723 research outputs found
How does transverse (hydrodynamic) flow affect jet-broadening and jet-quenching ?
We give the modification of formulas for -broadening and energy
loss which are necessary to calculate parton interactions in a medium with
flow. Arguments are presented leading to the conclusion that for large
-spectra observed in heavy ion collisions at RHIC, the influence of
transverse flow on the determination of the "quenching power" of the produced
medium is small. This leaves open the question of the interpretation of data in
a consistent perturbative framework.Comment: 8 pages and 4 figures; version v2 includes more consistent notations
and correction of fig.2; version v3 contains a misprint correction, an added
sentence in section 3C and in the Introduction as well as in section 4 a
rephrasing of comments about references [31,32,35
Multiplicity distributions inside parton cascades developing in a medium
The explanation of the suppression of high-pT hadron yields at RHIC in terms
of jet-quenching implies that the multiplicity distributions of particles
inside a jet and jet-like particle correlations differ strongly in
nucleus-nucleus collisions at RHIC or at the LHC from those observed at e+e- or
hadron colliders. We present a framework for describing the medium-induced
modification, which has a direct interpretation in terms of a probabilistic
medium-modified parton cascade, and which treats leading and subleading partons
on an equal footing. We show that our approach can account for the strong
suppression of single inclusive hadron spectra measured in Au-Au collisions at
RHIC, and that this implies a characteristic distortion of the single inclusive
distribution of soft partons inside the jet. We determine, as a function of the
jet energy, to what extent the soft fragments within a jet can be measured
above some momentum cut.Comment: 5 pages, 4 eps-figures; talk given at Hot Quarks 2006, Villasimius
(Sardinia, Italy), May 15-20, 200
Can baseline ultrasound results help to predict failure to achieve DAS28 remission after 1 year of tight control treatment in early RA patients?
Background: At present, there are no prognostic parameters unequivocally predicting treatment failure in early rheumatoid arthritis (RA) patients. We investigated whether baseline ultrasonography (US) findings of joints, when added to baseline clinical, laboratory, and radiographical data, could improve prediction of failure to achieve Disease Activity Score assessing 28 joints (DAS28) remission (<2.6) at 1 year in newly diagnosed RA patients. Methods: A multicentre cohort of newly diagnosed RA patients was followed prospectively for 1 year. US of the hands, wrists, and feet was performed at baseline. Clinical, laboratory, and radiographical parameters were recorded. Primary analysis was the prediction by logistic regression of the absence of DAS28 remission 12 months after diagnosis and start of therapy. Results: Of 194 patients included, 174 were used for the analysis, with complete data available for 159. In a multivariate model with baseline DAS28 (odds ratio (OR) 1.6, 95% confidence interval (CI) 1.2-2.2), the presence of rheumatoid factor (OR 2.3, 95% CI 1.1-5.1), and type of monitoring strategy (OR 0.2, 95% CI 0.05-0.85), the addition of baseline US results for joints (OR 0.96, 95% CI 0.89-1.04) did not significantly improve the prediction of failure to achieve DAS28 remission (likelihood ratio test, 1.04; p=0.31). Conclusion: In an early RA population, adding baseline ultrasonography of the hands, wrists, and feet to commonly available baseline characteristics did not improve prediction of failure to achieve DAS28 remission at 12 months
Role of ultrasonography in diagnosing early rheumatoid arthritis and remission of rheumatoid arthritis - a systematic review of the literature
Introduction: Ultrasonography (US) might have an added value to clinical examination in diagnosing early rheumatoid arthritis (RA) and assessing remission of RA. We aimed to clarify the added value of US in RA in these situations performing a systematic review.Methods: A systematic literature search was performed for RA, US, diagnosis and remission. Methodological quality was assessed; the wide variability in the design of studies prohibited pooling of results.Results: Six papers on the added value of US diagnosing early RA were found, in which at least bilateral metacarpophalangeal (MCP), wrists and metatarsophalangeal (MTP) joints were scanned. Compared to clinical examination, US was superior with regard to detecting synovitis and predicting progression to persistent arthritis or RA. Eleven papers on assessing remission were identified, in which at least the wrist and the MCP joints of the dominant hand were scanned. Often US detected inflammation in patients clinically in remission, irrespective of the remission criteria used. Power Doppler signs of synovitis predicted X-ray progression and future flare in patients clinically in remission.Conclusions: US appears to have added value to clinical examination for diagnosing of RA when scanning at least MCP, wrist and MTP joints, and, when evaluating remission of RA, scanning at least wrist and MCP joints of the dominant hand. For both purposes primarily power Doppler US might be used since its results are less equivocal than those of greyscale US
Herpes simplex virus 1 amplicon vector-mediated siRNA targeting epidermal growth factor receptor inhibits growth of human glioma cells in vivo
In primary glioblastomas and other tumor types, the epidermal growth factor receptor (EGFR) is frequently observed with alterations, such as amplification, structural rearrangements, or overexpression of the gene, suggesting an important role in glial tumorigenesis and progression. In this study, we investigated whether posttranscriptional gene silencing by vector-mediated RNAi to inhibit EGFR expression can reduce the growth of cultured human gli36 glioma cells. To "knock down" EGFR expression, we have created HSV-1-based amplicons that contain the RNA polymerase III-dependent H1 promoter to express double-stranded hairpin RNA directed against EGFR at two different locations (pHSVsiEGFR I and pHSVsiEGFR II). We demonstrate that both pHSVsiEGFR I and pHSVsiEGFR II mediated knock-down of transiently transfected full-length EGFR or endogenous EGFR in a dose-dependent manner. The knock-down of EGFR resulted in the growth inhibition of human glioblastoma (gli36-luc) cells both in culture and in athymic mice in vivo. Cell cycle analysis and annexin V staining revealed that siRNA-mediated suppression of EGFR induced apoptosis. Overall HSV-1 amplicons can mediate efficient and specific posttranscriptional gene silencing. Copyright © The American Society of Gene Therapy
Training medical specialists to communicate better with patients with medically unexplained physical symptoms (MUPS). A randomized, controlled trial
Background Patients with medically unexplained physical symptoms (MUPS) are prevalent 25-50% in general and specialist care. Medical specialists and residents often find patients without underlying pathology difficult to deal with, whereas patients sometimes don't feel understood. We developed an evidence-based communication training, aimed to improve specialists' interviewing, information-giving and planning skills in MUPS consultations, and tested its effectiveness. Methods The intervention group in this multi-center randomized controlled trial received a 14-hour training program to which experiential learning and feedback were essential. Using techniques from Cognitive Behavioral Therapy, they were stimulated to seek interrelating factors (symptoms, cognitions, emotions, behavior, and social environment) that reinforced a patient's symptoms. They were taught to
Plane-symmetric inhomogeneous magnetized viscous fluid universe with a variable
The behavior of magnetic field in plane symmetric inhomogeneous cosmological
models for bulk viscous distribution is investigated. The coefficient of bulk
viscosity is assumed to be a power function of mass density . The values of cosmological constant for these models are
found to be small and positive which are supported by the results from recent
supernovae Ia observations. Some physical and geometric aspects of the models
are also discussed.Comment: 18 pages, LaTex, no figur
Phonon-mediated anisotropic superconductivity in the Y and Lu nickel borocarbides
We present scanning tunneling spectroscopy and microscopy measurements at low
temperatures in the borocarbide materials RNi2B2C (R=Y, Lu). The characteristic
strong coupling structure due to the pairing interaction is unambiguously
resolved in the superconducting density of states. It is located at the
superconducting gap plus the energy corresponding to a phonon mode identified
in previous neutron scattering experiments. These measurements also show that
this mode is coupled to the electrons through a highly anisotropic
electron-phonon interaction originated by a nesting feature of the Fermi
surface. Our experiments, from which we can extract a large electron-phonon
coupling parameter lambda (between 0.5 and 0.8), demonstrate that this
anisotropic electron-phonon coupling has an essential contribution to the
pairing interaction. The tunneling spectra show an anisotropic s-wave
superconducting gap function.Comment: 5 pages, 3 figure
Exact Hypersurface-Homogeneous Solutions in Cosmology and Astrophysics
A framework is introduced which explains the existence and similarities of
most exact solutions of the Einstein equations with a wide range of sources for
the class of hypersurface-homogeneous spacetimes which admit a Hamiltonian
formulation. This class includes the spatially homogeneous cosmological models
and the astrophysically interesting static spherically symmetric models as well
as the stationary cylindrically symmetric models. The framework involves
methods for finding and exploiting hidden symmetries and invariant submanifolds
of the Hamiltonian formulation of the field equations. It unifies, simplifies
and extends most known work on hypersurface-homogeneous exact solutions. It is
shown that the same framework is also relevant to gravitational theories with a
similar structure, like Brans-Dicke or higher-dimensional theories.Comment: 41 pages, REVTEX/LaTeX 2.09 file (don't use LaTeX2e !!!) Accepted for
publication in Phys. Rev.
A Conflict Model for Strategists and Managers
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67210/2/10.1177_000276427201500604.pd
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