Advances in Solid State Joining of High Temperature Alloys

Many of the metals used in the oil and gas industry are difficult to fusion weld including titanium and its alloys. Thus solid state joining processes, such as friction stir welding (FSWing) and a patented modification termed thermal stir welding (TSWing), are being pursued as alternatives to produce robust structures more amenable to high pressure applications. Unlike the FSWing process where the tool is used to heat the workpiece, TSWing utilizes an induction coil to preheat the material prior to stirring thus minimizing the burden on the weld tool and thereby extending its life. This study reports on the initial results of using a hybrid (H)-TSW process to join commercially pure, 1.3cm thick panels of titanium (CP Ti) Grade 2

Thermal Emission from Warm Dust in the Most Distant Quasars

We report new continuum observations of fourteen z~6 quasars at 250 GHz and fourteen quasars at 1.4 GHz. We summarize all recent millimeter and radio observations of the sample of the thirty-three quasars known with 5.71<=z<=6.43, and present a study of the rest frame far-infrared (FIR) properties of this sample. These quasars were observed with the Max Plank Millimeter Bolometer Array (MAMBO) at 250 GHz with mJy sensitivity, and 30% of them were detected. We also recover the average 250 GHz flux density of the MAMBO undetected sources at 4 sigma, by stacking the on-source measurements. The derived mean radio-to-UV spectral energy distributions (SEDs) of the full sample and the 250 GHz non-detections show no significant difference from that of lower-redshift optical quasars. Obvious FIR excesses are seen in the individual SEDs of the strong 250 GHz detections, with FIR-to-radio emission ratios consistent with that of typical star forming galaxies. Most 250 GHz-detected sources follow the L_{FIR}--L_{bol} relationship derived from a sample of local IR luminous quasars (L_{IR}>10^{12}L_{\odot}), while the average L_{FIR}/L_{bol} ratio of the non-detections is consistent with that of the optically-selected PG quasars. The MAMBO detections also tend to have weaker Ly\alpha emission than the non-detected sources. We discuss possible FIR dust heating sources, and critically assess the possibility of active star formation in the host galaxies of the z~6 quasars. The average star formation rate of the MAMBO non-detections is likely to be less than a few hundred M_{\odot} yr^{-1}, but in the strong detections, the host galaxy star formation is probably at a rate of \gtrsim10^{3} M_{\odot} yr^{-1}, which dominates the FIR dust heating.Comment: 32 pages with 6 figures; ApJ, in press; Added references; Corrected typo

The First Extrasolar Planet Discovered with a New Generation High Throughput Doppler Instrument

We report the detection of the first extrasolar planet, ET-1 (HD 102195b), using the Exoplanet Tracker (ET), a new generation Doppler instrument. The planet orbits HD 102195, a young star with solar metallicity that may be part of the local association. The planet imparts radial velocity variability to the star with a semiamplitude of $63.4\pm2.0$ m s$^{-1}$ and a period of 4.11 days. The planetary minimum mass ($m \sin i$) is $0.488\pm0.015$ $M_J$.Comment: 42 pages, 11 figures and 5 tables, Accepted for publication in Ap

The Postcollapse core of M15 imaged with the HST planetary camera

We have obtained U-band images of the M15 core with the Planetary Camera of the Hubble Space Telescope. We are able to resolve stars down to the main-sequence turnoff (m_v≈ 19.4) into the cluster center. We use crowded field photometry techniques to decompose M15 into bright resolved stars and a residual component consisting of stars at turnoff brightness or fainter. The residual component comprises 59% of the cluster light and follows a y = -0.71 power-law distribution for r > 1". The residual component flattens off interior to this radius and has a large core with r_c = 2".2 = 0.13 pc. The core size may reflect postcollapse core expansion. The resolved stars have a slightly shallower distribution (y = - 0.53) but have an abrupt overdensity for r < 1".5, which accounts for the unresolved surface brightness cusp at ground resolution. The bright stars do not become more highly concentrated at still smaller radii, however; neither the bright stars nor the residual component form a cusp at subarcsecond resolution. The total central density of light in all components is 8 x 10^5 L_☉ pc^(-3) (U-band). The Peterson, Seitzer, and Cudworth central velocity dispersion implies a high core M/L ≈ 8 (U-band). The existence of a core rather than a cusp at the 0.1 pc scale may imply that the centrally deduced dark matter is in a diffuse form rather than a massive black hole

Aptamer-based multiplexed proteomic technology for biomarker discovery

Interrogation of the human proteome in a highly multiplexed and efficient manner remains a coveted and challenging goal in biology. We present a new aptamer-based proteomic technology for biomarker discovery capable of simultaneously measuring thousands of proteins from small sample volumes (15 [mu]L of serum or plasma). Our current assay allows us to measure ~800 proteins with very low limits of detection (1 pM average), 7 logs of overall dynamic range, and 5% average coefficient of variation. This technology is enabled by a new generation of aptamers that contain chemically modified nucleotides, which greatly expand the physicochemical diversity of the large randomized nucleic acid libraries from which the aptamers are selected. Proteins in complex matrices such as plasma are measured with a process that transforms a signature of protein concentrations into a corresponding DNA aptamer concentration signature, which is then quantified with a DNA microarray. In essence, our assay takes advantage of the dual nature of aptamers as both folded binding entities with defined shapes and unique sequences recognizable by specific hybridization probes. To demonstrate the utility of our proteomics biomarker discovery technology, we applied it to a clinical study of chronic kidney disease (CKD). We identified two well known CKD biomarkers as well as an additional 58 potential CKD biomarkers. These results demonstrate the potential utility of our technology to discover unique protein signatures characteristic of various disease states. More generally, we describe a versatile and powerful tool that allows large-scale comparison of proteome profiles among discrete populations. This unbiased and highly multiplexed search engine will enable the discovery of novel biomarkers in a manner that is unencumbered by our incomplete knowledge of biology, thereby helping to advance the next generation of evidence-based medicine

Stellar photometry with the Hubble Space Telescope Wide-field/Planetary camera - A progress report

We describe the prospects for the use of the Wide-Field/Planetary Camera (WFPC) for stellar photometry. The large halos of the point-spread function (PSF) resulting from spherical aberration and from spatial, temporal, and color variations of the PSF are the main limitations to accurate photometry. Degradations caused by crowding are exacerbated by the halos of the PSF. Here we attempt to quantify these effects and determine the current accuracy of stellar photometry with the WFPC. In realistic cases, the brighter stars in crowded fields have 0.09 mag errors; fainter stars have larger errors depending on the degree of crowding. We find that measuring Cepheids in Virgo Cluster galaxies is not currently possible without inordinate increases in exposure times

LSST Science Book, Version 2.0

A survey that can cover the sky in optical bands over wide fields to faint magnitudes with a fast cadence will enable many of the exciting science opportunities of the next decade. The Large Synoptic Survey Telescope (LSST) will have an effective aperture of 6.7 meters and an imaging camera with field of view of 9.6 deg^2, and will be devoted to a ten-year imaging survey over 20,000 deg^2 south of +15 deg. Each pointing will be imaged 2000 times with fifteen second exposures in six broad bands from 0.35 to 1.1 microns, to a total point-source depth of r~27.5. The LSST Science Book describes the basic parameters of the LSST hardware, software, and observing plans. The book discusses educational and outreach opportunities, then goes on to describe a broad range of science that LSST will revolutionize: mapping the inner and outer Solar System, stellar populations in the Milky Way and nearby galaxies, the structure of the Milky Way disk and halo and other objects in the Local Volume, transient and variable objects both at low and high redshift, and the properties of normal and active galaxies at low and high redshift. It then turns to far-field cosmological topics, exploring properties of supernovae to z~1, strong and weak lensing, the large-scale distribution of galaxies and baryon oscillations, and how these different probes may be combined to constrain cosmological models and the physics of dark energy.Comment: 596 pages. Also available at full resolution at http://www.lsst.org/lsst/sciboo

Systematic Estimates of Decadal Predictability for Six CGCMs

Initial-value predictability measures the degree to which the initial state can influence predictions. In this paper, the initial-value predictability of six atmosphere–ocean general circulation models in the North Pacific and North Atlantic is quantified and contrasted by analyzing long control integrations with time invariant external conditions. Through the application of analog and multivariate linear regression methodologies, average predictability properties are estimated for forecasts initiated from every state on the control trajectories. For basinwide measures of predictability, the influence of the initial state tends to last for roughly a decade in both basins, but this limit varies widely among the models, especially in the North Atlantic. Within each basin, predictability varies regionally by as much as a factor of 10 for a given model, and the locations of highest predictability are different for each model. Model-to-model variations in predictability are also seen in the behavior of prominent intrinsic basin modes. Predictability is primarily determined by the mean of forecast distributions rather than the spread about the mean. Horizontal propagation plays a large role in the evolution of these signals and is therefore a key factor in differentiating the predictability of the various models

The Case against a Smoker's License

Tobacco continues to kill millions of people around the world each year and its use is increasing in some countries, which makes the need for new, creative, and radical efforts to achieve the tobacco control endgame vitally important. One such effort is discussed in this PLOS Medicine Debate, where Simon Chapman presents his proposal for a "smoker's license" and Jeff Collin argues against. Chapman sets out a case for introducing a smart card license for smokers designed to limit access to tobacco products and encourage cessation. Key elements of the smoker's license include smokers setting daily limits, financial incentives for permanent license surrender, and a test of health risk knowledge for commencing smokers. Collin argues against the proposal, saying that it would shift focus away from the real vector of the epidemic--the tobacco industry--and that by focusing on individuals it would censure victims, increase stigmatization of smokers, and marginalize the poor