10 research outputs found
SU 1,4 as a dynamical group for the mesons: Analysis of all the discrete representations
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Selective antitumour activity and ER[alpha] molecular docking studies of newly synthesized d-homo fused steroidal tetrazoles
- Author
- Publication venue
- 'Royal Society of Chemistry (RSC)'
- Publication date
- 01/12/2017
- Field of study
Changes in levels of serotonine and bradykininogene and oxidase activity of ceruloplasmine in simulated infectious-allergic (rheumatic) encephalitis in dogs
- Author
- A. L. Scherbel
- A. P. Corrado
- Bozhko Bozhkov
- C. J. Smyth
- C. R. Diniz
- G. Bendixen
- G. L. Asherson
- G. Ungar
- H. A. Ravin
- I. B. Tichomirov
- J. Jakimov
- J. Lecomte
- J. Monard
- J. P. Girard
- J. R. Vane
- J.-L. Parrot
- J.-L. Parrot
- Jakim Jakimov
- L. Thomas
- M. Saragea
- N. I. Undrizov
- S. Pissarev
- T. M. Rivers
- W. Feldberg
- W. Feldberg
- W. T. Beraldo
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Synthesis and anticancer cell potential of steroidal 16,17-seco-16,17a-dinitriles: Identification of a selective inhibitor of hormone-independent breast cancer cells
- Author
- Ajduković
- Altomare
- Anderson
- Andjelka S. Ćelić
- Andrea R. Nikolić
- Bines
- Brozic
- Chumsri
- David-Beabes
- DeVore
- Dimitar S. Jakimov
- Djurendić
- Djurendić
- Edward T. Petri
- Endo
- Ertl
- Evgenija A. Djurendić
- Farrugia
- Fleming
- Folkerd
- Ghosh
- Gong
- Gruvberger-Saal
- Gupta
- Hanwell
- Jordan
- Katarina M. Penov Gaši
- Lavecchia
- Law
- Leese
- Manas
- Marcos-Escribano
- Marija N. Sakač
- Maurelli
- Morris
- Olivera R. Klisurić
- Patani
- Pedretti
- Penning
- Pereira de Jesus-Tran
- Ren
- Sakač
- Schiavon
- Siegfried
- Skliris
- Tanenbaum
- Teno
- Thomas
- Valachis
- Vis
- Vis
- Wang
- Wishart
- Wolf
- Woo
- Yadav
- Ziauddin
- Zoppi
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
New oxygen-containing androstane derivatives: Synthesis and biological potential
- Author
- A Daina
- A Kasal
- A Segaloff
- AK Ghose
- AS Abdel-Razek
- CA Lipinski
- DF Veber
- Dimitar S Jakimov
- Dušan Đ Škorić
- E Djurendić
- EA Djurendić
- EA Djurendić
- Evgenija A Djurendić
- FA Larik
- GA Potter
- I Muegge
- Ivana Z Kuzminac
- JFS Carvalho
- JFS Carvalho
- JFS Carvalho
- K David
- L Misra
- L Rárová
- Lucie Rárová
- M Beato
- M Garrido
- M Todorov
- Marija N Sakač
- Marina P Savić
- MMDS Cepa
- MP Savić
- MP Savić
- MP Savić
- MR Nathan
- NT Shahidi
- P Ghosh
- P Joshi
- RE Parker
- S Naz
- T Mosmann
- W Chen
- W Zhang
- W-Y Chen
- WJ Egan
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Hydrogen-Bonding Interactions in Peptide Nucleic Acid and Deoxyribonucleic Acid: A Comparative Study
- Author
- Arora N.
- Asensio A.
- Barone V.
- Becke A. D.
- Berman
- Cances E.
- Cossi M.
- Demers D. B.
- Dueholm K. L.
- Egholm M.
- Egholm M.
- Egholm M.
- Egholm M.
- Egholm M.
- Faruqi A. F.
- Frisch M. J.
- Gorb L.
- Griffin T. J.
- Grzeskowiak K.
- Guerra C. F.
- Gurlie R.
- Gurlie R.
- Hariharan P. C.
- Hariharan P. C.
- Hasegawa K.
- Hobza P.
- Hyrup B.
- Jakimov D.
- Kawahara S.
- Kawahara S.
- Lammertsma K.
- Lee C. T.
- Leijon M.
- Li H.
- Lukeman P. S.
- Mennucci B.
- Mennucci B.
- Nielsen P. E.
- Nielsen P. E.
- Nielsen P. E.
- Nielsen P. E.
- Olah G. A.
- Rasmussen H.
- Ray A.
- Rega N.
- Richardson N. A.
- Richardson N. A.
- Schneider B.
- Schneider B.
- Seeman N. C.
- Seeman N. C.
- Seeman N. C.
- Seeman N. C.
- Seeman N. C.
- Sponer J.
- Sponer J.
- Sponer J.
- Sponer J.
- Sponer J.
- Sponer J.
- Sponer J.
- Sponer J.
- Sponer J.
- Sponer J.
- Sponer J.
- Sponer J.
- Sponer J.
- Subirana J. A.
- Takano Y.
- Tomac S.
- Tomasi J.
- Varnai P.
- Wesolowski S. S.
- Wittung P.
- Yanson I. K.
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
Lipoprotein(a) and Benefit of PCSK9 Inhibition in Patients With Nominally Controlled LDL Cholesterol
- Author
- Abbas J.
- Abbate A.
- Abdallah M.
- Abdullakutty J.
- Abdullkutty J.
- Abhyanakar A. D.
- Aboyans V.
- Abrantes J. A. M.
- Abu-Fadel M.
- Accini Mendoza J. L.
- Acevedo M.
- Adamkova V.
- Adamo A.
- Adhyapak S.
- Agarwal H.
- Aggarwal R.
- Aggarwal R. K.
- Aguirre A.
- Ahmed H.
- Ahremark U.
- Ahuad Guerrero R. A.
- Aidar Ayoub J. C.
- Aitken D.
- Akatova E.
- Akhter F.
- Ako J.
- Akright L.
- Akyea-Djamson A.
- Al Joundi T.
- Al-Windy N. Y. Y.
- Alan D.
- Albert S.
- Alcocer Gamba M. A.
- Alexander J. H.
- Alexander K.
- Alexandru T. M.
- Alings M.
- Alonso A.
- Alonso Martin J. J.
- Alsweiler C.
- Alvarisqueta A. F.
- Alves De Lima A. E.
- Amarasekera S.
- Amarasena N.
- Amidon T.
- Amir O.
- Amlani M.
- Amosova E.
- Amuchastegui M.
- Anchante Hernandez H. A.
- Andersen D.
- Andersen K.
- Andersen R.
- Anderson J.
- Ando K.
- Annam S.
- Anscombe R.
- Antonio Llamas Esperon G.
- Apostolovic S. R.
- Appel K. -F.
- Arambula R. S.
- Arandjelovic A.
- Araneda G.
- Arango Benecke J. L.
- Arbel Y.
- Arif I.
- Armaganijan L.
- Aroca C. C.
- Aroney C.
- Arstall M. A.
- Asanin M. R.
- Asita de Silva H.
- Assi N.
- Atar S.
- Athyros V.
- Auguadro C.
- Ayaz M.
- Aylward P. E.
- Azizad M. M.
- Babic Z.
- Badreddine E.
- Bagai A.
- Bagriy A.
- Bahit M. C.
- Bai F.
- Baldari D.
- Balinovac J.
- Ball E.
- Bang L. E.
- Banuru S.
- Barakovic F.
- Baranov E.
- Baranova E.
- Barbarash O. L.
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- Barr C.
- Barraud P.
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- Bartels G. L.
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- Bayat J.
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Background: Guidelines recommend nonstatin lipid-lowering agents in patients at very high risk for major adverse cardiovascular events (MACE) if low-density lipoprotein cholesterol (LDL-C) remains ≥70 mg/dL on maximum tolerated statin treatment. It is uncertain if this approach benefits patients with LDL-C near 70 mg/dL. Lipoprotein(a) levels may influence residual risk. Objectives: In a post hoc analysis of the ODYSSEY Outcomes (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) trial, the authors evaluated the benefit of adding the proprotein subtilisin/kexin type 9 inhibitor alirocumab to optimized statin treatment in patients with LDL-C levels near 70 mg/dL. Effects were evaluated according to concurrent lipoprotein(a) levels. Methods: ODYSSEY Outcomes compared alirocumab with placebo in 18,924 patients with recent acute coronary syndromes receiving optimized statin treatment. In 4,351 patients (23.0%), screening or randomization LDL-C was 13.7 mg/dL or ≤13.7 mg/dL; corresponding adjusted treatment hazard ratios were 0.82 (95% CI: 0.72-0.92) and 0.89 (95% CI: 0.75-1.06), with Pinteraction = 0.43. Conclusions: In patients with recent acute coronary syndromes and LDL-C near 70 mg/dL on optimized statin therapy, proprotein subtilisin/kexin type 9 inhibition provides incremental clinical benefit only when lipoprotein(a) concentration is at least mildly elevated. (ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab; NCT01663402
Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial
- Author
- Abbas J.
- Abbate A.
- Abdallah M.
- Abdullakutty J.
- Abhyanakar A. D.
- Aboyans V.
- Abrantes J. A. M.
- Abu-Fadel M.
- Accini Mendoza J. L.
- Acevedo M.
- Adamkova V.
- Adamo A.
- Adhyapak S.
- Agarwal H.
- Agergaard Jensen S.
- Aggarwal R.
- Aggarwal R. K.
- Agnetti V.
- Aguirre A.
- Ahmed H.
- Ahremark U.
- Ahuad Guerrero R. A.
- Airaksinen J.
- Aitken D.
- Akatova E.
- Akhter F.
- Ako J.
- Akright L.
- Akyea-Djamson A.
- Al Joundi T.
- Al-Windy N. Y.
- Alan D.
- Albert S.
- Alcocer Gamba M. A.
- Alexander J. H.
- Alexander K.
- Alexandru T. M.
- Alexopoulos D.
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- Zweiker R.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
Background: After acute coronary syndrome, diabetes conveys an excess risk of ischaemic cardiovascular events. A reduction in mean LDL cholesterol to 1·4–1·8 mmol/L with ezetimibe or statins reduces cardiovascular events in patients with an acute coronary syndrome and diabetes. However, the efficacy and safety of further reduction in LDL cholesterol with an inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) after acute coronary syndrome is unknown. We aimed to explore this issue in a prespecified analysis of the ODYSSEY OUTCOMES trial of the PCSK9 inhibitor alirocumab, assessing its effects on cardiovascular outcomes by baseline glycaemic status, while also assessing its effects on glycaemic measures including risk of new-onset diabetes. Methods: ODYSSEY OUTCOMES was a randomised, double-blind, placebo-controlled trial, done at 1315 sites in 57 countries, that compared alirocumab with placebo in patients who had been admitted to hospital with an acute coronary syndrome (myocardial infarction or unstable angina) 1–12 months before randomisation and who had raised concentrations of atherogenic lipoproteins despite use of high-intensity statins. Patients were randomly assigned (1:1) to receive alirocumab or placebo every 2 weeks; randomisation was stratified by country and was done centrally with an interactive voice-response or web-response system. Alirocumab was titrated to target LDL cholesterol concentrations of 0·65–1·30 mmol/L. In this prespecified analysis, we investigated the effect of alirocumab on cardiovascular events by glycaemic status at baseline (diabetes, prediabetes, or normoglycaemia)—defined on the basis of patient history, review of medical records, or baseline HbA1c or fasting serum glucose—and risk of new-onset diabetes among those without diabetes at baseline. The primary endpoint was a composite of death from coronary heart disease, non-fatal myocardial infarction, fatal or non-fatal ischaemic stroke, or unstable angina requiring hospital admission. ODYSSEY OUTCOMES is registered with ClinicalTrials.gov, number NCT01663402. Findings: At study baseline, 5444 patients (28·8%) had diabetes, 8246 (43·6%) had prediabetes, and 5234 (27·7%) had normoglycaemia. There were no significant differences across glycaemic categories in median LDL cholesterol at baseline (2·20–2·28 mmol/L), after 4 months' treatment with alirocumab (0·80 mmol/L), or after 4 months' treatment with placebo (2·25–2·28 mmol/L). In the placebo group, the incidence of the primary endpoint over a median of 2·8 years was greater in patients with diabetes (16·4%) than in those with prediabetes (9·2%) or normoglycaemia (8·5%); hazard ratio (HR) for diabetes versus normoglycaemia 2·09 (95% CI 1·78–2·46, p<0·0001) and for diabetes versus prediabetes 1·90 (1·65–2·17, p<0·0001). Alirocumab resulted in similar relative reductions in the incidence of the primary endpoint in each glycaemic category, but a greater absolute reduction in the incidence of the primary endpoint in patients with diabetes (2·3%, 95% CI 0·4 to 4·2) than in those with prediabetes (1·2%, 0·0 to 2·4) or normoglycaemia (1·2%, −0·3 to 2·7; absolute risk reduction pinteraction=0·0019). Among patients without diabetes at baseline, 676 (10·1%) developed diabetes in the placebo group, compared with 648 (9·6%) in the alirocumab group; alirocumab did not increase the risk of new-onset diabetes (HR 1·00, 95% CI 0·89–1·11). HRs were 0·97 (95% CI 0·87–1·09) for patients with prediabetes and 1·30 (95% CI 0·93–1·81) for those with normoglycaemia (pinteraction=0·11). Interpretation: After a recent acute coronary syndrome, alirocumab treatment targeting an LDL cholesterol concentration of 0·65–1·30 mmol/L produced about twice the absolute reduction in cardiovascular events among patients with diabetes as in those without diabetes. Alirocumab treatment did not increase the risk of new-onset diabetes. Funding: Sanofi and Regeneron Pharmaceuticals
Apolipoprotein B, Residual Cardiovascular Risk After Acute Coronary Syndrome, and Effects of Alirocumab.
- Author
- Abbas Jalal
- Abbate Antonio
- Abdallah mouhamad
- Abdullakutty Jabir
- Abdullkutty Jabir
- Abhyanakar Atul D
- Aboyans Victor
- Abrantes José Antonio M
- Abu-Fadel Mazen
- Accini Mendoza Jose L
- Acevedo Monica
- Adamkova Vera
- Adamo Antony
- Adhyapak Srilakshmi
- Agarwal Himanshu
- Aggarwal Rahul
- Aggarwal Rajesh K
- Agnetti Veronique
- Aguirre Arnoldo
- Ahmed Hinan
- Ahremark Ulf
- Ahuad Guerrero Rodolfo A
- Aidar Ayoub José Carlos
- Airaksinen Juhani
- Aitken Denise
- Akatova Evgenia
- Akhter Faiq
- Ako Junya
- Akright Laura
- Akyea-Djamson Ayim
- Al Joundi Tammam
- Al-Windy Nadea YY
- Alan David
- Albert Seals
- Alcocer Gamba Marco Antonio
- Alexander John H.
- Alexander Karen
- Alexandru Tom M
- Alings Marco
- Alings Marco
- Alonso Martin Joaquin J
- Alonso Alvaro
- Alsweiler Caroline
- Alvarisqueta Andrés F
- Alves De Lima Alberto E
- Amarasekera Stanley
- Amarasena Naomali
- Amidon Thomas
- Amir Offer
- Amlani Mohamadali
- Amosova Ekaterina
- Amuchastegui Marcos
- Anchante Hernandez Henry A
- Andersen Dorthe
- Andersen Kjell
- Andersen Rolf
- Anderson Jay
- Anderson Jay
- Ando Kenji
- Annam Sharath
- Anscombe Russell
- Apostolovic Svetlana R.
- Appel Karl-Friedrich
- Arambula Rafael Suarez
- Arandjelovic Aleksandra
- Araneda Guillermo
- Arango Benecke Juan L
- Arbel Yaron
- Arif Imran
- Armaganijan Luciana
- Aroca Carlos Cotes
- Aroney Constantine
- Arstall Margaret A
- Asanin Milika R.
- Assi Nizar
- Aswegen Dina Van
- Atar Shaul
- Athyros Vasilios
- Auguadro Carla
- Ayaz Mohammad
- Aylward Philip E
- Aylward Philip E
- Aylward Philip E
- Aylward Philip E
- Azizad Masoud M
- Babić Zdravko
- Badreddine Emmy
- Bagai Akshay
- Bagriy Andriy
- Bahit Maria Cecilia
- Bai Feng
- Baldari Duccio
- Balinovac Jovan
- Ball Eric
- Ball Eric
- Bang Lia E
- Banuru Sridhar
- Barakovic Fahir
- Baranov Evgeny
- Baranova Elena
- Barbarash Olga L
- Barbato Emanuele
- Barna Olga M
- Barone-Rochette Gilles
- Barr Craig
- Barraud Pauline
- Barrera Silva Sandra I
- Barrucco Robert
- Bartels Gerard L
- Basart Dirk
- Bashir Riyaz
- Bata Iqbal
- Batushkin Valeriy
- Bayat Junaid
- Bayram Llamas Edmundo Alfredo
- Bayron Carlos
- Beauloye Christophe
- Bednarski Janusz
- Behrens Steffen
- Bejuit Raphael
- Bekkouche Mhamed
- Belhassane Abdelkader
- Beltran Pascale
- Benbernou Fadela
- Benedicto Amparo
- Bengrait Nafissa
- Bengston James
- Bengus Cristina M
- Benov Haralambi O
- Berdan Lisa
- Berger Rudolf
- Berglund Stefan
- Berk Martin
- Berland Jacques
- Berli Mario A
- Berlowitz Michael
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- Bernan Alisa
- Berthou Christelle
- Berti Sergio
- Bezault Madeleine
- Bhagwat Ajit
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- Bhatt Deepak L.
- Bhatt Deepak L.
- Binde Ronald
- Birchem Jessica
- Bittner Vera A.
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- Blanquicett Marco
- Blicharski Tomasz
- Blok Thomas
- Blonder Ronald
- Blumberg Eduardo DS
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- Bokern Marcel JJA
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- Borger-Van Der Burg Alida
- Borse Rohidas
- Bortnick Anna
- Bos Robert J
- Botelho Ana
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- Bouancheau Cecile
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- Bourgeois Ronald
- Brabham David
- Braganza Denise
- Braun- Dullaeus Rüdiger
- Bravo Mannucci Jorge E
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- Brennan J. Matthew
- Brigui Imane
- Brocklehurst Maddy
- Brodison Adrian
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- Budaj Andrzej
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- Busmane Arija
- Bustamante Labarta Miguel H
- Busz-Papiez Benita
- Butler Rob
- Butters Julie
- Bystryk Leszek
- Böcker Dirk
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- Caccavo Alberto
- Caetano Francisca
- Caime Guillermo D
- Calabrò Paolo
- Calderon Ticona Jorge R
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- Cambier Patrick
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- Chalavarya Gopal
- Chaleff Fred
- Chandna Harish
- Chane Majed
- Chang Mark
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- Kozuma Ken
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- Krawczyk Justine
- Krichmar Perry
- Kristensen Kjeld S
- Kristjan Arved
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- Laufs Ulrich
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- Leung Raymond
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- Li Ying
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- Liberman Alberto
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- Libov Igor
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- Liu Ming-En
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- Matei Adrian V
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- Peng Daoquan
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- Pereira Edward
- Pereira Helder H
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- Pesant Yves
- Petranov Stanislav L
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- Piatti Piermarco
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- Picone Mark
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- Vulic Dusko
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- Waisman Gabriel D
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- Wozniak Julianna
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- Wu Chun
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- Xenakis Mark
- Xiang Meixiang
- Xu Biao
- Xu Dingli
- Xu Xiping
- Xu Yizhou
- Yagensky Andriy
- Yakushin Sergey
- Yan Bryan PY
- Yang Eric
- Yang Xiangjun
- Yang Xinchun
- Yao Zhuhua
- Yazdani Shahram
- Yañez Mario
- Yee Ong Hean
- Yin Wei-Hsian
- Yong Huo
- Yoon Jung Han
- Younis Liwa
- Yu Yihua
- Yuan Zuyi
- Yusoff Khalid
- Yusoff Khalid
- Zahger Doron
- Zahr Firas
- Zaidman Cesar J
- Zainea Mark
- Zaman Azfar
- Zamorano Jose Luis
- Zapata Gerardo
- Zea Nunez Carlos A
- Zeiher Andreas M.
- Zeiher Andreas M.
- Zhang Ruiyan
- Zhang Wenwu
- Zhang Xuelian
- Zhang Zheng
- Zhao Shuiping
- Zhao Xingsheng
- Zheleznyy Volodymyr
- Zheng Yang
- Zheng Zeqi
- Zhong Yi
- Zhou Yujie
- Zhu Hong
- Zhu Jianhua
- Zirlik Andreas
- Zizka Jiri
- Zobouyan Isabelle
- Zong Wenxia
- Zrazhevsky Konstantin
- Zukermann Robert
- Zurakowski Aleksander
- Zvi Vered
- Zwart Peter
- Zweiker Robert
- Édes István
- Šikić Jozica
- Štambuk Kresimir
- Šuligoj Nataša Černič
- Žuran Ivan
- Publication venue
- American Heart Association
- Publication date
- 30/08/2022
- Field of study
Background: Apolipoprotein B (apoB) provides an integrated measure of atherogenic risk. Whether apoB levels and apoB lowering hold incremental predictive information on residual risk after acute coronary syndrome beyond that provided by low-density lipoprotein cholesterol is uncertain. Methods: The ODYSSEY OUTCOMES trial (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) compared the proprotein convertase subtilisin/kexin type 9 inhibitor alirocumab with placebo in 18 924 patients with recent acute coronary syndrome and elevated atherogenic lipoproteins despite optimized statin therapy. Primary outcome was major adverse cardiovascular events (MACE; coronary heart disease death, nonfatal myocardial infarction, fatal/nonfatal ischemic stroke, hospitalization for unstable angina). Associations between baseline apoB or apoB at 4 months and MACE were assessed in adjusted Cox proportional hazards and propensity score–matched models. Results: Median follow-up was 2.8 years. In proportional hazards analysis in the placebo group, MACE incidence increased across increasing baseline apoB strata (3.2 [95% CI, 2.9–3.6], 4.0 [95% CI, 3.6–4.5], and 5.5 [95% CI, 5.0–6.1] events per 100 patient-years in strata 35–<50, and ≤35 mg/dL, respectively). Compared with propensity score–matched patients from the placebo group, treatment hazard ratios for alirocumab also decreased monotonically across achieved apoB strata. Achieved apoB was predictive of MACE after adjustment for achieved low-density lipoprotein cholesterol or non–high-density lipoprotein cholesterol but not vice versa. Conclusions: In patients with recent acute coronary syndrome and elevated atherogenic lipoproteins, MACE increased across baseline apoB strata. Alirocumab reduced MACE across all strata of baseline apoB, with larger absolute reductions in patients with higher baseline levels. Lower achieved apoB was associated with lower risk of MACE, even after accounting for achieved low-density lipoprotein cholesterol or non–high-density lipoprotein cholesterol, indicating that apoB provides incremental information. Achievement of apoB levels as low as ≤35 mg/dL may reduce lipoprotein-attributable residual risk after acute coronary syndrome. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT01663402.gov; Unique identifier: NCT01663402.URL: https://www
Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial
- Author
- Abbas Jalal
- Abbate Antonio
- Abdallah Mouhamad
- Abdullakutty Jabir
- Abhyanakar Atul D
- Aboyans Victor
- Abrantes José Antonio M
- Abu-Fadel Mazen
- Accini Mendoza Jose L
- Acevedo Monica
- Adamkova Vera
- Adamo Antony
- Adhyapak Srilakshmi
- Agarwal Himanshu
- Agergaard Jensen Steen
- Aggarwal Rahul
- Aggarwal Rajesh K
- Agnetti Veronique
- Aguirre Arnoldo
- Ahmed Hinan
- Ahremark Ulf
- Ahuad Guerrero Rodolfo A.
- Airaksinen Juhani
- Aitken Denise
- Akatova Evgenia
- Akhter Faiq
- Ako Junya
- Akright Laura
- Akyea-Djamson Ayim
- Al Joundi Tammam
- Al-Windy Nadea YY
- Alan David
- Albert Seals
- Alcocer Gamba Marco Antonio
- Alexander John H.
- Alexander Karen
- Alexandru Tom M
- Alexopoulos Dimitrios
- Alings Marco
- Alonso Martin Joaquin J
- Alonso Orcajo Norberto
- Alonso Alvaro
- Alsweiler Caroline
- Alvarisqueta Andrés F.
- Alves De Lima Alberto E.
- Amarasekera Stanley
- Amarasena Naomali
- Amidon Thomas
- Amir Offer
- Amlani Mohamadali
- Amosova Ekaterina
- Amuchastegui Marcos
- Anchante Hernandez Henry A
- Andersen Dorthe
- Andersen Kjell
- Andersen Rolf
- Anderson Jay
- Ando Kenji
- Andrzej Lipko Jan
- Annam Sharath
- Anscombe Russell
- Apostolovic Svetlana R.
- Appel Karl-Friedrich
- Arandjelovic Aleksandra
- Araneda Guillermo
- Arango Benecke Juan L
- Arbel Yaron
- Arif Imran
- Armaganijan Luciana
- Aroney Constantine
- Arstall Margaret A
- Asanin Milika R.
- Assi Nizar
- Atar Shaul
- Athyros Vasilios
- Auguadro Carla
- Ayaz Mohammad
- Aylward Philip E.
- Ayoub José Carlos Aidar
- Azizad Masoud M
- Babić Zdravko
- Baccara-Dinet Marie
- Badreddine Emmy
- Bagai Akshay
- Bagriy Andriy
- Bahit Maria Cecilia
- Bai Feng
- Balaguer Recena Javier
- Baldari Duccio
- Balinovac Jovan
- Ball Eric
- Ball Eric
- Bang Lia E
- Banuru Sridhar
- Barakovic Fahir
- Baranov Evgeny
- Baranova Elena
- Barbarash Olga L
- Barbato Emanuele
- Barna Olga M
- Barone-Rochette Gilles
- Barr Craig
- Barraud Pauline
- Barrera Silva Sandra I
- Barrucco Robert
- Bartels Gerard L
- Basart Dirk
- Bashir Riyaz
- Bata Iqbal
- Batushkin Valeriy
- Bayat Junaid
- Bayram Llamas Edmundo Alfredo
- Bayron Carlos
- Beauloye Christophe
- Bednarski Janusz
- Behrens Steffen
- Bejuit Raphael
- Bekkouche Mhamed
- Belhassane Abdelkader
- Beltran Pascale
- Benbernou Fadela
- Benedicto Amparo
- Bengrait Nafissa
- Bengston James
- Bengus Cristina M
- Benov Haralambi O
- Benčić Martina Lovrić
- Berdan Lisa
- Berger Rudolf
- Berglund Stefan
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- Berman Brett
- Bernan Alisa
- Bernardez-Pereira Sabrina
- Berthou Christelle
- Berti Sergio
- Betton Johansen Peter
- Bezault Madeleine
- Bhagwat Ajit
- Bhagwat Ravi
- Bhansali Prasant
- Bhatt Deepak L
- Bhatt Deepak L.
- Binde Ronald
- Birchem Jessica
- Bittner Vera A
- Bittner Vera A.
- Blanquicett Marco
- Blicharski Tomasz
- Blok Thomas
- Blonder Ronald
- Blumberg Eduardo DS
- Boccara Franck
- Bodanese Luiz C
- Bodí Peris Vicente
- Bojovski Stojko
- Bokarev Igor
- Bokern Marcel JJA
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- Botelho Roberto V
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- Bouancheau Cecile
- Bougon Nathalie
- Bourgeois Ronald
- Brabham David
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- Cianciarulo Joseph
- Citron Bernard
- Civeira Murillo Fernando
- Claeys Marc
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- Cristian Gabriel
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- Cuccia Claudio
- Cui Lan
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- Ding Chunhua
- Dion Danielle
- Do Rose
- Dodds III George
- Dodic Slobodan
- Dohad Suhail
- Doi Yasuji
- Dombrowski Keith
- Domokos Szilvia
- Doncovska Snezana
- Dong Shaohong
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- Duda Norberto
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- Feitosa Gilson S
- Fell David
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- Fenton Sarah
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- Fernandez Ruiz Ricardo L
- Fernandez Trujillo Angela M
- Fernandez Mauricio
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- Ferrari Emile
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- Florenzano Fernando
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- Fong Peter
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- Heredia Landeo Javier
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- Kapin Tibor
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- Karna Sunil
- Karpenko Oleksandr
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- Katz Amos
- Kaucak Vladimir
- Kavaliauskiene Roma
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- Kimura Takeshi
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- Kostis John
- Kotha Purushotham
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- Kristensen Kjeld S
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- Li Huanming
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- Pincetti Cristian
- Pintarić Hrvoje
- Piovaccari Giancarlo
- Pirenne Bruno
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- Podoleanu Cristian GC
- Podpera Ivo
- Poh Kian-Keong
- Pojskic Belma
- Poklukar Janez
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- Ponnamperuma Chandrike
- Pontaga Natalija
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- Ranasinghe Gotabhaya
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- Shaburishvili Tamaz
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- Shetty Sanjay
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- Shinde Rituparna
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- Shvarts Yury
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- Singal Dinesh
- Singh Narendra
- Singsaas Erlend gyllensten
- Sinha Dhurjati
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- Sirisena Thilak
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- Soran Handrean
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- Speirs Shawn
- Spinar Jindrich
- Sporn Daniel
- Spriggs Douglas
- Sprigings David
- Sritara Piyamitr
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- Staneta Pawel
- Stanislavchuk Mykola
- Stankovic Aleksandar
- Stapleton Dwight
- Starcevic Boris
- Starmer Gregory
- Stasek Josef
- Stasiewski Arkadiusz
- Steg Ph. Gabriel
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- Steiner Stephan
- Stellbrink Christoph
- Stewart Ralph
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- Sun Yingxian
- Sun Yuemin
- Sundelin Torbjörn
- Sundram P. Sandy
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- Sussex Bruce
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- Szarek Michael
- Szarek Michael
- Szigeti Zsolt
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- Tan Edgar
- Tang I-Shing Justin
- Tashchuk Viktor
- Tasic Nebojsa
- Ternouth Ian
- Terzic Ibrahim
- Tesloianu Dan N
- Tespili Maurizio
- Teufel Edward
- Thackray Simon
- Thakkar Maitreya
- Thanvi Sunil
- Thew Stephen
- Timothy Eichenlaub
- Tirador Louie
- Tissera Nirmali
- Todic Branislava
- Todorov Georgi V
- Toledo Pablo
- Toma Mustafa
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- Tonnessen Glen
- Torstensson Ingemar
- Toursarkissian Nicole
- Tov Naveh
- Treasure II Charles
- Tretyakova Tatyana V
- Trevelyan Jasper
- Tricoci Pierluigi
- Tricoci Pierluigi
- Troquay Roland PTh
- Trotter Charlene
- Tsai Wei-Chuan
- Tse Hung-Fat
- Tseluyko Vira
- Tumbev Haralin S
- Turgeman Yoav
- Turi Tibor
- Turk Samir
- Tuñón Fernández José
- Tuñón José
- Tuñón José
- Tyrenko Vadim V
- Tzekova Maria L
- Ueda Yasunori
- Uehara Hiroki
- Uematsu Masaaki
- Ueng Kwo-Chang
- Ungi Imre
- Ural Ertan
- Urina Triana Miguel A
- Ushakov Olexiy
- Utsu Noriaki
- Vahula Veiko
- Vakaluyk Ihor
- Vakili Babak
- Valdivielso Pedro
- Valgimigli Marco
- Valiris Janine
- Vallejos Julio A.
- Van Aswegen Dina
- Van Der Wal Ruud MA
- Van Der Zwaan Coenraad C
- Van Diepen Sean
- Van Haelst Paulus
- Van Kesteren Henricus
- Van Zyl Louis J
- Vardas Panagiotis
- Vardi Gil
- Vargas Gonzales Rolando J
- Varleta Paola
- Vatutin Mykola
- Vedere Amarnath
- Vedin Ola
- Vejar Margarita
- Velcheva Elena S
- Velicka Zdenek
- Verdel Gerardus JE
- Vered Zvi
- Verrier Melanie
- Vervoort Geert
- Vetrovec George
- Vico Marisa L.
- Vida Manuel
- Videbaek Lars
- Vidotti Maria H
- Vidovich Mladen
- Viergever Eric P
- Viigimaa Margus
- Vijay Nampalli
- Vijayaraghavan Ram
- Vikman Saila
- Viktorova Inna
- Vincendet Marion
- Violini Roberto
- Vishnevsky Alexander Y
- Vizel Saul
- Vo Anthony
- Voevoda Mikhail I
- Vogel Robert
- Vohra Rakesh
- Vora Kishor
- Vora Kishor
- Voyce Stephen
- Vrolix Mathias CM
- Vulic Dusko
- Vuurmans Tycho
- Vázquez de Prada José Antonio
- Vöhringer Hans Friedrich
- Völler Heinz
- Wada Atsuyuki
- Waider Winfried
- Waisman Gabriel D
- Waites Jonathon H
- Wali Andreas
- Walichiewicz Piotr Maria
- Waltenberger Johannes
- Waltman Jonathan
- Wan Mohamed Wan Mohd Izani
- Wang Jian'An
- Wang Jianzhong
- Wang Jingfeng
- Wattanakit Keattiyoat
- Wei Meng
- Weidinger Franz
- Weil Joachim
- Weintraub Howard
- Weiss Robert
- Weißbrodt Matthias
- Welka Stephen
- Welker James
- Welker James
- Wells Terry
- Wells Terry
- Werner Christian
- Werner Nikos
- Westbrook Melissa
- Westerhausen Donald
- Whitaker Jack
- White Harvey D
- White Harvey D.
- White Harvey D.
- White Lindsey
- White Matthew
- Wiersma Jacobijne J
- Wijeyasingam Santharaj
- Wilkins Gerard
- Wilkinson Peter
- Willems Frank F
- Wilson Matthew D.
- Wilson Samuel
- Winkelmann Bernhard
- Wiseman Alan
- Witt Nils
- Wlodarczak Adrian
- Wojewoda Pawel
- Wolfovitz Efrat
- Wollaert Bart
- Wong Yuk-Ki
- Wongpraparut Nattawut
- Worner Diz Fernando
- Wozniak Julianna
- Wright Scott
- Wu Chun
- Xavier Denis
- Xenakis Mark
- Xiang Meixiang
- Xu Biao
- Xu Dingli
- Xu Xiping
- Xu Yizhou
- Yagensky Andriy
- Yakushin Sergey
- Yan Andrew T.
- Yan Bryan PY
- Yang Eric
- Yang Xiangjun
- Yang Xinchun
- Yao Zhuhua
- Yazdani Shahram
- Yañez Mario
- Yerra Shiv Kumar
- Yin Wei-Hsian
- Yong Huo
- Yoon Jung Han
- Younis Liwa
- Yu Yihua
- Yuan Zuyi
- Yusoff Khalid
- Zahger Doron
- Zahr Firas
- Zaidman Cesar J.
- Zainea Mark
- Zaman Azfar
- Zamorano Jose Luis
- Zapata Gerardo
- Zea Nunez Carlos A
- Zeiher Andreas M
- Zeiher Andreas M.
- Zhang Ruiyan
- Zhang Wenwu
- Zhang Xuelian
- Zhang Zheng
- Zhao Shuiping
- Zhao Xingsheng
- Zheleznyy Volodymyr
- Zheng Yang
- Zheng Zeqi
- Zhong Yi
- Zhou Yujie
- Zhu Hong
- Zhu Jianhua
- Zirlik Andreas
- Zizka Jiri
- Zobouyan Isabelle
- Zong Wenxia
- Zrazhevsky Konstantin
- Zukermann Robert
- Zurakowski Aleksander
- Zvi Vered
- Zwart Peter
- Zweiker Robert
- Édes István
- Černič Šuligoj Nataša
- Šikić Jozica
- Štambuk Kresimir
- Žuran Ivan
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
Background After acute coronary syndrome, diabetes conveys an excess risk of ischaemic cardiovascular events. A reduction in mean LDL cholesterol to 1.4-1.8 mmol/L with ezetimibe or statins reduces cardiovascular events in patients with an acute coronary syndrome and diabetes. However, the efficacy and safety of further reduction in LDL cholesterol with an inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) after acute coronary syndrome is unknown. We aimed to explore this issue in a prespecified analysis of the ODYSSEY OUTCOMES trial of the PCSK9 inhibitor alirocumab, assessing its effects on cardiovascular outcomes by baseline glycaemic status, while also assessing its effects on glycaemic measures including risk of new-onset diabetes