Metastable supersymmetry breaking in N=2 non-linear sigma-models

We perform a general study of the issue of metastability for supersymmetry-breaking vacua in theories with N=1 and N=2 global supersymmetry. This problem turns out to capture all the important qualitative features of the corresponding question in theories with local supersymmetry, where gravitational effects induce only quantitative modifications. Moreover, it allows to directly compare the conditions arising in the N=1 and N=2 cases, since the latter becomes particular case of the former in the rigid limit. Our strategy consists in a systematic investigation of the danger of instability coming from the sGoldstini scalars, whose masses are entirely due to supersymmetry breaking mass-splitting effects. We start by reviewing the metastability conditions arising in general N=1 non-linear sigma-models with chiral and vector multiplets. We then turn to the case of general N=2 non-linear sigma-models with hyper and vector multiplets. We first reproduce and clarify the known no-go theorems applying to theories with only Abelian vector multiplets and only hyper multiplets, and then derive new results applying to more general cases. To make the comparison with N=1 models as clear as possible, we rely on a formulation of N=2 models where one of the supersymmetries is manifestly realized in terms of ordinary superfields, whereas the other is realized through non-trivial transformations. We give a self-contained account of such a construction of N=2 theories in N=1 superspace, generalizing previous work on various aspects to reach a general and coordinate-covariant construction. We also present a direct computation of the supertrace of the mass matrix.Comment: 50 pages, no figures; v2 minor corrections and addition of comments and reference

Metastable supersymmetry breaking in N=2 non-linear sigma-models

Abstract We perform a general study of the issue of metastability for supersymmetrybreaking vacua in theories with N = 1 and N = 2 global supersymmetry. This problem turns out to capture all the important qualitative features of the corresponding question in theories with local supersymmetry, where gravitational effects induce only quantitative modifications. Moreover, it allows to directly compare the conditions arising in the N = 1 and N = 2 cases, since the latter becomes particular case of the former in the rigid limit. Our strategy consists in a systematic investigation of the danger of instability coming from the sGoldstini scalars, whose masses are entirely due to supersymmetry breaking mass-splitting effects. We start by reviewing the metastability conditions arising in general N = 1 non-linear sigma-models with chiral and vector multiplets. We then turn to the case of general N = 2 non-linear sigma-models with hyper and vector multiplets. We first reproduce and clarify the known no-go theorems applying to theories with only Abelian vector multiplets and only hyper multiplets, and then derive new results applying to more general cases. To make the comparison with N = 1 models as clear as possible, we rely on a formulation of N = 2 models where one of the supersymmetries is manifestly realized in terms of ordinary superfields, whereas the other is realized through non-trivial transformations. We give a self-contained account of such a construction of N = 2 theories in N = 1 superspace, generalizing previous work on various aspects to reach a general and coordinate-covariant construction. We also present a direct computation of the supertrace of the mass matrix

N=2 supersymmetry breaking at two different scales

We study N=2 spontaneous supersymmetry breaking at two different scales with matter fields in hypermultiplets charged under the gauge group that should involve at least two U(1) factors. Off-shell analysis is possible in the dual single-tensor formulation of the hypermultiplets. Massless fermions can naturally arise from pseudo-real representations of the gauge group that allow a reformulation of the problem of chirality in N=2 theories. The above properties are necessary ingredients towards constructing viable extensions of the Standard Model based on N=2 supersymmetry.Comment: 26 page

In high grade ovarian carcinoma, platinum-sensitive tumor recurrence and acquired-resistance derive from quiescent residual cancer cells that overexpress CRYAB, CEACAM6 and SOX2

International audienceMost High-Grade Ovarian Carcinomas (HGOCs) are sensitive to carboplatin (CBP)-based chemotherapy but frequently recur within 24 months. Recurrent tumors remain CBP-sensitive and acquire resistance only after several treatment rounds. Recurrences arise from a small number of residual tumor cells hardly amenable to investigation in patients. We developed Patient-Derived Xenografts (PDXs) that allow the study of these different stages of CBP-sensitive recurrence and acquisition of resistance. We generated PDX models from CBP-sensitive and intrinsically resistant HGOC. PDXs were CBP- or mock-treated and tumors were sampled, after treatment and at recurrence. We also isolated models with acquired-resistance from CBP-sensitive PDXs. All tumors were characterized at the histological and transcriptome levels. PDX models reproduced treatment response seen in the patients. CBP-sensitive residual tumors contained non-proliferating tumor cells clusters embedded in a fibrotic mesh. In non-treated PDX tumors and treated CBP-resistant tumors fibrotic tissue was not prevalent. Residual tumors had marked differences in gene expression when compared to naïve and recurrent tumors, indicating downregulation of cell cycle and proliferation and upregulation of interferon response and epithelial-mesenchymal transition. This gene expression pattern resembled that described in embryonal diapause and 'drug-tolerant persister' states. Residual and acquired-resistance tumors share the overexpression of three genes: CEACAM6, CRYAB, and SOX2.Immunostaining analysis showed strong CEACAM6, CRYAB, and SOX2 protein expression in CBP-sensitive residual and acquired resistance PDX, thus, confirming RNA profiling results. In HGOC PDX, CBP-sensitive recurrences arise from a small population of quiescent, drug-tolerant, residual cells embedded in a fibrotic mesh. These cells overexpress CEACAM6, CRYAB and SOX2, whose overexpression is also associated with acquired resistance and poor patient prognosis. CEACAM6, CRYAB and SOX2 may, thus, serve as a biomarker to predict recurrence and emergence of resistant disease in CBP-treated HGOC patients

Short- and long-term results of total vs subtotal thyroidectomies in the surgical treatment of Graves' disease

Approximately one out of five patients with Graves' disease (GD) undergoes a thyroidectomy after a mean period of 18 months of medical treatment. This retrospective and non-randomized study from a teaching hospital compares short- and long-term results of total (TT) and subtotal thyroidectomies (ST) for this disease

Ostéopathies fragilisantes, maladie rénale chronique, malabsorptions, anomalies biologiques du métabolisme phosphocalcique : les bonnes indications pour un remboursement raisonné du dosage de vitamine D [Weakening osteopathies, chronic kidney disease, malabsorption, biological anomalies of calium/phosphorus metabolism: appropriate indications for a reasoned reimbursment of serum vitamin D measurement]

National audienceEditoria