54 research outputs found
Assessment of Skeletal Muscle Contractile Properties by Radial Displacement: The Case for Tensiomyography
- Author
- A Benítez Jiménez
- A Vanezis
- AM Hunter
- AM Murray
- Angus M. Hunter
- AR Ng
- B Dadebo
- B Šimunič
- B Šimunič
- B Šimunič
- B Šimunič
- C Bailey
- C Orizio
- C Orizio
- C Orizio
- C Orizio
- C Raeder
- CF Bolton
- Claudio Orizio
- D Barry
- D Krizaj
- D Morgan
- D Rodríguez-Matoso
- D Rodríguez-Matoso
- D Rodríguez-Ruiz
- D Rodríguez-Ruiz
- D Rodríguez-Ruiz
- D Zubac
- DT Barry
- E Alentorn-Geli
- E Alentorn-Geli
- E Bichler
- E Rey
- F Mandrile
- H Burger
- H-J Menzel
- HV Wilson
- I Loturco
- I Loturco
- J Morin
- J Olbrecht
- J Tous-Fajardo
- J Zavrsnik
- J-L Croisier
- J-L Croisier
- JM García-Manso
- JM García-Manso
- JM García-Manso
- JM Squire
- JV Frangioni
- K Kersevan
- K Koren
- KE Wilk
- L Brody
- L Carrasco
- L Luciani
- L Seidl
- LD Rusu
- Lewis J. Macgregor
- LJ Macgregor
- M Ariano
- M Ditroilo
- M Ditroilo
- M Gobbo
- M Marchetti
- M Petitjean
- Malcolm M. Fairweather
- Massimiliano Ditroilo
- MO Ibitoye
- N Giovanelli
- N Maeda
- N Shima
- ND Reeves
- NP Whitehead
- O García-García
- O García-García
- O García-García
- O García-García
- O García-García
- P Alvarez-Diaz
- P Kaczmarek
- P Madeleine
- P Madeleine
- PS Dias
- R Baskin
- R Dahmane
- R Dahmane
- R Dahmane
- R Margaria
- R Pišot
- R Pišot
- R Trivers
- RA Paula Simola de
- RJ Petrella
- RÁ Paula Simola de
- S Calvo
- S Gil
- S Regina Dias Da Silva
- SL Halson
- T Kardel
- T Reilly
- T Sugiyama
- T Wiewelhove
- T Wiewelhove
- T Zagar
- TK Evetovich
- V Valenčič
- V Valenčič
- Y Yoshitake
- Y Yoshitake
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Skeletal muscle operates as a near-constant volume system; as such muscle shortening during contraction is transversely linked to radial deformation. Therefore, to assess contractile properties of skeletal muscle, radial displacement can be evoked and measured. Mechanomyography measures muscle radial displacement and during the last 20 years, tensiomyography has become the most commonly used and widely reported technique among the various methodologies of mechanomyography. Tensiomyography has been demonstrated to reliably measure peak radial displacement during evoked muscle twitch, as well as muscle twitch speed. A number of parameters can be extracted from the tensiomyography displacement/time curve and the most commonly used and reliable appear to be peak radial displacement and contraction time. The latter has been described as a valid non-invasive means of characterising skeletal muscle, based on fibre-type composition. Over recent years, applications of tensiomyography measurement within sport and exercise have appeared, with applications relating to injury, recovery and performance. Within the present review, we evaluate the perceived strengths and weaknesses of tensiomyography with regard to its efficacy within applied sports medicine settings. We also highlight future tensiomyography areas that require further investigation. Therefore, the purpose of this review is to critically examine the existing evidence surrounding tensiomyography as a tool within the field of sports medicine
The trans-ancestral genomic architecture of glycemic traits
- Author
- Abecasis GR
- Adair LS
- Aguilar-Salinas CA
- Ahluwalia TS
- Alarcon-Riquelme ME
- Amin N
- An P
- Anasanti MD
- Appel EVR
- Arzumanyan Z
- Astrup A
- Aviles-Santa L
- Bakker SJL
- Baldassarre D
- Barroso I
- Becker DM
- Beekman M
- Beilin LJ
- Bergman RN
- Bergmann S
- Bertoni A
- Bielak LF
- Bisgaard H
- Black C
- Blueher M
- Boehm BO
- Boehnke M
- Boerwinkle E
- Bonnelykke K
- Bonnycastle LL
- Boomsma DI
- Bornstein SR
- Bottinger EP
- Boutin TS
- Bowden DW
- Brody JA
- Buchanan TA
- Burtt NP
- Cabrera CP
- Cade BE
- Cai Q
- Campbell A
- Campbell H
- Canouil M
- Caulfield MJ
- Chai JF
- Chai X
- Chambers JC
- Chan KHK
- Chang L-C
- Chang YC
- Chasman DI
- Chen BH
- Chen C-H
- Chen J
- Chen Y-DI
- Cheng C-Y
- Chitrala KN
- Chiu Y-F
- Chu AY
- Claringbould A
- Collins FS
- Corbin LJ
- Correa A
- Cucca F
- de Geus EJC
- de Haan HG
- de Silva HJ
- Dedoussis G
- Dehghan A
- Delgado GE
- Demirkan A
- Du S
- Duan Q
- Dupuis J
- Eiriksdottir G
- Elmstahl S
- Engmann J
- Evans MK
- Farmaki AE
- Fatumo SA
- Ferrannini E
- Ferrucci L
- Florez JC
- Franberg M
- Franks PW
- Frayling TM
- Froguel P
- Fuchsberger C
- Gao Y
- Gayan J
- Gigante B
- Giulianini F
- Gjesing AP
- Gloyn AL
- Goel A
- Gong JH
- Goodarzi MO
- Gordon-Larsen P
- Grallert H
- Grarup N
- Grimsgaard S
- Groop L
- Gudnason V
- Guo X
- Gustafsson S
- Hai Y
- Hamsten A
- Han S
- Hansen T
- Hartman CA
- Hartwig FP
- Hayward C
- He J
- Heckbert SR
- Heianza Y
- Heikkinen J
- Herder C
- Hicks AA
- Hong J
- Horikoshi M
- Horta BL
- Hottenga J-J
- Hsieh C-H
- Hsueh WA
- Huang T
- Huang W
- Huerta-Chagoya A
- Huo S
- Hwang MY
- Ichihara S
- Igase M
- Ikram MA
- Ingelsson E
- James PS
- Jarvelin M-R
- Jensen RA
- Johnson WC
- Jonas JB
- Jorgensen ME
- Joshi PK
- Jukema JW
- Kaakinen MA
- Kaleebu P
- Kalyani RR
- Kandeel FR
- Kaplan R
- Kardia SLR
- Kato N
- Katsuya T
- Kawaguchi T
- Keinanen-Kiukaanniemi SM
- Kentistou KA
- Khor CC
- Kiess W
- Kim B-J
- Kim YJ
- Kivimaki M
- Kleber ME
- Koerner A
- Koistinen HA
- Kolcic I
- Kooner IK
- Kooner JS
- Kovacs P
- Kuh D
- Kumari M
- Kutalik Z
- Kuulasmaa T
- Kuusisto J
- Laakso M
- Lai S
- Lakka TA
- Lall K
- Lam K
- Lange LA
- Langefeld CD
- Langenberg C
- Launer LJ
- Lauzon M
- Lawlor DA
- Leander K
- Lee NR
- Lemaitre RN
- Leong A
- Li H
- Li H
- Li M
- Li-Gao R
- Ligthart S
- Lin S-Y
- Lin X
- Lind L
- Lindgren C
- Lindstrom J
- Linneberg A
- Liu C-T
- Liu J
- Liu J
- Liu S
- Loh M
- Long J
- Loos RJF
- Lorenzo C
- Louie T
- Luan J
- Lyssenko V
- Maerz W
- Magi R
- Magnusson PKE
- Mahajan A
- Mangino M
- Marenne G
- Marzi C
- Matsubara T
- Matsuda F
- McCarthy MI
- Meigs JB
- Metspalu A
- Mingrone G
- Mohlke KL
- Montasser ME
- Mooijaart S
- Mook-Kanamori DO
- Moon S
- Moreno-Macias H
- Mori TA
- Morris AP
- Munroe PB
- Nabika T
- Nadkarni GN
- Nadler JL
- Nag A
- Nakatochi M
- Ndungu A
- Nelis M
- Nelson SC
- Neville MJ
- Njolstad I
- Noce D
- Nolte IM
- Noordam R
- Norris JM
- North KE
- O'Connell JR
- Ohyagi Y
- Oldehinkel AJ
- Ong KK
- Padmanabhan S
- Palmer CNA
- Palmer ND
- Parker SCJ
- Pedersen O
- Pennell CE
- Peters A
- Peyser PA
- Pistis G
- Polasek O
- Porteous DJ
- Pramstaller PP
- Preuss M
- Prokopenko I
- Province MA
- Psaty BM
- Qi L
- Qi Q
- Raffel LJ
- Raffield L
- Rasmussen-Torvik LJ
- Raulerson CK
- Rauramaa R
- Raven D
- Ray D
- Redline S
- Reilly DF
- Reiner A
- Rich SS
- Ridker PM
- Rivideneira F
- Robertson NR
- Rohde R
- Roll K
- Rosendaal FR
- Rotter JI
- Rudan I
- Rueedi R
- Ryan K
- Rybin D
- Saaristo TE
- Sabanayagam C
- Sandhu M
- Sandow K
- Sanna S
- Saramies J
- Sattar N
- Saxena R
- Schneiderman N
- Schraut KE
- Schuermann A
- Schurmann C
- Schwarz P
- Scott LJ
- Scott RA
- Selvin E
- Sennblad B
- Setoh K
- Sever P
- Shi J
- Shu X-O
- Sim X
- Slagboom PE
- Small KS
- Smith AV
- Smith BH
- Snieder H
- Sofer T
- Sorensen TIA
- Southam L
- Sparso T
- Spector TD
- Spracklen CN
- Stanton A
- Steves CJ
- Stewart ID
- Strawbridge RJ
- Stringham HM
- Stumvoll M
- Sun L
- Tabara Y
- Tai ES
- Takeuchi F
- Tan J
- Taylor KD
- Teslovich TM
- Thuesen B
- Timmers PRHJ
- Timpson NJ
- Tonjes A
- Tremoli E
- Trompet S
- Tsai MY
- Tuomilehto J
- Tusie T
- Uitterlinden A
- Uusitupa M
- van Dam RM
- van den Akker E
- van der Harst P
- van der Most PJ
- van Duijn C
- van Heemst D
- van Hylckama Vlieg A
- van Vliet-Ostaptchouk JV
- Vangipurapu J
- Varshney A
- Verweij N
- Vestergaard H
- Vitart V
- Vogel M
- Vollenweider P
- Vrijkotte TGM
- Waage J
- Wagenknecht LE
- Walker M
- Wang C
- Wang CA
- Wang H
- Wang N
- Wang T
- Wang Y
- Wang YX
- Wareham NJ
- Warren HR
- Watanabe RM
- Watkins H
- Wei WB
- Wen W
- Wheeler E
- Wickremasinghe AR
- Willems van Dijk K
- Willems SM
- Willemsen G
- Wilsgaard T
- Wilson JF
- Wong A
- Wong T-Y
- Wood AR
- Wu J-Y
- Wu P
- Wu Y
- Xiang AH
- Xie T
- Yanek LR
- Yao J
- Yengo L
- Yokota M
- Zafarmand MH
- Zeggini E
- Zemunik T
- Zhang W
- Zhang X
- Zhao J-H
- Zhao W
- Zheng W
- Zonderman AB
- Publication venue
- 'Nature Research Society'
- Publication date
- 31/05/2021
- Field of study
Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-analyses identified 242 loci (99 novel; P < 5 × 10−8), 80% of which had no significant evidence of between-ancestry heterogeneity. Analyses restricted to individuals of European ancestry with equivalent sample size would have led to 24 fewer new loci. Compared with single-ancestry analyses, equivalent-sized trans-ancestry fine-mapping reduced the number of estimated variants in 99% credible sets by a median of 37.5%. Genomic-feature, gene-expression and gene-set analyses revealed distinct biological signatures for each trait, highlighting different underlying biological pathways. Our results increase our understanding of diabetes pathophysiology by using trans-ancestry studies for improved power and resolution
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
- Abdelmonem SA
- Abdo WF
- Abellan AN
- Abellán AN
- Abellán AN
- Abellán AN
- Abrams ST
- Ackerley C
- Acuña M
- Adda M
- Adhikari NK
- Adriano G
- Adrie C
- Affatato R
- Affatato R
- Afonso-Rivero D
- Agarossi A
- Agarwal LK
- Ageeva T
- Agrawal R
- Aguayo-DeHoyos E
- Aguilar AL
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguirregabyria M
- Ahmadnia E
- Ahn C
- Ahn JY
- Ahn JY
- Ahn MY
- Ahn MY
- Aitken LM
- Akalaev R
- Akbarzadeh A
- Akcan-Arikan A
- Akhlagh SH
- Akhtar N
- AKI Research Group
- Akiduki N
- Akin S
- Akizuki N
- Akkoc T
- Ala-Kokko T
- Alanio A
- Albaiceta GM
- Albaladejo P
- Alberto F
- Albuisson E
- Alcala MA
- Alcázar L
- Aldabo-Pallas T
- Aldana NN
- Aldecoa C
- Alegría L
- Alejandro R
- Alejo GC
- Alejos RM
- Alexandrova E
- Algarte R
- Algarte R
- Algieri I
- Algora-Weber A
- Alhamdi Y
- Aliaga FA
- Aliberti S
- Alkan A
- Almudena PM
- Almudevar PM
- Almudevar PM
- Almudévar PM
- Altıntas ND
- Alvarez J
- Alves SC
- Alzola LM
- Amargianitakis V
- Amaro R
- Amato MB
- Ambler M
- Amerongen MP
- Amininejad T
- Amor LL
- Amorim V
- Anand RK
- Andersen LW
- Andersson S
- Andoh K
- Andrade AH
- Andrade AH
- Andrade AH
- Andrade G
- Andreis DT
- Andreis DT
- Annane D
- Antonelli M
- Antoniadou A
- Antonio C
- Antonucci E
- Antón DG
- Anzueto A
- Appiani F
- Aquevedo A
- Aragon C
- Araujo NJ
- Araujo VF
- ARIAM registry of adult cardiac surgery
- ARIAM-ANDALUCIA
- Arias CC
- Arias N
- Arias-Verdu MD
- Arias-Verdu MD
- Arias-Verdu MD
- Armaganidis A
- Arora MK
- Arora N
- Arrigo M
- Arslantas MK
- Artiguenave M
- Aslanian P
- Aspide R
- Asyralyyeva G
- Ataman S
- Ataman S
- Atchade E
- Atchade E
- Atchasiri S
- Athapattu P
- Atkins G
- Aublanc M
- Aublanc M
- Augustin P
- Augustin P
- Auquier P
- Avilés-Jurado FX
- Avramidis V
- Ayala LY
- Aydin M
- Azevedo JC
- Azevedo JR
- Aznar GP
- Babalis D
- Babini G
- Bachli EB
- Bader A
- Bader A
- Baena J
- Baidya DK
- Baikova VN
- Bakker J
- Balcázar LC
- Balcázar LC
- Baldassarri R
- Baldwin CE
- Balik M
- Ball I
- Ballin A
- Balsera B
- Banderas-Bravo ME
- Banderas-Bravo ME
- Bandert A
- Bangstad IL
- Baptista N
- Baquero JD
- Barbadillo S
- Barberet G
- Barberet G
- Barberet G
- Barbier J
- Barcenilla F
- Barea-Mendoza JA
- Barinas OD
- Baron AV
- Barrachina LG
- Barral M
- Basile-Filho A
- Bassi GL
- Bates D
- Battistini M
- Bauer M
- Bauer PR
- Baumstarck K
- Baumstarck K
- Bawin M
- Bazan N
- Bañeras J
- Beane A
- Beduneau G
- Beduneau G
- Beduneau G
- Beeharry SD
- Beerepoot M
- Begzjav T
- Beishuizen A
- Bell C
- Belletti A
- Bellissimo-Rodrigues F
- Belloli A
- Bellomo R
- Bellver BQ
- Belmonte R
- Ben-Hamouda N
- Bendel S
- Bendel S
- Benyamina M
- Beretta S
- Berg R
- Bergantino B
- Berghmans J
- Bernal FF
- Berric A
- Berrutti D
- Berthelsen RE
- Bertini P
- Bertini P
- Berto MB
- Besevli SG
- Bestle MH
- Bettex D
- Bettex DA
- Beunders R
- Bhasin D
- Bhattal MK
- Bhide S
- Bianchi I
- Bianchi I
- Bianzina S
- Bianzina S
- Bianzina S
- Bishop J
- Bissenova N
- Bisso MC
- Blans MJ
- Blobner M
- Bloomer MJ
- Blot K
- Blot S
- Blot S
- Boa F
- Bobi Q
- Bodingbauer M
- Bodí M
- Boer C
- Bogossian E
- Bonet S
- Bonn M
- Bonnet M
- Borges FK
- Bouadma L
- Boucekine M
- Bougouin W
- Bourenne J
- Boyd JG
- Boyd JG
- Bozbay S
- Bozza F
- Bradac O
- Brandon RA
- Brandon RB
- Braschi A
- Braschi A
- Braschi A
- Brasseur A
- Brasseur A
- Brasseur A
- Braune S
- Brazzi L
- Breitkreutz R
- Brianti R
- Brioni M
- Brochard L
- Brochard L
- Brochard L
- Brock N
- Brody DL
- Brook R
- Brousseau C
- Brown K
- Brugger SC
- Brugger SC
- Bruno F
- Bruno K
- Brusasco C
- Brusasco C
- Brusasco C
- Bruyere O
- Bucknall T
- Buddi S
- Buise M
- Buitinck SH
- Buranavanich P
- Bureau C
- Burle JF
- Burtin P
- Busico M
- Butler MB
- Butrov AV
- Caballero CH
- Caballero J
- Cabello JT
- Cabello JT
- Cabrera AR
- Cabrera JL
- Cabrera JL
- Cabrini L
- Cairus C
- Cakin O
- Caliskan K
- Calpe P
- Calvo CP
- Calvo SA
- Camargo M
- Cambronero JA
- Cameron C
- Campbell R
- Campelo FA
- Campelo FA
- Campos LM
- Cannesson M
- CAPCRI Study
- Capellier G
- Carbonara M
- Cardellino S
- Cardenas CL
- Cariou A
- Cariou A
- Carlesso E
- Carmona AF
- Carmona SA
- Carmona SA
- Carmona SA
- Carmona SA
- Carone M
- Carpio D
- Carratalá A
- Carreira MM
- Carrero-Gómez F
- Carreño ER
- Carreño R
- Carvalho JP
- Carvalho KV
- Casals XN
- Casals XN
- Cassina T
- Castañeda DP
- Castellana D
- Castellanos A
- Castellanos A
- Castillo-Lorente E
- Castillo-Lorente E
- Catalan M
- Catalán RM
- Catena E
- Catena E
- Cauwenberghs H
- Cavalcanti D
- Cavalheiro AM
- Cavalier E
- Cavicchi FZ
- Cavicchi FZ
- Cengiz M
- Ceriani R
- Cermelli S
- Cerović O
- Cha YS
- Chabanne R
- Chacon-Alves S
- Champigneulle B
- Champigneulle B
- Chan KC
- Chan KK
- Chan WS
- Chang CH
- Chang WY
- Chao A
- Chao A
- Chao AS
- Chao HC
- Chaouat M
- Charitidou E
- Charpentier C
- Charpentier J
- Charron C
- Chatelon J
- Chaudhari HK
- Chaussard M
- Chavanon O
- Chaves S
- Chelly J
- Chemam S
- Chen CM
- Chen CM
- Chen CW
- Chen CW
- Chen GQ
- Chen L
- Chen YS
- Chen YS
- Chen YS
- Cheng CC
- Cheng CC
- Cheng CC
- Cheng CC
- Cheng KC
- Cheng YJ
- Chernyshuk S
- Chevret S
- Chhor V
- Chiang CC
- Chiang CH
- Chiang CH
- Chiang CH
- Chiappa C
- Chiou KR
- Chiou KR
- Chiou KR
- Chiu LC
- Chiumello D
- Chiurazzi C
- Chiurazzi C
- Cho Y
- Cho YJ
- Cho YJ
- Choi JY
- Choi JY
- Choi KS
- Choi S
- Choi YJ
- Choi YY
- Chok L
- Cholkraisuwat J
- Cholley B
- Chondropoulos S
- Chou W
- Chouris I
- Chouvarda I
- Christopher KB
- Chrétien JM
- Chrétien JM
- Chrétien JM
- Chumaev A
- Chung CR
- Churchill K
- Chytas A
- Cinel I
- Cinnella G
- Citerio G
- Citerio G
- Clavel M
- Clemente EA
- Clermont G
- Cleyet M
- Cohen Y
- Colaprico A
- Colino L
- Collange O
- Colombo A
- Colombo A
- Colson P
- Combes A
- Concha P
- Connolly B
- Constan A
- Constan A
- Constan A
- Conte V
- Conti G
- Conti G
- Contreras KM
- Contreras MR
- Cook DJ
- Coombs M
- Cordeiro CP
- Cordero M
- Cordolcini V
- Cordovilla-Guardia S
- Cordón J
- Corona A
- Corona A
- Corradi F
- Corradi F
- Corradi F
- Correa-Chamorro E
- Corte FD
- Cortes ML
- Corzo L
- Coss-Bu JA
- Coss-Bu JA
- Costa MI
- Costa RC
- Costa RC
- Costa RC
- Costanzo E
- Cotoia A
- Cottini SR
- Cottle D
- Cotton H
- Cotton H
- Courant P
- Cowan R
- Creagh-Brown B
- Cressoni M
- Creteur J
- Creteur J
- Creteur J
- Creteur J
- Creteur J
- Creteur J
- Creteur J
- Creteur J
- Crimella F
- Cron N
- Cuellar AI
- Cui N
- Cunha MM
- Curiel-Balsera E
- Curiel-Balsera E
- Curinga M
- Curtis A
- Cuthbertson BH
- Cutuli SL
- Câmara M
- D'Arsigny C
- da Silva SL
- da Silva VZ
- Daga-Ruiz D
- Dalhuisen A
- Dalorzo M
- Damas P
- Dambrosio M
- Damås JK
- Das Neves A
- David H
- Davis C
- Davis P
- Day A
- de Abreu MG
- De Backer A
- De Brito-Ashurst I
- De Cassai A
- De Freitas FF
- De Gasperi A
- de Hoyos EA
- De la Calle-Pedrosa N
- de la Fuente MV
- De La Fuente-Martos C
- De La Fuente-Martos C
- De La Rica AS
- De la Torre MA
- De Maglie M
- De Maglie M
- de Molina FJ
- De Morton N
- de Oca Sandoval MA
- De Pascale G
- De Rosa S
- De Sanctis F
- De Silva AP
- De Sousa I
- de Vera AP
- de Wilde W
- De Zani D
- Deblier I
- DeBrunnar R
- Del Arco A
- Del Moral OL
- Del Olmo R
- Del Rosario CG
- Del Sorbo L
- Delgado CP
- Delgado MJ
- Delgado-Amaya M
- Demirkiran O
- Demoule A
- Denehy L
- Der Kinderen EP
- Descotte E
- Deshpande K
- Desmard M
- Desmard M
- Deveugele M
- Deye N
- Di Bello F
- Di Giancamillo M
- Di Gravio V
- Di Gregorio A
- Di Mussi R
- Di Rosso R
- Diaz DD
- Diaz P
- Dilek M
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- Dimopoulou IK
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- Engelberts D
- ENVIN-HELICS Study Group
- Erb J
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- Escórcio S
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- Espinasse F
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- Estella A
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- Fernández IF
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- Fernández-Mondéjar E
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- Filipe E
- FINNRESUSCI Study Group
- Fischer G
- Fleischmann E
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- Fromentin M
- Frontera PR
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- García-Martínez MV
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- Gavrychenko D
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- GETGAG Working Group
- GETGAG/SEMICYUC
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- Giesinger RE
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- Hernández A
- Hernández AA
- Hernández AA
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- Hernández-Tejedor A
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- Hualde JB
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- Hualde JB
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- Huang WC
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- Huber W
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- Hung CY
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- Hutchings S
- Hutchison R
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- Hwang GS
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- Ibsen M
- Idei M
- Idei M
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- Iglesias-Santiago A
- Ignacio ML
- Iida A
- Iijima H
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- Ilyina V
- Imanaka H
- Inaloo S
- Ince C
- Iotti GA
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- IPREA Study Group
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- Itenov TS
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- Jang BH
- Janotka M
- Janotka M
- Janotka M
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- Jansen N
- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
- Jardim JJ
- Jardim M
- Jareño A
- Javadpour S
- Jayasinghe S
- Jean-Baptiste S
- Jean-Baptiste S
- Jensen AE
- Jensen JU
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- Jeong IY
- Jeong WY
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- Jimenez-Herrera MF
- Jiménez GJ
- Jo YH
- Joachim J
- Jochmans S
- John G
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- Jonas M
- Jonas M
- Jones C
- Joshi R
- Joshi V
- Jovaisa T
- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
- Juan WC
- Juanas CA
- Judickas S
- Juez A
- Juliarena A
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- Jun IG
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- Jung KW
- Junior JM
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- Kaminsky GE
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- Kim JM
- Kim JW
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- Kolnikova I
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- Kouatchet A
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- Krishna B
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- Ku NS
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- Kulkarni AP
- Kumari BK
- Kumbamu A
- Kunze-Szikszay N
- Kurmukov IA
- Kurth T
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- Kwon HM
- Kwon WY
- Kwon WY
- Kwon WY
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- Labra C
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- Lafuente E
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- Lagos R
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- Lai CH
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- Lapteva K
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- Latini R
- Latini R
- Latini R
- Latorre J
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- Lattuada M
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- Lavrentieva A
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- Lichtenstein D
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- Lischinsky A
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- Lombardo MD
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- Lopez-Gude MJ
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- Loudet CI
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- MacKay A
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- Maghsoudi B
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- Marcos-Zambrano LJ
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- Martín-Loeches I
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- Martínez L
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- Martínez MP
- Martínez MV
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- Martínez-Carmona JF
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- Menendez R
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- Mercat A
- Mercat A
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- Merino-Vega D
- Messenger D
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- Midwinter MJ
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- Miguelena PR
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- Mora-Ordóñez JM
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- Morán I
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- Okayama Research Investigation Organizing Network (ORION)investigators
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- Yebenes JC
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- Yılmaz G
- Yilmazer F
- Yodice P
- Yokoyama M
- Yonis H
- Yonis H
- Yonis H
- Yoon SZ
- Yoruk F
- Yoshida K
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshihiro S
- Yoshitake E
- You KM
- Youn AM
- Young A
- Yu KM
- Yumoto T
- Yuzawa J
- Yuzawa J
- Zabaletta WJ
- Zabini D
- Zahorec M
- Zaien I
- Zakynthinos S
- Zanello M
- Zani D
- Zarantonello F
- Zayas B
- Zepeda EM
- Zeroual N
- Zerva L
- Zhang J
- Zhou JC
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- Zhovnir V
- Zibandah N
- Zijlstra F
- Zimmerman J
- Zogheib E
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- Zullino V
- Zwaag J
- Zýková I
- Álvarez JT
- Álvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
- Author
- A Abbott
- A Abou-Raya
- A Aljandali
- A Ambesi-Impiombato
- A Aydin
- A Balcerczyk
- A Besarab
- A Brzezinski
- A Campbell
- A Carrillo-Vico
- A Cavalli
- A Chattopadhyay
- A Chattopadhyay
- A Cherubini
- A Dey
- A Doms
- A Donovan
- A Donovan
- A Dávalos
- A Gaeta
- A Garny
- A Gnjec
- A Gomes
- A Gopalakrishnan
- A Hald
- A Henney
- A Hirayama
- A Hoffmann
- A Huber
- A Hugman
- A Iannetti
- A Ide-Ektessabi
- A Jacobs
- A Jeyabalan
- A Kahvejian
- A Karrar
- A Kasztler
- A Kibel
- A Kocyigit
- A Kotha
- A Kumral
- A Lass
- A Lecube
- A Lewén
- A Lotery
- A Maggio
- A Malek
- A Malik
- A Mantovani
- A Matsuzawa
- A Mitra
- A Monge
- A Murakami
- A Murakami
- A Murakami
- A Murakami
- A Mutti
- A Nijnik
- A Nunomura
- A Nunomura
- A Patt
- A Persson
- A Pietrangelo
- A Piga
- A Pirat
- A Post
- A Pradhan
- A Protti
- A Rattner
- A Ravati
- A Rehman
- A Reynolds
- A Richmond
- A Roetto
- A Roetto
- A Rostom
- A Rumbold
- A Russo
- A Rötig
- A Saltelli
- A Saltelli
- A Sandek
- A Sassano
- A Scalbert
- A Scalbert
- A Scalbert
- A Sica
- A Smahi
- A Sola
- A Stintzi
- A Szewczyk
- A Taguchi
- A Tedgui
- A Terman
- A Terman
- A Terman
- A Undas
- A Virdis
- A Wagner
- A Wagner
- A Wagner
- A Wagner
- A Wojas-Pelc
- A Wong
- A Xu
- A Yoritaka
- A Yoshimura
- A-L Barabási
- AA Andreadis
- AA Borisy
- AA Farooqui
- AA Qutub
- AA Qutub
- AA Vlessis
- AB Nathens
- AB Parsons
- AB Parsons
- AB Thompson
- AB Thomson
- AC Bayne
- AC Bharti
- AC Cave
- AC Mello Filho
- AD d'Hardemare
- AD de Silva
- Ad hoc committee on systemic lupus erythematosus response criteria for fatigue
- ADL van der
- AE Aust
- AE Baue
- AE Finefrock
- AE Heazell
- AE Heazell
- AE Kartikasari
- AEC Ihekwaba
- AEC Ihekwaba
- AF Tramontano
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- AH Koeppen
- AH Koeppen
- AH Tong
- AI Bush
- AI Bush
- AI Bush
- AI Bush
- AI Faden
- AJ Ghio
- AJ Ghio
- AJ Ghio
- AJ Hulbert
- AJ Kowaltowski
- AJ Lusis
- AJ Matthews
- AJ Reyes
- AJ van Oostrom
- AJ Watson
- AJ White
- AJ Williams
- AK Junk
- AL Beal
- AL Hemdahl
- AL Hopkins
- AL Hopkins
- AL Lagan
- AL Mark
- AL Sirén
- AL Sirén
- AL Sirén
- AL Takeda
- AM Abeles
- AM Borzychowski
- AM Choi
- AM Dolga
- AM Elneihoum
- AM Elneihoum
- AM Feist
- AM Harvey
- AM Jenkinson
- AM Lin
- AM Samuni
- AM Snyder
- AN Crowson
- AN Tabah
- AP Bolger
- AP Breen
- AP Liappis
- AR Kallianpur
- AR Kallianpur
- AR Martin
- AR Ness
- AR Rechner
- AR Rumbold
- AS Baldwin Jr
- AS Binbrek
- AS Kaprelyants
- AS Wierzbicki
- AT McKie
- AV Lebedev
- AV Perkins
- AV Rao
- AW Maresso
- AY Andreyev
- AY Sun
- B Chakravarti
- B Chance
- B Cronin
- B de Valk
- B De Vries
- B Desoize
- B Drayer
- B Faller
- B Goodell
- B Halliwell
- B Halliwell
- B Halliwell
- B Halliwell
- B Halliwell
- B Halliwell
- B Halliwell
- B Halliwell
- B Huppertz
- B Jayawardhana
- B Kwak
- B Lachili
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- B Mackenzie
- B Marshall
- B Mignotte
- B Oldenburg
- B Poeggeler
- B Pradines
- B Pradines
- B Regland
- B Russell
- B Schiessl
- B Shipley
- B Skibska
- B Sturm
- B Thorand
- B Wang
- B Wolff
- B Wolozin
- B Wolozin
- B Xu
- B Zhang
- B Zhou
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- BM Babior
- BN Ames
- BP Leung
- BP Oberg
- BP Yu
- BR Kwak
- BR Otto
- BS Chen
- BS van Asbeck
- BT Mossman
- BV Naidu
- BY Tung
- BØ Palsson
- C Arnaud
- C Beaumont
- C Behl
- C Biondi
- C Bolin
- C Bozzini
- C Breymann
- C Brooksbank
- C Bubici
- C Bubici
- C Burdon
- C Camaschella
- C Camaschella
- C Caris
- C Cavdar
- C Chen
- C Delaby
- C Demougeot
- C Finch
- C Fleury
- C García-Ruiz
- C Gasche
- C Gasche
- C Gerhäuser
- C Goble
- C Henry
- C Herce-Pagliai
- C Herder
- C Hershko
- C Hershko
- C Hershko
- C Hershko
- C Jacob
- C Kenyon
- C Knox
- C Kretz-Remy
- C Kunsch
- C Köhle
- C Leadbeater
- C Li
- C Lu
- C Manach
- C Manach
- C Manach
- C Mancuso
- C Moon
- C Moon
- C Mouralian
- C Muscoli
- C Peyssonnaux
- C Peyssonnaux
- C Peyssonnaux
- C Pigeon
- C Popa
- C Quintana
- C Ramassamy
- C Ramassamy
- C Ratledge
- C Rigamonti
- C Ritter
- C Ritter
- C Ritter
- C Savino
- C Savoia
- C Savoia
- C Schmeer
- C Shirky
- C Singh
- C Smith
- C Thrasivoulou
- C Trenkwalder
- C Troeger
- C Urbich
- C Vermylen
- C Vélez-Pardo
- C Vélez-Pardo
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- The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group
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- Publication venue
- Publication date
- 09/08/2008
- Field of study
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
A inclusão da perspectiva do paciente na consulta médica: um desafio na formação do médico
- Author
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- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Use of psychoactive substances by adolescents: current panorama
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- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- 01/01/2013
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Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention
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- North KE
- Ohlsson C
- Oldehinkel AJ
- Orho-Melander M
- Pacolet A
- Pare G
- Park T
- Pedersen NL
- Pedersen O
- Penninx BWJH
- Pers TH
- Perusse L
- Peters A
- Peyser PA
- Pillon NJ
- Polasek O
- Pool R
- Power C
- Prokopenko I
- Raitakari OT
- Reedik M
- Reiner AP
- Richmond RC
- Ridker PM
- Rivera NV
- Robiou-Du-Pont S
- Rotimi CN
- Rudan I
- Ryan K
- Samani NJ
- Sarzynski MA
- Schraut KE
- Schulz CA
- Scott LJ
- Scott RA
- Sidney S
- Siggeirsdottir K
- Sim X
- Smith AV
- Smith GD
- Smith JA
- Snieder H
- Sonestedt E
- Sorensen TIA
- Spector TD
- Stringham HM
- Strom M
- Tai ES
- Tanaka T
- Teo KK
- Teumer A
- Thomis MAI
- Thorand B
- Timpson NJ
- Tonjes A
- Tremblay A
- Turman C
- Uitterlinden AG
- Van Dam RM
- Van der Most PJ
- Van der Velde N
- Van Duijn CM
- Van Rooij FJA
- Van Schoor N
- Van Vliet-Ostaptchouk JV
- Vangipurapu J
- Vanmunster M
- Vidal PM
- Volker U
- Vollenweider P
- Volzke H
- Voortman T
- Waeber G
- Wang Z
- Wareham NJ
- Weir DR
- Wichmann HE
- Willemsen G
- Williams K
- Wilson JF
- Wong Q
- Xu HC
- Young KL
- Yuan JM
- Zhang XS
- Zhao JH
- Zhao W
- Zierath JR
- Zillikens MC
- Zonderman AB
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 07/09/2022
- Field of study
Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), leisure screen time (LST) and/or sedentary behavior at work. Loci associated with LST are enriched for genes whose expression in skeletal muscle is altered by resistance training. A missense variant in ACTN3 makes the alpha-actinin-3 filaments more flexible, resulting in lower maximal force in isolated type IIA muscle fibers, and possibly protection from exercise-induced muscle damage. Finally, Mendelian randomization analyses show that beneficial effects of lower LST and higher MVPA on several risk factors and diseases are mediated or confounded by body mass index (BMI). Our results provide insights into physical activity mechanisms and its role in disease prevention.Multi-ancestry meta-analyses of genome-wide association studies for self-reported physical activity during leisure time, leisure screen time, sedentary commuting and sedentary behavior at work identify 99 loci associated with at least one of these traits
Overlapping signals for translational regulation and packaging of influenza A virus segment 2
- Author
- A Buehlmann
- A Faisal
- A Smerieri
- A Treves
- A Treves
- AK Churchland
- AN Burkitt
- B Knight
- C Brody
- CE Shannon
- D Beamish
- D Marti
- DJ Amit
- DJ Amit
- E Nordlie
- Edmund T. Rolls
- ET Rolls
- ET Rolls
- ET Rolls
- ET Rolls
- ET Rolls
- ET Rolls
- ET Rolls
- ET Rolls
- ET Rolls
- ET Rolls
- ET Rolls
- ET Rolls
- ET Rolls
- ET Rolls
- ET Rolls
- ET Rolls
- ET Rolls
- ET Rolls
- ET Rolls
- ET Rolls
- ET Rolls
- G Deco
- G Deco
- G Deco
- GG de Polavieja
- GN Elston
- Gustavo Deco
- J Hertz
- Jianfeng Feng
- JJ Hopfield
- JV Verhagen
- L Albantakis
- L Franco
- M Abeles
- M Furman
- M Kadohisa
- M Kadohisa
- M Loh
- M Loh
- N Brunel
- P Miller
- R Ratcliff
- R Ratcliff
- RJ Baddeley
- S Panzeri
- S Panzeri
- Tristan J. Webb
- V Braitenberg
- Wael El-Deredy
- WB Levy
- WR Softky
- XJ Wang
- XJ Wang
- YH Liu
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2011
- Field of study
Influenza A virus segment 2 mRNA expresses three
polypeptides: PB1, PB1-F2 and PB1-N40, from AUGs
1, 4 and 5 respectively. Two short open reading
frames (sORFs) initiated by AUGs 2 and 3 are also
present. To understand translational regulation in
this system, we systematically mutated AUGs 1–4
and monitored polypeptide synthesis from
plasmids and recombinant viruses. This identified
sORF2 as a key regulatory element with opposing
effects on PB1-F2 and PB1-N40 expression. We
propose a model in which AUGs 1–4 are accessed
by leaky ribosomal scanning, with sORF2 repressing
synthesis of downstream PB1-F2. However, sORF2
also up-regulates PB1-N40 expression, most likely
by a reinitiation mechanism that permits skipping of
AUG4. Surprisingly, we also found that in contrast to
plasmid-driven expression, viruses with improved
AUG1 initiation contexts produced less PB1 in
infected cells and replicated poorly, producing
virions with elevated particle:PFU ratios. Analysis
of the genome content of virus particles showed
reduced packaging of the mutant segment
2 vRNAs. Overall, we conclude that segment
2 mRNA translation is regulated by a combination
of leaky ribosomal scanning and reinitiation, and
that the sequences surrounding the PB1 AUG
codon are multifunctional, containing overlapping
signals for translation initiation and for segmentspecific
packaging
Probability and the Way Out of the Great Quantum Muddle
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1988
- Field of study
Efetividade dos exercícios em cadeia cinética aberta e cadeia cinética fechada no tratamento da síndrome da dor femoropatelar
- Author
- Alberto Cliquet Junior
- Araujo RC
- Bennell K
- Bennett JG
- Brody LT
- Cerny K.
- Crossley K
- Cyrino ES
- De Luca CJ
- Doucette AS
- Escamilla RF
- Guilherme Lotierso Fehr
- Hanten WP
- João Batista de Miranda
- JV Basmajian
- Karst GM
- Kujala UM
- Lam PL
- Lieb FJ
- Merletti R
- Owings TM
- Powers CM
- Powers CM
- Sheehy P
- Souza DR
- Steinkamp LA
- Stiene HA
- Turker KS.
- Wilk KE
- Wilk KE
- Witvrouw E
- Witvrouw E
- Ênio Walker Azevedo Cacho
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
- …