HEIDEGGER AND INDIAN THINKING: THE HERMENEUTIC OF A “BELONGING-TOGETHER” OF NEGATION AND AFFIRMATION

ABSTRACT: According to Heidegger the questioning of Being is unique to western philosophical tradition, however we see that the hermeneutic of Being is explicit in inter-cultural context of thinking. Understanding Brahman as “one ” and “the same ” Śankara speaks together with Heidegger the same hermeneutic of ontological monism. Due to the reason that there is no explicit terminological equivalent of the word ‘Being ’ in Śankara’s thinking, the hermeneutic of Śankara’s ontological understanding of Brahman and its distinction as “Saguna ” and “Nirguna ” are not sufficiently explored. In an inter-cultural ontological context, it is important not to insist on terminological equivalence, but to search for hermeneutic depth. Similarly Madhyamaka-Buddhism of Nāgārjuna describes the universe as totally devoid of reality, called ‘Śūnya ’ or void, which is an expression of nihilism; it is comparable to Heidegger’s observation of the concealing of Being as “nihil”. The hermeneutic of these explicit ontological characters of Being, as concealment and un-concealment allow us to discover a sabotaging brotherhood, because the nihil and something are ontologically two essential sides of the same thinking

The Hermeneutic of Concealing and Un-concealing of Being in Madhyamaka-Buddhism and Advaita-Ved?nta

In the history of Indian philosophy the relationship between Advaita-Ved nta and Madhyamaka-Buddhism is constantly disputed It is argued how one thought has eventually benefited from the other This work explores the above-mentioned relationship in the context of Heidegger s intercession with Nietzsche where concealment and un-concealment are understood as explicit ontological characters of Being Subsequently N g rjuna s description of reality as nya or void is explored as an expression of nihilism nevertheless similar to Heidegger s observation of concealment of Being in nihil And Advaita-Ved nta as a thinking of non-duality expresses the hermeneutic of un-concealment of Being i e of one and the same These ontological characters of Being allow us to discover a sabotaging brotherhood between N g rjuna and ankara because the nihil and something are ontologically two essential sides of the same thinkin

SCREENING AND OPTIMIZATION OF VALACYCLOVIR NIOSOMES BY DESIGN OF EXPERIMENTS

Objective: The objective of the study was to perform a screening, optimization of valacyclovir niosomal formulation to achieve a sustained release of drug using the design of experiments by 32 full factorial design.Methods: Valacyclovir loaded niosomes were prepared using thin film hydration method by varying the ratio of Span 60 and Cholesterol. The prepared niosomes were evaluated for vesicle size, entrapment efficiency, cumulative drug release, fourier transformed infrared spectroscopy (FTIR), zeta potential and surface morphology by field emission scanning electron microscopy (FESEM).Results: The valacyclovir was successfully encapsulated and its entrapment efficiency ranged from 36.70 % to 50.62 %. The average vesicle size of the niosomes was found to be 431 to 623 nm. At 8th hour the drug release varied from 77.50% to 96.31 %. The optimized niosomes were multilamellar with a surface charge potential of about-43.2 mV. The studies revealed that the interaction of cholesterol and surfactant had a substantial effect on vesicle size, entrapment efficiency and drug release from the niosomes. The release kinetics of the optimized niosomes followed zero order kinetics with fickian diffusion controlled mechanism. The stability studies were performed for the optimized formulation and found that the formulation is stable at 4°C ± 2°C.Conclusion: Model equations were developed for the responses. No significant difference was observed between the predicted and observed value, showing that the developed model is reliable

Magnetic Properties of Textured Nanocrystalline Mn-Zn Ferrite Thin Films Fabricated by Pulsed Laser Deposition.

MnxZn1-xFe2O4 nanoparticles were chemically synthesized by co- precipitating metal ions in alkaline aqueous solutions. The XRD peaks match up to spinel ferrites without any multi phase indication and clear visibility of ferrite FT-IR absorption bands confirm single phase spinal formation. Particle size derived from XRD data is authenticated by TEM micrographs. Thin films fabricated from this material on quartz substrate by pulse laser deposition were characterised using XRD. The XRD data revealed formation of spinel structure with a reasonable degree of texture. AFM analysis confirms nano granular film morphology with dimensions comparable to that of target grain. Magnetic data obtained from textured nanocrystalline Mn-Zn ferrite thin film measurements made known enhanced coercivity. The observed enhanced coercivity is explained with due consideration of film texture and surface disorder that originated from Mn concentration specific initial adsorption prior to nucleation, resulting in directional film growth

Adaptation of counters redundant bits with the provision of dual supply and modified clock gating to favour of low power in VLSI

750-757The utilization of usual supply voltage and clock for repetitive state transistors in digital circuits is a fundamental driver for high power utilization. Most significant bit states of the counter stay longer than the least significant bit states and it has some repetitive states. To limit the supply voltage and stop the clock for MSB Flip Flop (FF) transistor, our method uses Control Combinational Logic, Voltage selector and Modified Integrated Clock Gating blocks. The LSB transistor always have a supply voltage of 1.2V and succession of the clock, while MSB transistor gets just 480mV and the clock will be stopped by the this technique. Bring down the supply voltage and quit the clock for redundant states either 0 or 1 in MSB. Meantime supply 1.2V and clock for state changes over from one state to next state. The experimental simulation was done in 45nm CMOS technology using Cadence virtuoso indicates that this asynchronous counter achieves a power savings of 23.57% and the same modified technique when applied to the counters with transmission-gate FF, hybrid-latch FF and sense amplifier FF will have more than 40% power savings and the technique applied in some benchmark circuits will have more than 22% power savings than existing techniques

Adaptation of counters redundant bits with the provision of dual supply and modified clock gating to favour of low power in VLS

The utilization of usual supply voltage and clock for repetitive state transistors in digital circuits is a fundamental driver for high power utilization. Most significant bit states of the counter stay longer than the least significant bit states and it has some repetitive states. To limit the supply voltage and stop the clock for MSB Flip Flop (FF) transistor, our method uses Control Combinational Logic, Voltage selector and Modified Integrated Clock Gating blocks. The LSB transistor always have a supply voltage of 1.2V and succession of the clock, while MSB transistor gets just 480mV and the clock will be stopped by the this technique. Bring down the supply voltage and quit the clock for redundant states either 0 or 1 in MSB. Meantime supply 1.2V and clock for state changes over from one state to next state. The experimental simulation was done in 45nm CMOS technology using Cadence virtuoso indicates that this asynchronous counter achieves a power savings of 23.57% and the same modified technique when applied to the counters with transmission-gate FF, hybrid-latch FF and sense amplifier FF will have more than 40% power savings and the technique applied in some benchmark circuits will have more than 22% power savings than existing techniques

NOVEL APPROACH IN E-LEARNING TO IMBIBE ENVIRONMENTAL AWARENESS

ABSTRACT Real world problems are often felt to be somebody else's problems. By transferring the real world problems to the virtual world the player experiences the gravity of the situation first hand, as he/she is forced to solve the problems of environmental degradation faced by his/her virtual town. This game, through the concept of infotainment aspires to help average individuals of all age groups to understand the importance of environment protection and enhancement and learn to lead an eco-friendly life. While the game is simple to play, the learning process is facilitated because all the available solutions to protect the Environment will be researched and implemented in the game. Players and spectators will subconsciously learn various methods to protect the environment

Microalgal biomass generation via electroflotation: a cost-effective dewatering technology

Microalgae are an excellent source of bioactive compounds for the production of a wide range of vital consumer products in the biofuel, pharmaceutical, food, cosmetics, and agricultural industries, in addition to huge upstream benefits relating to carbon dioxide biosequestration and wastewater treatment. However, energy-efficient, cost-effective, and scalable microalgal technologies for commercial-scale applications are limited, and this has significantly impacted the full-scale implementation of microalgal biosystems for bioproduct development, phycoremediation, and biorefinery applications. Microalgae culture dewatering continues to be a major challenge to large-scale biomass generation, and this is primarily due to the low cell densities of microalgal cultures and the small hydrodynamic size of microalgal cells. With such biophysical characteristics, energy-intensive solid–liquid separation processes such as centrifugation and filtration are generally used for continuous generation of biomass in large-scale settings, making dewatering a major contributor to the microalgae bioprocess economics. This article analyzes the potential of electroflotation as a cost-effective dewatering process that can be integrated into microalgae bioprocesses for continuous biomass production. Electroflotation hinges on the generation of fine bubbles at the surface of an electrode system to entrain microalgal particulates to the surface. A modification of electroflotation, which combines electrocoagulation to catalyze the coalescence of microalgae cells before gaseous entrainment, is also discussed. A technoeconomic appraisal of the prospects of electroflotation compared with other dewatering technologies is presented

Functional MRI Correlates of Carbon Dioxide Chemosensing in Persons With Epilepsy

ObjectivesSudden unexpected death in epilepsy (SUDEP) is a catastrophic epilepsy outcome for which there are no reliable premortem imaging biomarkers of risk. Percival respiratory depression is seen in monitored SUDEP and near SUDEP cases, and abnormal chemosensing of raised blood carbon dioxide (CO2) is thought to contribute. Damage to brainstem respiratory control and chemosensing structures has been demonstrated in structural imaging and neuropathological studies of SUDEP. We hypothesized that functional MRI (fMRI) correlates of abnormal chemosensing are detectable in brainstems of persons with epilepsy (PWE) and are different from healthy controls (HC).MethodsWe analyzed fMRI BOLD activation and brain connectivity in 10 PWE and 10 age- and sex-matched HCs during precisely metered iso-oxic, hypercapnic breathing challenges. Segmented brainstem responses were of particular interest, along with characterization of functional connectivity metrics between these structures. Regional BOLD activations during hypercapnic challenges were convolved with hemodynamic responses, and the resulting activation maps were passed on to group-level analyses. For the functional connectivity analysis, significant clusters from BOLD results were used as seeds. Each individual seed time-series activation map was extracted for bivariate correlation coefficient analyses to study changes in brain connectivity between PWE and HCs.Results(1) Greater brainstem BOLD activations in PWE were observed compared to HC during hypercapnic challenges in several structures with respiratory/chemosensing properties. Group comparison between PWE vs. HC showed significantly greater activation in the dorsal raphe among PWE (p < 0.05) compared to HCs. (2) PWE had significantly greater seed-seed connectivity and recruited more structures during hypercapnia compared to HC.SignificanceThe results of this study show that BOLD responses to hypercapnia in human brainstem are detectable and different in PWE compared to HC. Increased dorsal raphe BOLD activation in PWE and increased seed-seed connectivity between brainstem and adjacent subcortical areas may indicate abnormal chemosensing in these individuals. Imaging investigation of brainstem respiratory centers involved in respiratory regulation in PWE is an important step toward identifying suspected dysfunction of brainstem breathing control that culminates in SUDEP and deserve further study as potential imaging SUDEP biomarkers

Deciphering mollusc shell production: the roles of genetic mechanisms through to ecology, aquaculture and biomimetics

Most molluscs possess shells, constructed from a vast array of microstructures and architectures. The fully formed shell is composed of calcite or aragonite. These CaCO3 crystals form complex biocomposites with proteins, which although typically less than 5% of total shell mass, play significant roles in determining shell microstructure. Despite much research effort, large knowledge gaps remain in how molluscs construct and maintain their shells, and how they produce such a great diversity of forms. Here we synthesize results on how shell shape, microstructure, composition and organic content vary among, and within, species in response to numerous biotic and abiotic factors. At the local level, temperature, food supply and predation cues significantly affect shell morphology, whilst salinity has a much stronger influence across latitudes. Moreover, we emphasize how advances in genomic technologies [e.g. restriction site-associated DNA sequencing (RAD-Seq) and epigenetics] allow detailed examinations of whether morphological changes result from phenotypic plasticity or genetic adaptation, or a combination of these. RAD-Seq has already identified single nucleotide polymorphisms associated with temperature and aquaculture practices, whilst epigenetic processes have been shown significantly to modify shell construction to local conditions in, for example, Antarctica and New Zealand. We also synthesize results on the costs of shell construction and explore how these affect energetic trade-offs in animal metabolism. The cellular costs are still debated, with CaCO3 precipitation estimates ranging from 1-2 J/mg to 17-55 J/mg depending on experimental and environmental conditions. However, organic components are more expensive (~29 J/mg) and recent data indicate transmembrane calcium ion transporters can involve considerable costs. This review emphasizes the role that molecular analyses have played in demonstrating multiple evolutionary origins of biomineralization genes. Although these are characterized by lineage-specific proteins and unique combinations of co-opted genes, a small set of protein domains have been identified as a conserved biomineralization tool box. We further highlight the use of sequence data sets in providing candidate genes for in situ localization and protein function studies. The former has elucidated gene expression modularity in mantle tissue, improving understanding of the diversity of shell morphology synthesis. RNA interference (RNAi) and clustered regularly interspersed short palindromic repeats - CRISPR-associated protein 9 (CRISPR-Cas9) experiments have provided proof of concept for use in the functional investigation of mollusc gene sequences, showing for example that Pif (aragonite-binding) protein plays a significant role in structured nacre crystal growth and that the Lsdia1 gene sets shell chirality in Lymnaea stagnalis. Much research has focused on the impacts of ocean acidification on molluscs. Initial studies were predominantly pessimistic for future molluscan biodiversity. However, more sophisticated experiments incorporating selective breeding and multiple generations are identifying subtle effects and that variability within mollusc genomes has potential for adaption to future conditions. Furthermore, we highlight recent historical studies based on museum collections that demonstrate a greater resilience of molluscs to climate change compared with experimental data. The future of mollusc research lies not solely with ecological investigations into biodiversity, and this review synthesizes knowledge across disciplines to understand biomineralization. It spans research ranging from evolution and development, through predictions of biodiversity prospects and future-proofing of aquaculture to identifying new biomimetic opportunities and societal benefits from recycling shell products.FCT: UID/Multi/04326/2019; European Marine Biological Research Infrastructure Cluster-EMBRIC (EU H2020 research and innovation program) 654008; European Union Seventh Framework Programme [FP7] ITN project 'CACHE: Calcium in a Changing Environment' under REA 60505; NERC Natural Environment Research Council NE/J500173/1info:eu-repo/semantics/publishedVersio