628 research outputs found
Cosmological investigation of multi-frequency VLBI observations of ultra-compact structure in radio quasars
In this paper, we use multi-frequency angular size measurements of 58
intermediate-luminosity quasars reaching the redshifts and
demonstrate that they can be used as standard rulers for cosmological
inference. Our results indicate that, for the majority of radio-sources in our
sample their angular sizes are inversely proportional to the observing
frequency. From the physical point of view it means that opacity of the jet is
governed by pure synchrotron self-absorption, i.e. external absorption does not
play any significant role in the observed angular sizes at least up to 43 GHz.
Therefore, we use the value of the intrinsic metric size of compact
milliarcsecond radio quasars derived in a cosmology independent manner from
survey conducted at 2 GHz and rescale it properly according to predictions of
the conical jet model. This approach turns out to work well and produce quite
stringent constraints on the matter density parameter in the flat
CDM model and Dvali-Gabadadze-Porrati braneworld model. The results
presented in this paper pave the way for the follow up engaging multi-frequency
VLBI observations of more compact radio quasars with higher sensitivity and
angular resolution.Comment: 10 pages, 5 figures, 2 table, accepted for publication in European
Physical Journal
Planets Across Space and Time (PAST) IV: The Occurrence and Architecture of Kepler Planetary Systems as a Function of Kinematic Age Revealed by the LAMOST-Gaia-Kepler Sample
One of the fundamental questions in astronomy is how planetary systems form
and evolve. Measuring the planetary occurrence and architecture as a function
of time directly addresses this question. In the fourth paper of the Planets
Across Space and Time (PAST) series, we investigate the occurrence and
architecture of Kepler planetary systems as a function of kinematic age by
using the LAMOST-Gaia-Kepler sample. To isolate the age effect, other stellar
properties (e.g., metallicity) have been controlled. We find the following
results. (1) The fraction of stars with Kepler-like planets ()
is about 50% for all stars; no significant trend is found between
and age. (2) The average planet multiplicity ()
exhibits a decreasing trend (~2 significance) with age. It decreases
from ~3 for stars younger than 1 Gyr to ~1.8 for stars
about 8 Gyr. (3) The number of planets per star
() also shows a decreasing trend
(~2-3 significance). It decreases from ~1.6-1.7 for young stars
to ~1.0 for old stars. (4) The mutual orbital inclination of the planets
() increases from to as
stars aging from 0.5 to 8 Gyr with a best fit of
.
Interestingly, the Solar System also fits such a trend. The nearly independence
of ~50% on age implies that planet formation is robust and
stable across the Galaxy history. The age dependence of and
demonstrates planetary architecture is evolving, and planetary
systems generally become dynamically hotter with fewer planets as they age.Comment: 27 pages, 20 figures, 4tables, accepted for publication in A
Planets Across Space and Time (PAST). III. Morphology of the Planetary Radius Valley as a Function of Stellar Age and Metallicity in the Galactic Context Revealed by the LAMOST-Gaia-Kepler Sample
The radius valley, a dip in the radius distribution of exoplanets at ~1.9
Earth radii separates compact rocky Super-Earths and Sub-Neptunes with lower
density. Various hypotheses have been put forward to explain the radius valley.
Characterizing the radius valley morphology and its correlation to stellar
properties will provide crucial observation constraints on its origin mechanism
and deepen the understanding of planet formation and evolution. In this paper,
the third part of the Planets Across the Space and Time (PAST) series, using
the LAMOST-Gaia-Kepler catalog, we perform a systematical investigation into
how the radius valley morphology varies in the Galactic context, i.e.,
thin/thick galactic disks, stellar age and metallicity abundance ([Fe/H] and
[alpha/Fe]). We find that (1) The valley becomes more prominent with the
increase of both age and [Fe/H]. (2) The number ratio of super-Earths to
sub-Neptunes monotonically increases with age but decreases with [Fe/H] and
[alpha/Fe]. (3) The average radius of planets above the valley (2.1-6 Earth
radii) decreases with age but increases with [Fe/H]. (4) In contrast, the
average radius of planets below the valley (R < 1.7 Earth radii) is broadly
independent on age and metallicity. Our results demonstrate that the valley
morphology as well as the whole planetary radius distribution evolves on a long
timescale of giga-years, and metallicities (not only Fe but also other metal
elements, e.g., Mg, Si, Ca, Ti) play important roles in planet formation and in
the long term planetary evolution.Comment: Accepted for pubilication in AJ, 20 Pages, 10 figures, 2 Tables
(Appendix: 13 Figures
Up-regulation of hypoxia inducible factor-1α by cobalt chloride correlates with proliferation and apoptosis in PC-2 cells
<p>Abstract</p> <p>Background</p> <p>The exact mechanism of the effects of hypoxia on the proliferation and apoptosis in carcinoma cells is still conflicting. This study investigated the variation of hypoxia-inducible factor-1α(HIF-1α) expression and the apoptosis effect of hypoxia stimulated by cobalt chloride (CoCl<sub>2</sub>) in pancreatic cancer PC-2 cells.</p> <p>Methods</p> <p>PC-2 cells were cultured with different concentration (50-200 μmol/L) of CoCl<sub>2 </sub>after 24-120 hours to simulate hypoxia in vitro. The proliferation of PC-2 cells was examined by MTT assay. The cellular morphology of PC-2 cells were observed by light inverted microscope and transmission electron microscope(EM). The expression of HIF-1α on mRNA and protein level was measured by semi-quantitive RT-PCR and Western blot analysis. Apoptosis of PC-2 cells were demonstrated by flow cytometry with Annexin V-FITC/PI double staining.</p> <p>Results</p> <p>MTT assay showed that the proliferation of PC-2 cells were stimulated in the first 72 h, while after treated over 72 h, a dose- dependent inhibition of cell growth could be observed. By using transmission electron microscope, swollen chondrosomes, accumulated chromatin under the nuclear membrane and apoptosis bodies were observed. Flow cytometer(FCM) analysis showed the apoptosis rate was correlated with the dosage of CoCl<sub>2</sub>. RT-PCR and Western blot analysis indicated that hypoxia could up-regulate the expression of HIF-1α on both mRNA and protein levels.</p> <p>Conclusion</p> <p>Hypoxic microenvironment stimulated by CoCl<sub>2 </sub>could effectively induce apoptosis and influence cell proliferation in PC-2 cells, the mechanism could be related to up-expression of HIF-1α.</p
Evolutionary trajectories of snake genes and genomes revealed by comparative analyses of five-pacer viper
Snakes have numerous features distinctive from other tetrapods and a rich history of genome evolution that is still obscure. Here, we report the high-quality genome of the five-pacer viper, Deinagkistrodon acutus, and comparative analyses with other representative snake and lizard genomes. We map the evolutionary trajectories of transposable elements (TEs), developmental genes and sex chromosomes onto the snake phylogeny. TEs exhibit dynamic lineage-specific expansion, and many viper TEs show brain-specific gene expression along with their nearby genes. We detect signatures of adaptive evolution in olfactory, venom and thermal-sensing genes and also functional degeneration of genes associated with vision and hearing. Lineage-specific relaxation of functional constraints on respective Hox and Tbx limb-patterning genes supports fossil evidence for a successive loss of forelimbs then hindlimbs during snake evolution. Finally, we infer that the ZW sex chromosome pair had undergone at least three recombination suppression events in the ancestor of advanced snakes. These results altogether forge a framework for our deep understanding into snakes' history of molecular evolution
Relationships between athletic ability and academic performance in primary school students: A 3-year follow-up study
BackgroundThe aim of this study was to examine whether academic performance is associated with students' athletic ability in primary school.MethodsA 3-year follow-up study was conducted among 1,136 Chinese students. Sit-up and jump rope testers were used to measure 1-min sit-ups and 1-min jump ropes, respectively. Meanwhile, the Pittsburgh Sleep Quality Scale and the Beck Depression Inventory were used to estimate sleep quality and depression levels. The end-of-semester examinations were used to evaluate students' academic performance during the follow-up period.ResultsAfter adjusting for confounders, the mean change in Chinese language performance for participants stratified by 1-min sit-ups at baseline was 0.35 (95% CI: −0.37 to 0.76) for level 1 (slowest), 0.52 (95% CI: −0.54 to 1.08) for level 2, and 1.72 (95% CI: 1.14 to 2.30) for level 3 (fastest) (P for trend = 0.003); the mean change in math scores was 0.28 (95% CI: −0.50 to 0.95) for level 1 (slowest), 0.95 (95% CI: 0.38 to 1.52) for level 2, and 1.41 (95% CI: 0.82 to 1.99) for level 3 (fastest) (P for trend = 0.048). The mean change in foreign language scores was −0.45 (95% CI: −0.99 to −0.93) for level 1 (slowest), −0.14 (95% CI: −0.44 to 0.41) for level 2, and 0.69 (95% CI: 0.25 to 1.13) for level 3 (fastest) (P for trend = 0.004). The mean change in Chinese language performance for participants stratified by 1-min jump ropes at the baseline was 0.30 (95% CI: −0.16 to 0.76) for level 1 (slowest), 1.09 (95% CI: 0.42 to 1.76) for level 2, and 1.74 (95% CI: 1.14 to 2.35) for level 3 (fastest) (P for trend = 0.001). The mean change in math scores was 0.41 (95% CI: −0.11 to 0.92) for level 1 (slowest), 1.44 (95% CI: 0.69 to 2.19) for level 2, and 1.43 (95% CI: 0.76 to 2.10) for level 3 (fastest) (P for trend = 0.019). The mean change in foreign language performance was −0.71 (95% CI: −1.08 to −0.33) for level 1 (slowest), 0.95 (95% CI: −0.40 to 1.50) for level 2, and 0.91 (95% CI: 0.41 to 1.41) for level 3 (fastest) (P for trend < 0.001).ConclusionThis study suggests that participation in jump rope and sit-up exercises may positively affect students' academic performance
Cloning and molecular characterization of a mitogen-activated protein kinase gene from Poncirus trifoliata whose ectopic expression confers dehydration/drought tolerance in transgenic tobacco
The mitogen-activated protein kinase (MAPK) cascade plays pivotal roles in diverse signalling pathways related to plant development and stress responses. In this study, the cloning and functional characterization of a group-I MAPK gene, PtrMAPK, in Poncirus trifoliata (L.) Raf are reported. PtrMAPK contains 11 highly conserved kinase domains and a phosphorylation motif (TEY), and is localized in the nucleus of transformed onion epidermal cells. The PtrMAPK transcript level was increased by dehydration and cold, but was unaffected by salt. Transgenic overexpression of PtrMAPK in tobacco confers dehydration and drought tolerance. The transgenic plants exhibited better water status, less reactive oxygen species (ROS) generation, and higher levels of antioxidant enzyme activity and metabolites than the wild type. Interestingly, the stress tolerance capacity of the transgenic plants was compromised by inhibitors of antioxidant enzymes. In addition, overexpression of PtrMAPK enhanced the expression of ROS-related and stress-responsive genes under normal or drought conditions. Taken together, these data demonstrate that PtrMAPK acts as a positive regulator in dehydration/drought stress responses by either regulating ROS homeostasis through activation of the cellular antioxidant systems or modulating transcriptional levels of a variety of stress-associated genes
JUNO Conceptual Design Report
The Jiangmen Underground Neutrino Observatory (JUNO) is proposed to determine
the neutrino mass hierarchy using an underground liquid scintillator detector.
It is located 53 km away from both Yangjiang and Taishan Nuclear Power Plants
in Guangdong, China. The experimental hall, spanning more than 50 meters, is
under a granite mountain of over 700 m overburden. Within six years of running,
the detection of reactor antineutrinos can resolve the neutrino mass hierarchy
at a confidence level of 3-4, and determine neutrino oscillation
parameters , , and to
an accuracy of better than 1%. The JUNO detector can be also used to study
terrestrial and extra-terrestrial neutrinos and new physics beyond the Standard
Model. The central detector contains 20,000 tons liquid scintillator with an
acrylic sphere of 35 m in diameter. 17,000 508-mm diameter PMTs with high
quantum efficiency provide 75% optical coverage. The current choice of
the liquid scintillator is: linear alkyl benzene (LAB) as the solvent, plus PPO
as the scintillation fluor and a wavelength-shifter (Bis-MSB). The number of
detected photoelectrons per MeV is larger than 1,100 and the energy resolution
is expected to be 3% at 1 MeV. The calibration system is designed to deploy
multiple sources to cover the entire energy range of reactor antineutrinos, and
to achieve a full-volume position coverage inside the detector. The veto system
is used for muon detection, muon induced background study and reduction. It
consists of a Water Cherenkov detector and a Top Tracker system. The readout
system, the detector control system and the offline system insure efficient and
stable data acquisition and processing.Comment: 328 pages, 211 figure
Screening mutations of OTOF gene in Chinese patients with auditory neuropathy, including a familial case of temperature-sensitive auditory neuropathy
International audienceBackgroundMutations in OTOF gene, encoding otoferlin, cause DFNB9 deafness and non-syndromic auditory neuropathy (AN). The aim of this study is to identify OTOF mutations in Chinese patients with non-syndromic auditory neuropathy.Methods73 unrelated Chinese Han patients with AN, including one case of temperature sensitive non-syndromic auditory neuropathy (TS-NSRAN) and 92 ethnicity-matched controls with normal hearing were screened. Forty-five pairs of PCR primers were designed to amplify all of the exons and their flanking regions of the OTOF gene. The PCR products were sequenced and analyzed for mutation identification.ResultsFive novel possibly pathogenic variants (c.1740delC, c.2975_2978delAG, c.1194T>A, c.1780G>A, c.4819C > T) were identified in the group of 73 AN patients, in which two novel mutant alleles (c.2975_2978delAG + c.4819C > T) were identified in one Chinese TS-NSRAN case. Besides, 10 non-pathogenic variants of the OTOF gene were found in AN patients and controls.ConclusionsScreening revealed that mutations in the OTOF gene account for AN in 4 of 73(5.5%) sporadic AN patients, which shows a lower genetic load of that gene in contrast to the previous studies based on other populations. Notably, we found two novel mutant alleles related to temperature sensitive non-syndromic auditory neuropathy. This mutation screening study further confirms that the OTOF gene contributes to ANs and to TS-NSRAN
Polymerization-induced self-assembly of block copolymer nanoparticles via RAFT non-aqueous dispersion polymerization
There is considerable current interest in polymerization-induced self-assembly (PISA) via reversible addition–fragmentation chain transfer (RAFT) polymerization as a versatile and efficient route to various types of block copolymer nano-objects. Many successful PISA syntheses have been conducted in water using either RAFT aqueous dispersion polymerization or RAFT aqueous emulsion polymerization. In contrast, this review article is focused on the growing number of RAFT PISA formulations developed for non-aqueous media. A wide range of monomers have been utilized for both the stabilizer and core-forming blocks to produce diblock copolymer nanoparticles in either polar or non-polar media (including supercritical CO2 and ionic liquids) via RAFT dispersion polymerization. Such nanoparticles possess spherical, worm-like or vesicular morphologies, often with controllable size and functionality. Detailed characterization of such sterically stabilized diblock copolymer dispersions provides important insights into the various morphological transformations that can occur both during the PISA synthesis and also on subsequent exposure to a suitable external stimulus (e.g. temperature)
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