Modelo de gesti?n para la convivencia escolar basado en la conducta social

166 p. Recurso Electr?nicoLa gesti?n escolar en los establecimientos es un proceso sistem?tico que est? orientado al fortalecimiento de las instituciones y sus proyectos, con el fin de enriquecer los procesos pedag?gicos, directivos, comunitarios y administrativos. Existen infinidad de mecanismos para el mejoramiento de la convivencia, en la mayor?a de los casos descontextualizados. Por tal motivo, una estrategia de intervenci?n que surge de los problemas de conducta y personalidad de los estudiantes, permite garantizar un mayor grado de efectividad para la implementaci?n y el compromiso de los actores. La Instituci?n Educativa La Tigrera ubicada en la zona rural del municipio de Alvarado Tolima, no es ajena a los problemas de convivencia escolar; en ella, se presenta agresi?n f?sica, verbal, sexual, discriminaci?n de diversos tipos, sustentado en los anecdotarios de los estudiantes e indicadores de las pruebas externas que se aplican por el ICFES. Dicha situaci?n, es la motivaci?n para desarrollar la propuesta de investigaci?n titulada Modelo de Gesti?n para la Convivencia Escolar Basado en la Conducta Social, en la cual se plantea la identificaci?n de aspectos facilitadores y perturbadores del comportamiento social que determinan el perfil de socializaci?n de los estudiantes de la instituci?n. Los resultados de la aplicaci?n de las bater?as de socializaci?n permitieron identificar los elementos cr?ticos que requer?an una acci?n para mitigar los efectos sobre la convivencia escolar; constituy?ndose en la base previa para la estructuraci?n de una rueda l?gica, que permita generar acciones de mejora contempladas en la construcci?n e implementaci?n de la propuesta. Una vez implementado el modelo de gesti?n por parte de los directivos, docentes, padres de familia y estudiantes se aplic? una prueba post test para obtener los resultados y poder analizar los datos que permiten dar comprobaci?n de las hip?tesis planteadas. Es de resaltar, que la metodolog?a pretende un alcance descriptivo, un enfoque cuantitativo y un dise?o de tipo pre experimental; con una muestra no param?trica de la poblaci?n. Palabras Clave: Convivencia, Conducta, Gesti?n, Escolar.Management in educational institutions is a systematic process focused on the school strengthening and its projects, in order to improve pedagogical, managerial, community and administrative processes. There are many mechanisms for the school life improvement in most decontextualized cases. For this reason, an intervention strategy is arisen on the behavior and personality students problems, making it possible to guarantee greater effectiveness in the implementation and actors commitment. La Tigrera School located in Alvarado - Tolima rural area is no stranger to the living together problems; it presents physical, verbal and sexual assaults, various types of discrimination, reflected in the students' academic records and external tests indicators applied by ICFES. Previous context is motivation to develop this research called MANAGEMENT MODEL FOR SCHOOL LIFE BASED ON SOCIAL BEHAVIOR, in which, to identify facilitating and disturbing aspects of social behavior that determine socialization profile of the students is raised. Results from Socialization Batteries Test allowed identifying critical elements that required an action to mitigate effects on school life, constituting itself in the previous base for ?the logical wheel? structuring; it favored generating improvement actions contemplated in the proposal (construction and implementation). Once model was implemented by management team, teachers, parents and students, a post-test was applied to obtain results and analyze data that allow verifying hypotheses. In this way, methodology aims at a descriptive scope, a quantitative approach and a pre-experimental type design; with a population non-parametric sample. Keywords: School life, social behavior, School Management

Dise?o, construcci?n e implementaci?n del supermercado Huacho

El presente trabajo consta de la gesti?n de planificaci?n del proyecto de dise?o, construcci?n e implementaci?n del supermercado Huacho. Se emple? las buenas pr?cticas de la Gu?a del est?ndar PMBOK? 6ta edici?n. Este proyecto nace del requerimiento de una empresa retail, que tiene como objetivo estrat?gico incrementar los metros cuadrados de sala de venta. El proyecto consta de la construcci?n de un supermercado de 1600 metros cuadrados de sala de venta ubicado en la ciudad de Huacho y tiene como objetivo comercial satisfacer la demanda de los potenciales clientes en esa zona. Las fases del proyecto son: Gesti?n, Dise?o, Procura, construcci?n, implementaci?n y transferencia a operaciones. El proyecto se ha planificado teniendo en cuenta supuestos como la capacidad financiera de la empresa, terreno disponible y continuidad de la normatividad vigente; se han identificado tambi?n los condicionantes y restricciones dentro de los cuales se debe enmarcar el alcance tal como la fecha de finalizaci?n del proyecto

Cellular acidification as a new approach to cancer treatment and to the understanding and therapeutics of neurodegenerative diseases

During the last few years, the understanding of the dysregulated hydrogen ion dynamics and reversed proton gradient of cancer cells has resulted in a new and integral pH-centric paradigm in oncology, a translational model embracing from cancer etiopathogenesis to treatment. The abnormalities of intracellular alkalinization along with extracellular acidification of all types of solid tumors and leukemic cells have never been described in any other disease and now appear to be a specific hallmark of malignancy. As a consequence of this intracellular acid-base homeostatic failure, the attempt to induce cellular acidification using proton transport inhibitors and other intracellular acidifiers of different origins is becoming a new therapeutic concept and selective target of cancer treatment, both as a metabolic mediator of apoptosis and in the overcoming of multiple drug resistance (MDR). Importantly, there is increasing data showing that different ion channels contribute to mediate significant aspects of cancer pH regulation and etiopathogenesis. Finally, we discuss the extension of this new pH-centric oncological paradigm into the opposite metabolic and homeostatic acid-base situation found in human neurodegenerative diseases (HNDDs), which opens novel concepts in the prevention and treatment of HNDDs through the utilization of a cohort of neural and non-neural derived hormones and human growth factors

AGT haplotype in ITGA4 gene is related to antibody-mediated rejection in heart transplant patients

[Abstract] Introduction. One of the main problems involved in heart transplantation (HT) is antibody-mediated rejection (AMR). Many aspects of AMR are still unresolved, including its etiology, diagnosis and treatment. In this project, we hypothesize that variants in genes involved in B-cell biology in HT patients can yield diagnostic and prognostic information about AMR. Methods. Genetic variants in 61 genes related to B-cell biology were analyzed by next generation sequencing in 46 HT patients, 23 with and 23 without AMR. Results. We identified 3 single nucleotide polymorphisms in ITGA4 gene (c.1845G>A, c.2633A>G, and c.2883C>T) that conformed the haplotype AGT-ITGA4. This haplotype is associated with the development of AMR. Moreover, AMR patients with the haplotype AGT-ITGA4 present lower levels of integrin α-4 in serum samples compared to the reference GAC haplotype in control patients. Conclusion. We can conclude that polymorphisms in genes related to the biology of B-cells could have an important role in the development of AMR. In fact, the AGT haplotype in ITGA4 gene could potentially increase the risk of AMR.Instituto de Salud Carlos III; PI13/0217

Association between convalescent plasma treatment and mortality in COVID-19: a collaborative systematic review and meta-analysis of randomized clinical trials.

Funder: laura and john arnold foundationBACKGROUND: Convalescent plasma has been widely used to treat COVID-19 and is under investigation in numerous randomized clinical trials, but results are publicly available only for a small number of trials. The objective of this study was to assess the benefits of convalescent plasma treatment compared to placebo or no treatment and all-cause mortality in patients with COVID-19, using data from all available randomized clinical trials, including unpublished and ongoing trials (Open Science Framework, https://doi.org/10.17605/OSF.IO/GEHFX ). METHODS: In this collaborative systematic review and meta-analysis, clinical trial registries (ClinicalTrials.gov, WHO International Clinical Trials Registry Platform), the Cochrane COVID-19 register, the LOVE database, and PubMed were searched until April 8, 2021. Investigators of trials registered by March 1, 2021, without published results were contacted via email. Eligible were ongoing, discontinued and completed randomized clinical trials that compared convalescent plasma with placebo or no treatment in COVID-19 patients, regardless of setting or treatment schedule. Aggregated mortality data were extracted from publications or provided by investigators of unpublished trials and combined using the Hartung-Knapp-Sidik-Jonkman random effects model. We investigated the contribution of unpublished trials to the overall evidence. RESULTS: A total of 16,477 patients were included in 33 trials (20 unpublished with 3190 patients, 13 published with 13,287 patients). 32 trials enrolled only hospitalized patients (including 3 with only intensive care unit patients). Risk of bias was low for 29/33 trials. Of 8495 patients who received convalescent plasma, 1997 died (23%), and of 7982 control patients, 1952 died (24%). The combined risk ratio for all-cause mortality was 0.97 (95% confidence interval: 0.92; 1.02) with between-study heterogeneity not beyond chance (I2 = 0%). The RECOVERY trial had 69.8% and the unpublished evidence 25.3% of the weight in the meta-analysis. CONCLUSIONS: Convalescent plasma treatment of patients with COVID-19 did not reduce all-cause mortality. These results provide strong evidence that convalescent plasma treatment for patients with COVID-19 should not be used outside of randomized trials. Evidence synthesis from collaborations among trial investigators can inform both evidence generation and evidence application in patient care

Tiempo requerido para la intubaci\uf3n endotraqueal con la dosis de cebamiento del bromuro de vecuronio

Con la finalidad de evaluar el tiempo requerido para la intubaci\uf3n endotraqueal, con el uso de la dosis de cebamiento de romuro de vecuronio, fueron estudiados 40 pacientes adultos en edades comprendidas entre 18 y 45 a\uf1os, a quienes se les practic\uf3 dicha maniobra. Los pacientes fueron divididos en 2 grupos: grupo A con dosis de cebamiento (0.010 - 0.012 mgr/kgr) y grupo B con dosis total (0,25 mgr/kgr). Al grupo que se le administr\uf3 dosis de carga, present\uf3 relajaci\uf3n muscular excelente en los primeros 2', en tanto que los pacientes del grupo B presentaron relajaci\uf3n entre los 3 y 4', lo que nos permite concluir, que la dosis de cebamiento disminuye en un 50% aproximadamente el tiempo requerido para la intubaci\uf3n, lo que aminora los posibles traumatismos durante la realizaci\uf3n de la maniobra de permeabilizar las vias \ue1reas del paciente, beneficiando la integridad del mismo durante el acto quir\ufargic