelloch Robert
- Blumenthal Robert M.
- Bognár Gabriella
- Bogomolovas Julijus
- Bon Carlotta
- Boorman Jacob
- Borowska Anna
- Borriello Francesco
- Bowman Gregory R.
- Bradley Robert K.
- Bradshaw William J.
- Brady-Kalnay Susann M.
- Breton Hairol E.
- Bruning John B.
- Bruning John Burt
- Bryant-Friedrich Amanda
- Buckner Frederick S.
- Buroni Silvia
- Butler Brittany
- Byrne Lee J.
- Byun Soo Young
- Caflisch Amedeo
- Cakir Isin
- Caliandro Ileana
- Caljon Guy
- Cann Andrew B.
- Caporali Andrea
- Capuzzi Stephen J.
- Caroleo Maria Cristina
- Cathcart Ann M.
- Celano Stephanie L.
- Cerna Mark Vincent C. dela
- Chadni Somaia Haque
- Champion Matthew M.
- Chan Nei-Li
- Chapman Carly J.
- Chaton Catherine T.
- Chatterjee Arnab K.
- Chaudhuri Dipayan
- Chauhan Shefali
- Chaytow Helena
- Chen Daniel
- Chen Lifeng
- Chen Yicheng
- Chern Ting-Rong
- Chini Andrea
- Chou Tristan
- Chou Tsui-Fen
- Christensen Emily M.
- Christodoulides Myron
- Chu Shaoyou
- Chua Benjamin Soon Kai
- Chuah Janelle
- Chung Zara
- Chuong Patrick
- Ciccia Alberto
- Cildir Gökhan
- Cione Erika
- Clayton W. Brent
- Coles John G.
- Colomba Audrey
- Colotti Gianni
- Conn Graeme L.
- Conticello Silvestro G.
- Contreras Stephanie
- Cools Julie
- Coombe Deirdre R.
- Corson Timothy W.
- Cortopassi Gino
- Corvo Ileana
- Costoya Jose A.
- Cowen Leah E.
- Cox Bryan D.
- Cuddihy Andrew R.
- Cullinane Ryan T.
- Cunningham Kathryn A.
- Dahal Gopal
- Dallman Sydney
- Dame Remus T.
- Davtyan Aram
- De Keulenaer Gilles
- De Luise Monica
- de Oliveira Aldo Sena
- de Oliveira Saulo
- de Sousa Alessandra Mara
- de Souza Guilherme Eduardo
- Debonsi Hosana Maria
- Degterev Alexei
- DeHaan Nicholas
- Del Rio Flores Antonio
- Dempsey Garrett
- Desai Umesh R.
- Diallo Bakary N’tji
- Dickhout Jeffrey
- Dickinson Bryan C.
- Dieck Chelsea L.
- Dirksen Dorian
- do Monte-Neto Rubens Lima
- Dolce Vincenza
- Donaldson William A.
- Douville Renée N.
- Dowling David J.
- Drewry David H.
- Duggan Brendan M.
- Duncan Dustin
- Dymock Brian W.
- Dzhumaev Sergei
- D’Antuono Anna
- Ebright Richard H.
- Eckert Sam
- Edelman Benjamin L.
- Eitzen Gary
- ElSheikh Assmaa
- Englinger Bernhard
- Escaffre Olivier
- Espinoza Stefano
- Evans Jay D.
- Faller Kiterie M. E.
- Fan Erkang
- Fan Hua-Ying
- Fathallah M. Dahmani
- Feng Hui
- Ferrando Adolfo A.
- Ferraris Davide Maria
- Ferreira Jacob
- Ferreira Rafaela Salgado
- Fiermonte Giuseppe
- Finkelstein Joshua M.
- Fiorillo Annarita
- Fish Paul V.
- Foong Wuen Ee
- Foote Andrea Talbot
- Francisco Karol R.
- Frangos Zachary J.
- Fraser Cameron
- Freiberg Alexander N.
- Freywald Andrew
- Friedland Greg
- Fries Jacob
- Gadar Kavita
- Gandhi Neha S.
- Garaeva Alisa A.
- Garavaglia Silvia
- Garcia George A.
- García-Cuesta Eva M.
- Garmendia Antonio E.
- Gasparre Giuseppe
- Gavathiotis Evripidis
- Gebauer Jan M.
- Geden Sandra E.
- Geisbrecht Brian V.
- Gelardi Edoardo Luigi Maria
- Gerwick William H.
- Ghilarducci Kim
- Ghosh Agnidipta
- Giardini Miriam A.
- Gierse Robin Matthias
- Giesler Kyle
- Gillingwater Thomas H.
- Gingras Alexandre R.
- Giorgis Marta
- Girolimetti Giulia
- Glubb Dylan M.
- Glukhov Evgenia
- Gniewek Pawel
- Goldenberg Joshua M.
- Gong Bin
- Gorgoglione Ruggiero
- Granneman James G.
- Greene Geoffrey L.
- Greig Iain R.
- Gruber Joshua J.
- Guido Rafael V. C.
- Gumede Njabulo Joyfull
- Gunasekharan Vignesh
- Gupta Tushita
- Gupta Yogesh K.
- Gustincich Stefano
- Haas Arthur L.
- Hahn William C.
- Haikarainen Teemu
- Hammock Bruce D.
- Hannink Mark
- Hansen Kasper B.
- Hare Stephanie
- Harijan Rajesh K.
- Haupt Larisa M.
- He Yuan
- Hedstrom Lizbeth
- Hedstrom Lizbeth
- Heifets Abraham
- Henriksen Niel
- Herdendorf Timothy J.
- Hermle Tobias
- Herr Andrew B.
- Hickey Robert J.
- Hildeman David A.
- Hirsch Anna K. H.
- Ho Gregory
- Hopkins Kevin M.
- Hoppe Heinrich
- Horstmann Nicola
- Hosfield David J.
- Hossain Sakib
- Houry Walid A.
- Hsiao Edward C.
- Hu Di
- Hu Yanmei
- Huang Chang
- Huimei Chen
- Hussain Muhammad Saddam
- Iglesias Pablo
- Ikegami Tetsuro
- Ilari Andrea
- Inde Zintis
- Ingoglia Filippo
- Iommarini Luisa
- Ip Philbert
- Jackson Michael R.
- Jafar-Nejad Hamed
- Jayasinghe Thilina D.
- Jo Eunji
- Johannsen Sandra
- John Ashley L. St.
- Jones Peter L.
- Jossart Jennifer N.
- Jung Hoyoung
- Kahler Charlene M.
- Kampourakis Thomas
- Kandror Olga
- Karan Charles
- Katyal Sachin
- Kee Jung-Min
- Kee Jung-Min
- Keedy Daniel A.
- Kejriwal Rishabh
- Keller Charles
- Kelm Robert J.
- Kemet Chinyere Maat
- Kenyon Victor
- Kerr William G.
- Khalaf Noureddine Ben
- Kilkenny Mairi Louise
- Kim Hyeong Jun
- Kim Kyu Kwang
- Kootstra Neeltje A.
- Koppisetti Rama K.
- Korotkov Konstantin V.
- Kotzé Timothy J.
- Kováts Benjámin
- Kratz Jadel Müller
- Krishnamurthy Durga
- Krist David T.
- Kroon Erna Geessien
- Kushnir Alexander
- Kwiatkowski Jacek
- Laggner Christian
- Lai Kent
- Lake Robert J.
- Lam Andrew
- Lama Eleonora
- Lan Tong
- Landfear Scott M.
- Lasarte Juan José
- Lawrence Daniel A.
- Lee Andreia H.
- Lee Donghan
- Lee Gyeongeun
- Lee Jiyoun
- Lee Kyung Hyeon
- Lee Pil H.
- Legare Scott
- Lehtiö Lari
- Lembo Gaia
- Lempicki Camille
- Lenci Elena
- Leng Fenfei
- Lescar Julien
- Leung Elisa
- Leuzzi Giuseppe
- Levin Michael
- Li Hai
- Li Shan
- Li Wei
- Li Yihe
- Li Yong
- Li Yunlong
- Liao Jiayu
- Liao Junzhuo
- Lieberman Howard B.
- Lin Jiabei
- Lin Jiusheng
- Liou Benjamin
- Lisabeth Erika Mathes
- Liu Chen
- Liu Koting
- Liu Pengda
- Liu Pengda
- Liu Zhongle
- Lobb Kevin A.
- Lolicato Marco
- Lolli Marco Lucio
- Longo Nicola
- Lotsaris Irina
- Lowther W. Todd
- Loy Cody A.
- Lu Xin
- Luh Frank
- Lukacs Gergely L.
- Luo Dahai
- Lussier Marc P.
- Lynn Edward G.
- Machaca Khaled
- Maciag Joseph J.
- Macias Maria J.
- MacKeigan Jeffrey P.
- Mahmoodi Niusha
- Maksimainen Mirko M.
- Malkas Linda H.
- Maltarollo Vinícius Gonçalves
- Mameli Eleonora
- Manor Danny
- Mantri Chinmay Kumar
- Maranda Vincent
- Martin Katie R.
- Martin-Malpartida Pau
- Maruta Shinsaku
- Marx Steven O.
- Mason Emily R.
- Matheeussen An
- Matovic Nick
- Mattevi Andrea
- Maurice Martin St.
- Mayer Gaétan
- Maynes Jason T.
- Mazitschek Ralph
- McCarthy Ronan R.
- McDowell Mary Ann
- McManus Kirk James
- Mehedi Masfique
- Mehlman Tamar
- Mellado Mario
- Mellor Paul
- Merrill Nathan M.
- Michlewski Gracjan
- Milosavljevic Julian
- Minakova Anna
- Miner Jaden
- Moharreri Ehsan
- Molyneaux Kathleen A.
- Montanaro Anna
- Moore Hannah P.
- Moore Richard G.
- Moreda Teresa Lozano
- Moreira David
- Moreira Paulo Otávio Lourenço
- Morisseau Christophe
- Morrison Adrian
- Morten Brianna C.
- Mostert Konrad J.
- Mota Bruno Eduardo Fernandes
- Motyl Anna A. L.
- Mousa Jarrod J.
- Mowat Michael
- Muli Christine S.
- Mungrue Imran N.
- Mushtaq Aisha
- Musta Kirsikka
- Müller Anna
- Müller Christa E.
- Myhr Courtney
- Mysinger Michael
- Mysore Venkatesh
- Nagai Maira Harume
- Nagamori Kiyo
- Namasivayam Vigneshwaran
- Nasburg Joshua Alexander
- Ng Ho Leung
- Ng James
- Ngo Lien
- Ngoi Peter
- Nguyen Kong
- Novina Carl D.
- null null
- Ogunwa Tomisin Happy
- Ojha Anil K.
- Ojo Kayode K.
- Olson Steven H.
- Ortiz Diana
- Oyarzabal Julen
- O’Brien Terrence E.
- O’Connell Patrick
- O’Dea Austin
- O’Donoghue Anthony J.
- O’Mara Megan L.
- O’Mara Tracy A.
- O’Meara Timothy R.
- O’Sullivan Ann Marie
- Pai Vaibhav P.
- Paige Mikell
- Palazzo Teresa
- Panganiban Antonito T.
- Paparella Ashleigh S.
- Parang Keykavous
- Parico Gian Carlo G.
- Park Soonju
- Partch Carrie L.
- Pascal John M.
- Pasquali Marzia
- Patel Amit K.
- Paulino Cristina
- Pederick Jordan L.
- Peltier Cheryl
- Pemberton Ryan P.
- Perry Benjamin
- Perry J. Jefferson P.
- Petretto Enrico
- Pérez-Pertejo Yolanda
- Phadke Sameer
- Pham Kien
- Pineda-Lucena Antonio
- Poirier Steve
- Popowicz Grzegorz Maria
- Porcelli Anna Maria
- PrasadPrasad Srimukh Veccham Krishna
- Presser Adam G.
- Pressly Brandon
- Prikler Gergely
- Prince Ashutosh
- Puchades-Carrasco Leonor
- Pusztai Lajos
- Qi Xin
- Qin Xingping
- Qureshi Insaf Ahmed
- Rabal Obdulia
- Radhakrishnan Senthil K.
- Ramachandran Rajesh
- Randall Lía M.
- Rangarajan Amith Vikram
- Rayman Joseph B.
- Reglero Clara
- Reguera Rosa Maria
- Reidenbach Andrew G.
- Reis Joana
- Ribeiro Beatriz Murta Rezende Moraes
- Richardson Timothy I.
- Riches David W. H.
- Rizzi Menico
- Robinson Victoria L.
- Rocha Rafael Eduardo Oliveira
- Rodriguez G. Marcela
- Rodríguez-Frade José Miguel
- Rohde Kyle H.
- Ronchi Virginia Paola
- Ronning Donald R.
- Rosnik Andreana
- Roti Giovanni
- Rouzbeh Nirvan
- Rowswell-Turner Rachael B.
- Rubin Eric J.
- Rucinski Gwennan
- Safo Martin K.
- Sainas Stefano
- Salas Brenda P. Medellin
- Samantha Ariela
- Samudio Ben
- Santiago César
- Sarangapani Krishna
- Sarilla Suryakala
- Sarosiek Kristopher
- Schneider Nicholas O.
- Schroedl Stefan
- Scoffone Viola Camilla
- Segers Vincent F. M.
- Seo Seung-Yong
- Serafim Mateus Sá Magalhães
- Shaqra Ala M.
- Shek Stefani
- Shelburne Samuel A.
- Shim Heesung
- Shorter James
- Shoue Douglas A.
- Shum David
- Shyng Show-Ling
- Siderovski David P.
- Sidorova Yulia A.
- Silva Elany Barbosa
- Silvennoinen Olli
- Singh Nathanael
- Singh Neeraj
- Singh Rakesh K.
- Siqueira-Neto Jair L.
- Sishtla Kamakshi
- Sistla Jyothi C.
- Skorodinsky Maxim
- Slotboom Dirk J.
- Smith David M.
- Smith Kristiana S.
- Smrcka Alan V.
- So Jonathan
- Sobrado Pablo
- Soellner Matthew B.
- Solano Roberto
- Sorenson Jon M.
- Stafford Kate
- Stahl Andreas
- Statsyuk Alexander V.
- Stec Natalia
- Stecula Adrian
- Stetefeld Joerg
- Strauss Erick
- Stuchbury Grant David
- Su Leila
- Su Tong
- Su Zhengchen
- Sugamori Kim S.
- Sun Ying
- Suterwala Shabbir
- Svensson Fredrik
- Sverzhinsky Aleksandr
- Swart Tarryn
- Taglialatela Angelo
- Tam Heng-Keat
- Tandon Vasudha
- Tang Weiping
- Tang Young
- Tanner John J.
- Taylor Richard E.
- Teixeira Thaiz Rodrigues
- Teramoto Tadahisa
- Thai Van Chi
- Thayer Desiree
- Thomas Bill
- Thompson Erik W.
- Tilford Hannah
- Tiwari Rakesh Kumar
- Toh Alan Kie Leong
- Tomilov Alexey
- Toogood Peter
- Torner Carles
- Trabocchi Andrea
- Trader Darci J.
- Trakhtenberg Ephraim F.
- Trinh Nguyen Mai
- Truong Ha
- Tse-Dinh Yuk-Ching
- Tsimbalyuk Sofiya
- Tumes Damon J.
- Tye Mark A.
- Uribe Ruben Vazquez
- Valli Marilia
- van den Akker Focco
- van den Bedem Henry
- Van Doren Steven R.
- Van Grack Tessa
- Van Hung Le Vuong
- Van Pelt Natascha
- Van Remmen Holly
- Van Voorhis Wesley C.
- Vandenberg Robert J.
- Veit Guido
- Verhamme Ingrid M.
- Verma Rajkumar
- Viola Ronald E.
- Virtanen Anniina
- Vizeacoumar Franco J.
- Vizeacoumar Frederick S.
- Vleminckx Margot
- von Hundelshausen Philipp
- Voss Jan Hendrik
- Vrielink Alice
- Waggoner Stephen N.
- Walensky Loren D.
- Wallach Izhar
- Wang Feng
- Wang Jianghai
- Wang Jun
- Wang Xingyou
- Wang Zhenghe
- Warrington Jeffrey M.
- Watkins Joshua
- Wazir Sarah
- Weber Christian
- Welsbie Derek S.
- Wentworth Kelly L.
- Wert-Lamas Leon
- White Andrew
- White Simon J.
- Whitesell Luke
- Williams Tiffany
- Wilson Cornelia M.
- Wilson Mark A.
- Windisch Marc P.
- Wong Keith S.
- Woods Virgil A.
- Worley Brad
- Wu Pengpeng
- Wu Xiaoyang
- Wulff Heike
- Xiang Fei
- Xu Hongyang
- Xu Jiake
- Xu Jingyi
- Xu Sophia Q.
- Xu Xin
- Yan Riqiang
- Yang Chao-Yie
- Yen Yun
- Young Matthew A.
- Yu Fang
- Yu Xinfang
- Yuan Haynes
- Yuan Xinrui
- Zahler Stefan
- Zeina Christina M.
- Zelinskaya Natalia
- Zhang Dingqiang
- Zhang Gang
- Zhang Wenjun
- Zhang Xu
- Zhang Yan Jessie
- Zhang Zhiguo
- Zhao Jinshi
- Zhou Han
- Zhou Hui
- Zhou Jia
- Zhou Pei
- Zhou Shan
- Zhu Jiaqi
- Zhu Siran
- Zhu Yini
- Zhuo Ling
- Zochodne Douglas William
- Publication venue
- Publication date
- 01/01/2024
- Field of study
: High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNet® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, high-quality X-ray crystal structures, or manual cherry-picking of compounds. We show that the molecules selected by the AtomNet® model are novel drug-like scaffolds rather than minor modifications to known bioactive compounds. Our empirical results suggest that computational methods can substantially replace HTS as the first step of small-molecule drug discovery
Long-range angular correlations on the near and away side in p–Pb collisions at
- Author
- Abdiel Ramirez Reyes
- Adam Ryszard Kisiel
- Adam Tomasz Matyja
- Adam Wlodzimierz Jacholkowski
- Adam Szczepankiewicz
- Adela Kravcakova
- Aditya Nath Mishra
- Adrian Sevcenco
- Adriana Telesca
- Airton Deppman
- Ajay Kumar Dash
- Alberica Toia
- Alberto Baldisseri
- Alberto Collu
- Alberto Gago
- Alberto Masoni
- Alejandro Szanto de Toledo
- Alessandra Maria Mazzoni
- Alessandra Fantoni
- Alessandro De Falco
- Alessandro Feliciello
- Alessandro Grelli
- Alessandro Pesci
- Alexander Philipp Kalweit
- Alexander Akindinov
- Alexander Borissov
- Alexander Hansen
- Alexander Kluge
- Alexander Mamonov
- Alexander Nedosekin
- Alexander Ochirov
- Alexander Vinogradov
- Alexander Vodopianov
- Alexander Wilk
- Alexandr Tumkin
- Alexandre Alarcon do Passo Suaide
- Alexandre Nyanin
- Alexandre Rachevski
- Alexandre Shabetai
- Alexandru Florin Dobrin
- Alexandru Bercuci
- Alexei Kaidalov
- Alexei Khanzadeev
- Alexei Pavlinov
- Alexey Bogdanov
- Alexey Kuryakin
- Alexey Vyushin
- Alexis Jean Michel Mas
- Alfonso Tarazona Martinez
- Alfredo Musso
- Alice Zimmermann
- Alina Gabriela Grigoras
- Alis Rodriguez Manso
- Alla Maevskaya
- Alphonse Rademakers
- Amalia Pop
- Amaya Ofelia Casanova Diaz
- Ana Maria Marin
- Anais Annick Erica Bergognon
- Anand Kumar Dubey
- Anatoly Kolojvari
- Anders Garritt Knospe
- Anders Nils Erik Oskarsson
- Andras Gabor Agocs
- Andre Augustinus
- Andre Mischke
- Andrea Agostinelli
- Andrea Alici
- Andrea Dainese
- Andrea Danu
- Andrea Dubla
- Andrea Festanti
- Andrea Francescon
- Andrea Rossi
- Andreas Arend
- Andreas Morsch
- Andrei Geae Gheata
- Andrei Ionut Herghelegiu
- Andres Sandoval
- Andrew Marshall Adare
- Andrey Ivanov
- Andrey Kazantsev
- Andrey Reshetin
- Andrey Vasiliev
- Andrey Zarochentsev
- Andry Malala Rakotozafindrabe
- Andrzej Deloff
- Andrzej Rybicki
- Andzhey Asryan
- Angela Badala
- Anik Gupta
- Anitha Nyatha
- Anju Bhasin
- Ankita Goswami
- Anna Rita Reolon
- Annalisa De Caro
- Annalisa Mastroserio
- Annika Passfeld
- Anselmo Margotti
- Ante Bilandzic
- Anthony Timmins
- Antoine Xavier Lardeux
- Anton Alkin
- Anton Andronic
- Anton Jusko
- Antonin Maire
- Antonino Zichichi
- Antonio Carlos Oliveira Da Silva
- Antonio Di Mauro
- Antonio Juan Rubio Montero
- Antonio Ortiz Velasquez
- Antonio Uras
- Ara Grigoryan
- Armando Palmeri
- Arnaldi Roberta
- Arnulfo Martinez Davalos
- Arsen Hayrapetyan
- Arshad Ahmad
- Artem Konevskih
- Artur Krzysztof Szostak
- Arturo Alejandro Menchaca Rocha
- Arturo Fernandez Tellez
- Arturo Tauro
- Arvinder Singh Palaha
- Ashok Kumar Bhati
- Astrid Morreale
- Attilio Tarantola Peloni
- Attiq Ur Rehman
- Aurora Diozcora Vargas
- Austin Harton
- Ayben Karasu Uysal
- Baba Potukuchi
- Bae Svane Nielsen
- Barbara Erazmus
- Barbara Guerzoni
- Barthelemy von Haller
- Basanta Kumar Nandi
- Bastian Bathen
- Bedangadas Mohanty
- Benjamin Andreas Hess
- Benjamin Donigus
- Beole&apos
- Beomkyu Kim
- Beomsu Chang
- Bernard Hicks
- Bernd Stefan Windelband
- Bernhard Skaali
- Berzano Dario Carlo Domenico
- Betty Abelev
- Bianchi Livio
- Bikash Sinha
- Biswarup Paul
- Bjarte Kileng
- Bjorn Steven Nilsen
- Blahoslav Pastircak
- Blanco F.
- Bo Fenton Olsen
- Bogdan Theodor Rascanu
- Bogdan Vulpescu
- Boris Batyunya
- Boris Grinyov
- Boris Hippolyte
- Boris Polichtchouk
- Boris Wagner
- Bossu&apos
- Botta Elena
- Branislav Sitar
- Brigitte Cheynis
- Brijesh Kumar Srivastava
- Bruno Alessandro
- Bruno Espagnon
- Bruno Ghidini
- Bufalino Stefania
- Byounghee Han
- Cai Xu
- Camilo Ernesto Lara
- Carlos Albert Salgado
- Carlos Eugenio Perez Lara
- Carlos Pajares
- Carmelo Di Giglio
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- Krzysztof Redlich
- Kurepin A.
- Kurepin A. B.
- Kushal Das
- Kyoichiro Ozawa
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- Shiming Yang
- Shingo Sakai
- Shinichi Esumi
- Shinichi Hayashi
- Shtejer Diaz Katherin
- Shuaib Ahmad Khan
- Shuang Li
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- Siegfried Valentin Foertsch
- Silvia Arcelli
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- Simone Schuchmann
- Sitta Mario
- Smbat Grigoryan
- Sona Pochybova
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- Stefan Kirsch
- Stefan Rossegger
- Stefano Piano
- Subhash Singha
- Subhasis Chattopadhyay
- Subikash Choudhury
- Sudhir Raniwala
- Sudipan De
- Suh Urk Chung
- Sukalyan Chattopadhyay
- Sul Ah Ahn
- Sumit Basu
- Sun Kun Oh
- Sung Chul Lee
- Supriya Das
- Susanta Kumar Pal
- Svein Lindal
- Sven Gotovac
- Svetlana Kushpil
- Sylvain Chapeland
- Tadeusz Antoni Dobrowolski
- Taebong Moon
- Taesoo Kim
- Takafumi Niida
- Taku Gunji
- Tapan Kumar Nayak
- Tatiana Karavicheva
- Tatjana Susa
- Tatsuya Chujo
- Teodor Siemiarczuk
- Terry Awes
- Thanushan Kugathasan
- Theo Alexander Broker
- Thomas Michael Cormier
- Thomas Dietel
- Thomas Humanic
- Thomas Peitzmann
- Thorsten Kollegger
- Tim Schuster
- Timo Gunther Breitner
- Timothy Symons
- Timur Pocheptsov
- Tinku Sinha
- Tiziano Virgili
- Tobias Krawutschke
- Tomas Robert Aronsson
- Tomasz Jan Pawlak
- Tome Anticic
- Tomi Samuli Raiha
- Tomoya Tsuji
- Torsten Alt
- Toru Sugitate
- Trine Spedstad Tveter
- Tuomo Esa Aukusti Kalliokoski
- Tuva Richert
- Tyler Allen Browning
- Udo Wolfgang Kebschull
- Ulrich Michael Frankenfeld
- Ulrich Fuchs
- Uwe Westerhoff
- Valentina Zaccolo
- Valeria Muccifora
- Valerie Barret
- Valerio Altini
- Valery Kondratiev
- Valery Punin
- Vardanush Papikyan
- Vasco Miguel Chibante Barroso
- Vasile Catanescu
- Vasily Kushpil
- Vedran Nikolic
- Venelin Anguelov
- Vera Loggins
- Vercellin Ermanno
- Veronica Canoa Roman
- Victor Trubnikov
- Vikas Singhal
- Vincenzo Paticchio
- Vitaly Loginov
- Vito Lenti
- Vito Manzari
- Vladimir Ivanov
- Vladimir Kaplin
- Vladimir Kovalenko
- Vladimir Nikulin
- Vladimir Peskov
- Vladimir Pospisil
- Vladimir Samsonov
- Vladimir Vechernin
- Vladimir Wagner
- Vladislav Grigoriev
- Vladislav Manko
- Vojtech Petracek
- Volker Lindenstruth
- Weilin Yu
- Werner Riegler
- Wiktor Stanislaw Peryt
- Wisla Carena
- Wladyslaw Henryk Trzaska
- Woo Jin Park
- Xavier Bernard Lopez
- Xianbao Yuan
- Xiangrong Zhu
- Xianguo Lu
- Xiaoming Zhang
- Xitzel Sanchez Castro
- Yaldo Chris G.
- Yannick Denis Zoccarato
- Yaping Wang
- Yaroslav Berdnikov
- Yasuo Miake
- Yasuto Hori
- Yaxian Mao
- Yevgen Martynov
- Yifei Wang
- Yogendra Viyogi
- Yong Wook Baek
- Yorito Yamaguchi
- You Zhou
- Youngil Kwon
- Yury Kharlov
- Yury Kucheriaev
- Yury Pestov
- Yury Sibiriak
- Yury Vinogradov
- Yves Roland Schutz
- Yvonne Chiara Pachmayer
- Zabulon Vilakazi
- Zaida Conesa del Valle
- Zhongbao Yin
- Zubayer Ahammed
- Zuzana Harmanova
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2013
- Field of study
Off-label psychopharmacologic prescribing for children: History supports close clinical monitoring
- Author
- A Kahn
- A Patz
- AC Swann
- AE Bryant
- Albert T Derivan
- BL Gracious
- BL Strom
- BL Strom
- C Fleischhaker
- C Hiemke
- CE Koro
- CF Weiss
- Christopher J Kratochvil
- CJ Witkop Jr
- CS Camfield
- CU Correll
- CU Correll
- D Scheffner
- Daniel J Safer
- DF Klein
- DJ Safer
- DJ Safer
- DJ Safer
- DR Nordli
- E Brown
- EJ Garland
- EMEA
- EPG Vining
- FA Etwel
- FDA
- FDA
- FDA
- FE Dreifuss
- FJ Mackay
- G Glaeske
- G Gonzalez-Martin
- GJ Emslie
- Health Canada
- I Isojarvi
- J Binek
- J March
- JM Zito
- JM Zito
- JM Zito
- JM Zito
- Joerg M Fegert
- JR Farwell
- JS March
- Julie M Zito
- Laurence L Greenhill
- LL Brunton
- LL Greenhill
- M Gerlach
- M Gerlach
- ME Willy
- MH Teicher
- MJ Arduino
- MP Okamoto
- N Fost
- National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research
- NICHD
- NL Grauso-Eby
- P Baumann
- P Riederer
- R Goodwin
- R Roberts
- RA King
- RA Strickland
- RE Behrman
- RK Mirakhur
- S Turner
- SE Nissen
- SR Pliszka
- T Hammad
- TA Glauser
- TE Wilens
- VE Kinsey
- WH Green
- Publication venue
- BioMed Central
- Publication date
- 01/01/2008
- Field of study
The review presents pediatric adverse drug events from a historical perspective and focuses on selected safety issues associated with off-label use of medications for the psychiatric treatment of youth. Clinical monitoring procedures for major psychotropic drug classes are reviewed. Prior studies suggest that systematic treatment monitoring is warranted so as to both minimize risk of unexpected adverse events and exposures to ineffective treatments. Clinical trials to establish the efficacy and safety of drugs currently being used off-label in the pediatric population are needed. In the meantime, clinicians should consider the existing evidence-base for these drugs and institute close clinical monitoring
Underlying Event measurements in pp collisions at s=0.9 and 7 TeV with the ALICE experiment at the LHC
- Author
- A Buckley
- A Capella
- A. Kurepin
- A.B. Kurepin
- A.K. Dutta Majumdar
- Abdiel Ramirez Reyes
- Adam Ryszard Kisiel
- Adam Tomasz Matyja
- Adam Wlodzimierz Jacholkowski
- Aditya Nath Mishra
- Adrian Sevcenco
- Adriana Telesca
- Airton Deppman
- Ajay Kumar Dash
- Ajit Kumar Mohanty
- AK Aamodt
- Alain Baldit
- Alain Michalon
- Alberica Toia
- Alberto Baldisseri
- Alberto Gago
- Alberto Masoni
- Alberto Pulvirenti
- Alejandro Szanto de Toledo
- Alessandra Fantoni
- Alessandra Maria Mazzoni
- Alessandro De Falco
- Alessandro Ferretti
- Alessandro Grelli
- Alessandro Pesci
- Alexander Akindinov
- Alexander Borissov
- Alexander Hansen
- Alexander Kluge
- Alexander Mamonov
- Alexander Nedosekin
- Alexander Ochirov
- Alexander Philipp Kalweit
- Alexander Vinogradov
- Alexander Vodopianov
- Alexander Wilk
- Alexandr Tumkin
- Alexandre Alarcon do Passo Suaide
- Alexandre Nyanin
- Alexandre Rachevski
- Alexandre Shabetai
- Alexandru Bercuci
- Alexandru Florin Dobrin
- Alexei Kaidalov
- Alexei Khanzadeev
- Alexei Pavlinov
- Alexey Bogdanov
- Alexey Kuryakin
- Alexey Vyushin
- Alexis Jean-Michel Mas
- Alfredo Musso
- Alice Zimmermann
- Alina Gabriela Grigoras
- Alla Maevskaya
- Alphonse Rademakers
- Amalia Pop
- Amaya Ofelia Casanova Diaz
- Ana Maria Marin
- Anand Kumar Dubey
- Anatoly Fedunov
- Anatoly Kolojvari
- Anders Nils Erik Oskarsson
- Andras Gabor Agocs
- Andre Augustinus
- Andre Mischke
- Andrea Agostinelli
- Andrea Alici
- Andrea Dainese
- Andrea Danu
- Andrea De Azevedo Moregula
- Andrea Rossi
- Andreas Arend
- Andreas Morsch
- Andrei George Gheata
- Andrei Ionut Herghelegiu
- Andres Sandoval
- Andrew Marshall Adare
- Andrey Ivanov
- Andrey Kazantsev
- Andrey Korneev
- Andrey Reshetin
- Andrey Vasiliev
- Andrey Zarochentsev
- Andry Malala Rakotozafindrabe
- Andrzej Deloff
- Andrzej Rybicki
- Andzhey Asryan
- Angela Badala
- Anik Gupta
- Anitha Nyatha
- Anju Bhasin
- Ankita Goswami
- Anna Piccotti
- Anna Rita Reolon
- Annalisa De Caro
- Annalisa Mastroserio
- Annika Passfeld
- Anselmo Margotti
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- Arvinder Singh Palaha
- Ashok Kumar Bhati
- Aurora Diozcora Vargas
- Ayben Karasu Uysal
- B Andersson
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- Barthelemy von Haller
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- T Aaltonen
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- T Sjöstrand
- T Sjöstrand
- T Sjöstrand
- T Sjöstrand
- Tadeusz Antoni Dobrowolski
- Taebong Moon
- Taesoo Kim
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- Tomi Samuli Raiha
- Tomoya Tsuji
- Torsten Alt
- Toru Sugitate
- Trine Spedstad Tveter
- Tuomo Esa Aukusti Kalliokoski
- Udo Wolfgang Kebschull
- Ulrich Fuchs
- Ulrich Michael Frankenfeld
- Uwe Westerhoff
- V Khachatryan
- Valeria Muccifora
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- Vardanush Papikyan
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- Vera Loggins
- Veronica Canoa Roman
- Vincenzo Paticchio
- Vitaly Loginov
- Vito Lenti
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- Vladislav Manko
- Vojtech Petracek
- Volker Lindenstruth
- Vyacheslav Demanov
- Weilin Yu
- Werner Riegler
- Wiktor Stanislaw Peryt
- Wisla Carena
- Wladyslaw Henryk Trzaska
- Won Woong Jung
- Woo Jin Park
- Xavier Bernard Lopez
- Xianbao Yuan
- Xiangrong Zhu
- Xianguo Lu
- Xiaomei Li
- Xiaoming Zhang
- Xitzel Sanchez Castro
- Xu Cai
- Yannick Denis Zoccarato
- Yaping Wang
- Yaroslav Berdnikov
- Yasser Corrales Morales
- Yasuo Miake
- Yasuto Hori
- Yaxian Mao
- Yevgen Martynov
- Yifei Wang
- Yogendra Viyogi
- Yong Wook Baek
- You Zhou
- Youngil Kwon
- Yury Kharlov
- Yury Kucheriaev
- Yury Pestov
- Yury Sibiriak
- Yury Vinogradov
- Yves Le Bornec
- Yves Roland Schutz
- Yvonne Chiara Pachmayer
- Zabulon Vilakazi
- Zaida Conesa del Valle
- Zhongbao Yin
- Zoe Louise Matthews
- Zubayer Ahammed
- Zuzana Harmanova
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Impact of pre- and early per-treatment FDG-PET based dose-escalation on local tumour control in fractionated irradiated FaDu xenograft tumours
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/12/2016
- Field of study
Nonlinear behavior in high-intensity discharge lamps
- Author
- Publication venue
- 'IOP Publishing'
- Publication date
- Field of study
HIV-1 Transmission by Dendritic Cell-specific ICAM-3-grabbing Nonintegrin (DC-SIGN) Is Regulated by Determinants in the Carbohydrate Recognition Domain That Are Absent in Liver/Lymph Node-SIGN (L-SIGN)*
- Author
- Publication venue
- American Society for Biochemistry and Molecular Biology
- Publication date
- 01/01/2010
- Field of study
In this study, we identify determinants in dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN) necessary for human immunodeficiency virus, type 1 (HIV-1), transmission. Although human B cell lines expressing DC-SIGN efficiently capture and transmit HIV-1 to susceptible target cells, cells expressing the related molecule liver/lymph node-specific ICAM-3-grabbing nonintegrin (L-SIGN) do not. To understand the differences between DC-SIGN and L-SIGN that affect HIV-1 interactions, we developed Raji B cell lines expressing different DC-SIGN/L-SIGN chimeras. Testing of the chimeras demonstrated that replacement of the DC-SIGN carbohydrate-recognition domain (CRD) with that of L-SIGN was sufficient to impair virus binding and prevent transmission. Conversely, the ability to bind and transmit HIV-1 was conferred to L-SIGN chimeras containing the DC-SIGN CRD. We identified Trp-258 in the DC-SIGN CRD to be essential for HIV-1 transmission. Although introduction of a K270W mutation at the same position in L-SIGN was insufficient for HIV-1 binding, an L-SIGN mutant molecule with K270W and a C-terminal DC-SIGN CRD subdomain transmitted HIV-1. These data suggest that DC-SIGN structural elements distinct from the oligosaccharide-binding site are required for HIV-1 glycoprotein selectivity
Where Brain, Body and World Collide
- Author
- Abelev Betty
- Adam Jaroslav
- Adamova Dagmar
- Adare Andrew Marshall
- Aggarwal Madan
- Aglieri Rinella Gianluca
- Agocs Andras Gabor
- Agostinelli Andrea
- Aguilar Salazar Saul
- Ahammed Zubayer
- Ahmad Arshad
- Ahmad Nazeer
- Ahn Sang Un
- Ahn Sul-Ah
- Akindinov Alexander
- Aleksandrov Dmitry
- Alessandro Bruno
- Alfaro Molina Jose Ruben
- Alici Andrea
- Alkin Anton
- Almaraz Avina Erick Jonathan
- Alme Johan
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- Wikne Jon
- Wilde Martin Rudolf
- Wilk Alexander
- Wilk Grzegorz Andrzej
- Williams Crispin
- Windelband Bernd Stefan
- Xaplanteris Karampatsos Leonidas
- Yaldo Chris G
- Yamaguchi Yorito
- Yang Hongyan
- Yang Shiming
- Yasnopolsky Stanislav
- Yi JunGyu
- Yin Zhongbao
- Yoo In-Kwon
- Yoon Jongik
- Yu Weilin
- Yuan Xianbao
- Yushmanov Igor
- Zaccolo Valentina
- Zach Cenek
- Zampolli Chiara
- Zaporozhets Sergey
- Zarochentsev Andrey
- Zavada Petr
- Zaviyalov Nikolai
- Zbroszczyk Hanna Paulina
- Zelnicek Pierre
- Zgura Sorin Ion
- Zhalov Mikhail
- Zhang Haitao
- Zhang Xiaoming
- Zhou Daicui
- Zhou Fengchu
- Zhou You
- Zhu Jianhui
- Zhu Jianlin
- Zhu Xiangrong
- Zichichi Antonino
- Zimmermann Alice
- Zinovjev Gennady
- Zoccarato Yannick Denis
- Zynovyev Mykhaylo
- Zyzak Maksym
- Publication venue
- Publication date
- 01/01/1998
- Field of study
The production cross section of electrons from semileptonic decays of beauty hadrons was measured at mid-rapidity (|y| < 0.8) in the transverse momentum range 1 < pt < 8 Gev/c with the ALICE experiment at the CERN LHC in pp collisions at a center of mass energy sqrt{s} = 7 TeV using an integrated luminosity of 2.2 nb^{-1}. Electrons from beauty hadron decays were selected based on the displacement of the decay vertex from the collision vertex. A perturbative QCD calculation agrees with the measurement within uncertainties. The data were extrapolated to the full phase space to determine the total cross section for the production of beauty quark-antiquark pairs
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