The thetis bay factory, historic background and taphonomy of pinniped bonebeds

Las costas de Península Mitre, en el extremo oriental de la Isla Grande de Tierra del Fuego, albergan gran cantidad de apostaderos de pinnípedos que fueron objeto de la explotación intensiva por parte de loberos europeos, estadounidenses y criollos desde el siglo XVIII. En la década de 1940 en bahía Thetis funcionó una factoría dedicada a la obtención de cueros y aceite de estos animales, de la cual aún se conservan restos de algunas de sus instalaciones y grandes acumulaciones de huesos de los animales faenados. En este artículo se ofrecen datos históricos sobre la explotación de pinnípedos en la región de Península Mitre y las modalidades de obtención y aprovechamiento a escala industrial de estas presas realizadas en la factoría de bahía Thetis. Asimismo, se presentan los análisis zooarqueológicos y tafonómicos de camadas de huesos (bonebeds) de pinnípedos emplazadas en un sector de esta bahía. Los resultados presentados nos permiten profundizar en algunas propuestas previas en las cuales se sostiene que estas camadas de huesos son producto de una acumulación secundaria, generada por la acción de las mareas, de restos descartados por la faena de animales en la factoría de lobos marinos que funcionó en esta bahía.Several Otarid rookeries are located along the coasts of the Península Mitre, at the Eastern end of the Isla Grande de Tierra del Fuego, which were the subject of intensive exploitation by European, American and Criollo sealers since the 18th century. In the 1940s, a factory for extracting leather and oil from these animals was established in Thetis Bay. Remains of its facilities are still preserved, along with large accumulations of bones from animals slaughtered there. This paper provides historical data on the exploitation of pinnipeds in Península Mitre and on the methods for obtaining and exploiting these marine mammals at an industrial scale. The paper likewise includes the zooarchaeological and taphonomic analyses of pinniped bonebeds located in a sector of Thetis Bay. The presented results allow us to delve into some previous proposals which argue that these bonebeds are the product of a secondary accumulation - generated by tidal action - of remains discarded after the animal slaughter at the factoryFil: Vazquez, Martin Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Austral de Investigaciones Científicas; ArgentinaFil: Santiago, Fernando Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Austral de Investigaciones Científicas; ArgentinaFil: Zangrando, Atilio Francisco Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Austral de Investigaciones Científicas; Argentin

A fatal case of Nocardia otitidiscaviarum pulmonary infection and brain abscess: taxonomic characterization by molecular techniques

We report on a rare case of pulmonary Nocardiosis and brain abscess caused by Nocardia otitidiscaviarum in an elderly woman with chronic obstructive pulmonary disease. Taxonomic identification involved phenotypic testing, restriction fragment length polymorphism (RFLP), and complete 16S rRNA gene sequencing

Psychological Effects of a 1-Month Meditation Retreat on Experienced Meditators: The Role of Non-attachment

Background: There are few studies devoted to assessing the impact of meditation-intensive retreats on the well-being, positive psychology, and personality of experienced meditators. We aimed to assess whether a 1-month Vipassana retreat: (a) would increase mindfulness and well-being; (b) would increase prosocial personality traits; and (c) whether psychological changes would be mediated and/or moderated by non-attachment. Method: A controlled, non-randomized, pre-post-intervention trial was used. The intervention group was a convenience sample (n = 19) of experienced meditators who participated in a 1-month Vipassana meditation retreat. The control group (n = 19) comprised matched experienced meditators who did not take part in the retreat. During the retreat, the mean duration of daily practice was 8-9 h, the diet was vegetarian and silence was compulsory. The Experiences Questionnaire (EQ), Non-attachment Scale (NAS), Positive and Negative Affect Schedule (PANAS), Satisfaction With Life Scale (SWLS), Temperament Character Inventory Revised (TCI-R-67), Five Facets Mindfulness Questionnaire (FFMQ), Self-Other Four Immeasurables (SOFI) and the MINDSENS Composite Index were administered. ANCOVAs and linear regression models were used to assess pre-post changes and mediation/moderation effects. Results: Compared to controls, retreatants showed increases in non-attachment, observing, MINDSENS, positive-affect, balance-affect, and cooperativeness; and decreases in describing, negative-others, reward-dependence and self-directedness. Non-attachment had a mediating role in decentring, acting aware, non-reactivity, negative-affect, balance-affect and self-directedness; and a moderating role in describing and positive others, with both mediating and moderating effects on satisfaction with life. Conclusions: A 1-month Vipassana meditation retreat seems to yield improvements in mindfulness, well-being, and personality, even in experienced meditators. Non-attachment might facilitate psychological improvements of meditation, making it possible to overcome possible ceiling effects ascribed to non-intensive practices

Diagnosis of pulmonary embolism in patients with acute exacerbations of chronic obstructive pulmonary disease: a cross-sectional study

Introduction: Pulmonary embolism (PE) remains a frequent complication in patients with chronic obstructive pulmonary disease (COPD). It is unclear that the extent to which the traditional risk stratifying scores for PE are accurate in this population. Methods: Cross-sectional study of adult patients with COPD and suspected PE included in an Institutional Registry of Thromboembolic Disease at a tertiary teaching hospital in the city of Buenos Aires, Argentina. We estimated the area under the receiver operating characteristic curves (AU-ROC), sensitivity and specificity of the Wells and Geneva scores using a positive computed tomography angiography as the gold standard for PE. We also estimated the sensitivity and specificity for the presence of isolated worsening of dyspnea at presentation, without other cardinal symptoms of acute exacerbation of COPD. Results: A total of 168 patients were included, of which 22% had confirmed PE. The AUC was 0.66 (95% CI 0.56-0.76) and 0.56 (95% CI 0.45-0.67) for the Wells and Geneva, respectively. Considering the most widely used cutoff points, the sensitivity and specificity were 24% and 90% for the Wells and 59% and 43% for the Geneva score, respectively. Isolated worsening of dyspnea on presentation had a sensitivity of 92% and specificity of 37%. Conclusions: Both Wells and Geneva scores exhibit poor diagnostic accuracy for the diagnosis of PE in patients with COPD. The presence of isolated worsening of dyspnea on presentation could be an easy to identify criteria for the initial triage in this population. Further validation of our findings remains warranted.Fil: Maritano Furcada, Joaquín. Hospital Italiano; ArgentinaFil: Castro, Horacio Matías. Hospital Italiano; ArgentinaFil: de Vito, Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Grande Ratti, María Florencia. Hospital Italiano; ArgentinaFil: Posadas Martinez, Maria Lourdes. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Italiano; ArgentinaFil: Giunta, Diego Hernan. Hospital Italiano; ArgentinaFil: Vazquez, Fernando Javier. Hospital Italiano; ArgentinaFil: Ferreyro, Bruno Leonel. Hospital Italiano; Argentina. University of Toronto; Canad

Nutraceutic effect of free condensed tannins of lysiloma acapulcensis (kunth) benth on parasite infection and performance of pelibuey sheep

Abstract Forty-five Pelibuey sheep were experimentally infested with nematodes to evaluate the effect of three free condensed tannin (FCT) levels of Lysiloma acapulcensis on fecal egg counts (FECs), packed cell volumes (PCV), ocular mucosa colors (OMC), average daily gain (ADG), and adult nematode count. Five treatments were used: 12.5, 25.0, and 37.5 mg of FCT kg−1 of body weight (BW); sterile water (control); and ivermectine (0.22 mg kg−1 of BW) as chemical group. The data were processed through repeated measure- ment analysis. Even though the three FCT doses decreased (P < 0.05) the FEC, the highest reduction was obtained with 37.5 mg kg−1 of BW. No differences were observed in PCV and OMC. Higher ADG (P < 0.05) was observed with 37.5 mg kg−1 of BW of FCT. The count of adult nematodes (females and males) in the higher dose of FCT was similar to chemical treatment. Dose of 37.5 mg kg−1 of BW decreased the parasite infection and improved the lamb performance. Therefore, this dose could be used as a nutraceutic product in sheep production.This work was undertaken with funds from the Universidad Autónoma del Estado de México (Project UAEM 1026/2014RIFC). Our gratitude also goes to the Mexican National Council for Science and Technology (CONACYT) for the grant received by Cesar García Hernández

Coronary Artery Disease and Prognosis of Heart Failure with Reduced Ejection Fraction.

Our aim was to determine the prognostic impact of coronary artery disease (CAD) on heart failure with reduced ejection fraction (HFrEF) mortality and readmissions. From a prospective multicenter registry that included 1831 patients hospitalized due to heart failure, 583 had a left ventricular ejection fraction of <40%. In total, 266 patients (45.6%) had coronary artery disease as main etiology and 137 (23.5%) had idiopathic dilated cardiomyopathy (DCM), and they are the focus of this study. Significant differences were found in Charlson index (CAD 4.4 ± 2.8, idiopathic DCM 2.9 ± 2.4, p < 0.001), and in the number of previous hospitalizations (1.1 ± 1, 0.8 ± 1.2, respectively, p = 0.015). One-year mortality was similar in the two groups: idiopathic DCM (hazard ratio [HR] = 1), CAD (HR 1.50; 95% CI 0.83-2.70, p = 0.182). Mortality/readmissions were also comparable: CAD (HR 0.96; 95% CI 0.64-1.41, p = 0.81). Patients with idiopathic DCM had a higher probability of receiving a heart transplant than those with CAD (HR 4.6; 95% CI 1.4-13.4, p = 0.012). The prognosis of HFrEF is similar in patients with CAD etiology and in those with idiopathic DCM. Patients with idiopathic DCM were more prone to receive heart transplant.This research was funded by CIBERCV I and supported by the Instituto de Salud Carlos III. L.V. is funded by the Instituto de Salud Carlos III, Spain (CM20/00104 and ).S

Mortalidad y recurrencia de la enfermedad tromboembólica venosa en pacientes adultos: cohorte prospectiva

INTRODUCCIÓN: La enfermedad tromboembólica venosa (ETV) es una patología que aumenta con la edad. Objetivo: comparar la sobrevida de los ancianos y los jóvenes con un primer episodio de ETV aguda y sintomática. MATERIALES Y MÉTODOS: Cohorte prospectiva de casos incidentes de ETV incluidos en el Registro Institucional de Enfermedad Tromboembólica venosa (NCT01372514) del Hospital Italiano de Buenos Aires entre 2012-2014, dividido en grupos jóvenes (17-64 años) y ancianos (≥ 65 años). Todos los pacientes fueron seguidos anualmente para evaluar el tiempo a la recurrencia (progresión o nuevo evento sintomático de ETV) como eventos competitivos en contexto de muerte y sangrado mayor. Se presentaron los riesgos crudos (c) y ajustados (a). RESULTADOS: se incluyeron 446 pacientes, el 63% (292) fueron mayores de 65 años. La sobrevida fue menor en los ancianos comparados con los jóvenes (p 0.007), a los 3 meses 87% vs 95% y al año 73% vs 87%, respectivamente. Los ancianos presentaron un HRc1,71 y HR a 1.68. La recurrencia global fue 5% (IC 95% 3-8) al mes, 6% (IC 95% 4-9) a los 3 meses, 8% (IC 95% 6-11) al año y 13% (IC 95% 9-18) a los dos años. No se encontró asociación entre la edad y la recurrencia sub hazard 0.8(IC 0,34-1,86). El sangrado ocurrió en un 9% (39) de los pacientes. CONCLUSIONES: La mortalidad global en pacientes con ETV confirmada es mayor en la población anciana. No hubo diferencias en relación a la recurrencia de ETV, ni el sangrado y tampoco con la edad.INTRODUCTION: Venous thromboembolic disease (VTE) is a pathology that increases with age. OBJECTIVE: to compare the survival of the elderly and the young with a first episode of acute and symptomatic VTE. MATERIALS AND METHODS: Prospective cohort of incident VTE cases included in the Institutional Registry of Venous Thromboembolic Disease (NCT01372514) of the Italian Hospital of Buenos Aires between 2012-2014, divided into young groups (17-64 years old) and elderly (65 years old). All the patients were followed annually to assess the time to recurrence (progression or new symptomatic event of VTE) as competitive events in the context of death and major bleeding. Raw (c) and adjusted (a) risks were presented. RESULTS: 446 patients were included, 63% (292) were older than 65 years. Survival was lower in the elderly compared to the young (p 0.007), at 3 months 87% vs. 95% and at one year 73% vs. 87%, respectively. The elderly had a HRc1.71 and HR at 1.68. The overall recurrence was 5% (95% CI 3-8) at one month, 6% (95% CI 4-9) at 3 months, 8% (95% CI). 6-11) at one year and 13% (95% CI 9-18) at two years. No association was found between age and recurrence sub hazard 0.8 (CI 0.34- 1.86). Bleeding occurred in 9% (39) of the patients. CONCLUSIONS: The overall mortality in patients with confirmed VTE is higher in the elderly population. There were no differences in relation to the recurrence of VTE, or bleeding, and neither with age.INTRODUÇÃO: A doença tromboembólica venosa (TEV) é uma patologia que aumenta com a idade. OBJETIVO: comparar a sobrevida de idosos e jovens com um primeiro episódio de TEV agudo e sintomático. MATERIAIS E MÉTODOS:Coorte prospectiva de casos de TEV incidentes incluídos no Registro Institucional de Doença Tromboembólica Venosa (NCT01372514) do Hospital Italiano de Buenos Aires entre 2012-2014, divididos em grupos jovens (17 a 64 anos) e idosos (65 anos) velho). Todos os pacientes foram acompanhados anualmente para avaliar o tempo de recorrência (progressão ou novo evento sintomático de TEV) como eventos competitivos no contexto de morte e sangramento grave. Os riscos brutos (c) e ajustados (a) foram apresentados. RESULTADOS:446 pacientes foram incluídos, 63% (292) tinham idade superior a 65 anos. A sobrevida foi menor nos idosos em comparação aos jovens (p 0,007), aos 3 meses 87% vs. 95% e aos um ano 73% vs. 87%, respectivamente. Os idosos apresentaram HRc1.71 e FC em 1,68. A recorrência geral foi de 5% (IC95% 3-8) em um mês, 6% (IC95% 4-9) em 3 meses, 8% (IC95%). 6-11) em um ano e 13% (IC95% 9-18) em dois anos. Não foi encontrada associação entre idade e recorrência sub-risco 0,8 (IC 0,34-1,86). Ocorreu sangramento em 9% (39) dos pacientes. CONCLUSÕES: A mortalidade geral em pacientes com TEV confirmado é maior na população idosa. Não houve diferenças em relação à recorrência de TEV ou sangramento e nem com a idade.Fil: Posadas Martinez, Maria Lourdes. Hospital Italiano. Departamento de Medicina. Servicio de Clínica Médica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Pagotto, Vanina Laura. Hospital Italiano. Departamento de Medicina. Servicio de Clínica Médica; ArgentinaFil: Grande Ratti, Maria Florencvia. Hospital Italiano. Departamento de Medicina. Servicio de Clínica Médica; ArgentinaFil: Alfie, Veronica. Hospital Italiano. Departamento de Medicina. Servicio de Clínica Médica; ArgentinaFil: Andresik, Diego. Hospital Italiano. Departamento de Medicina. Servicio de Clínica Médica; ArgentinaFil: Torres Gomez, Felipe. Hospital Italiano. Departamento de Medicina. Servicio de Clínica Médica; ArgentinaFil: Giunta, Diego Hernan. Hospital Italiano. Departamento de Medicina. Servicio de Clínica Médica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Luxardo, Rosario. Hospital Italiano. Departamento de Medicina. Servicio de Clínica Médica; ArgentinaFil: Scolnik, Marina. Hospital Italiano. Departamento de Medicina. Servicio de Clínica Médica; ArgentinaFil: Vazquez, Fernando Javier. Hospital Italiano. Departamento de Medicina. Servicio de Clínica Médica; Argentin

Antioxidant and Antimicrobial Capacity of Phenolic Compounds of Mango (Mangifera indica L.) Seed depending upon the Extraction Process

The extraction method is critical for the recovery of phenolic compounds. The main goal was to evaluate the effect of an extraction process from mango seed on their phenolic profile, antioxidant and antimicrobial capacities. Phenolic extraction was performed in different steps: maceration, alkaline hydrolysis, acid/alkaline hydrolysis, polar and non-polar fraction of an ethyl acetate separation.The macerated extract showed a higher variety of polyphenols from mango seed:gallic (138.36 µg/g dry weight), coumaric (65.36 µg/g), ferulic (1376.67 µg/g) , chlorogenic (57.75 µg/g) anddicaffeoylquinic (219.29 µg/g) acids, catechin (16.78 µg/g) and rutin (6678.62µg/g). In alkaline hydrolyzed extract most of these compounds were lost, ferulic acid decreased 1356.77 µg/g dw and gallic acid increased 1383.89 µg/g dw. Gallic and chlorogenic acids increased 165 and 969. 45 µg/g dw respectively in acid/alkaline hydrolyzed, 109.57 and 841.38 µg/g dw respectively in non-polar and 277.15 and 77.88 µg/g dw respectively in polar extracts related to the macerated extract. Rutin was found only in acid/hydrolyzed and non-polar extract in lesser amount (87.62 and 78.51 µg/g dw) compared to macerated extract. The content of phenolic compounds was higher for the macerated extract (phenols=484.42 mg GAE/g and flavonoids=86.59 mg QE/g) than for the other steps. Acid/alkaline hydrolysis increased the antioxidant activity (1787.67 μmol TE/g for DPPH and 3692.86 μmol TE/g for TEAC); while the alkaline hydrolysis increased the antimicrobial effectivity (MIC=2.5 mg/mL for bacteria and 0.5 mg/mL for yeast). Results indicate that the acid or alkaline hydrolysis yields a stronger antioxidant and antimicrobial extract

The incorporation of the SDGs in the Technical Architecture and Building plan (2021) of the University of Alcalá

[EN] The Bachelor's degrees of the first round of verifications (2008), have the obligation to review and renew their teaching approaches, since neither the ways of teaching, nor the ways of practicing the profession, nor the technologies are the same in 2021. There is an opportunity to update the contents and the interrelation between them. The Sustainable Development Goals (SDGs) can and should be part of this process of teaching innovation. This is the case of the evolution of the Degree in Science and Technology of Building, to the Degree in Technical Architecture and Building, recently approved (March 2021). The objective of the communication is to present the method followed for the integration of the SDGs in the verification process. The way practiced to determine the goals of each SDG to be incorporated is analyzed. The prioritization of the character of transversality in the planned approach, not as a specific subject but integrated, coordinated, and related between the different subjects in which it is progressively integrated into the degree. Finally, the definitive incorporation procedure to the Plan, its documentary and conceptual reflection, and the implementation forecast, the monitoring and control processes for the 2021/2022 academic year will be discussed.[ES] Las titulaciones de Grado de la primera tanda de verificaciones (2008), tienen la obligación de revisar y renovar sus planteamientos docentes, ya que ni los modos de enseñar, ni los modos de ejercer la profesión, ni las tecnologías son las mismas en 2021. Se presenta una oportunidad de actualización de los contenidos y la interrelación entre ellos. Los Objetivos de Desarrollo Sostenible (ODS) pueden y deben formar parte de este proceso de innovación docente. Es el caso de la evolución del Grado en Ciencia y Tecnología de la Edificación, al Grado de Arquitectura Técnica y Edificación, aprobado recientemente (marzo 2021). El objetivo de la comunicación es presentar el método seguido para la integración de los ODS en el proceso de verificación. Se analiza el modo practicado para determinar las metas de cada ODS a incorporar. La priorización del carácter de transversalidad en el enfoque planificado, no como materia específica sino integrada, coordinada, y relacionada entre las diferentes asignaturas en las que se integra de forma progresiva en la titulación. Por último se comentará el procedimiento de incorporación definitiva al Plan, su reflejo documental y conceptual, y la previsión de implantación, los procesos de seguimientos y control para el curso 2021/2022.Da Casa Martín, F.; Baño Nieva, A.; Vega Ballesteros, JM.; Delgado Conde, I.; Maza Vazquez, F.; Fernandez Tapia, E.; Temiño Vela, J.... (2021). La incorporación de los ODS en el plan de estudios de Arquitectura Técnica y Edificación (2021) de la Universidad de Alcalá. En EDIFICATE. I Congreso de Escuelas de Edificación y Arquitectura Técnica de España. Editorial Universitat Politècnica de València. 409-421. https://doi.org/10.4995/EDIFICATE2021.2021.13543OCS40942

Smoking and age-related macular degeneration: review and update

Age-related macular degeneration (AMD) is one of the main socioeconomical health issues worldwide. AMD has a multifactorial etiology with a variety of risk factors. Smoking is the most important modifiable risk factor for AMD development and progression. The present review summarizes the epidemiological studies evaluating the association between smoking and AMD, the mechanisms through which smoking induces damage to the chorioretinal tissues, and the relevance of advising patients to quit smoking for their visual health