6,255 research outputs found
A monolithic and flexible fluoropolymer film microreactor for organic synthesis applications
A photocurable and viscous fluoropolymer with chemical stability is a highly desirable material for fabrication of microchemical devices. Lack of a reliable fabrication method, however, limits actual applications for organic reactions. Herein, we report fabrication of a monolithic and flexible fluoropolymer film microreactor and its use as a new microfluidic platform. The fabrication involves facile soft lithography techniques that enable partial curing of thin laminates, which can be readily bonded by conformal contact without any external forces. We demonstrate fabrication of various functional channels (similar to 300 mu m thick) such as those embedded with either a herringbone micromixer pattern or a droplet generator. Organic reactions under strongly acidic and basic conditions can be carried out in this film microreactor even at elevated temperature with excellent reproducibility. In particular, the transparent film microreactor with good deformability could be wrapped around a light-emitting lamp for close contact with the light source for efficient photochemical reactions with visible light, which demonstrates easy integration with optical components for functional miniaturized systems.open1112Ysciescopu
Three-loop HTL QCD thermodynamics
The hard-thermal-loop perturbation theory (HTLpt) framework is used to
calculate the thermodynamic functions of a quark-gluon plasma to three-loop
order. This is the highest order accessible by finite temperature perturbation
theory applied to a non-Abelian gauge theory before the high-temperature
infrared catastrophe. All ultraviolet divergences are eliminated by
renormalization of the vacuum, the HTL mass parameters, and the strong coupling
constant. After choosing a prescription for the mass parameters, the three-loop
results for the pressure and trace anomaly are found to be in very good
agreement with recent lattice data down to , which are
temperatures accessible by current and forthcoming heavy-ion collision
experiments.Comment: 27 pages, 11 figures; corresponds with published version in JHE
Three-loop HTL gluon thermodynamics at intermediate coupling
We calculate the thermodynamic functions of pure-glue QCD to three-loop order
using the hard-thermal-loop perturbation theory (HTLpt) reorganization of
finite temperature quantum field theory. We show that at three-loop order
hard-thermal-loop perturbation theory is compatible with lattice results for
the pressure, energy density, and entropy down to temperatures .
Our results suggest that HTLpt provides a systematic framework that can used to
calculate static and dynamic quantities for temperatures relevant at LHC.Comment: 24 pages, 13 figs. 2nd version: improved discussion and fixing typos.
Published in JHE
Parathyroid hormone, cognitive function and dementia: a systematic review
BACKGROUND: Metabolic factors are increasingly recognized to play an important role in the pathogenesis of Alzheimer's disease and dementia. Abnormal parathyroid hormone (PTH) levels play a role in neuronal calcium dysregulation, hypoperfusion and disrupted neuronal signaling. Some studies support a significant link between PTH levels and dementia whereas others do not. METHODS: We conducted a systematic review through January 2014 to evaluate the association between PTH and parathyroid conditions, cognitive function and dementia. Eleven electronic databases and citation indexes were searched including Medline, Embase and the Cochrane Library. Hand searches of selected journals, reference lists of primary studies and reviews were also conducted along with websites of key organizations. Two reviewers independently screened titles and abstracts of identified studies. Data extraction and study quality were performed by one and checked by a second reviewer using predefined criteria. A narrative synthesis was performed due to the heterogeneity of included studies. RESULTS: The twenty-seven studies identified were of low and moderate quality, and challenging to synthesize due to inadequate reporting. Findings from six observational studies were mixed but suggest a link between higher serum PTH levels and increased odds of poor cognition or dementia. Two case-control studies of hypoparathyroidism provide limited evidence for a link with poorer cognitive function. Thirteen pre-post surgery studies for primary hyperparathyroidism show mixed evidence for improvements in memory though limited agreement in other cognitive domains. There was some degree of cognitive impairment and improvement postoperatively in observational studies of secondary hyperparathyroidism but no evident pattern of associations with specific cognitive domains. CONCLUSIONS: Mixed evidence offers weak support for a link between PTH, cognition and dementia due to the paucity of high quality research in this area.NIHR PenCLAHRCAlzheimer’s AssociationRosetrees TrustMary Kinross Charitable TrustJames Tudor FoundationHalpin TrustNorman Family Charitable Trus
A dynamical systems approach to optimizing irrigation strategy under the influence of land-atmosphere feedbacks.
The soil-moisture feedback describes how precipitation amount, timing and intensity react to spatial anomalies in surface moisture. For heterogeneous moisture distributions with moist/dry patches on the scale of 10− 50km, numerical studies supported by observations indicate a negative soil-moisture feedback, where it rains more over dry patches (Imamovic, 2018; Rieck et al., 2014). The circulation established by the heterogeneous soil-moisture patches not only modifies the spatial rain distribution but allows for more water to be extracted from the atmosphere, thereby increasing the domain mean precipitation.
We here suggest that the negative soil-moisture feedback can be exploited when irrigating agricultural land: if farmers cooperate by following a spatially heterogeneous irrigation pattern, they can increase both their collective time-mean precipitation and thus the total water available for growing crops. However, the spatially non-local nature of the feedback allows individual farmers to exploit this strategy, thereby saving their own resources; a typical ‘tragedy of commons’ situation.
We formulate this setup in terms of an optimisation problem and study its parameter phase space, both analytically and numerically, in order to understand optimal rules and the consequences of the players’ choice to cooperate vs. compete. Different constraints in terms of water availability (reservoir) and average soil moisture as defined by the evaporation timescale are explored.
Reducing the details of the land-atmosphere interaction into simple feedback parameters helps to elucidate the complex interactions between the precipitation, soil moisture and the human intervention by irrigation. Taking into account the negative soil-moisture feedback in irrigation models opens up new strategies to optimise water management and thereby increase crop yield
Immediate Surgical Repositioning Following Intrusive Luxation: A Case Report and Review of the Literature
This report presents a case of severe intrusive luxation of mature maxillary lateral incisor in a 10-year-old boy. The intruded tooth was immediately repositioned (surgical extrusion) and splinted within 2 h following injury. Tetracycline therapy was initiated at the time of repositioning and maintained for 10 days. Pulp removal and calcium hydroxide treatment of the root canal was carried out after repositioning. Splint was removed 1 month later. Definitive root canal treatment with gutta percha was accomplished at the second month recall. Clinical and radiographic examination 28 months after the surgical extrusion revealed satisfactory apical and periodontal healing
Resummation scheme for 3d Yang-Mills and the two-loop magnetic mass for hot gauge theories
Perturbation theory for non-Abelian gauge theories at finite temperature is
plagued by infrared divergences caused by magnetic soft modes ,
which correspond to the fields of a 3d Yang-Mills theory. We revisit a gauge
invariant resummation scheme to solve this problem by self-consistent mass
generation using an auxiliary scalar field, improving over previous attempts in
two respects. First, we generalise earlier SU(2) treatments to SU(N). Second,
we obtain a gauge independent two-loop gap equation, correcting an error in the
literature. The resulting two-loop approximation to the magnetic mass
represents a correction to the leading one-loop value, indicating a
reasonable convergence of the resummation.Comment: 16 pages, 3 figure
A ferroelectric memristor
Memristors are continuously tunable resistors that emulate synapses.
Conceptualized in the 1970s, they traditionally operate by voltage-induced
displacements of matter, but the mechanism remains controversial. Purely
electronic memristors have recently emerged based on well-established physical
phenomena with albeit modest resistance changes. Here we demonstrate that
voltage-controlled domain configurations in ferroelectric tunnel barriers yield
memristive behaviour with resistance variations exceeding two orders of
magnitude and a 10 ns operation speed. Using models of ferroelectric-domain
nucleation and growth we explain the quasi-continuous resistance variations and
derive a simple analytical expression for the memristive effect. Our results
suggest new opportunities for ferroelectrics as the hardware basis of future
neuromorphic computational architectures
Estimation of a probability in inverse binomial sampling under normalized linear-linear and inverse-linear loss
Sequential estimation of the success probability in inverse binomial
sampling is considered in this paper. For any estimator , its quality
is measured by the risk associated with normalized loss functions of
linear-linear or inverse-linear form. These functions are possibly asymmetric,
with arbitrary slope parameters and for
respectively. Interest in these functions is motivated by their significance
and potential uses, which are briefly discussed. Estimators are given for which
the risk has an asymptotic value as tends to , and which guarantee that,
for any in , the risk is lower than its asymptotic value. This
allows selecting the required number of successes, , to meet a prescribed
quality irrespective of the unknown . In addition, the proposed estimators
are shown to be approximately minimax when does not deviate too much from
, and asymptotically minimax as tends to infinity when .Comment: 4 figure
Ising model for distribution networks
An elementary Ising spin model is proposed for demonstrating cascading
failures (break-downs, blackouts, collapses, avalanches, ...) that can occur in
realistic networks for distribution and delivery by suppliers to consumers. A
ferromagnetic Hamiltonian with quenched random fields results from policies
that maximize the gap between demand and delivery. Such policies can arise in a
competitive market where firms artificially create new demand, or in a solidary
environment where too high a demand cannot reasonably be met. Network failure
in the context of a policy of solidarity is possible when an initially active
state becomes metastable and decays to a stable inactive state. We explore the
characteristics of the demand and delivery, as well as the topological
properties, which make the distribution network susceptible of failure. An
effective temperature is defined, which governs the strength of the activity
fluctuations which can induce a collapse. Numerical results, obtained by Monte
Carlo simulations of the model on (mainly) scale-free networks, are
supplemented with analytic mean-field approximations to the geometrical random
field fluctuations and the thermal spin fluctuations. The role of hubs versus
poorly connected nodes in initiating the breakdown of network activity is
illustrated and related to model parameters
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