199 research outputs found
Altered renal hemodynamics and impaired myogenic responses in the fawn-hooded rat
The present study examined whether an abnormality in the myogenic response
of renal arterioles that impairs autoregulation of renal blood flow (RBF)
and glomerular capillary pressure (PGC) contributes to the development of
renal damage in fawn-hooded hypertensive (FHH) rats. Autoregulation of
whole kidney, cortical, and medullary blood flow and PGC were compared in
young (12 wk old) FHH and fawn-hooded low blood pressure (FHL) rats in
volume-replete and volume-expanded conditions. Baseline RBF, cortical and
medullary blood flow, and PGC were significantly greater in FHH than in
FHL rats. Autoregulation of renal and cortical blood flow was
significantly impaired in FHH rats compared with results obtained in FHL
rats. Myogenically mediated autoregulation of PGC was significantly
greater in FHL than in FHH rats. PGC rose from 46 +/- 1 to 71 +/- 2 mmHg
in response to an increase in renal perfusion pressure from 100 to 150
mmHg in FHH rats, whereas it only increased from 39 +/- 2 to 53 +/- 1 mmHg
in FHL rats. Isolated perfused renal interlobular arteries from FHL rats
constricted by 10% in response to elevations in transmural pressure from
70 to 120 mmHg. In contrast, the diameter of vessels from FHH rats
increased by 15%. These results indicate that the myogenic response of
small renal arteries is altered in FHH rats, and this contributes to an
impaired autoregulation of renal blood flow and elevations in PGC in this
strain
Heavy Quark Fragmentation into Baryons in a Quark-Diquark Model
In the framework of the nonrelativistic QCD and a quark-diquark model of
baryons we have obtained the fragmentation functions for heavy quark to split
into spin-1/2 and spin-3/2 double heavy baryons. It was predicted the
production rates as well as the shape of the energy spectra for the and
baryons in the region of peak at LEP collider.Comment: LaTeX, 9 pages, 2 figure
Impaired autoregulation of renal blood flow in the fawn-hooded rat
The responses to changes in renal perfusion pressure (RPP) were compared
in 12-wk-old fawn-hooded hypertensive (FHH), fawn-hooded low blood
pressure (FHL), and August Copenhagen Irish (ACI) rats to determine
whether autoregulation of renal blood flow (RBF) is altered in the FHH
rat. Mean arterial pressure was significantly higher in conscious,
chronically instrumented FHH rats than in FHL rats (121 +/- 4 vs. 109 +/-
6 mmHg). Baseline arterial pressures measured in
ketamine-Inactin-anesthetized rats averaged 147 +/- 2 mmHg (n = 9) in FHH,
132 +/- 2 mmHg (n = 10) in FHL, and 123 +/- 4 mmHg (n = 9) in ACI rats.
Baseline RBF was significantly higher in FHH than in FHL and ACI rats and
averaged 9.6 +/- 0.7, 7.4 +/- 0.5, and 7.8 +/- 0.9 ml. min-1. g kidney
wt-1, respectively. RBF was autoregulated in ACI and FHL but not in FHH
rats. Autoregulatory indexes in the range of RPPs from 100 to 150 mmHg
averaged 0.96 +/- 0.12 in FHH vs. 0.42 +/- 0.04 in FHL and 0.30 +/- 0.02
in ACI rats. Glomerular filtration rate was 20-30% higher in FHH than in
FHL and ACI rats. Elevations in RPP from 100 to 150 mmHg increased urinary
protein excretion in FHH rats from 27 +/- 2 to 87 +/- 3 microg/min,
whereas it was not significantly altered in FHL or ACI rats. The
percentage of glomeruli exhibiting histological evidence of injury was not
significantly different in the three strains of rats. These results
indicate that autoregulation of RBF is impaired in FHH rats before the
development of glomerulosclerosis and suggest that an abnormality in the
control of renal vascular resistance may contribute to the development of
proteinuria and renal failure in this strain of rats
Constraints on growth index parameters from current and future observations
We use current and future simulated data of the growth rate of large scale
structure in combination with data from supernova, BAO, and CMB surface
measurements, in order to put constraints on the growth index parameters. We
use a recently proposed parameterization of the growth index that interpolates
between a constant value at high redshifts and a form that accounts for
redshift dependencies at small redshifts. We also suggest here another
exponential parameterization with a similar behaviour. The redshift dependent
parametrizations provide a sub-percent precision level to the numerical growth
function, for the full redshift range. Using these redshift parameterizations
or a constant growth index, we find that current available data from galaxy
redshift distortions and Lyman-alpha forests is unable to put significant
constraints on any of the growth parameters. For example both CDM and
flat DGP are allowed by current growth data. We use an MCMC analysis to study
constraints from future growth data, and simulate pessimistic and moderate
scenarios for the uncertainties. In both scenarios, the redshift
parameterizations discussed are able to provide significant constraints and
rule out models when incorrectly assumed in the analysis. The values taken by
the constant part of the parameterizations as well as the redshift slopes are
all found to significantly rule out an incorrect background. We also find that,
for our pessimistic scenario, an assumed constant growth index over the full
redshift range is unable to rule out incorrect models in all cases. This is due
to the fact that the slope acts as a second discriminator at smaller redshifts
and therefore provide a significant test to identify the underlying gravity
theory.Comment: 13 pages, 5 figures, matches JCAP accepted versio
Relativistically invariant analysis of polarization effects in exclusive deuteron electrodisintegration process
A general formalism for the calculation of the differential cross section and
polarization observables, for the process of deuteron electrodisintegration, is
developed in the framework of relativistic impulse approximation. A detailed
analysis of the general structure of the differential cross section and
polarization observables for the reaction is derived, using
the formalism of the structure functions. The obtained expressions have a
general nature and they hold in the one--photon--exchange mechanism, assuming
P--invariance of the hadron electromagnetic interaction. The model of
relativistic impulse approximation is introduced and the final state
interaction is taken into account by means of the unitarization of the helicity
amplitudes. A detailed description of the unitarization procedure is also
presented.
Using different parametrizations of the deuteron wave functions, the
following polarization observables are calculated in the kinematical region of
quasi--elastic deuteron electrodisintegration: the asymmetry for the scattering
of longitudinally polarized electrons on a polarized deuteron target, the
proton and neutron polarizations (for longitudinally polarized electron beam or
vector--polarized deuteron target). The sensitivity to the neutron electric
form factor is also thorougly investigated.
The predictions of the model are compared with the results of recent
polarization measurements and a good agreement with the existing experimental
data has been obtained.Comment: 90 pages, 17 figure
Recommended from our members
Sources, seasonality, and trends of southeast US aerosol: an integrated analysis of surface, aircraft, and satellite observations with the GEOS-Chem chemical transport model
We use an ensemble of surface (EPA CSN, IMPROVE, SEARCH, AERONET), aircraft (SEAC4RS), and satellite (MODIS, MISR) observations over the southeast US during the summer–fall of 2013 to better understand aerosol sources in the region and the relationship between surface particulate matter (PM) and aerosol optical depth (AOD). The GEOS-Chem global chemical transport model (CTM) with 25 × 25 km2 resolution over North America is used as a common platform to interpret measurements of different aerosol variables made at different times and locations. Sulfate and organic aerosol (OA) are the main contributors to surface PM2.5 (mass concentration of PM finer than 2.5 μm aerodynamic diameter) and AOD over the southeast US. OA is simulated successfully with a simple parameterization, assuming irreversible uptake of low-volatility products of hydrocarbon oxidation. Biogenic isoprene and monoterpenes account for 60 % of OA, anthropogenic sources for 30 %, and open fires for 10 %. 60 % of total aerosol mass is in the mixed layer below 1.5 km, 25 % in the cloud convective layer at 1.5–3 km, and 15 % in the free troposphere above 3 km. This vertical profile is well captured by GEOS-Chem, arguing against a high-altitude source of OA. The extent of sulfate neutralization (f = [NH4+]/(2[SO42−] + [NO3−]) is only 0.5–0.7 mol mol−1 in the observations, despite an excess of ammonia present, which could reflect suppression of ammonia uptake by OA. This would explain the long-term decline of ammonium aerosol in the southeast US, paralleling that of sulfate. The vertical profile of aerosol extinction over the southeast US follows closely that of aerosol mass. GEOS-Chem reproduces observed total column aerosol mass over the southeast US within 6 %, column aerosol extinction within 16 %, and space-based AOD within 8–28 % (consistently biased low). The large AOD decline observed from summer to winter is driven by sharp declines in both sulfate and OA from August to October. These declines are due to shutdowns in both biogenic emissions and UV-driven photochemistry. Surface PM2.5 shows far less summer-to-winter decrease than AOD and we attribute this in part to the offsetting effect of weaker boundary layer ventilation. The SEAC4RS aircraft data demonstrate that AODs measured from space are consistent with surface PM2.5. This implies that satellites can be used reliably to infer surface PM2.5 over monthly timescales if a good CTM representation of the aerosol vertical profile is available
The structure of the Yang-Mills spectrum for arbitrary simple gauge algebras
The mass spectrum of pure Yang-Mills theory in 3+1 dimensions is discussed
for an arbitrary simple gauge algebra within a quasigluon picture. The general
structure of the low-lying gluelump and two-quasigluon glueball spectrum is
shown to be common to all algebras, while the lightest three-quasigluon
glueballs only exist when the gauge algebra is A, that is in
particular . Higher-lying glueballs are shown to
exist only for the A, D and E gauge
algebras. The shape of the static energy between adjoint sources is also
discussed assuming the Casimir scaling hypothesis and a funnel form; it appears
to be gauge-algebra dependent when at least three sources are considered. As a
main result, the present framework's predictions are shown to be consistent
with available lattice data in the particular case of an
gauge algebra within 't Hooft's large- limit.Comment: 21 pages, 4 figures; remarks added, typos corrected in v2. v3 to
appear in EPJ
Hypothetical model ignores many important pathophysiologic mechanisms in fibromyalgia
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