Jeanne O. Jackson to Mr. Meredith (1 October 1962)

https://egrove.olemiss.edu/mercorr_pro/1317/thumbnail.jp

Stimulation of Amorphizing Reactions in Co-Si Multi-Layers

Co-Si multi-layer specimens do not normally amorphize. To possibly stimulate amorphization, Ti was added by evaporation and the specimens were annealed at 300 and 400 degrees Celsius. The results showed that amorphization occurred at 400 degrees Celsius in the presence of Ti, but did not occur at 300 degrees Celsius. Further research would be necessary to conclude whether the amorphization was stimulated by the addition of Ti or the temperature increase

Exploring Dating as an Occupation for Young Heterosexual Women in Ireland

Purpose – Dating is a meaningful occupation for many single people. The occupation of dating has transformed considerably in Ireland due to recent changes in Irish culture and the advent of online dating technology. The purpose of this study was to explore the complexities and intricacies of dating in an Irish context. Design/methodology/approach – A qualitative research approach was used and data were collected using semi-structured interviews with ten heterosexual women (age 24-34) living in urban areas of Ireland. Data were analysed using inductive thematic analysis (Braun and Clarke, 2006). Findings – Dating did not fully resonate with their experience, but they did not have an alternative term. The form of dating was influenced by cultural, temporal, physical and virtual contexts. Beliefs about dating, fluctuating emotions and feelings of mortification because of the stigma of online dating created meaning for participants and influenced their use of strategies to improve resilience. While dating was not a preferred occupation for participants because of its arduous nature and fluctuations in emotion, it was seen as essential to fulfil the function of finding a romantic partner or partner in occupation. Connections between participant experiences and occupational science are discussed to address the lexicon of dating and the form, function and meaning of dating. Originality/value – This study contributes to occupational science knowledge by revealing the occupational understandings of dating as an emerging and dynamic occupation in a rapidly changing culture of Ireland

Exploring the Occupation of Dating For Young Women Living in Ireland

Background:The discipline of occupational science has called for an increase in research focusing on the study of occupations. Gray (1997) stated that occupational therapy could benefit from “a more profound understanding of the essence of occupation” (p. 15). Dickie (2003) argues that “one way to achieve this understanding is to examine occupations directly” (p. 120). Dating is an occupation that has not been examined directly and has recently undergone rapid changes in its practice. Although occupational science research has been done on mate selection (Krishnagiri, 1996), there is a dearth of literature exploring the actual activities surrounding mate selection, how one actually participates actively in this selection which the researcher will refer to as dating. This study will address the gap in the literature by exploring the occupation of dating and the experience of young women participating in dating occupations in Ireland. Method:A qualitative approach will be used to explore the occupation of dating. Data collection will include the use of semi-structured interviews, direct observation, and cultural material. Interviews will be audiotaped, transcribed. Field notes taken during observation and interviews will be coded using thematic analysis to generate common themes across cases (Braun & Clarke, 2006). Results:Findings will be reported using themes generated from thematic analysis. Conclusion:To be determined. Research to be completed by Spring 2016. Application to Practice:Implications for understanding the occupation of dating will be discussed with relevance to occupational therapy practice

Synthesis, characterization, and catalytic reactivity of first-row transition metal CCC pincer complexes

Catalysis is such a ubiquitous process that over 75% of existing chemical processes and 90% of newly developed processes utilize catalysts. Understanding how to improve and create new catalysts is therefore essential to developing new products as well as greener and more efficient processes. One way to improve the environmental impact of these reactions is to move away from using less biocompatible second- and third-row transition metal catalysts and replace them with first-row transition metal catalysts. However, first-row metals tend to engage in one-electron radical chemistry much more readily than the typically desired two-electron reactions. One way to induce first-row transition metals to engage in the desired reactions is to use strong-field ligand frameworks. Strong-field ligands cause the d-orbital splitting of the metal center to increase in energy, often leading to low-spin electronic configurations which favor two-electron reactivity. N-heterocyclic carbenes (NHCs) are popular strong-field ligands due to their inherent stability and oxidative robustness, especially compared to phosphines. Combining NHCs with pincer ligand frameworks provides even more stable complexes. Therefore, we investigated a variety of monoanionic, bis(carbene), strong-field pincers with first-row transition metals. A variety of ArCCC (Ar = Mes, DIPP) and RCcCcC (R = benzyl, t-butyl) pincer ligand frameworks were developed and their metalation investigated. The RCcCcC pincers were successfully metalated with nickel generating (RCcCcC)Ni(II)Br complexes (R = benzy, t-butyl). DIPPCCC pincers, previously metalated with nickel and cobalt in our group, have been extended to iron as well. The metalation method first goes through a zwitterionic intermediate which was isolated and characterized before being reduced in situ to yield the (DIPPCCC)Fe(II)H(L)(L’) complexes. A distinct electronic effect was observed on the Fe−H when varying the L-type ligands coordinated to the iron center. Reactivity of these iron hydrides with CO2 showed insertion into the Fe−H bond to form a κ2-OOCH complex (L = PMe3, L’ = N2). This complex was also independently synthesized starting from (DIPPCCC)Fe(II)Cl(PMe3)2. The zwitterionic metalation method was also extended to other first-row transition metals. The synthesis and characterization of zwitterionic complexes, H2(DIPPCCC)M(II)Cl3 (M = Mn, Co, Ni), was accomplished and the in situ reduction lead to metalation using cobalt and nickel. An alternate metalation method, transmetalation from zirconium, into similar CCC pincer ligand frameworks has been previously established by the Hollis group. Utilizing a similar procedure zirconium complexes were synthesized and characterized (ArCCC)Zr(IV)X3 (Ar = Mes, DIPP). The transmetalation to iron, cobalt, and nickel were all successful with both ligand derivatives. Our group has studied cobalt catalysts, (MesCCC)Co(I)L, for the hydrogenation of alkenes and semi-hydrogenation of alkynes and were interested in extending the hydrogenation further to more polar functional groups. Nitrile hydrogenation is a difficult reaction both in terms of activating the C−N triple bond and selectivity among products. We discovered a mild set of reaction conditions that selectively formed the primary amine for a variety of different substrates. During our mechanistic work we determined that the process is actually Lewis acid-assisted and is in fact undergoing a two-electron catalytic process. During the investigation and subsequent publication of this work another product, the secondary aldimine, was seen under some reaction conditions. Modifying our reaction parameters, we discovered we could also selectively form the secondary aldimine product starting from the nitrile. This represents only the second example of a cobalt catalyst that can perform the hydrogenation of nitriles with selectivity to the secondary aldimine. Our condition switchable system also provided exceptionally mild reaction conditions compared to other first-row transition metal catalysts for nitrile hydrogenation

Making secret hiding places: An occupation of childhood

From Crossref journal articles via Jisc Publications RouterHistory: received 2023-01-31, accepted 2023-06-20, epub 2023-08-31, issued 2023-08-31, published 2023-08-31Article version: VoRPublication status: PublishedSarah Kantartzis - ORCID: 0000-0001-5191-015X https://orcid.org/0000-0001-5191-015XPlace-making refers to the emotional attachment people have to a place and has been adopted as a concept in occupational science. In this paper, Relph’s perspective on place-making is associated with how place-making has been discussed in occupational science. Relph’s viewpoint serves as a basis for understanding secret hiding places from children’s perspectives. During data collection for a study investigating children’s perceptions of inclusive playgrounds (Wenger et al., Citation2021), secret hiding places were a recurring topic. This paper aims to explore secret hiding places from the children’s perspective, with a special focus on place-making. To accomplish this, a literature review was undertaken and findings combined with data from two previously conducted studies using qualitative content analysis. From the analysis three categories were developed describing the making of secret hiding places, the purpose of secret hiding places, and play occupations that children do in secret hiding places. The findings suggest that place-making can be seen as an occupation of childhood, related to the physical construction of the secret hiding place itself and the formation of attachment to the place through occupations that are shaped by social interactions and result in meaningful experiences.aheadofprintaheadofprin

Opening Session

Chancellor Motley Jessica Cicchino – Insurance Institute for Highway Safety, National crash trends Jeanne Hathaway – MA DPH Injury Prevention Epidemiologist, MA context Beth Dugan – UMass Boston, Fatal Accidents in MA involving drivers age 65+; Summit aim

Family life and autistic children with sensory processing differences: A qualitative evidence synthesis of occupational participation

Autistic children with sensory processing differences successfully navigate and engage in meaningful family daily occupations within home and community environments through the support of their family. To date however, much of the research on autistic children with sensory processing differences, has primarily been deficit focused, while much of the caregiver research has focused on issues of distress, burden, effort, and emotional trauma in coping with their child's diagnosis. This study aimed to conduct a qualitative evidence synthesis, using a meta-ethnographic approach to explore the gap identified in understanding successful occupational experiences of family participation and daily family routines when supporting an autistic child with sensory processing differences and to offer an alternative strengths-based perspective. Inclusion criteria were studies which were peer-reviewed qualitative design, published from 2000 to 2021, and that concerned parents/caregivers' perspectives of family occupations of children diagnosed with autism spectrum disorder. Studies were electronically searched in eight databases from October to December 2021 and 23 studies were identified which met the inclusion criteria. Noblit and Hare's seven step approach for conducting analysis in meta-ethnography was used, and three themes identified: (1) sensory processing differences in daily life, (2) what is hard about hard, and (3) orchestrating family life. Results identified the centrality of sensory experiences in understanding family life. Living with unpredictability while orchestrating certainty through routines was core to successful participation. This review provides insights into how parents negotiate the complexities of constructing family life when living with an autistic child. The results can inform the design of future interventions that specifically address the relationship between meaningful participation in family occupations and daily routines and sensory processing in autistic children

4S-Hydroxylation of insulin at ProB28 accelerates hexamer dissociation and delays fibrillation

Daily injections of insulin provide lifesaving benefits to millions of diabetics. But currently available prandial insulins are suboptimal: The onset of action is delayed by slow dissociation of the insulin hexamer in the subcutaneous space, and insulin forms amyloid fibrils upon storage in solution. Here we show, through the use of non-canonical amino acid mutagenesis, that replacement of the proline residue at position 28 of the insulin B-chain (ProB28) by (4S)-hydroxyproline (Hzp) yields an active form of insulin that dissociates more rapidly, and fibrillates more slowly, than the wild-type protein. Crystal structures of dimeric and hexameric insulin preparations suggest that a hydrogen bond between the hydroxyl group of Hzp and a backbone amide carbonyl positioned across the dimer interface may be responsible for the altered behavior. The effects of hydroxylation are stereospecific; replacement of ProB28 by (4R)-hydroxyproline (Hyp) causes little change in the rates of fibrillation and hexamer disassociation. These results demonstrate a new approach that fuses the concepts of medicinal chemistry and protein design, and paves the way to further engineering of insulin and other therapeutic proteins