12 research outputs found
A Multi-Center Comparison of VO2peak Trainability Between Interval Training and Moderate Intensity Continuous Training
- Author
- Anja Bye
- Anja Bye
- Brendon J. Gurd
- Camilla J. Williams
- Christopher M. Hearon
- David J. Bishop
- David J. Bishop
- Dorthe Stensvold
- Emeline M. Van Craenenbroeck
- Erin J. Howden
- Ilaria Croci
- Ilaria Croci
- Ioannis Papadimitriou
- Jacob T. Bonafiglia
- Jeff S. Coombes
- Jenna L. Taylor
- Jonathan P. Little
- Joyce S. Ramos
- Monique E. Francois
- Nele Pattyn
- Nicholas Harvey
- Nir Eynon
- Paul Beckers
- Robert G. Fassett
- Sarah Voisin
- Satyam Sarma
- Shelley E. Keating
- Sylvan L.J.E. Janssen
- Sylvan L.J.E. Janssen
- Trishan Gajanand
- Ulrik Wisloff
- Ulrik Wisloff
- Véronique A. Cornelissen
- Xu Yan
- Xu Yan
- Zhixiu Li
- Publication venue
- 'Frontiers Media SA'
- Publication date
- 01/01/2019
- Field of study
There is heterogeneity in the observed VO2peak response to similar exercise training, and different exercise approaches produce variable degrees of exercise response (trainability). The aim of this study was to combine data from different laboratories to compare VO2peak trainability between various volumes of interval training and Moderate Intensity Continuous Training (MICT). For interval training, volumes were classified by the duration of total interval time. High-volume High Intensity Interval Training (HIIT) included studies that had participants complete more than 15 min of high intensity efforts per session. Low-volume HIIT/Sprint Interval Training (SIT) included studies using less than 15 min of high intensity efforts per session. In total, 677 participants across 18 aerobic exercise training interventions from eight different universities in five countries were included in the analysis. Participants had completed 3 weeks or more of either high-volume HIIT (n = 299), low-volume HIIT/SIT (n = 116), or MICT (n = 262) and were predominately men (n = 495) with a mix of healthy, elderly and clinical populations. Each training intervention improved mean VO2peak at the group level (P \u3c 0.001). After adjusting for covariates, high-volume HIIT had a significantly greater (P \u3c 0.05) absolute VO2peak increase (0.29 L/min) compared to MICT (0.20 L/min) and low-volume HIIT/SIT (0.18 L/min). Adjusted relative VO2peak increase was also significantly greater (P \u3c 0.01) in high-volume HIIT (3.3 ml/kg/min) than MICT (2.4 ml/kg/min) and insignificantly greater (P = 0.09) than low-volume HIIT/SIT (2.5 mL/kg/min). Based on a high threshold for a likely response (technical error of measurement plus the minimal clinically important difference), high-volume HIIT had significantly more (P \u3c 0.01) likely responders (31%) compared to low-volume HIIT/SIT (16%) and MICT (21%). Covariates such as age, sex, the individual study, population group, sessions per week, study duration and the average between pre and post VO2peak explained only 17.3% of the variance in VO2peak trainability. In conclusion, high-volume HIIT had more likely responders to improvements in VO2peak compared to low-volume HIIT/SIT and MICT
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.
- Author
- Ab Majid MA
- Ab Rahman AS
- Ab Rahman R
- Abayasinghe C
- Abbott T
- Abdullah NH
- Abdur-Rahman L
- Abeloos J
- Abernethy C
- Abidin UN
- Abrunhosa A
- Absar M
- Adam S
- Adams D
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- Ademola A
- Adenekan A
- Adenike O
- Adeolu AA
- Adetoye A
- Adewale B
- Adigun T
- Adolfsson A
- Aflori L
- Africander C
- Afshari A
- Agarwal V
- Agodirin O
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- Wang Y
- Wang Z
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- Ward J
- Wasmund C
- Wassall R
- Watanabe Oliveira HR
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- Wendling PR
- Wessels JD
- Wetzel P
- Weyland A
- White S
- White S
- whitehouse A
- Whitman Z
- Whittle N
- Whitworth H
- Whysall K
- Wibrandt I
- Wickboldt N
- Wickenhauser R
- Wid WM
- Widmark C
- Wiegand-Loehnert C
- Wighton E
- Wigmore G
- Wijeysundera D
- Wikner M
- Wild J
- Wildes T
- Wildi S
- Williams A
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- Wilscott-Davids C
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- Winstone U
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- Wittmann M
- Wolfer A
- Wollaston J
- Wong C
- Wong CW
- Wong JY
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- Wong KWK
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- Wong WL
- Woodgate A
- Woolsey A
- Woon YL
- Worreth M
- Wouters P
- Wrench I
- Wright S
- Wu C
- Wu C
- Wu J
- Wu J
- Wu Q
- Wu S
- Wyffels P
- Wylie K
- Xia J
- Xia Y
- Xia Z-Y
- Xiao W
- Xiao W
- Xie G
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- Xie J
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- Xifara A
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- Xiong Y
- Xouplidis K
- Xu G-J
- Xu L
- Xu L
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- Xue R
- Yagnik A
- Yan Y
- Yang J
- Yang L
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- Yang T
- Yang Y
- Yao S
- Yao Y
- Yap HL
- Yarwood J
- Yassaee A
- Ye H
- Ye H
- Yegnaram S
- Yeh E
- Yin N
- Yip CP
- Yong J
- Yu HC
- Yu S
- Yu T
- Yu Y
- Yuan D
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- Yuan J
- Yuan Y
- Yuliana A
- Zaimi D
- Zakynthinos S
- Zamudio D
- Zangrillo A
- Zapata DDM
- Zbitnew G
- Zeidan L
- Zeng Q
- Zerman L
- Zettergren J
- Zhang B
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- Zhang H
- Zhang H
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- Zhang M
- Zhang Q
- Zhang R
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- Zhang X
- Zhang X
- Zhang X
- Zhang X
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Y
- Zhao B
- Zhao B
- Zhao C
- Zhao J
- Zhao J
- Zhao L
- Zhao L
- Zhao S
- Zhao T
- Zhao W
- Zhao W
- Zhao X
- Zhen J
- Zheng K
- Zheng L
- Zheng T
- Zhong Y
- Zhou C
- Zhou D
- Zhou H
- Zhou H
- Zhou J
- Zhou J
- Zhou J
- Zhou X-J
- Zhu X
- Zhu X
- Zhu Y
- Zhu Z
- Zhuang X
- Zilis G
- Zin NHM
- Zingerle N
- Zingg U
- Zoerner F
- Zonneveldt H
- Zou X
- Zoulamoglou M
- Zsisku L
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700
Exercise-induced Cardiac Troponin T Release in Veteran Athletes Recovered from COVID-19
- Author
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2022
- Field of study
A multi-center comparison of V2peak trainability between interval training and moderate intensity continuous training
- Author
- Anja Bye
- Anja Bye
- Brendon J. Gurd
- Camilla J. Williams
- Christopher M. Hearon
- David J. Bishop
- David J. Bishop
- Dorthe Stensvold
- Emeline M. Van Craenenbroeck
- Erin J. Howden
- Ilaria Croci
- Ilaria Croci
- Ioannis Papadimitriou
- Jacob T. Bonafiglia
- Jeff S. Coombes
- Jenna L. Taylor
- Jonathan P. Little
- Joyce S. Ramos
- Monique E. Francois
- Nele Pattyn
- Nicholas Harvey
- Nir Eynon
- Paul Beckers
- Robert G. Fassett
- Sarah Voisin
- Satyam Sarma
- Shelley E. Keating
- Sylvan L.J.E. Janssen
- Sylvan L.J.E. Janssen
- Trishan Gajanand
- Ulrik Wisloff
- Ulrik Wisloff
- Véronique A. Cornelissen
- Xu Yan
- Xu Yan
- Zhixiu Li
- Publication venue
- 'Frontiers Media SA'
- Publication date
- 01/01/2019
- Field of study
There is heterogeneity in the observed (V) over dotO(2peak) response to similar exercise training, and different exercise approaches produce variable degrees of exercise response (trainability). The aim of this study was to combine data from different laboratories to compare (V) over dotO(2peak) trainability between various volumes of interval training and Moderate Intensity Continuous Training (MICT). For interval training, volumes were classified by the duration of total interval time. High-volume High Intensity Interval Training (HIIT) included studies that had participants complete more than 15 min of high intensity efforts per session. Low-volume HIIT/Sprint Interval Training (SIT) included studies using less than 15 min of high intensity efforts per session. In total, 677 participants across 18 aerobic exercise training interventions from eight different universities in five countries were included in the analysis. Participants had completed 3 weeks or more of either high-volume HIIT (n = 299), low-volume HIIT/SIT (n = 116), or MICT (n = 262) and were predominately men (n = 495) with a mix of healthy, elderly and clinical populations. Each training intervention improved mean (V) over dotO(2peak) at the group level (P < 0.001). After adjusting for covariates, high-volume HIIT had a significantly greater (P < 0.05) absolute (V) over dotO(2peak) increase (0.29 L/min) compared to MICT (0.20 L/min) and low-volume HIIT/SIT (0.18 L/min). Adjusted relative(V) over dotO(2peak) increase was also significantly greater (P < 0.01) in high-volume HUT (3.3 ml/kg/min) than MICT (2.4 mVkg/min) and insignificantly greater (P = 0.09) than low-volume HIIT/SIT (2.5 mUkg/min). Based on a high threshold for a likely response (technical error of measurement plus the minimal clinically important difference), high-volume HIIT had significantly more (P < 0.01) likely responders (31%) compared to low-volume HIIT/SIT (16%) and MICT (21%). Covariates such as age, sex, the individual study, population group, sessions per week, study duration and the average between pre and post (V) over dotO(2peak) explained only 17.3% of the variance in (V) over dot O-2peak trainability. In conclusion, high-volume HIIT had more likely responders to improvements in (V) over dotO(2peak) compared to low-volume HIIT/SIT and MICT
A multi-center comparison of <tex>VO_{2}$</tex>peak trainability between interval training and moderate intensity continuous training
- Author
- Beckers Paul
- Bishop David J.
- Bonafiglia Jacob T.
- Bye Anja
- Comelissen Veronique A.
- Coombes Jeff S.
- Croci Ilaria
- Eynon Nir
- Fassett Robert G.
- Francois Monique E.
- Gajanand Trishan
- Gurd Brendon J.
- Harvey Nicholas
- Hearon Christopher M., Jr.
- Howden Erin J.
- Janssen Sylvan L. J. E.
- Keating Shelley E.
- Li Zhixiu
- Little Jonathan P.
- Papadimitriou Loannis
- Pattyn Nele
- Ramos Joyce S.
- Sarma Satyam
- Stensvold Dorthe
- Taylor Jenna L.
- van Craenenbroeck Emeline
- Voisin Sarah
- Williams Camilla J.
- Wisloff Ulrik
- Yan Xu
- Publication venue
- Publication date
- 01/01/2019
- Field of study
A Multi-Center Comparison of (V) over dotO(2peak) Trainability Between Interval Training and Moderate Intensity Continuous Training
- Author
- Beckers Paul
- Bishop David J
- Bonafiglia Jacob T
- Bye Anja
- Coombes Jeff S
- Cornelissen Veronique A
- Croci Ilaria
- Eynon Nir
- Fassett Robert G
- Francois Monique E
- Gajanand Trishan
- Gurd Brendon J
- Harvey Nicholas
- Hearon Christopher M
- Howden Erin J
- Janssen Sylvan LJE
- Keating Shelley E
- Li Zhixiu
- Little Jonathan P
- Papadimitriou Loannis
- Pattyn Nele
- Ramos Joyce S
- Sarma Satyam
- Stensvold Dorthe
- Taylor Jenna L
- Van Craenenbroeck Emeline M
- Voisin Sarah
- Williams Camilla J
- Wisloff Ulrik
- Yan Xu
- Publication venue
- 'Frontiers Media SA'
- Publication date
- 05/02/2019
- Field of study
There is heterogeneity in the observed O2peak response to similar exercise training, and different exercise approaches produce variable degrees of exercise response (trainability). The aim of this study was to combine data from different laboratories to compare O2peak trainability between various volumes of interval training and Moderate Intensity Continuous Training (MICT). For interval training, volumes were classified by the duration of total interval time. High-volume High Intensity Interval Training (HIIT) included studies that had participants complete more than 15 min of high intensity efforts per session. Low-volume HIIT/Sprint Interval Training (SIT) included studies using less than 15 min of high intensity efforts per session. In total, 677 participants across 18 aerobic exercise training interventions from eight different universities in five countries were included in the analysis. Participants had completed 3 weeks or more of either high-volume HIIT (n = 299), low-volume HIIT/SIT (n = 116), or MICT (n = 262) and were predominately men (n = 495) with a mix of healthy, elderly and clinical populations. Each training intervention improved mean O2peak at the group level (P < 0.001). After adjusting for covariates, high-volume HIIT had a significantly greater (P < 0.05) absolute O2peak increase (0.29 L/min) compared to MICT (0.20 L/min) and low-volume HIIT/SIT (0.18 L/min). Adjusted relative O2peak increase was also significantly greater (P < 0.01) in high-volume HIIT (3.3 ml/kg/min) than MICT (2.4 ml/kg/min) and insignificantly greater (P = 0.09) than low-volume HIIT/SIT (2.5 mL/kg/min). Based on a high threshold for a likely response (technical error of measurement plus the minimal clinically important difference), high-volume HIIT had significantly more (P < 0.01) likely responders (31%) compared to low-volume HIIT/SIT (16%) and MICT (21%). Covariates such as age, sex, the individual study, population group, sessions per week, study duration and the average between pre and post O2peak explained only 17.3% of the variance in O2peak trainability. In conclusion, high-volume HIIT had more likely responders to improvements in O2peak compared to low-volume HIIT/SIT and MICT.status: publishe
Genome wide association study of response to interval and continuous exercise training: the Predict-HIIT study
- Author
- Ashton Kevin J
- Beckers Paul
- Bishop David J
- Bonafiglia Jacob T
- Brown Matthew A
- Bye Anja
- Coombes Jeff S
- Cornelissen Véronique A
- Cox Emily R
- Croci Ilaria
- Eynon Nir
- Fassett Robert G
- Francois Monique E.
- Gajanand Trishan
- Griffiths Lyn R
- Gurd Brendon J
- Harvey Nicholas
- Haupt Larisa M
- Hearon Christopher M
- Howden Erin J
- Jacques Macsue
- Janssen Sylvan L J E
- Keating Shelley E
- Lea Rodney A
- Li Zhixiu
- Little Jonathan P.
- Papadimitriou Ioannis
- Ramos Joyce S
- Sarma Satyam
- Stensvold Dorthe
- Taylor Jenna L
- Torquati Luciana
- Van Craenenbroeck Emeline M
- Williams Camilla J
- Wisloff Ulrik
- Yan Xu
- Publication venue
- BioMed Central
- Publication date
- 01/01/2021
- Field of study
Background:
Low cardiorespiratory fitness (V̇O₂peak) is highly associated with chronic disease and mortality from all causes. Whilst exercise training is recommended in health guidelines to improve V̇O2peak, there is considerable inter-individual variability in the V̇O₂peak response to the same dose of exercise. Understanding how genetic factors contribute to V̇O₂peak training response may improve personalisation of exercise programs. The aim of this study was to identify genetic variants that are associated with the magnitude of V̇O₂peak response following exercise training.
Methods:
Participant change in objectively measured V̇O₂peak from 18 different interventions was obtained from a multi-centre study (Predict-HIIT). A genome-wide association study was completed (n = 507), and a polygenic predictor score (PPS) was developed using alleles from single nucleotide polymorphisms (SNPs) significantly associated (P < 1 × 10⁻⁵) with the magnitude of V̇O₂peak response. Findings were tested in an independent validation study (n = 39) and compared to previous research.
Results:
No variants at the genome-wide significance level were found after adjusting for key covariates (baseline V̇O₂peak, individual study, principal components which were significantly associated with the trait). A Quantile–Quantile plot indicates there was minor inflation in the study. Twelve novel loci showed a trend of association with V̇O₂peak response that reached suggestive significance (P 0.1). Significant correlations were found for beta coefficients of variants in the Predict-HIIT (P < 1 × 10⁻⁴) and the validation study (P < × 10⁻⁶), indicating that general effects of the loci exist, and that with a higher statistical power, more significant genetic associations may become apparent.
Conclusions:
Ongoing research and validation of current and previous findings is needed to determine if genetics does play a large role in V̇O₂peak response variance, and whether genomic predictors for V̇O2peak response trainability can inform evidence-based clinical practice.
Trial registration Australian New Zealand Clinical Trials Registry (ANZCTR), Trial Id: ACTRN12618000501246, Date Registered: 06/04/2018,
http://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=374601&isReview=true
.Health and Social Development, Faculty of (Okanagan)Non UBCHealth and Exercise Sciences, School of (Okanagan)ReviewedFacult
Kuluttajabarometri maakunnittain 2000, 2. neljännes
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- Ab Majid MA
- Ab Rahman AS
- Ab Rahman R
- Abayasinghe C
- Abbott T
- Abdullah NH
- Abdur-Rahman L
- Abeloos J
- Abernethy C
- Abidin UN
- Abrunhosa A
- Absar M
- Adam S
- Adams D
- Adams G
- Adamson M
- Adekola O
- Adelaja Y
- Ademola A
- Adenekan A
- Adenike O
- Adeolu AA
- Adetoye A
- Adewale B
- Adigun T
- Adolfsson A
- Aflori L
- Africander C
- Afshari A
- Agarwal V
- Agodirin O
- Aguero Vera M
- Aguzzoli C
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- Ahmed J
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- Aignatoaie M
- Aimoniotou-Georgiou E
- Akanmu O
- Akerman N
- Akinwale M
- Akring I
- Al 'Amri K
- Al Anizi M
- Al hussaini S
- Al-Soudaine Y
- Aladin H
- Alagbe-Briggs O
- Alaman Laguarda G
- Albaj S
- Alcock D
- Alcock L
- Aldecoa C
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- Aleixo FB
- Alexander H
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- Allsop J
- Almeida W
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- Alves MJ
- Amador JCB
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- Anagnou A
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- Asudo F
- Athanasakis E
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- Zamudio D
- Zangrillo A
- Zapata DDM
- Zbitnew G
- Zeidan L
- Zeng Q
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- Zoerner F
- Zonneveldt H
- Zou X
- Zoulamoglou M
- Zsisku L
- Publication venue
- Tilastokeskus
- Publication date
- 11/07/2000
- Field of study
Suomen virallinen tilasto (SVT
Use of failure-to-rescue to identify international variation in postoperative care in low-, middle- and high-income countries: a 7-day cohort study of elective surgery
- Author
- Ab Majid MA
- Ab Rahman AS
- Ab Rahman R
- Abayasinghe C
- Abbott T
- Abdullah NH
- Abdur-Rahman L
- Abeloos J
- Abernethy C
- Abidin UN
- Abrunhosa A
- Absar M
- Adam S
- Adams D
- Adams G
- Adamson M
- Adekola O
- Adelaja Y
- Ademola A
- Adenekan A
- Adenike O
- Adeolu AA
- Adetoye A
- Adewale B
- Adigun T
- Adolfsson A
- Aflori L
- Africander C
- Afshari A
- Agarwal V
- Agodirin O
- Aguero Vera M
- Aguzzoli C
- Ahmad A
- Ahmad N
- Ahmad T
- Ahmad T
- Ahmad Y
- Ahmed A
- Ahmed J
- Ai Y
- Aignatoaie M
- Aimoniotou-Georgiou E
- Akanmu O
- Akerman N
- Akinwale M
- Akring I
- Al 'Amri K
- Al Anizi M
- Al hussaini S
- Al-Soudaine Y
- Aladin H
- Alagbe-Briggs O
- Alaman Laguarda G
- Albaj S
- Alcock D
- Alcock L
- Aldecoa C
- Aldecoa C
- Aleixo FB
- Alexander H
- Alexander M
- Alexander-Sefre F
- Alherz F
- Ali H
- Ali M
- Ali S
- Alias A
- Alias AH
- Alias RLR
- Alit MA
- Allen S
- Allen SJ
- Allison J
- Alloj C
- Allorto NL
- Allsop J
- Almeida W
- Alonso E
- Alphonsus C
- Alvares D
- Alves MJ
- Amador JCB
- Ameer Y
- Amendola CP
- Ami N
- Amstrup-Hansen L
- Anagnou A
- Andersen C
- Anderson C
- Anderson C
- Anderson F
- Anderson P
- Andreadaki E
- Andreou A
- Andreou P
- Andrew A
- Andrews E
- Angermair S
- Angus K
- Anillo V
- Antal O
- Antill P
- Antoniadou E
- Antonina W
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- Apostolou K
- Applewhaite C
- Aquino LPG
- Ar P
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- Ardern D
- Argue R
- Arkalaki E
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- Arshad MA
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- Arustei M
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- Arya A
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- Asimakos A
- Asudo F
- Athanasakis E
- Atiku M
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- Attwood C
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- Avila Sanchez FJ
- Avila EJD
- Avis J
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- Ayyaz H
- Azam UAA
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- Aziz FZ
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- Bandeira ME
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- Bao Q
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- Chandrasekharan S
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- Chazova E
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- Cheeseman M
- Cheing Y
- Chen C
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- Yegnaram S
- Yeh E
- Yin N
- Yip CP
- Yong J
- Yu HC
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- Yu T
- Yu Y
- Yuan D
- Yuan F
- Yuan J
- Yuan J
- Yuan Y
- Yuliana A
- Zaimi D
- Zakynthinos S
- Zamudio D
- Zangrillo A
- Zapata DDM
- Zbitnew G
- Zeidan L
- Zeng Q
- Zerman L
- Zettergren J
- Zhang B
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- Zhang Q
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- Zhang X
- Zhang X
- Zhang X
- Zhang X
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Y
- Zhao B
- Zhao B
- Zhao C
- Zhao J
- Zhao J
- Zhao L
- Zhao L
- Zhao S
- Zhao T
- Zhao W
- Zhao W
- Zhao X
- Zhen J
- Zheng K
- Zheng L
- Zheng T
- Zhong Y
- Zhou C
- Zhou D
- Zhou H
- Zhou H
- Zhou J
- Zhou J
- Zhou J
- Zhou X-J
- Zhu X
- Zhu X
- Zhu Y
- Zhu Z
- Zhuang X
- Zilis G
- Zin NHM
- Zingerle N
- Zingg U
- Zoerner F
- Zonneveldt H
- Zou X
- Zoulamoglou M
- Zsisku L
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2017
- Field of study
This was an investigator-initiated study funded by Nestle Health Sciences through an unrestricted research grant and by a National Institute for Health Research (UK) Professorship held by R.P. The study was sponsored by Queen Mary University of London
Prospective observational cohort study on grading the severity of postoperative complications in global surgery research
- Author
- Abayasinghe Chamika
- Abbas Muntadhar
- Abbott T. E. F.
- Abbott Tom
- Abdullah Noor Hairiza
- Abdur-Rahman Lukman
- Abeloos Jacques
- Abernethy Caroline
- Abidin Ucu Nurhadiat
- Abrunhosa Alexandra
- Absar Mohammed
- Adam Suwayba
- Adams George
- Adamson Michael
- Adekola Oyebola
- Adelaja Yemi
- Ademola Adeyinka
- Adenekan Anthony
- Adenike Odewabi
- Adeolu Augustine A
- Adetoye Adedapo
- Adewale Badru
- Adigun Tinuola
- Adolfsson Anne
- Aflori Laura
- Africander Cucu
- Afshari Arash
- Agarwal Vandana
- Agodirin Olayide
- Aguzzoli Crisitiano
- Ahmad Abdurrahman
- Ahmad Norfaizan
- Ahmad T.
- Ahmad Tahania
- Ahmad Yousra
- Ahmed Ahmed
- Ahmed Jamil
- Ahmed Tahania
- Ai Yanqiu
- Aignatoaie Mariana
- Aimoniotou-Georgiou Eleni
- Akanmu Olanrewaju
- Akerman Nik
- Akinwale Mukaila
- Al Amri Khalid
- Al Hussaini Sabah
- Al-Soudaine Yassr
- Aladin Hafiz
- Alagbe-Briggs Olubusola
- Albaj Safauldeensalem
- Alcock David
- Alcock Liam
- Aldecoa Cesar
- Aldecoa Cesar
- Aleixo Fábia Berganton
- Alexander Hazel
- Alexander Maini
- Alexander-Sefre Farhad
- Alherz Fadhel
- Ali Hani
- Ali Marlynn
- Ali Sarah
- Alias Abdul Hafiz
- Alias Anita
- Alias Raja Liza Raja
- Allen Samantha
- Allen Sara Jane
- Allison Joanna
- Alloj Chiara
- Allorto Nikki Leigh
- Allsop Joanne
- Almeida William
- Alonso Eduardo
- Alonso José Ignacio
- Alphonsus Christella
- Alvares Danielle
- Alves Maria Joao
- Amador Juan Carlos Bravo
- Ameer Yusuf
- Amendola Cristina Prata
- Ami Noam
- Amstrup-Hansen Louise
- Anagnou Athina
- Andersen Cheme
- Anderson Charlotte
- Anderson Colette
- Anderson Frank
- Anderson Philip
- Andreadaki Evangelia
- Andreou Alexandros
- Andreou Prematie
- Andrew Alyson
- Andrews Emma
- Angel Miguel Paludi
- Angermair Stefan
- Angus Kirsty
- Anillo Victor
- Anizi Mashel Al
- Antal Oana
- Antill Philip
- Antoniadou Eleni
- Apagaki Eymorfia
- Apostolou Konstantinos
- Applewhaite Christopher
- Applewhaite Christopher
- Aquino Laura Patricia González
- Ar Praburaj
- Araujo Daniela Marques
- Arawwawala Dilshan
- Ardern Diane
- Argue Ruth
- Aribawa Mahaalit Alit
- Arkalaki Eleni
- Armaganidis Apostolos
- Armstrong John
- Armstrong Richard
- Arnaoutoglou Christina
- Arnaoutoglou Elena
- Arnold Glenn
- Arrandale Lindsay
- Arrich James
- Arrigo Mario
- Arshad Homa
- Arshad Mohammed Asif
- Artiles Tania Socorro
- Arumugam Swarna
- Arustei Mirela
- Arvaniti Kostoula
- Arvaniti Kostoula
- Arya Aryabiantara
- Arya Shobhit
- Asimakos Andreas
- Aslam M
- Asudo Felicia
- Athanasakis Elias
- Atiku Mamuda
- Attrill Elizabeth
- Attwood Clare
- Auer Patrick
- Avidan Michael
- Avila Erendira Jocelin Dominguez
- Avis Joanne
- Awad Hadi
- Axioti Elena
- Azam Ummi Azmira Ahmad
- Azambuja Pedro
- Azevedo Caroline
- Aziz Faizal Zuhri
- Baas Peter
- Baghirzada Leyla
- Bai Hui-Ping
- Baillie Shelley
- Baines Duncan
- Baio Thalissa Hermínia
- Bairaktari Aggeliki
- Baker Gerard
- Baker Katie-Anne
- Baker Paul
- Balain Birender
- Balajonda Naraida
- Balanescu Andreea
- Balasubramaniam Madhu
- Baldisserotto Sérgio
- Baldwin Jacqueline
- Baldwin Matthew
- Balfoussia Danai
- Bali Christina
- Bandeira Maria Expedito
- Banerjee Robin
- Bankewitz Carla
- Banner-Goodspeed Valerie
- Bao Qi
- Barcraft-Barnes Helena
- Barneto Lisa
- Barnett Andrew
- Barraclough James
- Barras Jean-Pierre
- Barrett Stephen
- Barrett Wendy Joan
- Basanth Sujith
- Batchelor Nick
- Bateman Brian
- Bates Alexander
- Bates Sarah
- Batista Hugo Dias
- Bauchmuller Kris
- Bauer Marlene
- Baumgarten Georg
- Baxter Linden
- Beaton Ceri
- Beattie Scott
- Beattie Scott
- Beattie Scott
- Beavis Vanessa
- Beavis Vanessa
- Bechan Sudha
- Beer Johan
- Bejia Tarek
- Belciu Ioana
- Belda Margarita Tormo
- Bell Gillian
- Bell Rachel
- Bell Rachel
- Bell Stephanie
- Bellandi Mattia
- Bello Jibril
- Beloeil Helene
- Belskiy Vladislav
- Beltran Anna Valle
- Ben-Menachem Erez
- Benavent Pau
- Benevento Angelo
- Bengeri Sheshagiri
- Bennett Cambell
- Bennett Michael
- Bennett Rachael
- Bennett Victoria
- Bentley Conor
- Beretta Luigi
- Berg Andrew
- Berg Bianca
- Bergin Colin
- Bernard Andre
- Bernard Andre
- Bernard Andre
- Bernat Maria Jose
- Berntsen Emer
- Berntsen Emer
- Bertram Wendy
- Bester Delia
- Bester Marlet
- Bettega Fernanda
- Bettinelli Alessandra
- Bhardwaj Neeraj
- Bhatia Kailash
- Bhula Chettan
- Bi Yanbing
- Biais M.
- Biais Matthieu
- Biais Matthieu
- Biccard Bruce
- Biccard Bruce M
- Bidd Heena
- Bidd Heena
- Bidgoli Jawad
- Biffen Andrew
- Bignami Elena
- Bilolikar Anjali
- Birch Julie
- Bishop David Gray
- Biyase Thuli
- Bizios Christol
- Blackwell Clare
- Blackwood Douglas
- Blaj Mihaela
- Blakemore Stephen P
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- De Bruyne Ann
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- De Kegel Dirk
- De Meyer Jenine N
- De Oliveira Mirella Cristine
- Deacon Matthew
- Deblaere Isabel
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- Deen Tariq
- Deepak Shantal
- Deighton Kerry
- Deja Maria
- Del Valle Santiago Garcia
- Delgado García David R
- Demartines Nicolas
- Dempsey Ged
- Dempster Angie
- Denham Samuel
- Dent Kathy
- Dermitzaki Despina
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- Du Fang
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- Dudgeon Lucy
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- Eggleston Christopher
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- Foord Denise
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- Futier E.
- Futier Emmanuel
- Futier Emmanuel
- Gaitanakis Stylianos
- Gall Lewis
- Gallacher Pete
- Gallard Sian
- Gallego Laura
- Gama N Sibusiso
- Gambhir Rajiv
- Ganter Donna Louise
- Ganter Michael T
- Gao Hong
- Garcia Carolina Soledad Romero
- Garcia Juliana
- Garcia-Saiz Irene
- García-Pérez Maria Luisa
- Gardikou Varvara Vanessa
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- Garg Atul
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- Giancarlo Luigi
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- Glover Lyn
- Goad Ehab Helmy Abdel
- Goebel Ulrich
- Goga Ismail E
- Goga Riaz
- Goldberg Olivia
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- Gondo Prisca
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- Granum Simon Nørgaard
- Graterol Juan
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- Gray Carol
- Gray Catherine
- Gray Sophie
- Greaves K. E.
- Greaves Rosanna
- Green Garyth M
- Green-Thompson Randolph
- Greene Michael
- Gregory Peter
- Grey Ben
- Griffiths Ewen
- Grigoras Ioana
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- Grintescu Ioana
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- Grubmueller Karl Gernot
- Gudaca Mariethel
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- Guttenthaler Vera
- Guy Kramer
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- Habicher Marit
- Hack Yvonne
- Haddow J.
- Haddow James
- Hadebe Bernard
- Hadfield Daniel
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- Hamilton Caroline
- Hamzah Zulkarnain
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- Harden Catherine
- Hare Gregory
- Hariharan Vimal
- Harrichandparsad R
- Harries Rhiannon
- Harris Benjamin
- Harris Clair
- Harris James
- Harris Meredyth
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- Harsan Cristian Remus
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- Haselberger Simone
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- Hedin Annika
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- Helmy Naeder
- Hennings Charles
- Hering Jens Peter
- Hernandez Carlos B
- Hernandez Miguel
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- Hesketh Sue
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- Hewson Russell
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- Hicks Catherine
- Hidayatullah Rahmat
- Hiesmayr Michael
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- Hinther Ashley
- Hinther Ashley
- Hinxman Honor
- Hitchcock Rachael
- Hoare Siobhan
- Hobrok Maria
- Hodgkiss Tracey
- Hodgson Richard E
- Hodzovic Emil
- Hoedt Marielle
- Hoeft Andreas
- Hoeft Andreas
- Hofer Christoph
- Hofer Christoph
- Hoffer Franz
- Hoffmann João
- Holaubek Caroline
- Holden Douglas
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- Hopkins Thomas
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- Hosdurga Gurunath
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- Houston Kendra
- Houweling Peter
- Hove Mazvangu Onie
- Hovendal Claus
- Hu Liu
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- Hubner Martin
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- Hulme Jonathan
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- Hunt Jane
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- Hutchings Melanie
- Hutchins David
- Hutton Monica
- Huygens Christel
- Huynh Wilson Binh Quan
- Hwan Haifang
- Härtl Christine
- Hübner Martin
- Hüppe Michael
- Iasonidou Christina
- Idowu Olusola
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- Iloabachie Ikechukwu
- Ilyina Yana
- Incertis Raul
- Indra Imai
- Ioannidis Orestis
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- Ionita Victor
- Iosep Gabriel Florin
- Ip Peter
- Irshad Mariam
- Ischaki Eleni
- Ishimaru Alexander
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- Jacobs Tom
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- Jain Megha
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- Jammer Ib
- Jansen Tracy-Lee
- Janssen Bruno
- Januszewska Marta
- Januszewska Marta
- Jaquet Yves
- Jardim Jaquelline
- Jawad Monir
- Jee Chiun Chen
- Jeeraz Mohammud A
- Jeffery Holly
- Jeffs Carol
- Jehosua Brillyan
- Jelschen Florian
- Jemmett Kim
- Jemna Ramona
- Jenkins Nia
- Jenkins Nicole
- Jensen-Gadegaard Peter
- Jesus Joana Sofia Teixeira
- Jeyanthan Somasundaram
- Ji Binbin
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- Jones Timothy
- Joory Kavita
- Jordaan J
- Joseph James
- Jowitt Tom
- Juj Joanne
- Julian Howes
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- Kaunang Jonathan
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- Keenan Samantha
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- Kirov Mikhail
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- Klarin Bengt
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- Kotsalas Nikolaos
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- Kowalski Stephen
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- Krystopchuk Andriy
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- Kurnia Andri
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- Kwok Andy
- Kwok Dilys
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- Kyomugisha Edward
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- Ladha Karim
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- Legashov Kirill
- Legaspi Regina
- Legouge Marie Lim
- Legutko Dagmara A
- Lehur Paul
- Lei Min
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- Lena Arian
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- Lilitsis Emmanouhl
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- Liu Yi
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- Walder Bernhard
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- Wang Jin
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- Wang Leilei
- Wang Li
- Wang Lijun
- Wang Sheng
- Wang Shenhui
- Wang Shun
- Wang Tianlong
- Wang Weixing
- Wang Xiu-Li
- Wang Yuelan
- Wang Yuting
- Wang Zhen
- Wang Zhen
- Wang Zhi
- Wang Zhipeng
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- Wasmund Christina
- Wassall Richard
- Watson Anthony
- Watson Nicholas
- Watt Philip
- Waugh Darren
- Waweru Peter
- Waworuntu Neil
- Waymouth Ellen
- Weatherall Lucie
- Weatherill J
- Webb Stephen
- Weber Eric
- Webombesa Antonina
- Wei Jianfeng
- Weimann Joerg
- Weller Debbie
- Welsh Sarah
- Wen Xiao Hong
- Wen Yazhou
- Wen Zhiting
- Wendling Paulo Rafael
- Weng Cheng Wong
- Wessels Joseph D
- Wet Jacques
- Wetzel Peter
- Weyland Andreas
- White Steve
- White Stuart
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- Whittle Nicola
- Whitworth Helen
- Whysall Karen
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- Wickenhauser Reinhart
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- Wijeysundera Duminda
- Wijeysundera Duminda
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- Woolsey Adrianna
- Woolsey Adrianna
- Woon Yuan Liang
- Worreth Marc
- Wouters Patrick
- Wouters Patrick
- Wrench Ian
- Wright Sally
- Wu Chao
- Wu Chi
- Wu Jie
- Wu Jie
- Wu Qiong
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- Xiong Xiapei
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- Xu Guan-Jie
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- Yagnik Anmol
- Yan Yixiu
- Yang Jian
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- Yang Tianqin
- Yang Yang
- Yao Shanglong
- Yao Yurui
- Yap Huey Ling
- Yarwood Jamie
- Yassaee Arrash
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- Ye Hui
- Yegnaram Shashikant
- Yeh Erlinda
- Yin Ning
- Yip Chi Pang
- Yong Johnny
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- Yun Bai
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- Zamudio Diana
- Zangrillo Alberto
- Zapata Darcy Danitza Mari
- Zbitnew Geoff
- Zeggeren Laura
- Zeidan Lisa
- Zeng Qiuting
- Zettergren Jan
- Zhang Baoling
- Zhang Enman
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- Zhang Huan
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- Zhang Yan
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- Zhang Ye
- Zhang Yuan
- Zhao Bing
- Zhao Bo
- Zhao Chong
- Zhao Jiashi
- Zhao Jinning
- Zhao Lei
- Zhao Shuna
- Zhao Ting
- Zhao Weihong
- Zhao Weilu
- Zhao Xiaoying
- Zhen Jungang
- Zheng Kang
- Zheng Lina
- Zheng Tianzhao
- Zhong Yi
- Zhou Ce
- Zhou Dachun
- Zhou Haidong
- Zhou Haiyan
- Zhou Jiali
- Zhou Jialong
- Zhou Jing
- Zhou Xian-jin
- Zhu Xiaomao
- Zhu Yi
- Zhu Zhipeng
- Zhuang Xiuxiu
- Zilis Georgios
- Zin Nor Hafizah Mohd
- Zingerle Nicolette
- Zingg Urs
- Zoerner Frank
- Zonneveldt Harry
- Zou Xiaohua
- Zoulamoglou Menelaos
- Zsisku Lajos
- Zundert Tom
- Zyl Rebekka
- åkring Irene
- Ögren Katrin
- Publication venue
- 'Wiley'
- Publication date
- 22/10/2018
- Field of study
Background
The Clavien–Dindo classification is perhaps the most widely used approach for reporting postoperative complications in clinical trials. This system classifies complication severity by the treatment provided. However, it is unclear whether the Clavien–Dindo system can be used internationally in studies across differing healthcare systems in high- (HICs) and low- and middle-income countries (LMICs).
Methods
This was a secondary analysis of the International Surgical Outcomes Study (ISOS), a prospective observational cohort study of elective surgery in adults. Data collection occurred over a 7-day period. Severity of complications was graded using Clavien–Dindo and the simpler ISOS grading (mild, moderate or severe, based on guided investigator judgement). Severity grading was compared using the intraclass correlation coefficient (ICC). Data are presented as frequencies and ICC values (with 95 per cent c.i.). The analysis was stratified by income status of the country, comparing HICs with LMICs.
Results
A total of 44 814 patients were recruited from 474 hospitals in 27 countries (19 HICs and 8 LMICs). Some 7508 patients (16·8 per cent) experienced at least one postoperative complication, equivalent to 11 664 complications in total. Using the ISOS classification, 5504 of 11 664 complications (47·2 per cent) were graded as mild, 4244 (36·4 per cent) as moderate and 1916 (16·4 per cent) as severe. Using Clavien–Dindo, 6781 of 11 664 complications (58·1 per cent) were graded as I or II, 1740 (14·9 per cent) as III, 2408 (20·6 per cent) as IV and 735 (6·3 per cent) as V. Agreement between classification systems was poor overall (ICC 0·41, 95 per cent c.i. 0·20 to 0·55), and in LMICs (ICC 0·23, 0·05 to 0·38) and HICs (ICC 0·46, 0·25 to 0·59).
Conclusion
Caution is recommended when using a treatment approach to grade complications in global surgery studies, as this may introduce bias unintentionally