Aviat: La lucha de los padres contra la droga

Cinquenes Jornades de Foment de la Investigació de la FCHS (Any 1999-2000

Adding pharmacogenomics to the development of new marine-derived anticancer agents

Nature has always been a highly productive tool in the development of anticancer therapies. Renewed interest in the potential of this tool has recently been sparked by the realization that the marine ecosystem can be used for the discovery and development of new compounds with clinical potential in advanced resistant tumors. These compounds can be incorporated into combination approaches in a chronic therapy scenario. Our marine anticancer program is using the sea to develop new agents with activity in resistant solid tumors and to identify new cellular targets for therapeutic intervention. This review describes the integration of different pharmacogenomic tools in the development of Yondelis™, Aplidin(® )and Kahalalide F, three marine-derived compounds currently in Phase II or III development. Our results are reinforcing the targeted selectivity of these agents and opening the gates for customized therapies in cancer patients in the near future

The presence of sportswomen in regional press in Spain. A study of front-page main images

Investigaciones académicas han señalado en reiteradas ocasiones que la información deportiva se comporta como un ámbito excluyente con la mujer profesional del deporte, cuya poca visibilidad mediática no se corresponde ni con la creciente participación ni con los éxitos conseguidos por el deporte femenino en los últimos años. En este estudio se analiza la presencia de la mujer deportista en las imágenes de portada en la prensa regional española durante todo el año 2018. La fotografía de portada se constituye como el principal reclamo de la primera página, en la que a su vez se reflejan cuáles son los criterios editoriales seguidos por cada medio. La muestra de análisis la forman nueve diarios de proximidad que cuentan con destacadas secciones de Deportes: El Correo, El Diario Vasco, El Periódico, Diario de Navarra, Ideal de Granada, Heraldo de Aragón, La Vanguardia, La Verdad y La Voz de Galicia. Además, a modo comparativo, se incluyen dos periódicos de difusión nacional (El Mundo y El País) y uno puramente deportivo (Marca). Los resultados del estudio señalan que la prensa diaria regional da más visibilidad a las mujeres deportistas que medios con alcance nacional y que las muestran siempre en relación con su deporte y sin connotaciones peyorativas en el tratamiento textual y visual de la información.Research on sports journalism has stressed repeatedly an underrepresentation of sportswomen in the news agenda. This does not correspond to the increasing female participation and success in sports these last years. This study analyses the presence of sportswomen in the front-page main images from regional newspapers in Spain during 2018, a complete year-period. The main photograph turns out to be the first atraction to readers in the front page, which also indicates editorial decisión-making at each media outlet. The sample for this analysis is comprised of nine local and regional dailies with outstanding sports desks: El Correo, El Diario Vasco, El Periódico, Diario de Navarra, Ideal de Granada, Heraldo de Aragón, La Vanguardia, La Verdad and La Voz de Galicia. Besides, to come to comparative results, two national (El Mundo and El País) and one sports newspaper (Marca) are included in this study. Results show sportswomen are more visible in regional daily newspapers rather than in national ones and always appear in relation to sports and without any pejorative connotation in texts or images

Focus on sports as a key element to make community for Spanish local press. A study of front-page images

Esta investigación analiza la importancia estratégica los contenidos sobre deporte en la prensa regional española a la hora de hacer comunidad y estrechar vínculos afectivos con los lectores. Para ello se han estudiado todas las portadas publicadas en sus ediciones en papel por los doce principales diarios regionales (La Vanguardia, El Periódico, Levante, Las Provincias, La Voz de Galicia, El Faro de Vigo, El Correo, El Diario Vasco, Heraldo de Aragón, Diario de Burgos, El Diario Montañés y Diario de Navarra) en el periodo comprendido entre el 1 de enero y el 31 de mayo de 2016. El estudio se ha completado con una revisión de diferentes coberturas deportivas especiales desarrolladas por diarios regionales en los últimos añosThis research analyses the strategic importance of sports news in the regional daily press in Spain as far as the creation of community and strenghtening of emotional relationships to readers are concerned. To this end, this paper contains a study of all front pages of twelve leading regional daily newspapers in Spain (La Vanguardia, El Periódico, Levante, Las Provincias, La Voz de Galicia, El Faro de Vigo, El Correo, El Diario Vasco, Heraldo de Aragón, Diario de Burgos, El Diario Montañés and Diario de Navarra) published from January 1st to May 31st in 2016. Moreover, this research also comprises a revision of several special sports coverages developed by regional dailies during these last years

Nonlinear analysis of time series generated by schizophrenic patients

Producción CientíficaFocusing on a particular feature, the ability to create random rhythms, our study is aimed at the analysis of cognitive performance in patients with schizophrenia, comparing them with normal subjects. We have developed a new cognitive test using methods from nonlinear dynamical systems theory, with the objective of measuring the subject's capacity of developing a random rhythm

Footwear bio-modelling: An industrial approach

There is a growing need within the footwear sector to customise the design of the last from which a specific footwear style is to be produced. This customisation is necessary for user comfort and health reasons, as the user needs to wear a suitable shoe. For this purpose, a relationship must be established between the user foot and the last with which the style will be made; up until now, no model has existed that integrates both elements. On the one hand, traditional customised footwear manufacturing techniques are based on purely artisanal procedures which make the process arduous and complex; on the other hand, geometric models proposed by different authors present the impossibility of implementing them in an industrial environment with limited resources for the acquisition of morphometric and structural data for the foot, apart from the fact that they do not prove to be sufficiently accurate given the non-similarity of the foot and last. In this paper, two interrelated geometric models are defined, the first, a bio-deformable foot model and the second, a deformable last model. The experiments completed show the goodness of the model, with it obtaining satisfactory results in terms of comfort, efficiency and precision, which make it viable for use in the sector

A new methodological approach for shoe sole design and validation

Shoe soles are extremely complex to design and manufacture due to their organically shaped but technically precise nature and their manufacturing constraints. Consequently, there is a need for the increased design process flexibility offered by the use of specific CAD methodologies and techniques, to facilitate the work of expert designers and permit effective construction of the three-dimensional elements comprising the complete structure. Recent advances in additive manufacturing systems have extended the possibilities of shoe sole design. These systems can be used to create the final mould and to incorporate dynamic elements that are of particular value in sports footwear. In this article, we present a new methodology for the design and validation of shoe soles. The methodology assists designers in the design concept process and in transfer of the design to manufacturing. The model incorporates both a structural and a functional approach. To this end, a set of specific tools have been developed that can be used to quantify design quality. For example, the model calculates the coefficient of friction or slip resistance, necessary to comply with international standards concerning safety footwear.The financial support of this study comes from IVACE (Instituto Valenciano de Competitividad Empresarial) project: DIHUCA—complex tread designs for footwear soles (IMDEEA/2015/4)

The Importance of Liming with an Appropriate Liming Material: Long-Term Experience with a Typic Palexerult

[EN] Aluminium phytotoxicity is considered the main limiting factor for crop productivity in agricultural acid soils. Liming is a common practice used to improve acidic soil properties, but an appropriate liming material is essential for both agricultural productivity and environmental sustainability. A long-term field experiment with two liming amendments (dolomitic limestone and limestone) was developed during 10 years to determine the changes in soil acidity and assess the effects on crop (rye) yields. Although the adverse effects of the soil acidity conditions were alleviated with both amendments tested, dolomitic limestone was the most effective in the short- and long-term period. In terms of the saturation of exchange complex, dolomitic limestone had a better efficiency, likely based on its rate of dissolution. No significant changes in soil organic matter and exchangeable potassium levels between the treatments tested were found. Both liming materials significantly increased the rye total biomass, but interestingly, significant correlations were showed between tissue levels of magnesium and biomass production, but not between the latter and calcium. The increases in rye biomass production compared with control soils at the end of the research were the following: dolomitic limestone, 47%, and limestone, 32%. A link between an increase in magnesium bioavailability and biomass production was found, as well as between magnesium rye content and total, spike and stem biomass. Hence, it could conceivably be hypothesized that since magnesium is crucial for the transport of assimilates from source leaves to sink organs, alleviating its deficiency leads to avoiding the reducing growth rate of sink organs. Although further investigations are needed to gain a better understanding of liming on the biological, chemical and physical soil properties in the long term, our research provides support for the conceptual premise that an appropriate selection of liming material is crucial for the productivity of acid soils.S

Measuring prediction capacity of individual verbs for the identification of protein interactions

AbstractMotivation: The identification of events such as protein–protein interactions (PPIs) from the scientific literature is a complex task. One of the reasons is that there is no formal syntax to denote such relations in the scientific literature. Nonetheless, it is important to understand such relational event representations to improve information extraction solutions (e.g., for gene regulatory events).In this study, we analyze publicly available protein interaction corpora (AIMed, BioInfer, BioCreAtIve II) to determine the scope of verbs used to denote protein interactions and to measure their predictive capacity for the identification of PPI events. Our analysis is based on syntactical language patterns. This restriction has the advantage that the verb mention is used as the independent variable in the experiments enabling comparability of results in the usage of the verbs. The initial selection of verbs has been generated from a systematic analysis of the scientific literature and existing corpora for PPIs.We distinguish modifying interactions (MIs) such as posttranslational modifications (PTMs) from non-modifying interactions (NMIs) and assumed that MIs have a higher predictive capacity due to stronger scientific evidence proving the interaction. We found that MIs are less frequent in the corpus but can be extracted at the same precision levels as PPIs. A significant portion of correct PPI reportings in the BioCreAtIve II corpus use the verb “associate”, which semantically does not prove a relation.The performance of every monitored verb is listed and allows the selection of specific verbs to improve the performance of PPI extraction solutions. Programmatic access to the text processing modules is available online (www.ebi.ac.uk/webservices/whatizit/info.jsf) and the full analysis of Medline abstracts will be made through the Web pages of the Rebholz group