2,191 research outputs found
Robust design of Si/Si3N4 high contrast grating mirror for mid-infrared VCSEL application
A Si/Si3N4 high contrast grating mirror has been designed for a VCSEL
integration in mid-infrared ({\lambda} = 2.65 m). The use of an
optimization algorithm which maximizes a VCSEL mirror quality factor allowed
the adjustment of the grating parameters while keeping large and shallow
grating pattern. The robustness with respect to fabrication error has been
enhanced thanks to a precise study of the grating dimension tolerances. The
final mirror exhibits large high reflectivity bandwidth with a polarization
selectivity and several percent of tolerance on the grating dimensions.Comment: The final publication is available at http://www.springerlink.com,
Optical and Quantum Electronics (2012) Online Firs
Report of the GDR working group on the R-parity violation
This report summarizes the work of the "R-parity violation group" of the
French Research Network (GDR) in Supersymmetry, concerning the physics of
supersymmetric models without conservation of R-parity at HERA, LEP, Tevatron
and LHC and limits on R-parity violating couplings from various processes. The
report includes a discussion of the recent searches at the HERA experiment,
prospects for new experiments, a review of the existing limits, and also
theoretically motivated alternatives to R-parity and a brief discussion on the
implications of R-parity violation on the neutrino masses.Comment: 60 pages, LaTeX, 22 figures, 2 table
N=2 ICRH of H majority plasmas in JET-ILW
Heating single ion species plasmas with ICRF is a challenging task: Fundamental ion cyclotron heating (w = w(ci)) suffers from the adverse polarization of the RF electric fields near the majority cyclotron resonance while second harmonic heating (w =2w(ci)) typically requires pre-heating of the plasma ions to become efficient. Recently, w =2wci ICRF heating was tested in JET-ILW hydrogen plasmas in the absence of neutral beam injection (L-mode). Despite the lack of pre-heating, up to 6MW of ICRF power were coupled to the plasma leading to a transition to H-mode for P-ICRH>5MW in most discharges. Heating efficiencies between 0.65-0.85 were achieved as a combination of the low magnetic field adopted (enhanced finite Larmor radius effects) and the deliberate slow rise of the ICRF power, allowing time for a fast ion population to gradually build-up leading to a systematic increase of the wave absorptivity. Although fast ion tails are a common feature of harmonic ICRF heating, the N=2 majority heating features moderate tail energies (<500keV) except at very low plasma densities (n(e0)<3x10(19)/m(3)), where fast H tails in the MeV range developed and fast ion losses became significant, leading to enhanced plasma wall interaction. The main results of these experiments will be reported
The Transcriptomic Landscape of Prostate Cancer Development and Progression: An Integrative Analysis
Next-generation sequencing of primary tumors is now standard for transcriptomic studies,
but microarray-based data still constitute the majority of available information on other clinically
valuable samples, including archive material. Using prostate cancer (PC) as a model, we developed
a robust analytical framework to integrate data across different technical platforms and disease
subtypes to connect distinct disease stages and reveal potentially relevant genes not identifiable from
single studies alone. We reconstructed the molecular profile of PC to yield the first comprehensive
insight into its development, by tracking changes in mRNA levels from normal prostate to high-grade
prostatic intraepithelial neoplasia, and metastatic disease. A total of nine previously unreported
stage-specific candidate genes with prognostic significance were also found. Here, we integrate
gene expression data from disparate sample types, disease stages and technical platforms into one
coherent whole, to give a global view of the expression changes associated with the development
and progression of PC from normal tissue through to metastatic disease. Summary and individual
data are available online at the Prostate Integrative Expression Database (PIXdb), a user-friendly
interface designed for clinicians and laboratory researchers to facilitate translational research
The Transcriptomic Landscape of Prostate Cancer Development and Progression: An Integrative Analysis
Next-generation sequencing of primary tumors is now standard for transcriptomic studies,
but microarray-based data still constitute the majority of available information on other clinically
valuable samples, including archive material. Using prostate cancer (PC) as a model, we developed
a robust analytical framework to integrate data across different technical platforms and disease
subtypes to connect distinct disease stages and reveal potentially relevant genes not identifiable from
single studies alone. We reconstructed the molecular profile of PC to yield the first comprehensive
insight into its development, by tracking changes in mRNA levels from normal prostate to high-grade
prostatic intraepithelial neoplasia, and metastatic disease. A total of nine previously unreported
stage-specific candidate genes with prognostic significance were also found. Here, we integrate
gene expression data from disparate sample types, disease stages and technical platforms into one
coherent whole, to give a global view of the expression changes associated with the development
and progression of PC from normal tissue through to metastatic disease. Summary and individual
data are available online at the Prostate Integrative Expression Database (PIXdb), a user-friendly
interface designed for clinicians and laboratory researchers to facilitate translational research
Characterisation of local ICRF heat loads on the JET ILW
When using Ion Cyclotron Range of Frequency (ICRF) heating, enhanced
heat-fluxes are commonly observed on some plasma facing components close to the
antennas. Experiments have recently been carried out on JET with the new
ITER-Like-Wall (ILW) to characterize the heat flux to the JET ICRF antennas.
Using Infra-Red thermography and thermal models of the tiles, heat-fluxes were
evaluated from the surface temperature increase during the RF phase of L-mode
plasmas. The maximum observed heat-flux intensity was ~ 4.5 MW/m2 when
operating with -{\pi}/2 current drive strap phasing at power level of 2MW per
antenna and with a 4 cm distance between the plasma and the outer limiters.
Heat-fluxes are reduced when using dipole strap phasing. The fraction of ICRF
power deposited on the antenna limiters or septa was in the range 2-10% for
dipole phasing and 10-20% with +/-{\pi}/2 phasing.Comment: 22 pages, 6 figure
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