Anomalous dimensions of leading twist conformal operators

We extend and develop a method for perturbative calculations of anomalous dimensions and mixing matrices of leading twist conformal primary operators in conformal field theories. Such operators lie on the unitarity bound and hence are conserved (irreducible) in the free theory. The technique relies on the known pattern of breaking of the irreducibility conditions in the interacting theory. We relate the divergence of the conformal operators via the field equations to their descendants involving an extra field and accompanied by an extra power of the coupling constant. The ratio of the two-point functions of descendants and of their primaries determines the anomalous dimension, allowing us to gain an order of perturbation theory. We demonstrate the efficiency of the formalism on the lowest-order analysis of anomalous dimensions and mixing matrices which is required for two-loop calculations of the former. We compare these results to another method based on anomalous conformal Ward identities and constraints from the conformal algebra. It also permits to gain a perturbative order in computations of mixing matrices. We show the complete equivalence of both approaches.Comment: 21 pages, 4 figures; references adde

Is DNA methylation in the brain a mechanism of alcohol use disorder?

Alcohol use disorder (AUD) is a worldwide problem. Unfortunately, the molecular mechanisms of alcohol misuse are still poorly understood, therefore successful therapeutic approaches are limited. Accumulating data indicate that the tendency for compulsive alcohol use is inherited, suggesting a genetic background as an important factor. However, the probability to develop AUD is also affected by life experience and environmental factors. Therefore, the epigenetic modifications that are altered over lifetime likely contribute to increased risk of alcohol misuse. Here, we review the literature looking for the link between DNA methylation in the brain, a common epigenetic modification, and AUD-related behaviors in humans, mice and rats. We sum up the main findings, identify the existing gaps in our knowledge and indicate future directions of the research

Operator mixing in N=4 SYM: The Konishi anomaly revisited

In the context of the superconformal N=4 SYM theory the Konishi anomaly can be viewed as the descendant $K_{10}$ of the Konishi multiplet in the 10 of SU(4), carrying the anomalous dimension of the multiplet. Another descendant $O_{10}$ with the same quantum numbers, but this time without anomalous dimension, is obtained from the protected half-BPS operator $O_{20'}$ (the stress-tensor multiplet). Both $K_{10}$ and $O_{10}$ are renormalized mixtures of the same two bare operators, one trilinear (coming from the superpotential), the other bilinear (the so-called "quantum Konishi anomaly"). Only the operator $K_{10}$ is allowed to appear in the right-hand side of the Konishi anomaly equation, the protected one $O_{10}$ does not match the conformal properties of the left-hand side. Thus, in a superconformal renormalization scheme the separation into "classical" and "quantum" anomaly terms is not possible, and the question whether the Konishi anomaly is one-loop exact is out of context. The same treatment applies to the operators of the BMN family, for which no analogy with the traditional axial anomaly exists. We illustrate our abstract analysis of this mixing problem by an explicit calculation of the mixing matrix at level g^4 ("two loops") in the supersymmetric dimensional reduction scheme.Comment: 28 pp LaTeX, 3 figure

Does Small Ruminant Lentivirus Infection in Goats Predispose to Bacterial Infection of the Mammary Gland? A Preliminary Study

The aim of this study was to determine whether asymptomatic small ruminant lentivirus seropositive (SRLV-SP) goats were more susceptible to bacterial infection of the udder when lactating by comparing the presence and species of pathogenic bacteria in their milk with the values for seronegative goats (SRLV-SN). Milk samples were collected during morning milking on days 20, 40, 60, 150, and 210 of lactation for three consecutive years and subjected to bacteriological examination. Staphylococcus caprae and S. xylosus were the most frequent strains identified in both SRLV-SP and SRLV-SN goats. The prevalence of pathogenic bacteria was the highest in the 1st lactation, regardless of SRLV status. Moreover, the prevalence of pathogenic bacteria was significantly higher in SRLV-SP goats, but only those in the 5th or further lactation (p = 0.010). This suggests a relationship between long-lasting SRLV infection and susceptibility to bacterial infections of the udder

A three-loop test of the dilatation operator in N=4 SYM

We compute the three-loop anomalous dimension of the BMN operators with charges J=0 (the Konishi multiplet) and J=1 in N=4 super-Yang-Mills theory. We employ a method which effectively reduces the calculation to two loops. Instead of using the superconformal primary states, we consider the ratio of the two-point functions of suitable descendants of the corresponding multiplets. Our results unambiguously select the form of the N=4 SYM dilatation operator which is compatible with BMN scaling. Thus, we provide evidence for BMN scaling at three loops.Comment: 38 pages LaTeX, 4 figures, references adde

On twist-two operators in N=4 SYM

We propose a mechanism for calculating anomalous dimensions of higher-spin twist-two operators in N=4 SYM. We consider the ratio of the two-point functions of the operators and of their superconformal descendants or, alternatively, of the three-point functions of the operators and of the descendants with two protected half-BPS operators. These ratios are proportional to the anomalous dimension and can be evaluated at n-1 loop in order to determine the anomalous dimension at n loops. We illustrate the method by reproducing the well-known one-loop result by doing only tree-level calculations. We work out the complete form of the first-generation descendants of the twist-two operators and the scalar sector of the second-generation descendants.Comment: references added; typos correcte

Epigenetic activation of antiviral sensors and effectors of interferon response pathways during SARS-CoV-2 infection

Recent studies have shown that methylation changes identified in blood cells of COVID-19 patients have a po-tential to be used as biomarkers of SARS-CoV-2 infection outcomes. However, different studies have reported different subsets of epigenetic lesions that stratify patients according to the severity of infection symptoms, and more importantly, the significance of those epigenetic changes in the pathology of the infection is still not clear. We used methylomics and transcriptomics data from the largest so far cohort of COVID-19 patients from four geographically distant populations, to identify casual interactions of blood cells' methylome in pathology of the COVID-19 disease. We identified a subset of methylation changes that is uniformly present in all COVID-19 patients regardless of symptoms. Those changes are not present in patients suffering from upper respiratory tract infections with symptoms similar to COVID-19. Most importantly, the identified epigenetic changes affect the expression of genes involved in interferon response pathways and the expression of those genes differs be-tween patients admitted to intensive care units and only hospitalized. In conclusion, the DNA methylation changes involved in pathophysiology of SARS-CoV-2 infection, which are specific to COVID-19 patients, can not only be utilized as biomarkers in the disease management but also present a potential treatment target