Antitumor activity of Eugenia floccosa Bedd and Eugenia singampattiana Bedd leaves against Dalton ascites lymphoma in swiss albino mice

Abstract: The aim of the present study is to evaluate the atitumor effect of Eugenia floccosa and Eugenia singampattiana (Myrtaceae) leaves against DLA bearing Swiss Albino Mice. The effect of ethanol extracts of Eugenia floccosa and Eugenia singampattiana leaves on tumor growth and host's survival time was studied by the following parameters: tumor volume, viable and non viable cell count and life span of the host. Ethanol extracts of Eugenia floccosa and Eugenia singampattiana and combined extracts of Eugenia floccosa and Eugenia singampattiana were administrated at a 100mg/Kg body weight respectively once a day for 14 days, after 24h of tumor inoculation. Decrease in tumor volume and viable count were observed. Treatment with the above said extracts increase the mean survival time. Hematological studies reveal that the Hb content was decreased in DAL treated mice, whereas, restoration to near normal levels was observed in extracts treated animals. The results suggest that the ethanol extracts of Eugenia floccosa and Eugenia singampattiana leaves exhibits significant antitumor effects in DAL bearing mice

Biofabrication of Gold Nanoparticles Using Cressa cretica Leaf Extract and Evaluation of Catalytic and Antibacterial Efficacy

Biofabrication of nanoparticles using plant sources is considered the most vital method for nanoparticle syntheses, as the use of plant materials not only makes the process eco-friendly but also its abundance makes it less expensive. In this study, we aimed to develop a rapid and simple procedure for the synthesis of gold nanoparticles using aqueous Cressa cretica leaf extract as a reducing agent as well as a capping agent. The characteristics of biofabricated gold nanoparticles were examined using ultraviolet-visible absorption spectroscopy (UV-Vis), Fourier-transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), X-ray powder diffraction (XRD) and energy dispersive X-ray spectroscopy (EDX). As the results, the biofabricated gold nanoparticles were of hexagonal, pentagonal, spherical and rod shapes with 15-22 nm in size. FTIR studies disclosed that hydroxyl, amide and amine groups of Cressa cretica leaf broth were liable for the formation and stabilization of the gold nanoparticles. The antibacterial activity of the gold nanoparticles against human pathogens showed significant zones of inhibition. It confirmed that the biofabricated gold nanoparticles have great promise as an antibacterial agent. The biofabricated gold nanoparticles were used as catalysts in the reduction of 4-nitrophenol using sodium borohydride. The catalytic activity studies exhibited that the biofabricated gold nanoparticles had prominent catalytic activity. Furthermore, this green biofabric approach is a fast and easy alternative to chemical synthesis