Polycystic ovary syndrome and mental disorders: a systematic review and exploratory meta-analysis

Background: The association between depression, anxiety, and polycystic ovary syndrome (PCOS) is still unclear. Therefore, a systematic review and meta-analysis was conducted to assess the rates of comorbid psychiatric disorders among women with PCOS compared to women without it. Methods: PubMed/MEDLINE, Embase, PsycINFO, and Web of Science databases were searched from inception to November 27, 2015. Studies were eligible for inclusion if they were original reports in which the rates of mood (bipolar disorder, dysthymia, or major depressive disorder), obsessive-compulsive spectrum disorders, trauma- and stressor-related disorders, anxiety disorders or psychotic disorders, somatic symptom and related disorders, or eating disorders had been investigated among women with an established diagnosis of PCOS and compared with women without PCOS. Psychiatric diagnosis should have been established by means of a structured diagnostic interview or through a validated screening tool. Data were extracted and pooled using random effects models. Results: Six studies were included in the meta-analysisof these, five reported the rates of anxiety and six provided data on the rates of depression. The rate of subjects with anxiety symptoms was higher in patients with PCOS compared to women without PCOS (odds ratio (OR) =2.7695% confidence interval (CI) 1.26 to 6.02Log OR = 1.013P=0.011). The rate of subjects with depressive symptoms was higher in patients with PCOS compared to women without PCOS (OR = 3.5195% CI 1.97 to 6.24Log OR =1.255P < 0.001). Conclusion: Anxiety and depression symptoms are more prevalent in patients with PCOS.National Council for Scientific and Technological Development (CNPqConselho Nacional de Desenvolvimento Cientifico e Tecnologico) [305274/2014-7]Department of Psychiatry, Federal University of São Paulo (Escola Paulista de Medicina – UNIFESP), São Paulo, SP, BrazilDepartment of Psychiatry, Fortaleza University, Fortaleza, Ceará, BrazilLaboratory of Molecular Psychiatry Federal University of Rio Grande do Sul, Rio Grande do Sul, BrazilDepartment of Psychiatry, Federal University of Rio Grande do Sul, Rio Grande do Sul, BrazilDepartment of Psychiatry, Federal University of São Paulo (Escola Paulista de Medicina – UNIFESP), R Borges Lagoa 570, BR-04038020 Sao Paulo, SP, Brazil.CNPq: 305274/2014-7Web of Scienc

Jornadas de envolvimento parental em creche – um estudo longitudinal

Resumo Esta investigação enquadra-se no âmbito das pedagogias participativas - especificamente na Pedagogia-em-Participação (OLIVEIRA-FORMOSINHO &amp; FORMOSINHO, 2013, FORMOSINHO, 2016); foca o envolvimento das familias no cotidiano educativo de creche e a sua importância para o bem-estar e aprendizagem das crianças. O estudo apresenta três jornadas de envolvimento parental no cotidiano educativo em creche ao longo de três anos letivos num centro de educação de infância de Lisboa. A metodologia desta investigação qualitativa desenvolve-se através de um estudo de caso praxeológico (FORMOSINHO &amp; OLIVEIRA-FORMOSINHO, 2012) de natureza longitudinal. A ética do estudo é enquadrada pelas normas da EECERA European Early Childhood Education Research Association. Esta pesquisa pretende contribuir para a compreensão da importância que o envolvimento das famílias no cotidiano das aprendizagens das crianças tem para a construção da qualidade dos contextos de creche (PASSOS, 2017).

Cognitive function, cerebral microbleeds, radiotherapy, and bevacizumab in survivors of pediatric brain tumors

We read with great interest a recent paper published by Roddy et al showing a high (48.8%) 5-year cumulative incidence of cerebral microbleeds (CMB) and its association with cognitive dysfunction in a group with pediatric brain tumors who received cranial radiation therapy (CRT).1 We believe that exposing the association of CMB (or the associated underlying microvascular pathology) with cognitive impairment in this population will help draw attention to the importance of the topic in this specific growing population.info:eu-repo/semantics/publishedVersio

Propondo uma Biblioteca Digital Móvel para o contexto de Saúde: Criação e Refinamento do Protótipos de Alta Fidelidade em Um Projeto Real

Este trabalho apresenta a análise de aplicativos concorrentes de bibliotecas digitais para propor um novo aplicativo móvel no contexto da área de saúde. O aplicativo foi projetado considerando requisitos existentes de sistemas concorrentes e a opinião de usuários finais do sistema durante a validação dos protótipos do mesmo. Como resultado, foi possível desenvolver duas versões de um protótipo de alta fidelidade do sistema, apresentando o fluxo de interação entre o aluno que ir a usar a biblioteca digital e o sistema. Durante a validação do protótipo, especificidades sobre a utilização do mesmo foram levantadas como: (a) os recursos do aplicativo não seriam consumidos dentro do mesmo; e (b) o sistema não precisa apresentar todas as funcionalidades dos concorrentes para atender ao público alvo. Finalmente, de um modo geral, o protótipo foi avaliado em reuniões de grupo focal obtendo feedback positivo para sua implementação

A utilização de ferramentas Web 2.0 como suporte a processos de Gestão do Conhecimento

O artigo apresenta uma revisão de literatura sobre a aplicação da Web 2.0 nas organizações como elementos potencializadores da Gestão do Conhecimento, oferecendo uma visão geral sobre o tema. A pesquisa foi realizada na base de dados Scopus, no qual foram recuperados artigos das áreas de Business, Management e Accounting. Buscaram-se as publicações mais relevantes que tratam das aplicações da Web 2.0 nas organizações. Por meio de análise qualitativa, foram analisados os objetivos, as aplicações práticas e os resultados das publicações selecionadas. Percebe-se que a Web 2.0 exerce diversas influências aplicáveis a Gestão do Conhecimento, atuando principalmente sobre os processos de compartilhamento e aquisição do conhecimento.Sociedad Argentina de Informática e Investigación Operativ

Lysosome-mediated processing of chromatin in senescence

Cellular senescence is a stable proliferation arrest, a potent tumor suppressor mechanism, and a likely contributor to tissue aging. Cellular senescence involves extensive cellular remodeling, including of chromatin structure. Autophagy and lysosomes are important for recycling of cellular constituents and cell remodeling. Here we show that an autophagy/lysosomal pathway processes chromatin in senescent cells. In senescent cells, lamin A/C–negative, but strongly γ-H2AX–positive and H3K27me3-positive, cytoplasmic chromatin fragments (CCFs) budded off nuclei, and this was associated with lamin B1 down-regulation and the loss of nuclear envelope integrity. In the cytoplasm, CCFs were targeted by the autophagy machinery. Senescent cells exhibited markers of lysosomal-mediated proteolytic processing of histones and were progressively depleted of total histone content in a lysosome-dependent manner. In vivo, depletion of histones correlated with nevus maturation, an established histopathologic parameter associated with proliferation arrest and clinical benignancy. We conclude that senescent cells process their chromatin via an autophagy/lysosomal pathway and that this might contribute to stability of senescence and tumor suppression

Museums and cradles of diversity are geographically coincident for narrowly distributed Neotropical snakes

Factors driving the spatial configuration of centres of endemism have long been a topic of broad interest and debate. Due to different eco-evolutionary processes, these highly biodiverse areas may harbour different amounts of ancient and recently diverged organisms (paleo- and neo-endemism, respectively). Patterns of endemism still need to be measured at distinct phylogenetic levels for most clades and, consequently, little is known about the distribution, the age and the causes of such patterns. Here we tested for the presence of centres with high phylogenetic endemism (PE) in the highly diverse Neotropical snakes, testing the age of these patterns (paleo- or neo-endemism), and the presence of PE centres with distinct phylogenetic composition. We then tested whether PE is predicted by topography, by climate (seasonality, stability, buffering and relictualness), or biome size. We found that most areas of high PE for Neotropical snakes present a combination of both ancient and recently diverged diversity, which is distributed mostly in the Caribbean region, Central America, the Andes, the Atlantic Forest and on scattered highlands in central Brazil. Turnover of lineages is higher across Central America, resulting in more phylogenetically distinct PE centres compared to South America, which presents a more phylogenetically uniform snake fauna. Finally, we found that elevational range (topographic roughness) is the main predictor of PE, especially for paleo-endemism, whereas low paleo-endemism levels coincide with areas of high climatic seasonality. Our study highlights the importance of mountain systems to both ancient and recent narrowly distributed diversity. Mountains are both museums and cradles of snake diversity in the Neotropics, which has important implications for conservation in this region.Fil: Azevedo, Josué Anderson Rêgo. University Goteborg; Suecia. Gothenburg Global Biodiversity Centre; SueciaFil: Guedes, Thaís B.. University Goteborg; Suecia. Gothenburg Global Biodiversity Centre; Suecia. Universidade Estadual do Maranhão. Centro de Estudos Superiores de Caxias. Programa de Pós-graduação em Biodiversidade, Ambiente e Saúde; PortugalFil: Nogueira, Cristiano de Campos. Universidade de Sao Paulo; BrasilFil: Passos, Paulo. Universidade Federal do Rio de Janeiro; BrasilFil: Sawaya, Ricardo. Universidad Federal do Abc; BrasilFil: Prudente, Ana. Museu Paraense Emílio Goeldi; BrasilFil: Barbo, Fausto Erritto. Governo do Estado de Sao Paulo. Secretaria da Saude. Instituto Butantan; BrasilFil: Strüssmann, Christine. Universidade Federal do Mato Grosso do Sul; BrasilFil: Franco, Francisco L.. Governo do Estado de Sao Paulo. Secretaria da Saude. Instituto Butantan; BrasilFil: Arzamendia, Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto Nacional de Limnología. Universidad Nacional del Litoral. Instituto Nacional de Limnología; ArgentinaFil: Giraudo, Alejandro Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto Nacional de Limnología. Universidad Nacional del Litoral. Instituto Nacional de Limnología; ArgentinaFil: Argolo, Antonio. Universidade Estadual de Santa Cruz; BrasilFil: Jansen, Martin. Senckenberg Research Institute and Nature Museum; AlemaniaFil: Zaher, Hussam. Universidade de Sao Paulo; BrasilFil: Tonini, Joao Filipe Riva. Centre National de la Recherche Scientifique; Francia. Muséum National d'Histoire Naturelle; Francia. Sorbonne University; Francia. Harvard University; Estados UnidosFil: Faurby, Søren. University Goteborg; SueciaFil: Antonelli, Alexandre. University Goteborg; Sueci